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Recent Progress in Carbon-based Materials of Non-Noble Metal Catalysts for ORR in Acidic Environment

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Acta Metallurgica Sinica(English Letters) 2021年第7期34卷 885-899页

作者： Jie Lian Jin-Yu Zhao xiao-min wang College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of New Energy Materials and Devices Taiyuan University of TechnologyTaiyuan 030024China

Proton exchange membrane fuel cell(PEMFC)has important implications for the success of clean transportation in the *** of the key factors affecting the cost and performance of PEMFC is the cathode electrocatalyst for the oxygen reduction reaction(ORR)to overcome sluggish kinetics and instability in an acidic *** an essential component of the electrocatalyst,the support material largely determines the activity,mass transfer,charge transfer,and durability of the ***,the support material plays a critical role in the overall performance of the *** materials are widely used as electrocatalyst supports because of their high porosity,conductivity,chemical stability,and tunable ***,some new carbon-based materials with excellent structure have been introduced,such as carbon nanotubes,carbon nanowires,graphene,metal-organic framework(MOF)-derived carbon,and biomass-derived carbon *** with a variety of strategies,such as controllable construction of porous structures and surface defects,proper doping heteroatoms,the ingenious design of model electrocatalysts,and predictive theoretical calculation,a new reliable path was provided for further improving the performance of electrocatalysts and exploring the catalytic *** on the topic of carbon-based materials for ORR in acidic medium,this review summarizes the up-to-date progress and breakthroughs,highlights the factors affecting the catalytic activity and stability of ORR electrocatalysts in acids,and discusses their future application and development.

关键词： Carbon-based materials Non-noble metal electrocatalysts Acidic environment Oxygen reduction reaction Proton exchange membrane fuel cell

Geometric Phases Corrected by Stochastic Dephasing

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Communications in Theoretical Physics 2008年第5期49卷 1179-1181页

作者： MA xiao-San wang An-min Department of Modern Physics University of Science and Technology of China Hefei 230026 China

We analyze the effect of stochastic dephasing on geometric phases. The result implies that the correction of geometric phases relies on not only the fluctuation of the random variable in the stochastic process, but al... 详细信息

关键词： stochastic dephasing geometric phase

Difference in gene expression of macrophage between normal spleen and portal hypertensive spleen idendified by cDNA microarray

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World Journal of Gastroenterology 2007年第24期13卷 3369-3373页

作者： Feng Yan xiao-min wang Postdoctoral Station Department of Hepato-Biliary Surgery Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China Department of Hepato-Biliary Surgery Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

AIM: To identify the difference in gene expression of microphage (Mφ) between normal spleen and portal hypertensive spleen using cDNA microarrays and find new gene functions associated with hypersplenism in portal hypertension. METHODS: The Biostar-H140s chip containing 14 112 spots of cDNAs were used to investigate the difference of the expression. The total RNA extracted from macrophages isolated from both normal spleen and portal hypertensive spleen was reversely transcribed to cDNA with the incorporation of fluorescent (cy3 and cy5) labeled dCTP to prepare the hybridization probes. After hybridization, the gene chip was scanned for the fluorescent intensity. The differentially expressed genes were screened. That was repeated three times, and only the genes which had differential expression in all three chips were considered to be associated with hypersplenism in portal hypertension. RESULTS: Eight hundred and ninety-six, 1330 and 898 genes were identified to be differentially expressed in three chips, respectively. One hundred and twenty-one genes (0.86%) were identified to be differentially expressed in all three chips, including 21 up-regulated genes and 73 down-regulated genes. The differentially expressed genes were related to ionic channel and transport protein, cyclin, cytoskeleton, cell receptor, cell signal conduct, metabolism, immune, and so on. These genes might be related to the hypersplenism in portal ***: The investigations based on cDNA microarray can screen differentially expressed genes of macrophages between normal spleen and portal hypertensive spleen, thus may provide a new idea in studying the pathogenesis of hypersplenism in portal hypertension.

关键词： Hypersplenism Macrophage cDNA microarray

Breathers and solitons for the coupled nonlinear Schrodinger system in three-spine α-helical protein

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Chinese Physics B 2021年第10期30卷 231-238页

作者： xiao-min wang Peng-Fei Li Department of Physics Taiyuan Normal UniversityJinzhong 030619China Institute of Computational and Applied Physics Taiyuan Normal UniversityJinzhong 030619China

We mainly investigate the variable-coefficient 3-coupled nonlinear Schrodinger(NLS)system,which describes soli- ton dynamics in the three-spineα-helical protein with inhomogeneous *** variable-coefficient NLS equation is transformed into the constant coefficient NLS equation by similarity transformation *** Hirota method is used to solve the constant coefficient NLS equation,and then we get the one-and two-breather solutions of the variable-coefficient NLS *** results show that,in the background of plane waves and periodic waves,the breather can be transformed into some forms of combined soliton *** influence of different parameters on the soliton solution and the collision between two solitons are discussed by some graphs in *** results are helpful to study the soliton dynamics inα-helical protein.

关键词： breather soliton nonlinear Schrodinger system a-helical protein

Three-Di mensional Model for Strip Hot Rolling

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Journal of Iron and Steel Research International 2006年第1期13卷 23-26页

作者： ZHANG Guo-min xiao Hong wang Chun-hua Engineering College Yanshan University Qinhuangdao 066004 Hebei China

A three-dimensional model for strip hot rolling was developed, in which the plastic deformation of strip, the thermal crown of rolls, roll deflection and flattening were calculated by rigid-plastic finite element method, finite difference method, influential function method and elastic finite element method respectively. The roll wear was taken into consideration. The model can provide detailed information such as rolling pressure distribution, contact pressure distribution between backup rolls and work rolls, deflection and flattening of work rolls, lateral distribution of strip thickness, and lateral distribution of front and back tensions. The finish rolling on a 1 450 mm hot strip mill was simulated.

关键词： strip hot rolling model finite difference method influential function method finite element method

Down-regulation of extracellular signal-regulated kinase 1/2 activity in P-glycoprotein-mediated multidrug resistant hepatocellular carcinoma cells

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World Journal of Gastroenterology 2009年第12期15卷 1443-1451页

作者： Feng Yan xiao-min wang Chao Pan Quan-ming Ma Department of Hepatobiliary Surgery Postdoctoral Station Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China Department of Hepatobiliary Surgery Digestive Diseases Institute Xiamen University Xiamen 361004 Fujian Province China Department of Pathology Zhongshan HospitalXiamen university Xiamen 361004 Fujian Province China Department of Hepatobiliary Surgery Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

AIM： To study the expression and phosphorylation of extracellular signal-regulated kinase （ERK） i and ERK2 in multidrug resistant （MDR） hepatocellular carcinoma （HCC） cells.METHODS： MDR HCC cell lines, HepG2/adriamycin （ADM） and SMMC7721/ADM, were developed by exposing parental cells to stepwise increasing concentrations of ADM. MTT assay was used to determine drug sensitivity. Flow cytometry was employed to analyze cell cycle distribution and measure cell P-glycoprotein （P-gp） and multidrug resistant protein 1 （MRP1） expression levels. ERK1 and ERK2 mRNA expression lev-ls were measured by quantitative real-time PCR （QRTPCR）. Expression and phosphorylation of ERK1 and ERK2 were analyzed by Western blot.RESULTS： MTT assay showed that HepG2/ADM andSMMC7721/ADM were resistant not only to ADM, but also to multiple anticancer drugs. The P-gp expression was over 10-fold higher in HepG2/ADM cells than in HepG2 cells （8.92% ±0.22% vs 0.88% ± 0.05%, P 〈 0.001） and over 4-fold higher in SMMC7721/ADM cells than in SMMC7721 cells （7.37% ± 0.26% vs 1.74% ± 0.25%, P 〈 0.001）. However, the MRP1 expression was not significantly higher in HepG2/ADM and SMMC7721/ADM cells than in parental cells. In addition, the percentage of MDR HepG2/ADM and SMMC7721/ADM cells was significantly decreased in the G0/G1 phase and increased in the the S phase or G2/M phase. QRT-PCR analysis demonstrated that the ERK1 and ERK2 mRNA expression increased apparently in HepG2/ADM cells and decreased significantly in SMMC7721/ADM cells. Compared with the expression of parental cells, ERK1 and ERK2 protein expressions were markedly decreased in SMMC7721/ADM cells. However, ERK2 protein expression was markedly increased while ERK1 protein expression had no significant change in HepG2/ADM cells. Phosphorylation of ERK1 and ERK2 was markedly decreased in both HepG2/ADM and SMMC7721/ADM MDR cells.CONCLUSION： ERK1 and ERK2 activities are downregulated in P-gp-mediated MDR HCC cells. ERK1 or ERK2 might be a p

关键词： Multidrug resistance Extracellular signalregulated MAP kinases Hepatocellular carcinoma P-glycoprotein Multidrug resistance-associated protein

TRAFFIC EMISSION TRANSPORTATION IN STREET CANYONS

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Journal of Hydrodynamics 2009年第1期21卷 108-117页

作者： XIE xiao-min wang Jia-song HUANG Zhen Key Laboratory for Power Machinery and Engineering of State Education ministry Shanghai Jiao Tong University Shanghai 200240 China

Spatial distributions of traffic-related pollutants in street canyons were investigated by field measurements and Computational Fluid Dynamics （CFD）. Two typical street canyons were selected for field monitoring, and a three-dimensional numerical model was built based on Reynolds-averaged Navier-Stokes equations equipped with the standard κ-ε turbulence models for CFD simulations. The study shows that the pollutant concentrations of vehicle emission correlate well with the traffic volume variation, wind direction and wind speed. The wind direction and speed at the roof level determine overwhellmingly the flow field and the distributions of pollutant concentrations in the street canyon. When the wind speed is equal to zero, the pollutant concentrations on the breath height of the both sides of the street canyon are almost the same. When the wind direction is perpendicular to the street, one main vortex is formed with a shape depending on the building structure on both sides of the street, the pollutant is accumulated on the leeward side, and the pollutant concentrations at the breath height on the leeward side are 2 to 3 times as those at the breath height on the windward side. If the wind direction makes some angles with the street canyon, the pollutant concentration will be higher on the leeward side because one main vortex will also be formed in the vertical section of the canyon by the perpendicular component of the wind. But pollutant concentrations decrease in the canyon because pollutants are dispersed along the axis of the street. Pollutants at different heights of the vertical section decrease with height, i.e. there are concentration gradients in the vertical section, and the pollutant concentrations on the leeward side of the upstream building are much higher than those on the windward side of the downstream building.

关键词： traffic emission street canyon field measurement CFD modeling

Cytokine release syndrome complicated with rhabdomyolysis after chimeric antigen receptor T-cell therapy:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9398-9403页

作者： Lan Zhang Wei Chen xiao-min wang Shu-Qing Zhang Department of Hematology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Chimeric antigen receptor T-Cell(CAR-T)therapy is an effective new treatment for hematologic *** release syndrome(CRS)and neurologic toxicity are main ***-induced rhabdomyolysis(RM)followed by CART therapy treatment has not been previously *** SUMMARY We report a case of a 22-year-old woman with relapsed acute lymphoblastic leukemia obtained sequential cluster of differentiation(CD)19 and CD22 CAR-T *** patient experienced grade 3 CRS with RM,mild hypotension requiring intravenous fluids,and mild hypoxia and was managed effectively with the IL-6 receptor antagonist *** patient had no signs of immune effector cell-associated neurologic *** scans 30 d postCAR-T therapy demonstrated a complete remission,and the symptoms of muscle weakness improved through *** Myalgia is an easily overlooked symptom of severe CRS after CAR-T *** is necessary to monitor myoglobin levels when a patient presents with symptoms of myalgia or acute renal insufficiency.

关键词： Cytokine release syndrome Rhabdomyolysis Chimeric antigen receptor-T cell therapy Relapsed acute lymphoblastic leukemia Case report

Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network

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Neuroscience Bulletin 2012年第3期28卷 282-290页

作者： Li-Rong Huo Jian-Tao Liang Jun-Hua Zou Lan-Ying wang Qi Li xiao-min wang Department of Physiology Key Laboratory for Neurodegenerative Disorders of the Ministry of Education Capital Medical University Beijing 100069 China Peking University Center of Medical Genetics Beijing 100083 China Xuan Wu Hospital of Capital Medical University Beijing 100053 China Genminix Informatics Ltd. Co. Shanghai 201210 China

Objective Poly（rC）-binding protein 1 （PCBP1） belongs to the heterogeneous nuclear ribonucleoprotein family and participates in transcriptional and translational regulation. Previous work has identified transcripts targeted by both knockdown and overexpression of PCBP1 in SH-SY5Y neuroblastoma cells using a microarray or ProteomeLabTM protein fractionation 2-dimensions （PF-2D） and quadrupole time-of-flight mass spectrometer. The present study aimed to further determine whether these altered transcripts from major pathways （such as Wnt signaling, TGF-β signaling, cell cycling, and apoptosis） and two other genes, H2AFX and H2BFS （screened by PF-2D）, have spatial relationships. Methods The genes were studied by qRT-PCR, and dynamic Bayesian network analysis was used to rebuild the coordination network of these transcripts. Results PCBP1 controlled the expression or activity of the seven transcripts. Moreover, PCBP1 indirectly regulated MAP2K2, FOS, FST, TP53 and WNT7B through H2AFX or regulated these genes through SAT. In contrast, TP53 and WNT7B are regulated by other genes. Conclusion The seven transcripts and PCBP1 are closely associated in a spatial interaction network.

关键词： PCBP1 RNA interference overexpression Bayesian network