检索结果-南通市图书馆

Deciphering and integrating invariants for neural operator learning with various physical mechanisms

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第4期11卷 111-122页

作者： Rui Zhang Qi meng Zhi-Ming ma Academy of mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional layers.Compared to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants

Efficient removal of Cr(VI) by polydopamine-modified lignin from aqueous solution: Batch and XAFS studies

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Water Science and Engineering 2024年第1期17卷 51-61页

作者： xiao-jie Guo Wei-kang Fu Jing-yuan ma Bo-jun Xi Chen Wang meng-yao Guan College of materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China College of Textile and Garment Shaoxing UniversityShaoxing 312000China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Lignocellulose has the potential to become a bio-based adsorbent due to its biodegradability and renewability.In this study,a novel polydopamine functionalized-lignin(lignin@PDA),prepared via self-polymerization of dopamine(PDA)on lignin,was used as a bio-based adsorbent for rapid scavenging of hexavalent chromium(Cr(VI)).The morphology,functional groups,crystalline structure,and chemical composition of lignin@PDA were characterized with a scanning electron microscope-energy dispersive spectrometer,Fourier transform infrared spectroscopy,X-ray diffraction,and X-ray photoelectron spectroscopy.The Cr(VI)adsorption process of lignin@PDA was studied using batch experiments as a function of pH,ionic strength,adsorbent dose,and contact time at room temperature.The adsorption rate of lignin@PDA was five times greater than that of the unmodified lignin,with a maximum adsorption capacity of 102.6 mg/g in an acidic medium.The adsorption of Cr(VI)on lignin@PDA fit the pseudo-secondorder equation and the Freundlich model,indicating that the adsorption process was mainly dominated by chemisorption and surface complexation.The thermodynamic parameters showed that adsorption of Cr(VI)on lignin@PDA was an endothermic and spontaneous process.The X-ray absorption fine structure results showed that sorption and reduction of Cr(VI)into Cr(II)occurred simultaneously on lignin.Moreover,PDA coating not only improved the reactivity of lignin but also promoted the complete reduction of Cr(VI)by lignin.According to these results,polydopamine functionalized-lignin is a promising bio-based adsorbent for immobilization of Cr(VI)from wastewater.

关键词： Lignin Polydopamine Hexavalent chromium EXAFS Adsorption mechanism

Research on casing deformation prevention technology based on cementing slurry system optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1231-1240页

作者： Yan Yan meng Cai Wen-Hai ma xiao-Chuan Zhang Li-Hong Han Yong-Hong Liu State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment materials CNPC Tubular Goods Research InstituteXi©an710077ShaanxiChina College of Mechanical and Electrical Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Gas Evaluation and Exploitation Key Laboratory of Sichuan Province Chengdu610095SichuanChina CNPC Daqing Oilfield Company Daqing163453HeilongjiangChina

The casing deformation prevention technology based on the optimization of cement slurry is proposed to reduce the casing deformation of shale oil and gas wells during hydraulic fracturing. In this paper, the fracture mechanism of hollow particles in cement sheath was firstly analyzed by discrete element method, and the effect of hollow particles in cement on casing deformation was investigated by laboratory experiment method. Finally, field test was carried out to verify the improvement effect of the casing deformation based on cement slurry modification. The results show that the formation displacement can be absorbed effectively by hollow particles inside the cement transferring the excessive deformation away from casing. The particles in the uncemented state provide deformation space during formation slipping. The casing with diameter of 139.7 mm could be passed through by bridge plug with the diameter of 99 mm when the mass ratio of particle/cement reaches 1:4. According to the field test feedback, the method based on optimization of cement slurry can effectively reduce the risk of casing deformation, and the recommended range of hollow microbeads content in the cement slurry is between 15% and 25%.

关键词： Cement slurry Hollow ceramsite Casing deformation Formation slip Field test

Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei Qu xiao ma Lu-Yao ma xiao-xiao Chen Yu-Qin Wang xiao-Bing Qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human health.Owing to challenges in early diagnosis,most patients lose the opportunity for radical treatment when diagnosed.Nonetheless,recent advancements in cancer immunotherapy provide new directions for the treatment of HCC.For instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with HCC.However,tumor cells can evade the immune system through various mechanisms.With the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer vaccines.This review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

Data driven analysis reveals prognostic genes and immunological targets in human sepsis-associated acute kidney injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2024年第2期15卷 91-97页

作者： Qing Zhao Jinfu ma Jianguo xiao Zhe Feng Hui Liu Department of Diagnosis and Treatment of Cadres the First Medical CenterChinese PLA General HospitalBeijing 100853China Intensive Care Unit the 305th Hospital of Chinese PLABeijing 100032China Department of Critical Care Medicine the First Medical CenterChinese PLA General HospitalBeijing 100853China Nephrology Department the First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND:The molecular mechanism of sepsis-associated acute kidney injury(SA-AKI)is unclear.We analyzed co-differentially expressed genes(co-DEGs)to elucidate the underlying mechanism and intervention targets of SA-AKI.METHODS:The microarray datasets GSE65682,GSE30718,and GSE174220 were downloaded from the Gene Expression Omnibus(GEO)database.We identified the co-DEGs and constructed a gene co-expression network to screen the hub genes.We analyzed immune correlations and disease correlations and performed functional annotation of the hub genes.We also performed single-cell and microenvironment analyses and investigated the enrichment pathways and the main transcription factors.Finally,we conducted a correlation analysis to evaluate the role of the hub genes.RESULTS:Interleukin 32(IL32)was identified as the hub gene in SA-AKI,and the main enriched signaling pathways were associated with hemopoiesis,cellular response to cytokine stimulus,inflammatory response,and regulation of kidney development.Additionally,IL32 was significantly associated with mortality in SA-AKI patients.Monocytes,macrophages,T cells,and NK cells were closely related to IL32 and were involved in the immune microenvironment in SA-AKI patients.IL32 expression increased significantly in the kidney of septic mouse.Toll-like receptor 2(TLR2)was significantly and negatively correlated with IL32.CONCLUSION:IL32 is the key gene involved in SA-AKI and is significantly associated with prognosis.TLR2 and relevant immune cells are closely related to key genes.

关键词： Sepsis Acute kidney injury Interleukin 32 Toll-like receptor 2 Bioinformatics analysis

Research on virtual coupling technology in rail transit train collision protection

在线全文

学校读者我要写书评

暂无评论

Transportation Safety and Environment 2024年第1期6卷 40-46页

作者： Gaosong Li Jinbai Zou Weijie ma meng Lan School of Railway Transportation Shanghai Institute of TechnologyShanghai 201418China Shanghai Metro First Operation Co. LtdShanghai 201418China

In the research on the new generation of intelligent rail transit system,the prevention of train collision accidents is still a focus.Virtual coupling technology controls the running speed and interval distance of two or more trains cooperatively through Trainto-Train(T2T)direct communication technology.The aim is to form a coordinated logical system and jointly complete the train control and dispatching.In this paper,a virtual coupling train formation control method based on the model predictive control(MPC)framework is proposed.From the establishment of the virtual coupling system,the construction of an MPC model and decoupling method,how to integrate virtual coupling technology into the rail transit train collision protection is studied.The safety and reliability of the system are calculated through fault tree and the method of constructing reliability function.The research shows that if virtual coupling technology is used for train collision protection,the overall safety and reliability of the train control system is improved.

关键词： virtual coupling model predictive control collision protection

Design of an on‑chip wavelength conversion device assisted by an erbium‑ytterbium co‑doped waveguide amplifier

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2024年第2期17卷 51-60页

作者： Chen Zhou Xiwen He Mingyue xiao Deyue ma Weibiao Chen Zhiping Zhou School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Aerospace Laser Technology and System Department Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Hangzhou Aijie Optoelectronic Technology Co.Ltd. Hangzhou 311400China

In current documented studies,it has been observed that wavelength converters utilizing AlGaAsOI waveguides exhibit suboptimal on-chip wavelength conversion efficiency from the C-band to the 2μm band,generally falling below−20.0 dB.To address this issue,we present a novel wavelength conversion device assisted by a waveguide amplifier,incorporating both AlGaAs wavelength converter and erbium-ytterbium co-doped waveguide amplifier,thereby achieving a notable conversion efficiency exceeding 0 dB.The noteworthy enhancement in efficiency can be attributed to the specific dispersion design of the AlGaAs wavelength converter,which enables an upsurge in conversion efficiency to−15.54 dB under 100 mW of pump power.Furthermore,the integration of an erbium-ytterbium co-doped waveguide amplifier facilitates a loss compensation of over 15 dB.Avoiding the use of external optical amplifiers,this device enables efficient and high-bandwidth wavelength conversion,showing promising applications in various fields,such as optical communication,sensing,imaging,and beyond.

关键词： Silicon-based optoelectronics Wavelength conversion Waveguide amplifier 2μm band

Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue xiao Yan-wei ma Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and migration.Methods:HaCaT cells were treated with HSYA.Cell proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration assay.The mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,respectively.Circ_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with HSYA.The expression of circ_0084443 was detected by qRT-PCR.Results:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative regulator circ_0084443.

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Insulation Design Rule for a Spacer in SF_(6)/N_(2)-filled DC Gas Insulated Apparatus

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第2期10卷 727-735页

作者： Hongyang Zhou Guoming ma meng Zhang Cong Wang Youping Tu Chengrong Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and the Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijing 102206China

A recurring challenge of a DC SF_(6)/N_(2)-filled GIS/GIL apparatus is the charge accumulation at DC stress.The conventional design rules and knowledge of AC spacers may not be applicable for this new type of apparatus.A novel design rule is proposed considering the effect of accumulated charge on the threshold of electric field strength being resistant to the superposed voltage.A surface charge accumulation simulation model is introduced,and the key parameters in the simulation model are measured.In addition,an experimental platform for a 100 kV spacer flashover test is established.Spacer flashover tests under superimposed voltage with opposing polarities are carried out,and the withstanding voltage of the spacer is obtained.Finally,based on the proposed model,the threshold of the surface electric field strength(tangential component)on the DC spacer in SF_(6)/N_(2) mixed gases is discussed.For a reliable insulation design of a DC GIS/GIL apparatus filled with 0.7 MPa SF_(6)/N_(2),the threshold of surface electric field strength on the DC spacer is 12 kV/mm.The insulation design rule can be referenced in the design of a high-voltage DC SF_(6)/N_(2)-filled GIS/GIL apparatus.

关键词： Charge accumulation DC spacer flashover voltage SF_(6)/N_(2) threshold of surface electric field strength