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Glioma cell line proliferation controlled by different chemical functional groups in vitro

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Frontiers of Materials Science 2013年第1期7卷 69-75页

作者： Su-Ju XU Fu-Zhai CUI xiao-long yu Xiang-Dong KONG Xinyuan Institute of Medicine and Biotechnology School of Life Science Zhejiang Sci-Tech University Hangzhou 310018 China Institute of Regenerative Medicine anclBiomimetic Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

Glioma cell line C6 cultured on silicon surfaces modified by different chemical functional groups, including mercapto (-SH), carboxyl (-COOH), amino (-NH2), hydroxyl (-OH) and methyl (-CH3) groups, was studied here to investigate the influence of surface chemistry on the cell proliferation, adhesion and apoptosis. AFM confirmed the similar characteristic of different functional groups occupation. The adhering C6 exhibited morphological changes in response to different chemical functional groups. The C6 adhered to -COOH, -NH2, -OH and -CH3 surfaces and flattened morphology, while those on -SH surface exhibited the smallest contact area with mostly rounded morphology, which led to the death of cancer cells. The results of MTT assay showed that the -COOH and -NH2 groups promoted cell proliferation, while the -SH significantly inhibited the proliferation. Compared with other chemical functional groups, the -SH group exhibited its unique effect on the fate of cancer cells, which might provide means for the design of biomaterials to prevent and treat glioma.

关键词： glioma cell line C6 chemical functional group adhesion proliferation

CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 862-869页

作者： Lin-Hui yuan xiao-long Chen yu Di Mei-Lin Liu Department of Ophthalmology Shengjing Affiliated Hospital of China Medical University Shenyang 110000 Liaoning Province China

AIM： To investigate the role of CCR7/p-ERKI/2/VEGF signaling in the mouse model of oxygen-induced retinopathy （OIR）. METHODS： Neonatal C57BL/6J mice were evenly randomized into four groups： normoxia, OIR, OIR control （treated with scramble siRNA）, and OIR treated （treated with CCR7 siRNA）. Normoxia group was not specially handled. Postnatal day 7 （P7） mice in the OIR group were exposed to 75%±5% oxygen for 5d （P7-P12） and then maintained under normoxic conditions for 5d （P12-P17）. Mice in the OIR control and OIR treated groups were given injections of scramble or CCR7 siRNA plasmid on P12 before returning to normoxic conditions for 5d （P12-P17）. Retina samples were collected from all mice on P17, stained with adenosine diphosphatase （ADPase）, and retinal neovascularization （RNV） was assessed. Retinas were also stained with hematoxylin and eosin （H＆E） for RNV quantitation. The distribution and expression of CCR7, p-ERKI/2 and vas- cular endothelial growth factor （VEGF） were assessed via immunohistochemistry, Western blot, and quantitative real-time polymerase chain reaction （qRT-PCR）. RESULTS： High oxygen promoted retinal neovascularization （P〈0.05） and increased the number of endothelial nuclei in new vessels extending from the retina to the vitreous body; CCR7 promoted this process （P〈0.05）. CCR7 and VEGF mRNA were expressed at higher levels in the OIR and OIR control groups than in the normoxia and OIR treated groups. CCR7, p-ERK1/2, and VEGF protein were expressed in the retinas of mice in the OIR and OIR control groups. Intravitreal injection of CCR7 siRNA significantly reduced CCR7, p-ERKI/2, and VEGF expression in the OIR mouse model （all P〈0.05）. CCR7 significantly enhancedthe neovascularization and non-perfusion areas in the OIR group （P〈0,05）, CCR7 siRNA significantly reduced levels of p-ERK1/2 and VEGF as compared to OIR controls （P〈0.05）. CONCLUSION： These results suggest that CCR7/p-ERK I/2NEGF signaling plays an important role in OIR, CCR7 may be a p

关键词： chemokine receptor type 7 vascularendothelial growth factor extracellular signal-regulated kinase retinal neovascularization retinopathy ofpremamrity

Synthesis and characterization of novel polyimides based on thiazole-containing diamine

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Chinese Chemical Letters 2007年第10期18卷 1203-1204页

作者： Xin Zhao Yan Feng Li Shu Jiang Zhang xiao long-Wang yu Shao State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringInstitute of Biochemical Engineering ＆ Environmental Technology Lanzhou University Lanzhou 730000 China

A new kind of aromatic diamine monomer containing thiazole unit, 2-amino-5-（4-aminophenyl）-thiazole （AAPT）, was synthesized in three steps, starting from 4-nitroacetophenone. A novel thiazole-containing polyimide was prepared via the polycondensation of AAPT with 6FDA by one-step method. The resulting polyimide exhibits excellent solubility, film-forming capability and high thermal resistance.

关键词： Thiazole Thiazole-containing monomer Synthesis Aromatic diamine

V0405 Dra:A New Deep and Low Mass Ratio Contact Binary with Extremely Fast Decrease in the Orbital Period

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Research in Astronomy and Astrophysics 2024年第6期24卷 287-293页

作者： Chao-yue Li Lin-Qiao Jiang Jie Zheng Yi-Man Liu xiao-yu long Min Sun Han-Lu Zhang xiao-Man Tian School of Science Leshan Normal UniversityLeshan 614000China Center for Applied Optics Research Leshan Normal UniversityLeshan 614000China Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan Leshan 614000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Aeronautics Shandong Jiaotong UniversityJinan 250000China

V0405 Dra is a W UMa-type binary *** on the TESS data,we have conducted an orbital period study and performed a light curve analysis for the *** orbital period study reveals that the O-C curve for V0405 Dra exhibits secular decrease at an extremely high rate of d P/dt=-2.71×10^(-6)day year^(-1),along with periodic variations characterized by an amplitude of A_(3)=0.0032 day and a period of P_(3)=1.413 *** orbital periodic change is possibly due to the light-travel time effect resulting from an additional third body in the system,for which we estimate a minimum mass of M_(3)=0.77M_(⊙).By employing the 2013 version of the Wilson-Devinney(W-D)method to synthesize a light curve,we derived photometric solutions indicating that V0405 Dra is a new deep(f=68.7%)and low-mass ratio(q=0.175)contact *** fast decrease in its orbital period is likely caused by mass transfer from the more massive primary star to the less massive secondary star,or due to angular momentum *** further mass transfer and loss of angular momentum,the binary will gradually evolve into a tighter contact configuration,eventually leading to a merger into a single star,following the evolutionary paths suggested for such deep and low mass ratio contact binaries.

关键词： (stars:)binaries(including multiple):close (stars:)binaries:eclipsing stars:individual(V0405 Dra)

Effect of functional groups on the crystallization of ferric oxides/oxyhydroxides in suspension environment

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Frontiers of Materials Science 2012年第4期6卷 297-303页

作者： Qiong ZHOU Olga ALBERT Hua DENG xiao-long yu Yang CAO Jian-Bao LI Xin HUANG State Key Laboratory of New Ceramics and Fine Processing Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China College of Materials and Chemical Engineering Hainan UniversityHaikou 570228China ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry University Medical Center of the Johannes Gutenberg University MainzD-55128 MainzGermany Department of Oral and Maxillofacial Surgery Beiji-ng Stomatological HospitalCapital Medical LJniversityBeijing 100050China

This paper investigated the effects of five kinds of Au surfaces terminated with and without functional groups on the crystallization of ferric oxides/oxyhydroxides in the suspension condition. Self-assembled monolayers （SAMs） were used to create hydroxyl （-OH）, carboxyl （-COOH）, amine （-NH2） and methyl （-CH3） functionalized surfaces, which proved to be of the same surface density. The immersion time of substrates in the Fe（OH）3 suspension was divided into two time portions. During the first period of 2 h, few ferric oxide/oxyhydroxide was deposited except that E-Fe203 was detected on -NH2 surface. Crystallization for 10h evidenced more kinds of iron compounds on the functional surfaces. Goethite and maghemite were noticed on four functional surfaces, and maghemite also grew on Au surface. Deposition of ^-Fe203 was found on -OH surface, while the growth of orthorhombic and hexagon FeOOH were indicated on -NH2 surface. Considering the wide existence of iron compounds in nature, our investigation is a precedent work to the study of iron biomineralization in the suspension area.

关键词： biocrystallization suspension ferric oxide/oxyhydroxide functional group

Upconversion luminescent property and EPR study of NaGdF4：yb3＋/Tm3＋ synthesized by the hydrothermal method

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Frontiers of Materials Science 2015年第3期9卷 241-246页

作者： Jing LIU Jing-Ying ZHANG Kai LIU Hong-Jian GAO xiao-long yu Yang CAO Zhong-Xin LIU Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources Hainan University Haikou 570228 China

Water soluble upconversion （UC） luminescence hexagonal-phase NaGdF4： yb3＋/Tm3＋ nanoparticles have been successfully synthesized by the hydrothermal method. XRD, SEM, UC photoluminescence spectra and electron paramagnetic resonance （EPR） spectrum were used to characterize the nanoparticles. The intensity of UC emission region could be controlled through different sodium source and the fluorine source, 6PJ→8S7/2 emission of Gd3＋ is also observed at 310 nm. A broad spectrum with a dominant resonance at g of about 2 was observed by the EPR spectrum of the NaGdF4：Yb3＋/Tm3＋ nanoparticles. The transparent NaGdF4：yb3＋/Tm3＋ solution presented naked eye-visible violet-blue light under the 980 nm LD excitation. The current work paves the way for their potential application in infrared tomography and magnetic resonance imaging （MRI）.

关键词： hydrothermal method sodium source fluorine source electron paramagnetic resonance (EPR) magnetic resonance imaging (MRI)

Genetic Mechanism of Dominant Earliness in Kefeng A,a New Rice Cytoplasmic Male Sterile Line

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Rice science 2009年第4期16卷 267-273页

作者： xiao yu-long yu Chuan-yuan LEI Jian-guo LI Ma-zhong JIANG Lin WAN Jian-min Rice Research Institute Jiangxi Academy of Agricultural Sciences Nanchang 330200 China State Key Laboratory for Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China

Kefeng A is an early maturing indica cytoplasmic male sterile （CMS） line of rice. Combinations derived from Kefeng A and late maturing indica restorer lines showed dominant earliness to various extents. To understand the genetic basis of dominant earliness, the genotype of photoperiod-sensitive genes in Kefeng A was analyzed using a complete set of heading time near isogenic lines （NILs） EGO to EG7, ER, LR, T65, T65E^b, T65E^bm, T65m, NIL（Hd1） and NIL（Hd4）. Results indicated that Kefeng A contained two dominant photoperiod-sensitive alleles E1 and Se-1^U on E1 and Se-1 loci, respectively, and the genotype of photoperiod-sensitivity genes for heading time in Kefeng A was E1E1e2e2E3E3Se-1^USe-1UEf-1Ef-1. Based on the detected heading time genotype, in combination with the heading time of Kefeng A and the early maturing phenomenon in its derived F1 hybrids, it is speculated that Kefeng A might carry a dominant inhibitor gene Su-E7 for the dominant photoperiod- sensitive gene E1, and a recessive inhibitor gene i-Se-1 for another dominant photoperiod-sensitive gene Se-1. The reason why F1 hybrids from Kefeng A exhibited early maturing was hereby analyzed and the breeding value of dominant earliness related genes in Kefeng A was discussed.

关键词： dominant earliness heading time genotype genetic mechanism cytoplasmic male sterile line rice

Paramagnetism and improved upconversion luminescence properties of NaYF4：Yb,Er/NaGdF4 nanocomposites synthesized by a boiling water seed-mediated route

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Frontiers of Materials Science 2016年第1期10卷 38-44页

作者： Chao-Qing YANG Ao-Ju LI Wei GUO Peng-Hua TIAN xiao-long yu Zhong-Xin LIU Yang CAO Zhong-Liang SUN Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources Hainan University Haikou 570228 China

In a route boiling water served as reaction medium, a stoichiometric amount of rare-earth compound and fluoride are put into this system to form a-NaYF4：Yb, Er nuclei. Then prepared sample is heated at elevated temperature to improve the fluorescence intensity, and next a NaGdF4 shell grows on the surface of NaYF4 nuclei. NaYF4：Yb,ErlNaGdF4 core-shell structured upconversion nanoparticles （CSUCNPs） have been successfully synthesized by above route. The use of boiling water decreases the cubic-to-hexagonal phase transition temperature of NaYF4：Yb,Er to 350℃ and increases its upconversion （UC） luminescence intensity. A heterogeneous NaGdF4 epitaxially growing on the surface of Ln^3＋-doped NaYF4 not only improves UC luminescence, but also creates a paramagnetic shell, which can be used as contrast agents in magnetic resonance imaging （MRI）o The solution of CSUCNPs shows bright green UC fluorescence under the excitation at 980 nm in a power density only about 50 ***-2. A broad spectrum with a dominant resonance at g of about 2 is observed by the electron paramagnetic resonance （EPR） spectrum of CSUCNPs. Above properties suggest that the obtained CSUCNPs could be potential candidates for dual-mode optical/magnetic bioapplications.

关键词： boiling water upconversion nanoparticle fluorescence imaging paramagnetism

The Research on the Regulation to the Compensated Utilization of the Resource Assets in Telecommunication Service Industry: Wireless Frequency as a Study Case

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The Journal of China Universities of Posts and Telecommunications 2003年第2期10卷 56-61页

作者： long xiao yu (Xi’an Institute of Posts and Telecommunications, Xi’an 710061, P.R.China) Xi'an Institute of Posts and Telecommunications Xi'an 710061

This Paper focuses on the compensated utilization of resource assets such aswireless frequency. It supplies the methods of estimating value of resource assets based on theanalysis of its characteristics. It also analyzes the compensated policy-making and its affects onthe Telecommunication Service Providers (TSP) performance gained by using resource assets. Theresults of the research indicate that the compensated utilization will promote the TSP to improvetheir economic efficiency, and aid to build a fairer competitive environment in TelecommunicationService Industry (TSI) in China.

关键词： resource assets compensated utilization TSI