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Digital Extraction of Altitudinal Belt Spectra in the West Kunlun Mountains Using SPOT-VGT NDVI and SRTM DEM

Journal of Mountain Science 2010年第2期7卷 133-145页

作者： xiao Fei ling Feng du Yun XUE Huaiping WU Shengjun Institute of Geodesy & Geophysics Chinese Academy of Sciences Wuhan 430077 China

In this paper, a digital identification method for the extraction of altitudinal belt spectra of montane natural belts is presented. Acquiring the sequential spectra of digital altitudinal belts in mountains at an acceptable temporal frequency and over a large area requires extensive time and work if traditional methods of field investigation are to be used. Such being the case, often the altitudinal belts of a whole mountain or the belts at a regional scale are represented by single points. However, single points obviously cannot accurately reflect the spatial variety of altitudinal belts. In this context, a digital method was developed to extract the spectra of altitudinal belts from remote sensing data and SRTM DEM in the *** Kunlun Mountains. By means of the 4km resolution SPOT-4 vegetation 10-day composite NDVI, the horizontal distribution of altitudinal belts were extracted through supervised classification, with a total classification accuracy of 72.23%. Then, a way of twice-scan was used to realize the automatic transition of horizontal maps to vertical belts. The classification results of remote-sensing data could thus be transformed automatically to sequential spectra of digital altitudinal belts. The upper and lower lines of the altitudinal belts were then extracted by vertical scanning of the belts. Relationships between the altitudinal belts based on the montane natural zones concerning vegetation types and the geomorphological altitudinal belts discussed. As a tentative method, were also the digital extraction method presented here is effective at digitally identifying altitudinal belts, and could be helpful in rapid information extraction over large-scale areas.

关键词： Altitudinal belt spectra Kunlun Mountains NDVI Digital extraction

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Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats

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Asian Journal of Andrology 2009年第4期11卷 451-459页

作者： Ying Zhou Xiang-Qian xiao Lin-Feng Chen Rui Yang Jian-Dang Shi xiao-ling du Helmut Klocker Irwin Park Chung Lee Ju Zhang Department of Biochemistry and Molecular Biology College of Life Sciences Bioactive Materials Key Lab of Ministry of Education Nankai University Tianjin 300071 China Department of Medical Oncology Dana Farber Cancer Institute Harvard Medical School Boston MA 02115 USA Department of Urology Innsbruck Medical University Anichstrasse 35 A-6020 Innsbruck Austria The Department of Urology Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

It is known that human benign prostatic hyperplasia might arise from an estrogen/androgen （E/T） imbalance. We studied the response of castrated rat prostate to different ratios of circulating E/T. The castrated male Wistar rats were randomly injected with E/T at different ratios for 4 weeks. The prostates of E/T （1：100） group showed a distinct prostatic hyperplasia response by prostatic index, hematoxylin and eosin staining, and quantitative immunohistochemical analysis of a-smooth muscle actin （SMA）. In this group, cells positive for Vimentin, non-muscle myosin heavy chain （NMMHC） and proliferating cell nuclear antigen （PCNA） increased in the stroma and epithelium. Furthermore, the mRNA levels of smooth muscle myosin heavy chain （SMMHC） and NMMHC increased. So E/T at a ratio of 1：100 can induce a stromal hyperplastic response in the prostate of castrated rats. The main change observed was an increase of smooth muscle cells, whereas some epithelial changes were also seen in the rat prostates.

关键词： androgens castration estrogen prostatic hyperplasia rat stromal cells

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Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients

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Cancer Biology & Medicine 2016年第2期13卷 260-268页

作者： Wen-Ya Zhou Hong Zheng xiao-ling du Ji-Long Yang Department of Bone and Soft Tissue Tumor Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Tianjin 300060 China Department of Epidemiology and Biostatistics Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Tianjin 300060 China Department of Diagnostics Tianjin Medical University Tianjin 300061 China

The fibroblast growth factor receptor(FGFR) family plays important roles in regulating cell growth, proliferation, survival,differentiation and angiogenesis. Deregulation of the FGF/FGFR signaling pathway has been associated with multiple development syndromes and cancers, and thus therapeutic strategies targeting FGFs and FGFR in human cancer are currently being ***, few studies on the FGF/FGFR pathway have been conducted in sarcoma, which has a poor outcome with traditional treatments such as surgery, chemotherapy, and radiotherapy. Hence, in the present review, we provide an overview of the role of the FGF/FGFR pathway signal in sarcoma and FGFR inhibitors, which might be new targets for the treatment of sarcomas according to recent research.

关键词： Sarcoma FGFR signaling pathway FGFR inhibitors

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Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia

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Asian Journal of Andrology 2010年第5期12卷 735-743页

作者： Rui Yang Yu-Xia Ma Lin-Feng Chen Ying Zhou Zhan-Po Yang Yan Zhu xiao-ling du Jian-Dang Shi Hong-Shun Ma Ju Zhang Bioactive Materials Key Lab of Ministry of Education Department of Biochemistry and Molecular Biology College of Life Sciences Nankai University Tianjin 300071 China Dana Farber Cancer Institute Harvard Medical School Boston MA 02445 USA Department of Urology Tianjin First Central Hospital Tianjin 300192 China Molecular Cardiology Research Institute Tufts Medical Center Tufts University School of Medicine Boston MA 02111 USA

Estrogen has important roles in the initiation and development of benign prostatic hyperplasia （BPH）. Regulators of the estrogen receptor （ER） are tissue- and cell-specific. We evaluated the effect of estrogen antagonist, raloxifene （Ral）, on the prevention and treatment of BPH by investigating its effect on the proliferation of two different prostate cell lines： a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. We additionally evaluated its effect on prostatic hyperplasia induced by estrogen and androgen in a rat model. The effect of Ral on the prevention of prostatic hyperplasia was analyzed by haematoxylin and eosin staining and quantitative immunohistochemistry （IHC） for proliferating cell nuclear antigen and α-smooth muscle actin. In vitro and in vivo, tamoxifen （Tam）, another anti-estrogen drug, and finasteride （Fin）, a drug for the clinical treatment of BPH, served as efficacy controls. The in vitro data showed that neither Ral nor Tam alone affected the proliferation of WPMY-1 and BPH-1, but both antagonized the effect of oestradiol in promoting the proliferation of the two cells. Results from the IHC staining of the rat prostates indicated that, similar to Tam and Fin, Ral inhibited the proliferation of stromal cells in vivo. Interestingly, in contrast to Tam, both Ral and Fin inhibited the proliferation of epithelial cells. Furthemore, Ral treatment much strongly decreased the number of prostatic acini and the surrounding layers of smooth muscle cells than Fin （P 〈 0.05）. Our data showed for the first time that Ral may have a role in the response of the rat prostate to selective ER modulators.

关键词： estrogen prostatic hyperplasia raloxifene rats

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Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis

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Chinese Medical Journal 2015年第13期128卷 1787-1792页

作者： xiao-Long du ling-Shang Kong Qing-You Meng Aimin Qian Wen-Dong Li Hong Chen xiao-Qiang Li Cheng-Long Li Department of Vascular Surgery The Second Affiliated Hospital of Soochow University Suzhou 215000 Jiangsu China

Background： Catheter-directed thrombolysis （CDT） has been a mainstay in treating deep venous thrombosis （DVT）. However, the optimal dosage ofa thrombolytic agent is still controversial. The goal of this study was to evaluate the safety and efficacy of low dosage urokinase with CDT for DVT. Methods： A retrospective analysis was perfornaed using data from a total of 427 patients with DVT treated with CDT in our single center between July 2009 and December 2012. Early efficacy of thrombolysis was assessed with a thrombus score based on daily venography. The therapeutic safety was evahmted by adverse events. A venography or duplex ultrasound was performed to assess the outcome at 6 months, 1 year and 2 years postoperatively. Results： The mean total dose of 3.34 （standard deviation [SD] 1.38） million units of urokinase was administered during a mean of 5.18 （SD 2.28） days. Prior to discharge, Grade Ⅲ （complete lysis） was achieved in 154 （36%） patients; Grade II （50-99% lysis） in 222 （52%）： and Grade I （50%~ lysis） in 51 （12%）. The major complications included one intracranial hemorrhage, one henaatochezia, five gross hematuria, and one pulmonary embolism. Moreover, no death occurred in the study. Conclusions： Treatment of low-dose catheter-directed thrombosis is an efficacious and safe therapeutic approach in patients with DVT offering good long-term outcomes and minimal complications.

关键词： Catheter-based Interventions Deep Vein Thrombosis Endovascular Treatment Thrombolysis: Venous Disease

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An Improved Genetic Algorithm with Quasi-Gradient Crossover

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Journal of Electronic Science and Technology of China 2008年第1期6卷 47-51页

作者： xiao-ling Zhang Li du Guang-Wei Zhang Qiang Miao Zhong-Lai Wang School of Mechatronics Engineering University of Electronic Science andTechnology of China Chengdu 610054 China

The convergence of genetic algorithm is mainly determined by its core operation crossover operation. When the objective function is a multiple hump function, traditional genetic algorithms are easily trapped into local optimum, which is called premature conver- gence. In this paper, we propose a new genetic algorithm with improved arithmetic crossover operation based on gradient method. This crossover operation can generate offspring along quasi-gradient direction which is the Steepest descent direction of the value of objective function. The selection operator is also simplified, every individual in the population is given an opportunity to get evolution to avoid complicated selection algorithm. The adaptive mutation operator and the elitist strategy are also applied in this algorithm. The case 4 indicates this algorithm can faster converge to the global optimum and is more stable than the conventional genetic algorithms.

关键词： Adaptive mutation arithmetic crossover,elitist strategy genetic algorithm.

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2013年-2015年舟山海岛地区人乳头状瘤病毒E6/E7基因变迁分析

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中国卫生检验杂志 2017年第4期27卷 588-589,593页

作者：周晓杜玲舟山市妇幼保健院浙江舟山316004

目的调查和分析2013年-2015年舟山地区妇女的人乳头状瘤病毒(HPV)E6/E7 mRNA阳性率变迁。方法选取2013年1月-2015年12月在本院就诊的本地常住妇女503例,采集宫颈脱落细胞,荧光定量PCR法检测HPV E6/E7 mRNA表达,以HPV E6/E7 mRNA>103为... 详细信息

目的调查和分析2013年-2015年舟山地区妇女的人乳头状瘤病毒(HPV)E6/E7 mRNA阳性率变迁。方法选取2013年1月-2015年12月在本院就诊的本地常住妇女503例,采集宫颈脱落细胞,荧光定量PCR法检测HPV E6/E7 mRNA表达,以HPV E6/E7 mRNA>103为阳性。结果共计HPV E6/E7 mRNA阳性88例,总阳性率为17.49%。≤30岁组中,2015年的HPV E6/E7 mRNA阳性率高于2014年,差异有统计学意义(χ~2=4.08,P<0.05),≥41岁组中,2015年的HPV E6/E7 mRNA阳性率高于2014年,差异有统计学意义(χ~2=8.92,P<0.01)。2015年的乡村组HPV E6/E7 mRNA阳性率高于2014年,差异有统计学意义(χ~2=11.14,P<0.01)。结论舟山地区≥41岁和乡村妇女是HPV E6/E7 mRNA阳性高发人群,有必要对其加强宫颈癌病变监控。

关键词：人乳头状瘤病毒荧光定量聚合酶链式反应 E6/E7基因

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过氧化氢氧化降解壳聚糖的可控性研究

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武汉大学学报（自然科学版） 2000年第2期46卷 195-198页

作者：覃彩芹肖玲杜予民樊木施晓文武汉大学化学与环境科学学院武汉430072

壳聚糖能被过氧化氢氧化降解得到低分子量壳聚糖 ,所得产物分子量分布随平均分子量的下降而逐渐变窄 .其降解速度和产物特性受原料脱乙酰度、反应介质、H2 O2 用量、温度和反应时间的影响 .脱乙酰度越高的壳聚糖 ,降解反应越容易进行 .... 详细信息

壳聚糖能被过氧化氢氧化降解得到低分子量壳聚糖 ,所得产物分子量分布随平均分子量的下降而逐渐变窄 .其降解速度和产物特性受原料脱乙酰度、反应介质、H2 O2 用量、温度和反应时间的影响 .脱乙酰度越高的壳聚糖 ,降解反应越容易进行 .在酸性介质中的降解 ,其起始速度比在水中的降解要快 ,所得产物的分散度要小 ,到一定程度后受到 H+抑制 .实验结果表明 ,制备分子量 5万以上的壳聚糖产品在 6 0～ 70℃、H2 O2 用量比小于0 .2 5的中性体系中就可以完成 ;而制备分子量在 1.5～ 5万之间的壳聚糖 ,采用反应温度 70℃、H2 O2 用量比为 0 .5～ 1.5、介质为水的条件较适宜 ;盐酸体系有利于制备分子量 70 0 0左右的壳聚糖 ;要得到水溶性产物 ,可以使用 2 %醋酸或水两种介质 .因此 ,通过选择反应条件 ,可制备特定分子量范围的壳聚糖 .

关键词：壳聚糖氧化降解过氧化氢可控降解

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相选择性凝胶因子及其在油品污染处理中的应用研究进展

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高分子通报 2017年第1期 9-21页

作者：康晓玲杜洋赵瑾原续波侯信天津大学材料科学与工程学院天津300072 天津市材料复合与功能化重点实验室天津300072

近年来含油污水及海上油品泄漏问题日益严重,威胁着人类的生存环境和海洋生态环境。相选择性凝胶因子因其制备简单、生物相容性好、快速高效、可重复利用等优点为油品污染处理提供了新选择。本文首先介绍了相选择性凝胶因子的分类和自... 详细信息

近年来含油污水及海上油品泄漏问题日益严重,威胁着人类的生存环境和海洋生态环境。相选择性凝胶因子因其制备简单、生物相容性好、快速高效、可重复利用等优点为油品污染处理提供了新选择。本文首先介绍了相选择性凝胶因子的分类和自组装机理及相选择性凝胶因子的发展现状,重点对小分子凝胶因子进行了阐述,其中小分子凝胶因子包括氨基酸类、有机酸及其盐类、胆固醇类和糖类衍生物类等,并对有机高分子凝胶因子做了简单介绍;最后对相选择性凝胶因子的发展做出了展望。

关键词：凝胶因子相选择性胶凝油品污染

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： Wang, xiao Zeng, Jia Gan, Donglin ling, Kun He, Mingfang Li, Jianshu Lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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