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Position-sensitive plastic scintillator detector with WLS-fiber readout

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Nuclear Science and Techniques 2018年第8期29卷 186-192页

作者： Jia-Ning Dong Yun-Long Zhang Zhi-Yong Zhang Dong Liu Zi-Zong Xu xiao-lian wang Shu-Bin Liu State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Department of Physics University of Science and Technology of China Department of Modern Physics University of Science and Technology of China

In this paper,the design,construction,simulation,and performance of a position-sensitive plastic scintillator detector are *** readout of the detector uses wavelength-shifting fibers coupled with multi-anode photomultipliers(PMTs) for the x-and *** calibrating the multi-anode PMTs,a two-dimensional projection image of the square scintillator telescope hit by cosmic muons is *** performing a cosmic test with the Micromegas telescope,the position resolution of the detector was determined to reach approximately8.6 mm,which is close to the value obtained in physical simulation.

关键词：闪烁器纤维结位置塑料敏感读出 WLS 光电倍增管

Association between 5-hydroxytryptamine transporter gene-linked polymorphic region and smoking behavior in Chinese males

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Chinese Medical Journal 2009年第12期122卷 1365-1368页

作者： CHU Shui-lian xiao Dan wang Chen JING Hang Beijing Chao-yang Hospital Affiliated to Capital Medical University-Beijing Institute of Respiratory Medicine World Health Organization Collaboration Center for Tobacco or Health in China Beijing 100020 China

Background Tobacco use is the major risk factor for numerous health problems. However, only 5% of smokers can successfully quit without therapy owing to the highly addictive properties of nicotine. The serotoninergic system may be involved in smoking behavior because nicotine increases brain serotonin secretion, nicotine withdrawal decreases serotonin levels, and a selective serotonin reuptake inhibitor antagonizes the response to nicotine withdrawal. Serotonin transporter （5-HTT） is the most important protein, as it adjusts the serotonin concentration in the synaptic cleft. There is a polymorphism in the upstream regulatory region of the 5-HTT gene, named 5-hydroxytryptamine transporter gene-linked polymorphic region （5-HTTLPR）. Compared with the L allele, the S allele of the polymorphism is associated with decreased transcription efficiency of the 5-HTT gene. In this study, we investigated the relationship between this gene polymorphism and smoking behavior in Chinese males. Methods Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to find 5-HTTLPR gene polymorphisms in 144 smokers and 135 age-matched healthy non-smokers. A questionnaire was completed in all recruited subjects. Results The proportion of L/L （15.3% vs 5.2%） and S/L （50.0% vs 33.3%） genotypes was significantly higher in the smokers than that in the non-smokers （X^2=21.9; P 〈0.01）. The odds ratio （OR） adjusted by age, education, effects of family members and friends who smoke, and alcohol intake was 2.9 （95%CI 1.78-4.80）. In smokers, the number of cigarettes/day （L/L vs S/L vs S/S： 28±12 vs 20±8 vs 16±6, X^2=18.5, P 〈0.01）, smoking index （L/L vs S/L vs S/S： 561±446 vs 393±341 vs 237±201, X^2=12.5, P 〈0.01） and score on the Fagerstrom test for nicotine dependence （FTND）（L/L vs S/L vs S/S： 7.8±1.6 vs 6.2±2.5 vs 3.5±2.1, X2=48.3, P 〈0.01） were significantly higher in smokers with an L/L or S/L genotype than that in the smokers with the S/S genotype. There were

关键词： Serotonin transporter nicotine dependence 5-hydroxytryptamine transporter gene-linkedpolymorphic region

Microwave induces apoptosis in A549 human lung carcinoma cell line

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Chinese Medical Journal 2011年第8期124卷 1193-1198页

作者： SONG xiao-lian wang Chang-hui HU Hai-yang YU Chao BAI Chong Department of Respiratory Changhai Hospital the SecondMilitary Medical University Shanghai 200433 China

Background Microwaves have other biological effects on cancer as well besides killing tumor cells by *** studies showed that microwaves may induce apoptosis in some tumor cells. The apoptotic effect of microwaves may help in clinic to remove residual malignant cells nearby the primary lesion and avoid relapse subsequently. However,there is little evidence on this subject from lung cancer. We studied the effect of microwaves on inducing apoptosis in the human lung carcinoma cell line A549 cells, aiming to identify its effect on *** A549 cells were radiated by various intensities and durations of microwaves. Apoptosis induction in A549 cells was analyzed by morphological observations, tetrazolium blue color method （MTT） assays, flow cytometery,immunohistochemistry, and image *** Morphological changes in A549 cells, including cell shrinking and nuclear pycnosis, were observed after microwave radiation. Microwaves significantly inhibited metabolic activities and induced apoptosis in A549 cells. The results of the MTT assay showed a significant decrease of cell activities in all the radiation groups compared with the normal control （P ＜0.01）. The low point of cell activities often appeared at 6-12 hours after radiation. Apoptosis was also confirmed by flow cytometery. The early stage apoptotic rate reached 6.10%-17.98% and the advanced stage apoptotic rate ＋ necrosis rate reached 8.04%-44.06% at 6 hours after microwave irradiation, in contrast to 2.32% and 4.10% in the respective control groups. Down-regulation of Bcl-2 expression and up-regulation of p53 expression were observed by immunohistochemistry after radiation. In most treated groups, the down-regulation of Bcl-2 expression reached its lowest level at 3-6 hours after radiation （integrated optical density （IOD）-6 hours： 2.13±0.08-5.14±0.13 vs. control： 5.79±0.10, P＜0.01 ） and the up-regulation of P53 expression peaked at about 3 hours （IOD-3 hours： 2.61±0.13-8.07±0.11 vs. c

关键词： microwave lung neoplasms apoptosis A549 cell line

Method of Separating Cosmic-Ray Positrons from Electrons in the DAMPE Experiment

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Research in Astronomy and Astrophysics 2022年第3期22卷 115-121页

作者： Hao-Ting Dai Jing-Jing Zang Ying wang Chuan-Ning Luo Yun-Long Zhang Zhi-Yong Zhang Yi-Feng Wei Li-Bo Wu Cheng-Ming Liu Cong Zhao xiao-lian wang Zi-Zong Xu Guang-Shun Huang State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics and Electronic Engineering Linyi UniversityLinyi 276000China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Gran Sasso Science Institute (GSSI)

A method of identifying positron/electron species from the cosmic rays was studied in the DArk Matter Particle Explorer(DAMPE)*** there is no onboard magnet on the satellite,the different features imposed by the geomagnetic field on these two species were exploited for the particle *** of this method to the simulation of on-orbit electrons/positrons/protons and the real flight data proves that separately measuring the CR positrons/electrons with DAMPE is feasible,though limited by the field of view for the present observation *** analysis on the positron flux with this method can be expected in the future.

关键词： (ISM:)cosmic rays magnetic fields (cosmology:)dark matter

Energy correction based on fluorescence attenuation of DAMPE

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Research in Astronomy and Astrophysics 2020年第8期20卷 163-168页

作者： Li-Bo Wu Yun-Long Zhang Zhi-Yong Zhang Yi-Feng Wei Si-Cheng Wen Hao-Ting Dai Cheng-Ming Liu xiao-lian wang Zi-Zong Xu Guang-Shun Huang State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

The major scientific goals of the DArk Matter Particle Explorer(DAMPE)are to study cosmicray electrons(including positrons)and gamma rays from 5 GeV to 10 TeV and nuclei from Z=1 to 26 up to 100 *** deposited energy measured by the Bismuth Germanate Oxide(BGO)calorimeter of DAMPE is affected by fluorescence attenuation in BGO crystals that are 600 mm *** this work,an in-orbit attenuation calibration method is reported,and energy correction of the sensitive detector unit of the BGO calorimeter is also presented.

关键词： DAMPE BGO calorimeter fluorescence attenuation dark matter

Hes1,an important gene for activation of hepatic stellate cells,is regulated by Notch1 and TGF-β/BMP signaling

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World Journal of Gastroenterology 2015年第3期21卷 878-887页

作者： Kai Zhang Yan-Qiong Zhang Wen-Bing Ai Qing-Ting Hu Qiao-Juan Zhang Lin-Yan Wan xiao-lian wang Chang-Bai Liu Jiang-Feng Wu Medical College China Three Gorges University the Second College of Clinical Medical Science China Three Gorges University Institute of Molecular Biology Medical CollegeChina Three Gorges University

AIM:To determine the role of Notch1 and Hes1 in regulating the activation of hepatic stellate cells(HSCs) and whether Hes1 is regulated by transforming growth factor(TGF)/bone morphogenetic protein(BMP) ***:Immunofluorescence staining was used to detect the expression of desmin,glial fibrillary acidic protein and the myofibroblastic marker α-smooth muscle actin(α-SMA) after freshly isolated,normal rat HSCs had been activated in culture for different numbers of days(0,1,3,7 and 10 d).The expression of α-SMA,collagen1α2(COL1α2),Notch receptors(Notch1-4),and the Notch target genes Hes1 and Hey1 were analyzed by reverse transcriptase-polymerase chain *** reporter assays and Western blot were used to study the regulation of α-SMA,COL1α1,COL1α2 and Hes1 by NICD1,Hes1,CA-ALK3,and CA-ALK5 in HSC-T6 ***,the effects of inhibiting Hes1 function in HSC-T6 cells using a Hes1 decoy were also ***:The expression of Notch1 and Hes1 m RNAs was significantly down-regulated during the culture of freshly isolated *** HSC-T6 cells,Notch1 inhibited the promoter activities of α-SMA,COL1α1 and COL1α*** the other hand,Hes1 enhanced the promoter activities of α-SMA and COL1α2,and this effect could be blocked by inhibiting Hes1 function with a Hes1 ***,co-transfection of pc DNA3-CAALK3(BMP signaling activin receptor-like kinase 3) and pc DNA3.1-NICD1 further increased the expression of Hes1 compared with transfection of either vector alone in HSC-T6 cells,while pc DNA3-CA-ALK5(TGF-β signaling activin receptor-like kinase 5) reduced the effect of NICD1 on Hes1 ***:Selective interruption of Hes1 or maintenance of Hes1 at a reasonable level decreases the promoter activities of α-SMA and COL1α2,and these conditions may provide an anti-fibrotic strategy against hepatic fibrosis.

关键词： Hes1 Notch1 TGF-β/BMP Hepatic stellate cells Hepat

Relationship between symptom response and esophageal pH level on standard dose of esomeprazole treatment for gastroesophageal reflux disease

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Chinese Medical Journal 2010年第15期123卷 2012-2017页

作者： PENG Sui XIONG Li-shou xiao Ying-lian wang An-jiang LIN Jin-kun HU Pin-jin CHEN Min-hu Division of Gastroenterology & Hepatology the First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China

Background The relationship between symptom elimination and normalization of esophageal acid level of gastroesophageal reflux disease （GERD） on proton-pump inhibitor （PPI） therapy has been questioned. This study aimed to evaluate the relationship between symptom response and gastro-esophageal acidity control in Chinese patients with GERD on esomeprazole therapy, and to assess the role of 24-hour esophageal pH-metry after therapy in GERD *** GERD patients with typical reflux symptoms were enrolled and received esomeprazole 40 mg once daily for 4 weeks. Patients with positive baseline 24-hour esophageal pH-metry were divided into two groups depending on an additional dual-channel 24-hour pH-metry after treatment. The pH- group achieved normalization of esophageal pH level whereas the pH＋ group did *** Of the 80 patients studied, 76 had abnormal baseline esophageal pH levels. Of these, 90% （52/58） of symptom-free patients and 67% （12/18） of symptom-persistent patients achieved esophageal pH normalization after therapy （P=0.030）. The mean post-therapy gastric nocturnal percent time of pH 〈4.0 was significantly higher in pH＋group than that in pH- group （P 〈0.001） after therapy. The multivariate regression analysis identified hiatus hernia （P〈0.001） and persistent reflux symptom （P=0.004） were two independent factors predicting the low post-therapy esophageal pH *** Symptom elimination is not always accompanied by esophageal pH normalization, and vice *** pH-metry is recommended for GERD patients with hiatus hernia or with persistent reflux symptoms after PPI therapy.

关键词： gastroesophageal reflux esomeprazole symptom response esophageal pH level

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism Catalyst design Electrode Electrocatalysis

一种基于Mule-Transport机制的防空指挥系统软件服务交互方法

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中国电子科学研究院学报 2017年第1期12卷 85-89页

作者：赵晓莲王珩中国电子科技集团公司第二十八研究所江苏南京210007 信息系统工程重点实验室江苏南京210007

面向服务的防空指挥系统软件开发与集成已成为防空指挥系统建设中的关键问题之一。针对高时效性和安全性条件下的软件服务交互问题,本文提出了一种基于Mule-Transport机制的防空指挥系统软件服务交互方法。该方法在基于开源Mule的服务... 详细信息

面向服务的防空指挥系统软件开发与集成已成为防空指挥系统建设中的关键问题之一。针对高时效性和安全性条件下的软件服务交互问题,本文提出了一种基于Mule-Transport机制的防空指挥系统软件服务交互方法。该方法在基于开源Mule的服务运行环境基础上,利用Transport消息机制,以插件方式动态绑定军用传输协议,实现服务间交互。该方法采用Java语言实现,具有良好的可扩展性和移植性;服务交互试验表明该方法有效、可行,较好地满足了防空指挥系统环境时效性和安全性的要求。

关键词：服务交互 Transport消息机制 Mule 防空指挥系统面向服务