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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-jun Wu Qiu-Sha huang Hai-Xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang xiao-jun huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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Petrogenesis and tectonic implications of the Silurian adakitic granitoids in the eastern segment of the Qilian Orogenic Belt,Northwest China

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Acta Geochimica 2024年第1期43卷 72-86页

作者： Jiao-Long Zhao xiao-jun huang Pei-Qing Hu Zhen-Xi Yang Ying Fan Er-Teng Wang Fu-Bo Yang Jing-Yu Zhang School of Earth Sciences Key Laboratory of Mineral Resources in Western China(Gansu Province)Lanzhou UniversityLanzhou 730000China Nuclear Industry 247 Brigade Tianjin North China Geological Survey BureauTianjin 301800China Fourth Institute of Geological and Mineral Exploration of Gansu Provincial Bureau of Geology and Mineral Resources Jiuquan 735000China

Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 Ma and 432 ± 4 Ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline *** are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.

关键词： Silurian adakitic granitoids Petrogenesis Tectonic setting Qilian Orogenic Belt

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The Multi-sensitivity and Topological Sequence Entropy of Dynamical System with Group Action

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Acta Mathematica Sinica,English Series 2023年第4期39卷 663-684页

作者： xiao jun huang Bin ZHU College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China Chongqing Key Laboratory of Analytic Mathematics and Applications Chongqing UniversityChongqing 401331P R.China

In this paper,we study the relationship between the multi-sensitivity and the topological maximal sequence entropy of dynamical systems for general group ***,we also discuss the consistency of multi-sensitivity of a dynamical system(G■X)and its hyperspace dynamical system G■K(X).Moreover,we research the relationship between the multi-sensitivity of two dynamical systems and the multi-sensitivity of their product space dynamical ***,we prove that if the topological sequence entropy of G■X vanishes,then so does that of its induced system G■M(X);if the topological sequence entropy of G■X is positive,then that of its induced system G■M(X)is infinity.

关键词： Group action multi-sensitivity topological sequence entropy hyperspace induced system

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Relative Quasisymmetry and Quasim?bius Mappings in Quasi-metric Spaces

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Acta Mathematica Sinica,English Series 2022年第3期38卷 547-559页

作者： Hong jun LIU xiao jun huang Yue FAN School of Mathematical Sciences Guizhou Normal UniversityGuiyang550001P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing401331P.R.China

The aim of this paper is to investigate the relationship between relative quasisymmetry and quasimöbius in quasi-metric spaces,and show that a homeomorphism f isη-quasisymmetric relative to A if and only if it isθ-q... 详细信息

关键词： Quasisymmetric mapping quasimobius mapping three-point condition quasi-metric space

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A Note on the Uniqueness of Koebe–Andreev–Thurston Theorem

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Acta Mathematica Sinica,English Series 2012年第7期28卷 1469-1474页

作者： xiao jun huang Zi Peng WANG College of Mathematics and Statistics Chongqing University

In this paper, we present a new proof of the uniqueness of Koebe-Andreev-Thurston theorem. Our method is based on the argument principle in complex analysis and reviews the connection between the circle packing theore... 详细信息

关键词： Circle packing argument principle MSbius transformation

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SUPPRESSION OF CELL ADHESION ON POLYACRYLONITRILE-BASED MEMBRANES BY THE ANCHORING OF PHOSPHOLIPID MOIETIES

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Chinese Journal of Polymer Science 2006年第1期24卷 103-106页

作者： xiao-jun huang xiao-dan huang Ai-fu Che Zhi-kang Xu Ke Yao Institute of Polymer Science Zhejiang University Hangzhou 310027China Medical College Zhejiang University Hangzhou 310027 China

In this work, the membrane surface of poly（acrylonitrile-co-2-hydroxyethyl methacrylate）（PANCHEMA） was chemically modified by anchoring of phospholipid moieties. The process involved the reaction of hydroxyl groups on the membrane surface with 2-chloro-2-oxo-1,3,2-dioxaphospholane （COP） followed by the ring-opening reaction of COP with trimethylamine. Chemical differences between the original and the modified membranes were characterized by FT-IR and XPS, It was found that the amount of macrophage adhered on the modified membrane surface is substantially lower than that on polyacrylonitrile （PAN） and PANCHEMA membranes under the same condition, The morphological change of the adherent cell is also suppressed by the generation ofphospholipid moieties on the membrane surface.

关键词： Acrylonitrile copolymer Membrane Surface modification Phospholipid moieties Cell adhesion.

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NANOFIBROUS MATS WITH BIRD'S NEST PATTERNS BY ELECTROSPINNING

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Chinese Journal of Polymer Science 2012年第1期30卷 130-137页

作者： Xiang-yu Ye xiao-jun huang Zhi-kang Xu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Electrospun material with bio-inspired ordered architectures and patterns is very interesting,yet remains a *** report here that nanofibrous mats with bird＇s nest patterned structures can be directly electrospun from chlorinated polypropylene solutions doped with an ionic *** solution viscosity and the ionic liquid content are two dominant factors to influence the topological morphology of the nanofibrous *** patterned structures can be further modulated by the collection time of electrospinning,the humidity of environment and the design of *** suggest the electrostatic repulsion between the residual charges of the mat surface and the upcoming nanofibers plays a key role in the formation of the bird＇s nest patterns.

关键词： Electrospinning Ionic liquid Patterned structures

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A perfect mismatch: haploidentical hematopoietic stem cell transplantation overtakes a bend

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Cellular & Molecular Immunology 2023年第8期20卷 978-980页

作者： Meng Lv Hui-Dong Guo xiao-jun huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijingChina Peking-Tsinghua Center for Life Sciences BeijingChina

Matching for the major histocompatibility complex(MHC)—and more specifically,the human leukocyte antigen(HLA)system—has been the gold standard in transplantation for *** an HLA-matched donor is the preferred and str... 详细信息

关键词： hematopoietic leukocyte perfect

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SIMULATION OF ELECTRICAL FIELD FOR THE FORMATION MECHANISM OF BIRD'S NEST PATTERNED STRUCTURES BY ELECTROSPINNING

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Chinese Journal of Polymer Science 2013年第3期31卷 514-520页

作者： Xiang-yu Ye Yi-ning Jin xiao-jun huang Lei Luo 徐志康 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University Institute of Advanced Digital Technology and Instrument Zhejiang University

In our previous work, it was found that large electrospun from chlorinated polypropylene solution doped Bird＇s Nest patterned nanofibrous membranes can be simply with an ionic liquid, and a plausible formation mechanism of Bird＇s Nest patterned architectures was proposed. Here, we use Ansoft Maxwell version 12 software （3D, electrostatic solver） to simulate the electrical field distribution of the electrospinning setup, and to clarify the rationality of proposed formation mechanism. Calculation results clearly show that the introduction of charged nanofibrous bundles would produce a similar patterned electrical field distribution, which definitely confirms the important role of surface residual charges. The proposed mechanism can be well extended to other polymer systems including polystyrene, poly（acrylonitrile-co-acrylic acid） and chitosan/poly（ethylene oxide）.

关键词： Electrospinning Patterned structures Finite element analysis Electrical field Theoretical simulation.

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Joint Sample Position Based Noise Filtering and Mean Shift Clustering for Imbalanced Classification Learning

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Tsinghua Science and Technology 2024年第1期29卷 216-231页

作者： Lilong Duan Wei Xue jun huang xiao Zheng School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

The problem of imbalanced data classification learning has received much *** classification algorithms are susceptible to data skew to favor majority samples and ignore minority *** weighted minority oversampling technique(MWMOTE)is an effective approach to solve this problem,however,it may suffer from the shortcomings of inadequate noise filtering and synthesizing the same samples as the original minority *** this end,we propose an improved MWMOTE method named joint sample position based noise filtering and mean shift clustering(SPMSC)to solve these ***,in order to effectively eliminate the effect of noisy samples,SPMsC uses a new noise filtering mechanism to determine whether a minority sample is noisy or not based on its position and distribution relative to the majority *** that MWMOTE may generate duplicate samples,we then employ the mean shift algorithm to cluster minority samples to reduce synthetic replicate ***,data cleaning is performed on the processed data to further eliminate class *** on extensive benchmark datasets demonstrate the effectiveness of SPMsC compared with other sampling methods.

关键词： imbalanced data classification oversampling noise filtering clustering

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