SUPPRESSION OF CELL ADHESION ON POLYACRYLONITRILE-BASED MEMBRANES BY THE ANCHORING OF PHOSPHOLIPID MOIETIES

作     者：Xiao-jun Huang Xiao-dan Huang Ai-fu Che Zhi-kang Xu Ke Yao 

作者机构：Institute of Polymer Science Zhejiang University Hangzhou 310027China Medical College Zhejiang University Hangzhou 310027 China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2006年第24卷第1期

页      面：103-106页

核心收录：

学科分类：0817[工学-化学工程与技术] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.50273032) 

主　　题：Acrylonitrile copolymer Membrane Surface modification Phospholipid moieties Cell adhesion. 

摘      要：In this work, the membrane surface of poly（acrylonitrile-co-2-hydroxyethyl methacrylate） （PANCHEMA） was chemically modified by anchoring of phospholipid moieties. The process involved the reaction of hydroxyl groups on the membrane surface with 2-chloro-2-oxo-1,3,2-dioxaphospholane （COP） followed by the ring-opening reaction of COP with trimethylamine. Chemical differences between the original and the modified membranes were characterized by FT-IR and XPS, It was found that the amount of macrophage adhered on the modified membrane surface is substantially lower than that on polyacrylonitrile （PAN） and PANCHEMA membranes under the same condition, The morphological change of the adherent cell is also suppressed by the generation ofphospholipid moieties on the membrane surface.