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Implementation experience of a 12-month intervention to introduce intermittent kangaroo mother care to eight Chinese neonatal intensive care units

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World Journal of Pediatrics 2022年第12期18卷 849-853页

作者： Xin Liu xiao-hui chen Zhan-Kui Li Bei Cao Shao-Jie Yue Qiong-Yu Liu Chuan-Zhong Yang Chang-Yi Yang Ying-Xi Zhao Geng-Li Zhao Qi Feng Neonatal Intensive Care Unit Department of PediatricsPeking University First HospitalBeijing 100034China Department of Neonatology Nanjing Maternity and Child Health Care HospitalNanjingChina Department of Neonatology Northwest Women’s and Children’s HospitalXi’anChina Department of Neonatology The Maternal and Child Health Care Hospital of Hunan ProvinceChangshaChina Department of Neonatology Xiangya Hospital Central South UniversityChangshaChina Department of Neonatology Women&Children’s Health Care Hospital of LinyiLinyiChina Department of Neonatology Shenzhen Maternity&Child Healthcare HospitalShenzhenChina Department of Neonatology Fujian Provincial Maternity and Children’s HospitalFuzhouChina Nuffield Department of Medicine University of OxfordOxfordUK Department of Obstetrics and Gynecology Peking University First HospitalBeijingChina

Kangaroo mother care(KMC)is recommended by the World Health Organization for the care of preterm and low-birth-weight newborns.KMC has been shown to increase survival rates and the quality of life of preterm and low-birth-weight infants,including improved clinical outcomes,weight gain and thermoregulation when compared to conventional care[1,2,3].More recent research focused on KMC in high-risk preterm,critically ill newborns and newborns requiring special care,which suggested that KMC helped to stabilize the vital signs of preterm infants[4,5].KMC is well accepted and promoted by medical associations and professional organizations around the world[6,7].In November 2015 with support from the National Health Commission of China,participants from ten hospitals based in different areas of China received theoretical and practical training on KMC.During a four-year period,health professionals from these hospitals participated in theoretical and practical training,which included two operation training from foreign experts,two academic lectures,and three study tours to hospitals in the UK,Sweden and the Netherlands.During this period,the KMC Operational Manual for Premature Infants in China was developed,and a 12-month prospective multicenter study of KMC for preterm infants was conducted in the eight hospitals.In the present study,we further examine whether KMC was sustained as a practice during a 12-month period from April 2018 to March 2019 and the characteristics of preterm infants that received KMC.

关键词： mother sustained promoted

Microstructure and properties of hybrid additive manufacturing 316L component by directed energy deposition and laser remelting

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Journal of Iron and Steel Research(International) 2020年第7期27卷 842-848页

作者： xiao-hui chen Bo chen Xu cheng Guo-chao Li Zheng Huang National Engineering Laboratory of Additive Manufacturing for Large Metallic Components and Engineering Research CenterMinistry of Education on Laser Direct Manufacturing for Large Metallic ComponentsSchool of Materials Science and EngineeringBeihang UniversityBeijing 100191China Research Center for Processing AECC Shanghai Commercial Aircraft Engine Manufacturing Co.Ltd.Shanghai 201306China

Arc additive manufacturing is a high-productivity and low-cost technology for directly fabricating fully dense metallic components.However,this technology with high deposit rate would cause degradation of dimensional accuracy and surface quality of the metallic component.A novel hybrid additive manufacturing technology by combining the benefit of directed energy deposition and laser remelting is developed.This hybrid technology is successfully utilized to fabricate 316L component with excellent surface quality.Results show that laser remelting can largely increase the amount ofδphases and eliminateσphases in additive manufacturing 316L component surface due to the rapid cooling.This leads to the formation of remelting layer with higher microhardness and excellent corrosion resistance when compared to the steel made by directed energy deposition only.Increasing laser remelting power can improve surface quality as well as corrosion resistance,but degrade microhardness of remelting layer owing to the decrease inδphases.

关键词： Hybrid additive manufacturing Laser remelting Directed energy deposition Microstructure Corrosion resistance

An analysis of the mechanism underlying photocatalytic disinfection based on integrated metabolic networks and transcriptional data

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Journal of Environmental Sciences 2020年第6期32卷 28-37页

作者： xiao-Long Liang Zhan-Min Liang Shuo Wang xiao-hui chen Yao Ruan Qing-Ye Zhang Hong-Yu Zhang Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070PR China

Photocatalytic disinfection has long been used to combat pathogenic bacteria.However,the specific mechanism underlying photocatalytic disinfection and its corresponding targets remain unclear.In this study,an analysis of the potential mechanism underlying photocatalytic disinfection was performed based on integrated metabolic networks and transcriptional data.Two sets of RNA-seq data(wild type and a photocatalysis-resistant mutant mediated by titanium dioxide(TiO2))were processed to constrain the genome scale metabolic models(GSMM)of E.coli.By analyzing the metabolic network,the differential metabolic flux of every reaction was computed in constrained GSMM,and several significantly differential metabolic fluxes in reactions were extracted and analyzed.Most of these reactions were involved in the transmembrane transport of substances and occurred on the inner membrane or were an important component of the cell membrane.These results,which are consistent with the reported information,validated our analysis process.In addition,our work also identified other new and valuable metabolic pathways,such as the reaction ALCD2x,which has a great effect on the energy production process under bacterial anaerobic conditions.The DHAK reaction is also related to the metabolic process of ATP.These reactions with large differential metabolic fluxes merit further research.Additionally,to provide a strategy to address photocatalysis-resistant mutant bacteria,a metabolic compensation analysis was also performed.The metabolic compensation analysis results provided suggestions for a combined method that can effectively combat resistant bacteria.This method could also be used to explore the mechanisms of drug resistance in other microorganisms.

关键词： Photocatalytic disinfection Genome scale metabolic models(GSMM) RNA-seq analysis Mechanism Metabolic compensation

Effect of superplastic deformation on the bonding property of 00Cr25Ni7Mo3N duplex stainless steel

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International Journal of Minerals,Metallurgy and Materials 2012年第4期19卷 317-321页

作者： xiao-hui chen Xue-ping Ren hui Xu Jian-guo Tong Hai-yan Zhang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Sinosteel Equipment ＆ Engineering Co. Ltd. Beijing 100080 China

The superplastic deformation diffusion bonding of 00Cr25Ni7Mo3N duplex stainless steel was performed on a hot simulator. The microstructure of the bonding interface was characterized by scanning electron microscopy （SEM） and electron backscatter diffraction （EBSD）. The mechanical properties of the specimen were investigated by a shear strength test. The results indicated that the shear strength was improved with the increase of superplastic deformation reduction. When the deformation reduction was up to 50%, the shear strength of the specimen achieved 417 Mpa, approaching to that of the base metal. In addtion, the superplastic diffusion bonding technique was not very sensitive to surface roughness levels. When the surface roughness of the bonding specimen surpassed 0.416 pan （level G2）, the shear strength achieved at least 381 MPa.

关键词： stainless steel superplastic deformation diffusion bonding surface roughness shear strength

Bifunctional metal–organic frameworks toward photocatalytic CO2reduction by post-synthetic ligand exchange

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Rare Metals 2019年第5期38卷 413-419页

作者： xiao-hui chen Qin Wei Jin-Dui Hong Rong Xu Tian-Hua Zhou School of Chemical Engineering Fuzhou UniversityFuzhou 350002China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Photocatalytic reduction of CO2 to useful fuel has been identified as a promising strategy to address the energy and environmental issues.Development of welldefined photocatalysts toward CO2 reduction has attracted increasing interest to gain insight into the reactive mechanism.Herein,by post-synthetic ligand exchange,a bifunctional Re-based metal–organic framework(MOF)was successfully prepared.It not only serves as a photosensitizer but also acts as a catalyst for photochemical reduction of CO2.Furthermore,it is found that a Re-based MOF containing 30%Re-based ligands displays improved activity compared to MOF with 100%Re-based ligands.This work provides clues to the design and synthesis of bifunctional MOFs toward photocatalytic CO2 reduction.

关键词： Photocatalysis Metal-organic framework(MOF) CO2 reduction Post-synthesis

Authentication and distinction of Shenmai injection with HPLC fingerprint analysis assisted by pattern recognition techniques

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Journal of Pharmaceutical Analysis 2012年第5期2卷 327-333页

作者： Xue-Feng Lu Kai-Shun Bi Xu Zhao xiao-hui chen School of Pharmacy Shenyang Pharmaceutical UniversityWenhua Road 103Shenhe DistrictShenyang 110016China

In this paper, the feasibility and advantages of employing high performance liquid chromatographic （HPLC） fingerprints combined with pattern recognition techniques for quality control of Shenmai injection were investigated and demonstrated. The Similarity Evaluation System was employed to evaluate the similarities of samples of Shenmai injection, and the HPLC generated chromatographic data were analyzed using hierarchical clustering analysis （HCA） and soft independent modeling of class analogy （SIMCA）. Consistent results were obtained to show that the authentic samples and the blended samples were successfully classified by SIMCA, which could be applied to accurate discrimination and quality control of Shenmai injection. Furthermore, samples could also be grouped in accordance with manufacturers. Our results revealed that the developed method has potential perspective for the original discrimination and quality control of Shenmai injection.

关键词： Shenmai injection High performance liquidchromatography Fingerprint Pattern recognition

Risk Factors, Clinical Features and Prognosis for Subtypes of Ischemic Stroke in a Chinese Population

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Current Medical Science 2018年第2期38卷 296-303页

作者： Ya-fu TAN Li-xuan ZHAN xiao-hui chen Jian-jun QUO Chao QIN En XU Department of Neurology the First Affiliated Hospital of Guangxi Medical University Nanning 530021 China Institute of Neurosciences and Department of Neurology the Seeond Affiliated Hospital of Guangzhou Medical University Guangzhou 510260 China

It is unanimously accepted that stroke is a highly heterogeneous disorder. Different subtypes of ischemic stroke may have different risk factors, clinical features, and prognoses. The aim of this study was to evaluate the risk factors, clinical characteristics, and prognoses of different subtypes of ischemic stroke defined by the Trial of ORG10172 in Acute Stroke Treatment （TOAST） criteria. We prospectively analyzed the data from 530 consecutive patients who were admitted to our hospital with acute ischemic stroke within 7 days of stroke onset during the study period. Standardized data assessment was used and the cause of ischemic stroke was classified according to the TOAST criteria. Patients were followed up till 30 and 90 days after stroke onset. It was found that large-artery atherosclerosis was the most frequent etiology of stroke （37.4%）, and showed the highest male preponderance, the highest prevalence of previous transient ischemic attack, and the longest hospital stay among all subtypes. Small artery disease （36.4%） was associated with higher body mass index, higher plasma triglycerides, and lower plasma high-density lipoprotein cholesterol than cardioembolism. Cardioembolism （7.7%）, which was particularly common in the elderly （i.e., individuals aged 65 years and older）, showed the highest female preponderance, the highest prevalence of atrial fibrillation, the earliest presentation to hospital after stroke onset, the most severe symptoms on admission, the maximum complications associated with an adverse outcome, and the highest rate of stroke recurrence and mortality. Our results suggest that ischemic stroke should be regarded as a highly heterogeneous disorder. Studies involving risk factors, clinical features, and prognoses of ischemic stroke should differentiate between etiologic stroke subtypes.

关键词： ischemic stroke stroke classification stroke subtypes risk factors clinical features outcome

Quantitative analysis of a novel antimicrobial peptide in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2011年第3期1卷 191-196页

作者： Ruo-Wen Zhang Wen-Tao Liu Lu-Lu Geng xiao-hui chen Kai-Shun Bi School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmacy Medical Biology Centre Queen's University Belfast UK

We described the first results of a quantitative ultra performance liquid chromatographytandem mass spectrometry method for a novel antimicrobial peptide （phylloseptin, PSN-1）. Chromatographic separation was accomplished on a Waters bridged ethyl hybrid （BEH） C18 （50mm× 2.1 mm, 1.7 μm） column with acetonitrile-water （25：75, v/v） as isocratic mobile phase. Mass spectrometry detection was performed in the positive electrospray ionization mode and by monitoring of the transitions at m/z 679.6/120, 509.6/120 （PSN-1） and m/z 340.7/165 （Thymopentin, IS）. Protein precipitation was investigated and the recovery was satisfactory （above 82%）. The method was shown to be reproducible and reliable with intra-day precision below 5.3%, inter-day precision below 14.2%, and linear range from 0.02 to 2 lag/mL with r〉0.994. The method was successfully applied to a pharmacokinetic study of PSN-1 in rats after intravenous administration.

关键词： Antimicrobial peptide Phylloseptin Ultra performanceliquid chromatographytandem massspectrometry Pharmacokinetie

A novel surgical debridement technique for the treatment of Fournier’s gangrene

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Asian Journal of Andrology 2021年第5期23卷 541-542页

作者： xiao-hui chen Peng-Pai Qin Zhong-Xing Zhang Ji-Yan Lin Jing-Jing Zhang Department of Emergency Medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Division No.1 of Surgery Beijing Rectum HospitalBeijing 100035China Department of Cosmetic and Plastic Surgery Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361005China

Dear Editor,Fourniers gangrene(FG)is a life-threatening disease which is characterized by necrotizing fasciitis of the genital,perianal,and perineal regions1.FG was initially found in young healthy males in the late 1800s with the acute onset of fulminant idiopathic genital gangrene2.But now,FG has been seen in people of different ages,from newborn babies to the elderly3.

关键词： Fournier acute treatment