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Pulmonary vein isolation implemented by second-generation cryoballoon for treating hypertrophic cardiomyopathy patients with symptomatic atrial fibrillation:a case-control study

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Journal of Geriatric Cardiology 2020年第8期17卷 476-485页

作者： Zhong-Jing CAO xiao-gang guo Qi SUN Jian-Du YANG Hui-Qiang WEI Shu ZHANG Jian MA Arrhythmia Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical ScienceGuangzhouChina

Background Atrial fibrillation(AF)is a generally acknowledged turning-point of the natural history of hypertrophic cardiomyopathy(HCM);however,data from the cryoballoon ablation(CBA)for AF in HCM patients are relatively *** study aimed to evaluate the efficacy and safety of CBA in HCM patients with *** We retrospectively analyzed HCM patients among 1253 patients with symptomatic AF who underwent CBA for pulmonary vein isolation in a single *** study analyzed the AF recurrence and assessed the CBA indexes,including nadir temperature,time-to-isolation,CBA failure,pulmonary vein potentials(PVPs),and redo *** A total of 108 patients were included(mean age:59.0±6.9 years),27 patients(25%)had HCM,with the median follow-up duration of 25.5 *** one-year AF-free rates were 79.0%vs.63.0%(non-HCM ***),while the two-year AF-free rates were 77.8%vs.55.1%[hazard ratio(HR)=2.758,log-rank P=0.024].Patients with persistent AF had poor AF-free rates compared to those with paroxysmal AF(P<0.001).The CBA failure was the most common in the right inferior pulmonary veins,which had the lowest *** Cox regression analysis indicated that HCM and persistent AF were risk factors for AF recurrence(HR=2.74,95%CI:1.29–5.79,P=0.008;and HR=3.97,95%CI:1.85–8.54,P<0.001,respectively).Conclusions The CBA can be effectively and safely used to treat HCM patients with symptomatic *** freedom from AF for HCM patients after CBA is relatively low compared to that for non-HCM patients.

关键词： Atrial fibrillation Cryoballoon ablation Hypertrophic cardiomyopathy Pulmonary vein isolation

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The Association between Lower Incisal Inclination and Morphology of the Supporting Alveolar Bone—A Cone-Beam CT Study

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International Journal of Oral Science 2009年第4期1卷 217-223页

作者： Quan Yu xiao-gang Pan guo-ping Ji gang Shen Shanghai Key Laboratory of Stomatology Department of Orthodontics Shanghai Ninth People＇s Hospital Affiliated toShanghai Jiao Tong University School of Medicine Shanghai China

Aim To investigate the relationship between the positioning of the lower central incisor and physical morphology of the surrounding alveolar bone. Methodology Thirty-eight patients （18 males, 20 females）, with mean age of 13.4 years, were included in this study. As part of orthodontic treatment planning the patients were required to take dental Cone-beam CT （CBCT） covering the region of lower incisors, the sur- rounding alveolar bone and the mandibular symphysis. The cephalometric parameters were designed and measured to indicate the inclination of lower central incisor and physical morphology of the adjacent alveolar bone. Computer-aided descriptive statistical analysis was performed using SPSS 15.0 software package for Windows. A correlation analysis and a linear regression analysis between the incisor inclination and the alveolar bone morphology were performed. Results Significant positive correlations were found between the lower central incisor inclination and the morphological contour of the alveolar bone （P〈0.05）. The lower central incisor root apex was closer to the lingual alveolar crest when it was buccally inclined. Conclusion The morphology of the alveolar bone may be affected by incisal inclination.

关键词： Cone-beam CT (CBCT) alveolar bone incisorinclination

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Cryoballoon ablation of persistent atrial fibrillation for de novo pulmonary vein isolation:a single-center follow-up study

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Journal of Geriatric Cardiology 2022年第10期19卷 725-733页

作者： Zhong-Jing CAO xiao-gang guo Qi SUN Yan-Qiao CHEN Hai-Yang XIE Jian-Du YANG Hui-Qiang WEI Jia-Hui LI Jian MA Department of Cardiology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of Medicine UESTCChengduChina State Key Laboratory of Cardiovascular Disease Arrhythmia CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical ScienceGuangzhouChina

BACKGROUND Pulmonary vein isolation(PVI)alone for persistent atrial fibrillation(PersAF)remains *** characteristics of cryoballoon ablation(CBA)to treat PersAF and the blanking period recurrence are *** This study retrospectively analyzed patients with PersAF undergoing second-generation CBA for de novo *** post-procedural efficacy and survival analysis were compared between patients with different PersAF *** multivariate Cox regression analysis was used to detect the risk factors for *** and long-term recurrence were analyzed relative to each *** A total of 329 patients were enrolled,with a median PersAF duration of 4.0 months(interquartile range:2.0–12.0 months);257 patients(78.1%)were ***-Meier analysis of freedom from atrial fibrillation recurrence at 12,24,and 30 months showed 71.0%,58.5%,and 54.9%,*** PersAF had a relatively favorable survival rate and a narrow P-wave duration of restoring sinus rhythm compared with that of PersAF lasting more than three months(P<0.05).The multivariate Cox regression analysis revealed that PersAF duration and left atrial anteroposterior diameter≥42 mm were the risk factors for atrial fibrillation recurrence after CBA[hazard ratio(HR)=1.89,95%CI:1.01–1.4,P=0.042;HR=3.6,95%CI:2.4–5.4,P<0.001,respectively].The blanking period recurrence predicted the long-term recurrence(P<0.0001).CONCLUSIONS CBA of PersAF had safety and efficacy to reach de novo *** PersAF duration and left atrial size were risk factors for atrial fibrillation recurrence after *** period recurrence was associated with long-term recurrence.

关键词： balloon fibrillation atrial

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Modulational instability of a resonantly polariton condensate in discrete lattices

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Chinese Physics B 2023年第3期32卷 143-146页

作者：漆伟郭晓刚董亮伟张晓斐 Department of Physics Shaanxi University of Science and TechnologyXi'an 710021China

We study modulational instability of a resonantly polariton condensate in a discrete *** a discrete gain-saturation model,we derive the dispersion relation for the modulational instability by means of the linear-stability *** of the pumping strength,the nonlinearity,the strength of the detuning,and the coupling strength on the modulation instability are *** is found that the interplay between these parameters will dramatically change the modulational instability *** believe that the predicted results in this work can be useful for future possible experiment of exciton-polariton condensate in lattices.

关键词： modulational instability polariton condensate discrete lattices

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Estrogen receptor a gene PvulI polymorphism and coronary artery disease： a meta-analysis of 21 studies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第3期15卷 243-255页

作者： Jie DING Hui XU Xiang YIN Fu-rong ZHANG xiao-ping PAN Yi-an GU Jun-zhu CHEN xiao-gang guo Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Xiuzhou District Gaozhao Street Community Health Service Center Jiaxing 314031 China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Columbia University Medical Center New York NY l0032 USA

The association between the estrogen receptor a gene （ESR1） Pvull polymorphism （c.454-397T〉C） and coronary artery disease （CAD） is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios （ORs） with 95% confidence intervals （CIs） were used to assess the relationship between Pvull polymorphism and CAD. The poly- morphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 Pvull polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 Pvull polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 Pvull polymorphism has an important role in CAD susceptibility.

关键词： Estrogen receptor a gene Polymorphism Meta-analysis Coronary artery disease (CAD)

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Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation:a case report

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第5期21卷 411-415页

作者： Tian-ming XUAN Xing-xiang WANG Xiang-yuan PU Wei-li HAN xiao-gang guo Department of Cardiology the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Lung Transplantation the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

本文首次报告了重症新型冠状病毒肺炎(COVID-19)感染接受肺移植并行急症冠脉介入治疗的病例。通过对多学科协作成功救治的总结,为重症COVID-19救治提供经验。我们发现,重症COVID-19感染在肺移植术后可能出现多种危险因素诱发心肌梗死,... 详细信息

本文首次报告了重症新型冠状病毒肺炎(COVID-19)感染接受肺移植并行急症冠脉介入治疗的病例。通过对多学科协作成功救治的总结,为重症COVID-19救治提供经验。我们发现,重症COVID-19感染在肺移植术后可能出现多种危险因素诱发心肌梗死,急症冠脉介入治疗是救治此类患者的重要手段。

关键词：新型冠状病毒肺炎(COVID-19) 肺移植心肌梗死冠脉介入治疗

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Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood

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Acta Pharmacologica Sinica 2004年第8期 71-77页

作者： Jun-hui ZHU, Xing-xiang WANG, Jun-zhu CHEN, Yun-peng SHANG, Jian-hua ZHU, xiao-gang guo, Jian SUNDepartment of Cardiovascular Diseases, the First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China

AIM: To investigate whether puerarin can augment endothelial progenitor cells (EPCs) numbers, promote EPC proliferative, migratory, adhesive, and in vitro vasculogenesis capacity. METHODS: EPCs were characterized as adherent cells by double staining of DiLDL-uptake and lectin binding under a laser scanning confocal microscope. Expression of KDR, VEGFR-2, and AC 133 was detected by flow cytometry. EPCs proliferation, migration and in vitro vasculogenesis were determined with MTT assay, modified Boyden chamber assay, and in vitro vasculogenesis kit, respectively. EPCs adhesive assay was performed by replating those on fibronectin-coated dishes, then adherent cells were counted. RESULTS: Incubation of isolated human MNCs with puerarin 0.1-3 mmol/L increased the number of EPCs, EPC proliferative, migratory, adhesive, and in vitro vasculogenesis capacity in a concentration and time-dependent manner, which reached maximum at 3 mmol/L, 24 h (approximately 1-fold increase, P<0.01). CONCLUSION: Puerarin enhanced

关键词： puerarin isoflavones vascular endothelium stem cells cell differentiation vascular endothelial growth factor confocal microscopy

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Egr-1,the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats

Egr-1,the potential target of calcium channel blockers in ca...

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中国药理学会第十次全国学术会议

作者： Zhan-Qin Huang,Hai-Qing Li,Fu-xiao guo,gang-gang Shi (Department of Pharmacology,Medical College of Shantou University)

Aims In this study,we tested whether Egr-1 is a potential target of calcium channel blockers in cardioprotection with I/R *** We treated rats in vivo I/R and rat cultured cardiomyocytes in vitro hypoxia/reoxygenation(H/R) models with three types of classical calcium channel blockers(verapamil,diltiazem and nifedipine).Activity of creatine kinase(CK),lactate dehydrogenase(LDH),myeloperoxidase(MPO) superoxide dismutase(SOD) and level of malondialdehyde(MDA) in plasma and culture medium were measured to assess the degree of injury and inflammation of myocardial tissues and ***-1 mRNA and protein expressions were examined by RT-PCR and Western-blot *** Calcium channel blockers(verapamil,diltiazem and nifedipine) significantly attenuated myocardial injury,as shown by reduced release of CK and LDH,preserved SOD activity and decreased MDA production and MPO *** with cardioprotection by calcium channel blockers,the mRNA and protein expression of Egr-1 increased with I/R and H/R injury was significantly reduced in myocardial tissue and cultured *** These results suggested that the cardioprotective effects of calcium channel blockers with I/R or H/R injury might be mediated by downregulating Egr-1 expression. Egr-1 might be the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury.

关键词： Calcium channel blocker Early growth response gene-1 Ischemia/reperfusion Hypoxia/reoxygenation Myocardium cardiomyocyte

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Morphological Mechanism and Experimental Verification of Self-healing of Basalt-fiber Modified Water-soaked Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 171-186页

作者： xiao Minmin DONG Jinyong LI Chunyan guo Xu REN Jianguo School of Urban Construction and Safety Engineering Shanghai Institute of TechnologyShanghai 201418China

This study investigates the mechanism of action of representative molecules of basalt fibers on the healing of water-soaked *** parameters,morphological characteristics,interfacial healing energy,and interfacial healing strength were analyzed using molecular dynamics and macroscopic tests under different time,temperature,and water conditions to evaluate the specific states and critical conditions involved in *** results indicate that basalt-fiber molecules can induce rearrangement and a combination of water-soaked asphalt at the healing *** groups with different bonding states increase the interfacial adsorption capacity of water-soaked *** interaction between basalt fiber molecules and water molecules leads to a"hoop"phenomenon,while aromatics-2 molecules exhibit a"ring band aggregation"*** former reduces the miscibility of water and asphalt molecules,while the latter causes slow diffusion of the ***,a micro-macro dual-scale comparison of interfacial healing strength was conducted at temperatures of 297.15 and 312.15 K to identify the strength transition point and critical temperature of 299.4 K during the self-healing process of basalt-fiber modified water-soaked asphalt.

关键词： water-soaked asphalt basalt-fibers self-healing properties moisture status molecular characterization

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基于MMC的同相供电潮流控制器控制策略研究

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电力系统保护与控制 2017年第14期45卷 79-84页

作者：肖刚张译文郭育华王莉四川航天职业技术学院四川成都610100 西南交通大学磁浮技术与磁浮列车教育部重点实验室四川成都610031

模块化多电平换流器(MMC)与平衡变压器相结合的潮流控制器(PFC),可节省传统牵引供电系统中的匹配变压器,满足高压大功率的应用。首先介绍了系统工作原理,重点研究了其中单相MMC背靠背换流器两端的补偿电流。提出了一种综合控制策略,包... 详细信息

模块化多电平换流器(MMC)与平衡变压器相结合的潮流控制器(PFC),可节省传统牵引供电系统中的匹配变压器,满足高压大功率的应用。首先介绍了系统工作原理,重点研究了其中单相MMC背靠背换流器两端的补偿电流。提出了一种综合控制策略,包括变流器两端补偿电流的提取算法,子模块电容电压均衡控制,环流抑制策略以及PWM调制方法。最后在Matlab/Simulink中搭建了系统模型,分别对交直交型电力机车的牵引和再生制动工况进行仿真,验证了所提控制策略的有效性。

关键词：同相供电模块化多电平换流器潮流控制器控制策略

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