检索结果-南通市图书馆

Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2022年第3期42卷 498-504页

作者： Lei JIE Ru-tao HONG Yu-jie ZHANG Lu-lin SHA Wei CHEN xiao-fei ren Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityKey Laboratory of Digestive Disease of Anhui ProvinceHefei 230022China Department of Critical Care Medicine of Cardiothoracic Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Objective Melatonin has been reported to suppress inflammation and alleviate liver fibrosis,but its effect on autophagy in liver fibrosis has not been *** study investigated the effect of melatonin on autophagy in an animal model of liver fibrosis and the hepatic stellate cell(HSC)-T6 cell *** The model was established in rats through carbon tetrachloride treatment,and melatonin was administered at three doses(2.5,5.0,and 10.0 mg/kg).Haematoxylin and eosin staining and Van Gieson’s staining were performed to examine the pathological changes of *** expression of alpha-smooth muscle actin(α-SMA)and Beclin1 in liver tissues was detected by immunohistochemical *** protein levels ofα-SMA,Beclin1 and LC3 in the animal model were detected by Western blot analysis,and gene levels of Beclin1 and LC3 were detected by quantitative real-time PCR(qRT-PCR)in the animal ***-T6 cells were activated by platelet-derived growth factor-BB(PDGF-BB).The expression ofα-SMA,Beclin1 and collagen I was detected by Western blot analysis,and the gene expression of Beclin1 and LC3 was detected by *** Melatonin reduced the expression ofα-SMA,Beclin1 and LC3 in liver *** addition,melatonin inhibited the activation of HSC-T6 cells and the expression ofα-SMA,Beclin1 and LC3 in these *** results revealed that melatonin could inhibit autophagy and HSC *** Melatonin might ameliorate liver fibrosis by regulating autophagy,suggesting that melatonin is a potential therapeutic agent for liver fibrosis.

关键词： autophagy liver fibrosis hepatic stellate cells melatonin

Simplified p-i-n Perovskite Solar Cells with a Multifunctional Polyfullerene Electron Transporter

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第8期42卷 1060-1066页

作者： fei-fei Wang Tian-xiao Liu Ze-Wei Cui Ling-Yuan Wang Yun-Jie Dou xiao-Yu Shi Si-Wei Luo xiao-Dong Hu Zhi-Jun ren Yang-Yang Liu Yu Zhao Shang-Shang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 21003China

In prevailing p-i-n perovskite solar cells(PSCs),solution-processible fullerene molecules are widely used as electron-transporting layers(ETLs)but they typically suffer from poor uniformity and undesirable stability ***,a separate bathocuproine(BCP)layer is needed to block hole tran sfer,increasing fabrication complexity and ***,we address these limitations by develo ping a novel polymeric ETL(named PF BCP)synthesized by polymerizing C_(60)with *** innovative material achieves both efficient electron transport and hole blocking,while its excellent uniformity minimizes interface recombination and enhances ***,our blade-coated PSCs utilizing PFBCP achieve a high power conversion efficiency exceeding 22%and retain 91%of initial efficiency after 1200 h of light *** development not only paves the way for commercially viable PSCs but also opens avenues for future ETL design to realize even more efficient and stable PSCs.

关键词： Polyfullerene Perovskite solar cells Electron transporter Stability

A new method for evaluating wedges of steel plates and strips

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第7期31卷 1719-1735页

作者： xiao-bao Ma xiao-xin Ma Tao Wang Zhong-kai ren Yu-cheng ren College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Ministry of Education Engineering Research Center of Advanced Metal Composite Forming Technology and Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina China National Heavy Machinery Research Institute Co. Ltd.Xi'an 710018ShaanxiChina Faculty of Mechanical Engineering Hebei University of ArchitectureZhangjiakou 075000HebeiChina

To overcome the inaccuracy problem of the traditional wedge evaluation of steel plates and strips caused by the ran-domness of the thicknesses of two local points and improve the reliability of the wedge index,the double-centroid method for the wedge evaluation was proposed,and a model based on the centroid theory was ***,an integral model for the discrete thickness values of the cross-section profiles was *** discussion focused on the distinct characteristics of the two-point method,asymmetric method,and double-centroid method in evaluating the asymmetric distribution of *** three methods were employed to evaluate the wedge values of both the theoretical and measured cross-sections of steel plates and strips,and the accuracies of three wedge evaluation models were analyzed and *** results showed that the double-centroid method objectively reflects the degree and variation characteristics of the wedge values of the cross-sections of steel plates and strips,and this method is feasible,reliable,and outstanding.

关键词： Steel plate and strip Wedge Two-point method Double-centroid method Reliability

Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第3期16卷 287-304页

作者： fei Liu Jing xiao Lei-Hui Chen Yu-Yue Pan Jun-Zhang Tian Zhi-ren Zhang xiao-Chun Bai School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Health Management Guangdong Second Provincial General HospitalGuangzhou 510317Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People’s Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Centre of Reproduction Development and AgingFaculty of Health SciencesUniversity of MacaoMacao 999078China Department of Stomatology Guangdong Second Provincial General HospitalGuangzhou 510317Guangdong ProvinceChina Zhuhai Institute of Translational Medicine Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND The self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative *** cells can self-organise into microsized organ units,partially modelling tissue function and *** pulp organoids have been used to recapitulate the processes of tooth development and related ***,the lack of vasculature limits the utility of dental pulp *** To improve survival and aid in recovery after stem cell transplantation,we demonstrated the three-dimensional(3D)self-assembly of adult stem cell-human dental pulp stem cells(hDPSCs)and endothelial cells(ECs)into a novel type of spheroid-shaped dental pulp organoid in vitro under hypoxia and conditioned medium(CM).METHODS During culture,primary hDPSCs were induced to differentiate into ECs by exposing them to a hypoxic environment and *** hypoxic pretreated hDPSCs were then mixed with ECs at specific ratios and conditioned in a 3D environment to produce prevascularized dental pulp *** biological characteristics of the organoids were analysed,and the regulatory pathways associated with angiogenesis were *** The combination of these two agents resulted in prevascularized human dental pulp organoids(Vorganoids)that more closely resembled dental pulp tissue in terms of morphology and ***-cell RNA sequencing of dental pulp tissue and RNA sequencing of Vorganoids were integrated to analyse key regulatory pathways associated with *** biomarkers forkhead box protein O1 and fibroblast growth factor 2 were identified to be involved in the regulation of *** In this innovative study,we effectively established an in vitro model of Vorganoids and used it to elucidate new mechanisms of angiogenesis during regeneration,facilitating the development of clinical treatment strategies.

关键词： Human dental pulp stem cells Prevascularized organoids Integrated analyses Angiogenesis Forkhead box protein O1

An efficient parallel algorithm of variational nodal method for heterogeneous neutron transport problems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第4期35卷 29-45页

作者： Han Yin xiao-Jing Liu Teng-fei Zhang School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 2002040China

The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport ***,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational *** paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface *** algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without *** the formation tasks are completed,a collective operation merges and shares the matrix sets among the *** the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix ***-to-point communication is conducted between adjacent subdomains to exchange data along the *** accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test *** results obtained with multiple processors agree well with those obtained from Monte Carlo *** parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 *** addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.

关键词： Neutron transport Variational nodal method Parallelization KAIST JRR-3

Metamorphic P-T conditions and ages of garnet-biotite schists in the Dahongshan Group from the southwestern Yangtze Block

在线全文

学校读者我要写书评

暂无评论

Acta Geochimica 2024年第4期43卷 707-718页

作者： Jun-xiao Ma Guang-shu Yang Yong-feng Yan xiao-fei Xu Yun-hua ren Hui Zhao xiao-jun Zheng Yuan Qin Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Geological Team 306 of Yunnan Non-Ferrous Metals Geological Bureau Kunming 650217China Yunnan Provincial Bureau of Non-Ferrous Geology Kunming 650051China

The Dahongshan Group,situated at the southwestern margin of the Yangtze Block,represents a geological unit characterized by relatively high-grade metamorphism in the *** paper investigates the garnet-biotite schist from the Laochanghe Formation of the Dahongshan Group,employing an integrated approach that includes petrological analysis,phase equilibrium modeling,and zircon U-Pb *** schist is mainly composed of garnet,biotite,plagioclase,quartz,rutile,and *** equilibrium modeling revealed the peak metamorphic conditions of 8-9 kbar and 635-675°*** further integrating the prograde metamorphic profile of garnet and geothermobarometric results,a clockwise P-T metamorphic evolution path is constructed,which includes an increase in temperature and pressure during the prograde ***-ICP-MS zircon U-Pb dating and zircon Ti thermometry constrains the post-peak metamorphic age of 831.2±7.2 *** with previously reported results,it is revealed that the southwestern margin of the Yangtze Block experienced a large-scale regional metamorphism during the Neoproterozoic(890-750 Ma),which is related to the collisional orogenic *** may be associated with the late-stage assembly of the Rodinia supercontinent or with local compression and subduction processes during the breakup of the Rodinia supercontinent.

关键词： Southwestern Yangtze Block Dahongshan Group Phase equilibrium modeling Zircon U-Pb dating Neoproterozoic metamorphism

3D robust anisotropic diffusion filtering algorithm for sparse view neutron computed tomography 3D image reconstruction

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 13-29页

作者： Yang Liu Teng-fei Zhu Zhi Luo xiao-Ping Ouyang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China

The most critical part of a neutron computed tomography(NCT) system is the image processing algorithm,which directly affects the quality and speed of the reconstructed *** types of noise in the system can degrade the quality of the reconstructed ***,to improve the quality of the reconstructed images of NCT systems,efficient image processing algorithms must be *** anisotropic diffusion filtering(ADF) algorithm can not only effectively suppress the noise in the projection data,but also preserve the image edge structure information by reducing the diffusion at the image ***,we propose the application of the ADF algorithm for NCT image *** compare the performance of different algorithms in NCT systems,we reconstructed images using the ordered subset simultaneous algebraic reconstruction technique(OS-SART) algorithm with different regular terms as image processing *** the iterative reconstruction,we selected two image processing algorithms,the Total Variation and split Bregman solved total variation algorithms,for comparison with the performance of the ADF ***,the filtered back-projection algorithm was used for comparison with an iterative *** reconstructing the projection data of the numerical and clock models,we compared and analyzed the effects of each algorithm applied in the NCT *** on the reconstruction results,OS-SART-ADF outperformed the other algorithms in terms of denoising,preserving the edge structure,and suppressing *** example,when the 3D Shepp–Logan was reconstructed at 25 views,the root mean square error of OS-SART-ADF was the smallest among the four iterative algorithms,at only *** universal quality index,mean structural similarity,and correlation coefficient of the reconstructed image were the largest among all algorithms,with values of 0.9877,0.9878,and 0.9887,respectively.

关键词： NCT OS-SART Sparse-view Anisotropic diffusion filtering

Computational Experiments for Complex Social Systems:Integrated Design of Experiment System

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1175-1189页

作者： xiao Xue Xiangning Yu Deyu Zhou xiao Wang Chongke Bi Shufang Wang fei-Yue Wang College of Intelligence and Computing Tianjin UniversityTianjin 300350China School of Software Shandong UniversityJinan 250101China School of Artificial Intelligence Anhui UniversityHefei 230601China School of Geographic and Environmental Sciences Tianjin Normal UniversityTianjin 300387China Institute of Automation Chinese Academy of Sciences Beijing 100190China

Powered by advanced information industry and intelligent technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).And human factors have become crucial in the operations of complex social *** mechanical analysis and social simulations alone are powerless for analyzing complex social *** this backdrop,computational experiments have emerged as a new method for quantitative analysis of complex social systems by combining social simulation(e.g.,ABM),complexity science,and domain ***,in the process of applying computational experiments,the construction of experiment system not only considers a large number of artificial society models,but also involves a large amount of data and *** a result,how to integrate various data,model and knowledge to achieve a running experiment system has become a key *** paper proposes an integrated design framework of computational experiment system,which is composed of four parts:generation of digital subject,generation of digital object,design of operation engine,and construction of experiment ***,this paper outlines a typical case study of coal mine emergency management to verify the validity of the proposed framework.

关键词： artificial system operations

Recent progress in single crystal perovskite X-ray detectors

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： xiao LIU Jun ren Yu-Ang CHEN Xiangshun GENG Dan XIE Tian-Ling ren School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging