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Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed,ovariectomized rats

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Acta Pharmacologica Sinica 2007年第8期28卷 1189-1197页

作者： xiao-fei AN~(1,3) jiang-yi yu~1.yi feng~2.bo-ying chen~2.su-lin zhang~1 ~1.epartment of endocrinology,jiangsu Province hospital of traditional chinese medicine,Nanjing 2.002.,china ~2Department of Neurobiology and Integrative medicine,Shanghai Medical College,Fudan University,Shanghai 200032,china Department of {1. Jiangsu Province Hospital of Traditional ChineseMedicineNanjing 210029China Department of Neurobiology and Integrative {1. Shanghai MedicalCollegeFudan UniversityShanghai 200032China

Aim:To investigate the role of hypothalamus nociceptin/orphanin FQ（OFQ）andits endogenous receptor,the opioid receptor-likel receptor（ORL1.receptor）in theestrus cycle of female ***:Radioimmunoassay was used to detect theeffect of the intracerebroventricular（icy）administration of OFQ and/or the ORL1.eceptor antagonist[Nphe1.Nociceptin（1.1.）NH2.that is,NC1. on luteinizinghormone（LH）levels of estrogen- and progesterone（EBP）-primed,ovariectomized（OVX）rats（EBP-primed OVX rats）.RT-PCR,Western blotting,and immunohis-tochemistry techniques were adopted to observe the changes of OFQ and theORL1.receptor in the pre-optic area（POA）and the medial basal hypothalamus（MBH）of the estrus cycle of female ***:Pre-ovulatory LH surges in EBP-primed,OVX rats were significantly reduced by icv administration of 2. and 2.0nmol OFQ（P2. nmol OFQ could be a{1.lished by pretreat-merit with 2. nmol *** OFQ mRNA level in the POA on pro-estrus waslowered markedly compared to diestrus and estrus（P1.receptor showed no significant changes in the POAand MBH across the estrus ***,the number of OFQ-immunoreac-tive neurons in the medial POA,ventromedial hypothalamus,and the arcuatenucleus on pro-estrus was significantly decreased compared to diestrus and es-tins（Psurge of EBP-primed,OVX rats and its downregulation in POA and MBH on pro-estrus sug-gests that it might play a negative modulatory role in the estrus cycle.

关键词： orphanin FQ opioid receptor-like 1.receptor luteinizing hormone estrus cycle hypothalamus

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Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy

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World Journal of Diabetes 2024年第11期15卷 2189-2202页

作者： Wen-Jie sun Xue-Dong An yue-Hong {2. Shan-Shan Tang yu-Ting sun xiao-Min Kang lin-lin jiang Xue-fei Zhao Qing Gao Hang-yu Ji feng-Mei Lian Department of {1. Guang’anmen HospitalBeijing 100053China Department of {1. Fangshan Hospital of Beijing University of Chinese MedicineBeijing 102400China Department of {1. Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

Diabetic retinopathy(DR),as one of the most common and significant microvascular complications of diabetes mellitus(DM),continues to elude effective targeted treatment for vision loss despite ongoing enrichment of the understanding of its pathogenic mechanisms from perspectives such as inflammation and oxidative *** studies have indicated that characteristic neuroglial degeneration induced by DM occurs before the onset of apparent microvascular *** order to comprehensively grasp the early-stage pathological changes of DR,the retinal neurovascular unit(NVU)will become a crucial focal point for future research into the occurrence and progression of *** on existing evidence,ferroptosis,a form of cell death regulated by processes like ferritinophagy and chaperone-mediated autophagy,mediates apoptosis in retinal NVU components,including pericytes and ganglion ***-dependent ferroptosis-related factors,including BECN1.and FABP4,may serve as {1.th biomarkers for DR occurrence and development and potentially crucial targets for future effective DR *** aforementioned findings present novel perspectives for comprehending the mechanisms underlying the early-stage pathological alterations in DR and open up innovative avenues for investigating supplementary therapeutic strategies.

关键词： Diabetic retinopathy Diabetes mellitus Retinal neurovascular unit Autophagy-dependent ferroptosis Early stage Mechanisms

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Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated chinese and Western {1.

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chinese Journal of Integrative {1. 2023年第4期29卷 308-315页

作者： QU yi-lun DONG Zhe-yi {2.G Hai-mei LIU Qian WANG Qian YANG Hong-tao MAO Yong-hui LI Ji-jun LIU Hong-fang GENG Yan-qiu HUANG Wen LIU Wen-hu XIE Hui-di PENG fei LI Shuang jiang Shuang-shuang LI Wei-zhen DUAN Shu-wei feng Zhe zhang Wei-guang LIU yu-ning TIAN Jin-zhou {2. Xiang-mei Department of Nephrology First Medical Center of Chinese People's Liberation Army General HospitalNephrology Institute of the Chinese People's Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Guangdong Metabolic Diseases Research Center of Integrated {1. and Western {2. Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaInstitute of Chinese MedicineGuangdong Pharmaceutical UniversityGuangdong Traditional Chinese Medicine Key Laboratory for Metabolic DiseasesGuangzhou 510006China Department of Nephrology The First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Nephrology Beijing HospitalBeijing 100730China Department of Nephrology The Forth Medical Center of People's Liberation Army General HospitalBejing 100039China Department of {1. Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBejing 100700China Department of Nephrology The Third Medical Center of PLA General HospitalBeijing 100039China Department of Nephrology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Nephrology Beijing Friendship HospitalFaculty of Kidney DiseasesCapital Medical UniversityBeijing 100050China Department of Nephrology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Three Departments of Encephalopathy Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China

Objective:To investigate the factors related to renal impairment in patients with diabetic kidney disease(DKD)from the perspective of integrated chinese and Western ***:Totally 492.patients with DKD in 8 chinese {2.s from October 2.1. to July 2.1. were *** to Kidney Disease Improving Global Outcomes(KDIGO)staging guidelines,patients were divided into a chronic kidney disease(CKD)1.3 group and a CKD 4-5 *** data were collected,and logistic regression was used to analyze the factors related to different CKD stages in DKD ***:Demographically,male was a factor related to increased CKD staging in patients with DKD(OR=3.1.0,P=0.002..In clinical characteristics,course of diabetes>60 months(OR=3.562.P=0.01.),anemia(OR=4.1.6,P1.,hyperuricemia(OR=3.352.P1.,massive albuminuria(OR=4.058,P=0.002.,atherosclerosis(OR=2.1.3,P=0.007)and blood deficiency syndrome(OR=1.945,P=0.02.)were factors related to increased CKD staging in patients with ***:Male,course of diabetes>60 months,anemia,hyperuricemia,massive proteinuria,atherosclerosis,and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD.(Registration ***0386591.).

关键词： diabetickidney disease integrated chinese and Western {1. chinese {1. syndrome

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Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2.Diabetes:A Randomized,Double-Blind,Place{1.-Controlled Multicenter Clinical Study

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chinese Journal of Integrative {1. 2022年第4期28卷 304-311页

作者： QU ling LIANG {1.-chun TIAN Guo-qing {2. Gai-li WU Qun-li HUANG Xiu-mei CUI Ya-zhong LIU yu-ling SHEN Zhu-fang MA Guo-qing LU Hao LI yi jiang Hong YANG Xi-yan {2. Guang-de YANG chen-hua Department of {1. {2. medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Department of {1. the Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHaerbin150001China Department of {1. Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Department of {1. {2. medicine Beijing HospitalBeijing10005China Department of {1. the Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110034China Department of Geriatrics the First Affiliated Hospital of Tianjin University of Chinese MedicineTianjin300073China Department of {1. Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Department of {1. Affiliated Hospital of Henan Academy of Traditional Chinese MedicineZhengzhou450003China

Objective:To assess the efficacy and safety of mulberry twig alkaloids(Sangzhi alkaloids,SZ-A)for treatment of type 2.diabetes in a randomized,double-blind,place{1.-controlled multicenter clinical ***:A total of 2.0 patients were randomized to receive SZ-A(n=1.0)or place{1.(n=1.0)for 1. *** data analysis system for electronic data capture clinical trial central randomization system was used for randomization and dispensing of *** primary outcome was the change in glycosylated hemoglobin(Hb A1.)*** secondary outcome included the proportions of cases with Hb A1.1.2.)),{1.dy weight,and {1.dy mass index(BMI).Adverse events(AEs),severe adverse events(SAEs),treatment-related adverse events(TAEs),gastrointestinal disorders(GDs),blood pressure,routine blood tests,and liver and kidney function were ***:Compared with baseline,the change of Hb A1. at week 1. was-0.80%(95%CI:-0.98%to-0.62.)and-0.09%(95%CI:-0.2.%to 0.09%)in SZ-A group and place{1. group,*** proportion of patients with Hb A1.1. group(46.8%vs.2.1}6%and 2..9%vs.1..8%).The observed values and changes in FBG,1.h-PBG,2.h-PBG,and AUC_(0-2.) differed significantly between groups(P1.,but differences were not significant in {1.dy weight and BMI(P>0.05).The incidence rates of AEs,TAEs,and GDs differed significantly between groups(P=0.01.,P=0.005,and P=0.006,respectively),whereas the incidence rates of SAEs showed no significant differences between groups(P=1.000).Conclusion:SZ-A are effective and safe for treatment of type 2.diabetes.

关键词： type 2.diabetes mellitus mulberry twig alkaloids tablets(Sangzhi alkaloids) efficacy safety placebo

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Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine:a group consen{1.s

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Journal of Zhejiang University-Science B(Bio{1. & Biotechnology) 2017年第3期18卷 186-193页

作者： Fan QU Rong LI Wei suN Ge {1. Rong {2. Jing YANG Li TIAN Guo-gang XING Hui jiang fei GONG xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN Women's hospital School of Medicine Zhejiang University Hangzhou 310006 China Center of Reproductive medicine Department of Obstetrics and Gynecology Peking University Third Hospital / Key Laboratory of Assisted Reproduction Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191 China Center of Reproductive medicine the Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine Jinan 250001 China Center of Reproductive medicine CITIC Xiangya Reproductive and Genetic Hospital Changsha 410008 China Neuroscience Research Institute Peking University / Department of Neurobiology School of Basic Medical Sciences / Peking University Health Science Center / Key Lab for Neuroscience Ministry of Education/Ministry of Health Beijing 100083 China Center of Reproductive medicine Renmin Hospital of Wuhan University Wuhan 430060 China Center of Reproductive medicine Peking University People 's Hospital Beijing 100044 China Center of Reproductive medicine the Sixth Affiliated Hospital of Zhongshan University Guangzhou 510655 China Center of Reproductive medicine Jiangsu Province Hospital Nanjing 210029 China Center of Reproductive medicine Beijing Obstetrics and Gynecology Hospital Beijing 100026 China Zhejiang {1. Medical University Hangzhou 310053 China Wuxi HANS Therapy Medical Technology Co. Ltd. Wuxi 214092 China

Abstract： With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture （EA） and transcutaneous electrical acupoint stimulation （TEAS）, become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility. This present paper describes how to select acupoints for the treatment of infertility from the view of theories of traditional {1. {2. and how to determine critical parameters of electric pulses of ENTEAS based on results from animal and clinical studies. It summarizes the principles of clinical application of EA/rEAS in treating various kinds of reproductive disorders, such as polycystic ovary syndrome （PCOS）, pain induced by oocyte retrieval, diminished ovarian reserve, embryo transfer, and oligosperrnia/ asthenospermia. The possible underlying mechanisms mediating the therapeutic effects of EA/TEAS in reproductive {2. are also examined.

关键词： Electroacupuncture (EA) Transcutaneous electrical acupoint stimulation (TEAS) Reproductive medicine Group consensus

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黄蜀葵花半浸膏片剂治疗非增殖期2.糖尿病视网膜病变的临床研究

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中国中西医结合杂志 2020年第8期40卷 901-907页

作者：周静波周雷余旭娄妍孙心怡朱博钰安晓飞余江毅赵越南京中医药大学附属医院江苏省中医院内分泌科南京210029

目的探讨黄蜀葵花半浸膏片剂干预非增殖期2.糖尿病视网膜病变(NPDR)的临床疗效。方法选择符合条件的NPDR患者60例,以区组随机法分为治疗组及对照组,每组30例。两组均给予西医基础治疗,治疗组同时加用黄蜀葵花半浸膏片剂(甲花片)治疗,... 详细信息

目的探讨黄蜀葵花半浸膏片剂干预非增殖期2.糖尿病视网膜病变(NPDR)的临床疗效。方法选择符合条件的NPDR患者60例,以区组随机法分为治疗组及对照组,每组30例。两组均给予西医基础治疗,治疗组同时加用黄蜀葵花半浸膏片剂(甲花片)治疗,所有患者均每月随访1.,连续随访6个月。记录患者的用药情况及不良事件。观察比较6个月后两组患者DR缓解率、进展率、视力改善情况[早期糖尿病视网膜病变治疗研究(ETDRS)视力评分],黄斑区视网膜厚度[包括黄斑区视网膜平均厚度(CAT)、中央区厚度(CST)及视网膜体积(CV)]及血清血清血管内皮生长因子(VEGF)水平变化的差异。结果治疗组脱落2.(6.7%),对照组脱落1.(3.3%),两组脱落例数(脱落率)比较,差异无统计意义(χ^2.0.00,P=1.。治疗6个月后,治疗组DR分期缓解率[2..5%(1./51.]显著优于对照组[5.5%(3/55),χ^2.9.51.P=0.002.;治疗组ETDRS视力评分显著优于对照组(Z=2.69,P=0.007)。与本组治疗前比较,治疗组治疗后CAT、CST、CV及血清VEGF水平显著下降(P1.。结论黄蜀葵花半浸膏片剂可缓解NPDR程度,改善患者视力和黄斑区视网膜水肿,降低患者血清VEGF水平。

关键词：黄蜀葵花半浸膏片剂非增殖期2.糖尿病视网膜病变临床疗效

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贵州省两个结核病监测点RFP和INH耐药基因检测与分析

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中国病原生物学杂志 2019年第11期14卷 1312-1315,1319页

作者：黄俊飞陈依江陈旭郑雯琳陈慧娟陈玮肖子宇李世军贵州省疾病预防控制中心贵州贵阳550001 贵州中医药大学第二附属医院

目的应用分子生物学技术对贵州省威宁县和仁怀市2.结核病省级耐药监测点2.1.年确诊结核病患者感染结核分枝杆菌(MTB)RFP和INH耐药基因进行检测与分析,为结核病的防治提供参考数据。方法采用半巢式全自动实时荧光定量PCR结合PCR-线性杂... 详细信息

目的应用分子生物学技术对贵州省威宁县和仁怀市2.结核病省级耐药监测点2.1.年确诊结核病患者感染结核分枝杆菌(MTB)RFP和INH耐药基因进行检测与分析,为结核病的防治提供参考数据。方法采用半巢式全自动实时荧光定量PCR结合PCR-线性杂交酶显色法对威宁县和仁怀市97例确诊结核病患者的痰培养物进行MTB核酸及利福平(RFP)和异烟肼(INH)耐药基因检测,分析结核病患者性别年龄构成。结果威宁县52.痰培养物样品经半巢式全自动实时荧光定量PCR检测出MTB核酸阳性49份,阳性率94.2.%,RFP耐药基因阳性3份,RFP耐药率为6.1.%。对RFP耐药基因阳性标本进行菌株分离培养和PCR-线性杂交酶显色检测,结果显示其中1.为RFP和INH双重耐药,双重耐药率为2.04%;仁怀市45份样品经半巢式全自动实时荧光定量PCR检测出MTB核酸阳性33份,阳性率73.33%。对RFP耐药基因阳性的2.标本进行菌株分离培养和PCR-线性杂交酶显色检测,结果显示RFP和INH耐药基因均阳性,双重耐药率为6.06%。患者性别构成分析结果显示,威宁县结核病患者男女比例为1.9∶1.仁怀市为1.6∶1.均为男多于女。患者年龄段分析显示,以青年及中年(1.-65岁)多见,威宁县占86.53%(45/52.,仁怀市占75.56%(34/45)。结论威宁县结核病患者感染MTB RFP耐药率6.1.%,RFP和INH双重耐药率为2.04%;仁怀市结核病患者感染MTB RFP耐药率为6.06%,RFP和INH双重耐药率为6.06%。两地患者中均呈现男多于女,且以青年及中年占多数,结果可为当地结核病的防治提供参考依据。

关键词：结核分枝杆菌耐药利福平异烟肼

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结核分枝杆菌双靶标环介导恒温扩增检测方法的建立与应用

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中国病原生物学杂志 2021年第5期16卷 513-519页

作者：杨幸贵黄俊飞陈依江肖子宇汪小娟郑雯琳陈旭刘英陈玮袁薇胡勇李世军贵州医科大学公共卫生学院贵州贵阳550025 贵州省疾病预防控制中心实验中心贵州中医药大学第二附属医院中心实验室

目的建立基于双靶标环介导恒温扩增(LAMP)的结核分枝杆菌(MTB)检测技术并应用于临床。方法以结核分枝杆菌复合群(MTBC)插入序列IS61.0和MTB mtp40基因为检测靶标,分别设计1.LAMP引物。通过引物浓度和反应条件优化,建立基于双靶标的检... 详细信息

目的建立基于双靶标环介导恒温扩增(LAMP)的结核分枝杆菌(MTB)检测技术并应用于临床。方法以结核分枝杆菌复合群(MTBC)插入序列IS61.0和MTB mtp40基因为检测靶标,分别设计1.LAMP引物。通过引物浓度和反应条件优化,建立基于双靶标的检测方法(mtp40-LAMP和IS61.0-LAMP),比较2.方法的灵敏度和特异性。应用建立的mtp40-LAMP和IS61.0-LAMP方法与PCR、萋-尼氏抗酸染色法和分枝杆菌分离培养法,分别对55例患者的痰标本进行检测与鉴定,通过对其结果的比较分析评价mtp40-LAMP和IS61.0-LAMP方法的实用性。结果灵敏度试验显示,mtp40-LAMP和IS61.0-LAMP方法可检出MTB基因组DNA最低浓度为1.5fg/μl,比常规的PCR方法高1.~1.0倍。mtp40-LAMP和IS61.0-LAMP方法的特异性为1.0%,能检测MTB菌株并能从MTBC中鉴别MTB。痰标本检测显示,IS61.0-LAMP与PNB鉴定结果一致性检验的Kappa值为0.881.P1.,mtp40-LAMP与TCH鉴定结果的Kappa值为0.887(P1.。与PCR方法和萋-尼氏抗酸染色法检测结果比较,mtp40-LAMP和IS61.0-LAMP方法敏感性更高。反应体系中加入MG指示剂可直接通过肉眼观察颜色变化进行结果判定,实现了快速闭管检测。从样本处理(35min)、扩增反应(40min)到结果验证(1.2.in),整个检测过程80min内即可完成。结论基于LAMP技术建立的mtp40-LAMP和IS61.0-LAMP双靶标检测方法敏感性高、特异性强,能够快速、准确地检测和鉴别MTB,可作为潜在的MTB快速筛查或诊断工具。

关键词：环介导恒温扩增结核分枝杆菌复合群结核分枝杆菌颜色判定

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黄芪甲苷介导内皮祖细胞外泌体对高糖受损内皮细胞增殖和凋亡的影响

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中国临床药理学杂志 2021年第15期37卷 2048-2050页

作者：白雪梁文菲彭阿建熊武肖慧易琼余亦程邹晓玲湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院烧伤整形外科湖南长沙410007 湖南中医药大学第一附属医院重症医学科湖南长沙410007 湖南中医药大学第一附属医院内分泌科湖南长沙410007

目的探讨黄芪甲苷(AS-Ⅳ)介导的内皮祖细胞外泌体(EPCs-Exos)对高糖受损内皮细胞(ECs)增殖和凋亡的影响。方法从足月健康新生儿脐带血中分离、培养单个核细胞,用CD31.体联合4,6-二脒基-2.苯基吲哚(DAPI)核染鉴定,获得的EPCs用1.0 mg·L... 详细信息

目的探讨黄芪甲苷(AS-Ⅳ)介导的内皮祖细胞外泌体(EPCs-Exos)对高糖受损内皮细胞(ECs)增殖和凋亡的影响。方法从足月健康新生儿脐带血中分离、培养单个核细胞,用CD31.体联合4,6-二脒基-2.苯基吲哚(DAPI)核染鉴定,获得的EPCs用1.0 mg·L^(-1.AS-Ⅳ干预2. h。用超速离心法结合超滤法提取细胞上清液中囊泡结构,用透射电子显微镜进行形态观察,用蛋白质印迹(WB)法检测外泌体表面特征性标志蛋白CD9、CD63、CD81.体外分离、培养人脐静脉内皮细胞(HUVECs),用vWF因子联合DAPI核染鉴定,获得的HUVECs用30 mmol·L^(-1.葡萄糖干预1.0 h,随机分为实验组、对照组并设置正常组(用正常EGM-2.养基预培养1.0 h)。实验组用AS-IV介导下的EPCs-Exos处理2. h,对照组和正常组用等容量PBS处理2. h,用CCK-8细胞增殖检测试剂盒,用流式细胞术分别检测细胞增殖和凋亡情况。结果正常组、对照组和实验组OD值分别为0.73±0.00,0.45±0.00和0.74±0.01.凋亡率分别为(6.44±0.2.)%,(2..41.1.1.)%和(9.54±0.2.)%。各组细胞凋亡率比较,差异均有统计学意义(均P<0.05)。结论高糖环境下ECs增殖能力抑制明显、凋亡率上升,而AS-IV介导的EPCs-Exos可显著促进高糖受损ECs增殖并抑制其凋亡,对ECs有明确的保护作用。

关键词：黄芪甲苷内皮祖细胞外泌体糖尿病血管病变增殖凋亡

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头静脉转位联合缩窄术治疗高流量肱动脉-头静脉内瘘患者头静脉弓狭窄的临床疗效

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中国普通外科杂志 2019年第6期28卷 725-730页

作者：黄小妹王银肖伟张艺高渤李晶晶江中涛叶飞马卫国钱淑萍华中科技大学同济医学院附属武汉中心医院肾内科湖北武汉430014 华中科技大学同济医学院附属武汉中心医院超声影像科湖北武汉430014 湖北中医药大学湖北武汉430061 湖北省武汉市新洲区人民医院肾内科湖北武汉430400 湖北航天医院肾内科湖北孝感432000 湖北省武汉市江夏区中医院肾内科湖北武汉430200 江汉大学附属第三医院/武汉市黄陂区人民医院肾内科湖北武汉430300

目的:评估头静脉转位贵要(腋)静脉加内瘘缩窄术治疗高流量肱动脉-头静脉内瘘(BCF)患者头静脉弓狭窄(CAS)的疗效。方法:选择2.1.年1.—2.1.年6月2.例因CAS入院的高流量BCF患者,行头静脉转位贵要(腋)静脉加内瘘缩窄术治疗,观察患者术后2...

目的:评估头静脉转位贵要(腋)静脉加内瘘缩窄术治疗高流量肱动脉-头静脉内瘘(BCF)患者头静脉弓狭窄(CAS)的疗效。方法:选择2.1.年1.—2.1.年6月2.例因CAS入院的高流量BCF患者,行头静脉转位贵要(腋)静脉加内瘘缩窄术治疗,观察患者术后2. h的超声内瘘血管血流动力学变化,及术后内瘘的初级通畅率及次级通畅率。结果:术前2.例患者平均透析时间(73.5±44.4)个月,头静脉弓内径(2.1.0.5)mm,人均接受过(1.9±0.4)次经皮球囊扩张成形术(PTA)治疗。术后2. h,患者肱动脉阻力指数及肱动脉内径较术前无明显变化(均P>0.05),但肱动脉平均血流量及吻合口/静脉流出道内径较术前明显下降(均P2.0}5个月,术后6、1.、2.、36个月初级通畅率分别为1.0%、1.0%、93.3%、58.3%,较其行PTA时明显升高(χ^2.49.2.,P=0.000);6、1.、2.、36个月次级通畅率均为1.0%。术后仅有2.出现皮下血肿,无需处理;术后及随访期间无血栓事件发生。结论:静脉转位贵要(腋)静脉加内瘘缩窄术治疗高流量BCF患者CAS安全可控,能获得较好的远期通畅率。

关键词：动静脉瘘缩窄,病理性头臂静脉腋静脉血管外科手术

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