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The emerging roles of lysine-specific demethylase 4A in cancer:Implications in tumorigenesis and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 645-663页

作者： Guanjun Yang Changyun Li fan Tao Yanjun Liu Minghui zhu Yu Du Chenjie Fei Qiusheng She Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China School of Life Science and Engineering Henan University of Urban ConstructionPingdingshanHenan 467044China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Key Laboratory of Aquacultural Biotechnology Ministry of Education Ningbo UniversityNingboZhejiang 315211China

Lysine-specific demethylase 4 A(KDM4A,also named JMJD2A,KIA0677,or JHDM3A)is a demethylase that can remove methyl groups from histones H3K9me2/3,H3K36me2/3,and H1.4K26me2/me3.Accumulating evidence suggests that KDM4A is not only involved in body homeostasis(such as cell proliferation,migration and differentiation,and tissue development)but also associated with multiple human diseases,especially cancers.Recently,an increasing number of studies have shown that pharmacological inhibition of KDM4A significantly attenuates tumor progression in vitro and in vivo in a range of solid tumors and acute myeloid leukemia.Although there are several reviews on the roles of the KDM4 subfamily in cancer development and therapy,all of them only briefly introduce the roles of KDM4A in cancer without systematically summarizing the specific mechanisms of KDM4A in various physiological and pathological processes,especially in tumorigenesis,which greatly limits advances in the understanding of the roles of KDM4A in a variety of cancers,discovering targeted selective KDM4A inhibitors,and exploring the adaptive profiles of KDM4A antagonists.Herein,we present the structure and functions of KDM4A,simply outline the functions of KDM4A in homeostasis and non-cancer diseases,summarize the role of KDM4A and its distinct target genes in the development of a variety of cancers,systematically classify KDM4A inhibitors,summarize the difficulties encountered in the research of KDM4A and the discovery of related drugs,and provide the corresponding solutions,which would contribute to understanding the recent research trends on KDM4A and advancing the progression of KDM4A as a drug target in cancer therapy.

关键词： Cancer therapy Drug resistance Histone demethylation JmjC domain KDM4A

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Geographically and Temporally Weighted Regression in Assessing Dengue Fever Spread Factors in Yunnan Border Regions

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Biomedical and Environmental Sciences 2024年第5期37卷 511-520页

作者： zhu xiao Xiang WANG Song Wang LI Yan Fei ZHANG Ye Wu SU Xue Mei ZHAO xiao Tao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102211China Yunnan Institute of Parasitic Diseases Pu’er 665000YunnanChina

Objective This study employs the Geographically and Temporally Weighted Regression(GTWR)model to assess the impact of meteorological elements and imported cases on dengue fever outbreaks,emphasizing the spatial-temporal variability of these factors in border regions.Methods We conducted a descriptive analysis of dengue fever’s temporal-spatial distribution in Yunnan border areas.Utilizing annual data from 2013 to 2019,with each county in the Yunnan border serving as a spatial unit,we constructed a GTWR model to investigate the determinants of dengue fever and their spatio-temporal heterogeneity in this region.Results The GTWR model,proving more effective than Ordinary Least Squares(OLS)analysis,identified significant spatial and temporal heterogeneity in factors influencing dengue fever’s spread along the Yunnan border.Notably,the GTWR model revealed a substantial variation in the relationship between indigenous dengue fever incidence,meteorological variables,and imported cases across different counties.Conclusion In the Yunnan border areas,local dengue incidence is affected by temperature,humidity,precipitation,wind speed,and imported cases,with these factors’influence exhibiting notable spatial and temporal variation.

关键词： Dengue fever Meteorological factor Geographically and temporally weighted regression

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Bilateral iridocorneal endothelial syndrome-Chandler’s syndrome:a case report and literature review

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 773-776页

作者： xiao-Hua Pan Yu-Fei Tao Ming-Min Yang xiao-Li Shen Jiao Si Ming Li Ning fan Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina

Dear Editor,I ridocorneal endothelial syndrome(ICE)is a rare ocular disease first proposed by Eagle et al[1]in 1979.It is mainly characterized by corneal endothelial abnormalities,accompanied by iris atrophy,iris pigmented nodules and peripheral anterior synechiae.ICE syndrome is typically unilateral,and classified into three clinical variants based on the changes of the cornea and iris,including progressive iris atrophy,Chandler’s syndrome,and Cogan-Reese syndrome.

关键词： corneal atrophy clinical

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Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction

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Nuclear Science and Techniques 2024年第3期35卷 40-52页

作者： Ding-Han zhu Xiong Zhang xiao-Qiang Li Peng Li Yan-Bin Wang Shuang Zhang State Key Laboratory of NBC Protection for Civilian Beijing 102205China

In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such events.These pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric transmission.To quantitatively analyze the effects of different satellite detection altitudes,burst heights,and transmission angles on the physical processes of X-ray transport and energy fluence,we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction.The proposed method is an improvement over the traditional analytical method that only computes direct-transmission X-rays.The traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo method.Our improved method reduces this error to within 10% under the same conditions,even reaching 1% in certain scenarios.Moreover,its computation time is 48,000 times faster than that of the Monte Carlo method.These results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors,inverting nuclear detonation source terms,and assessing ionospheric effects.

关键词： High-altitude nuclear detonation Atmospheric transmission Pulsed X-rays Scattering correction Analytical method Monte Carlo method

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Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： Yu-Sheng zhu Si-Rui Zhou Hui-Hui Zhang Tong Wang xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)cells.METHODS:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL EGF.Erlotinib and EGFR siRNA were used to intervene EGF treatment.Cellular viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,respectively.EGFR/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot assay.EGFR was also determined by immunofluorescence staining.RESULTS:EGF treatment for 24h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR expression.Erlotinib suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein expressions.Erlotinib also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin proteins.Similarly,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin proteins.CONCLUSION:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE cells.EGFR inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell

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Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 731-739页

作者： xiao-Wen Sun Jing-Yi Xu Chang-Zhen zhu Si-Jia Li Lu-Jia Jin Zhi-Dong zhu Department of Gastrointestinal Surgery Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China Surgical Department Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China

BACKGROUND Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in anorectal surgery.They are venous clusters formed by con-gestion,expansion,and flexion of the venous plexus in the lower part of the rec-tum.Mixed hemorrhoids bleed easily and recurrently,and this can result in severe anemia.Hence,they may have a negative effect on the health of the patient and surgical treatment is required.Milligan-Morgan hemorrhoidectomy has been widely used since 1937 for the treatment of grade III and IV hemorrhoids.How-ever,most patients experience different degrees of postoperative pain that may cause anxiety.with mixed hemorrhoids post-surgery.METHODS The clinical data of patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy were collected retrospectively.The basic character-istics of the enrolled patients with mixed hemorrhoids were recorded,and based on the Goligher clinical grading system,the hemorrhoids were classified as grades III or IV.The endpoint of this study was the disappearance of pain in all patients.Quantitative data were presented as mean±SD,such as age,pain score,and QoL score.Student’s t-test was used to compare the groups.RESULTS A total of 164 patients were enrolled.The distribution of the visual analog scale pain scores of all patients at 3,7,14 and 28 d after surgery showed that post-surgery pain was significantly reduced with the passage of time.Fourteen days after the operation,the pain had completely disappeared in some patients.Twenty-eight days after the surgery,none of the patients experienced any pain.Comparing the World Health Or-ganization Quality of Life-BREF self-reporting questionnaire scores of patients between 14 and 28 d after surgery,we observed that the quality-of-life scores of the patients post-surgery had significantly improved.There were six items that were compared at 14-and 28-d post-surgery.The mean QoL score 28 d after surgery(4.79±0.46)was higher than that at 14 d post-surgery(3.79±0.57).The mean health condition

关键词： Hemorrhoids Mixed hemorrhoids Milligan organ hemorrhoidectomy Postoperative pain Quality of life Anesthesia mode

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Boosting spring runoff into the sea by reservoir regulation and its potential for estuarine fishery recovery

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Science China Earth Sciences 2024年第5期67卷 1591-1603页

作者： xiao WU Houjie WANG Yongyong fan Naishuang BI Chiyuan MIAO Jingping XU Zuosheng YANG College of Marine Geosciences Key Laboratory of Submarine Geosciences and Prospecting Technologyand Frontiers Science Center for Deep Ocean Multispheres and Earth SystemOcean University of ChinaQingdao 266100China Laoshan National Laboratory Qingdao 266061China Institute of the Yellow River Estuary and Coast Science Dongying 257000China State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Department of Ocean Science&Engineering Southern University of Science and TechnologyShenzhen 518055China

With global surge in reservoir construction over the past decades,river systems worldwide have been profoundly fragmented.Consequently,flow manipulation by reservoirs has altered the natural hydrological processes,resulting in extensive modifications of fluvial-marine ecosystems.Mitigating the adverse ecological consequences of reservoirs has become a global concern and has garnered increasing attention.The Yellow River,as one of the most extensively manipulated river systems globally,has experienced substantial changes in the amount and timing of water discharge due to the presence of numerous reservoirs scattered throughout its catchment area.These alterations have caused physicochemical changes in the estuary and subsequent modifications to the estuarine ecosystem.In recent years,the Yellow River Conservancy Committee initiated the release of water through the xiaolangdi Dam during the major spawning period of fisheries,specifically in the spring,with the aim of improving the estuarine ecological environment.From 2011 to 2020,a total of 84.05 km^(3)of water was discharged from the xiaolangdi Reservoir during spring seasons,of which 40%(33.16 km^(3))constituted water impounded within the reservoir during preceding months.Correspondingly,the spring water discharge from the Yellow River to the sea increased significantly from 1.50 km^(3)/yr to 3.46 km^(3)/yr in the past decade,leading to a decrease in estuarine salinity by 1.6 PSU.The estuarine fishery resources,such as fish eggs in the Yellow River estuary,have demonstrated evident improvement.The reservoir regulation in the Yellow River,which has successfully enhanced spring water discharge and subsequently restored estuarine fishery resources,presents an effective attempt for mitigating the adverse ecological effects associated with reservoirs.

关键词： Reservoir regulation Water release Spring runoff Estuarine ecosystem Yellow River

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Modifiable risk factors for esophageal cancer in endoscopic screening population:A modeling study

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Chinese Medical Journal 2024年第3期137卷 350-352页

作者： Qian Zhang fan Wang Hao Feng Jie Xing Shengtao zhu Hao Zhang Yang Li Wenqiang Wei Shutian Zhang Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijing 100050China Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China Statistical Consulting Center Renmin University of ChinaBeijing 100872China National Cancer Center National Clinical Research Center for CancerCancer InstituteChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Jizhong Energy Fengfeng Group HospitalHandanHebei 056000China RSS and China-Re Life Joint Lab on Public Health and Risk Management Renmin University of ChinaBeijing 100872China

To the Editor:Esophageal cancer,one of the most common cancer types in China,with an estimated 346,633 new cases and 323,600 deaths in 2022,is becoming an increasingly serious clinical and public health problem.^([1])The successful promotion of the self-management strategy has indicated that lifestyle modifications can be valuable in the primary prevention of cancer development.Adopting a healthy lifestyle has become a novel strategy for primary prevention and risk reduction in high-risk areas.Previous epidemiological studies have identified several lifestyle-related risk factors for esophageal cancer,including smoking and diet.^([2])Each factor can typically explain a modest proportion of cancer risk.However,when combined,these known risk factors may substantially affect the risk of esophageal cancer.Nevertheless,some risk factors for esophageal cancer are non-modifiable,including age,low socioeconomic status,and family history.Whether and how these non-modifiable risk factors affect primary cancer prevention by intervening with modifiable risk factors remain unclear.

关键词： esophageal prevention promotion

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Atmospheric Particulate Matter 2.5(PM_(2.5))Induces Cell Damage and Pruritus in Human Skin

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Biomedical and Environmental Sciences 2024年第2期37卷 216-220页

作者： HE Qiao XUE Wan Ting LI Li YI fan LING xiao GUO Miao Miao College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China China Light Industry Cosmetics Key Laboratory Beijing Technology and Business UniversityBeijing 100048China Beijing Lan Divine Technology Co.LTD Beijing 100872China

With the accelerated rate of urbanization in recent years,air pollution has become an environmental problem that requires urgent resolution,almost all of the world’s population exposed to pollution on a daily basis.A... 详细信息

关键词： pollution Skin Human

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Enterogenic Stenotrophomonas maltophilia migrates to the mammary gland to induce mastitis by activating the calcium-ROS-AMPK-mTOR-autophagy pathway

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Journal of Animal Science and Biotechnology 2024年第1期15卷 236-252页

作者： Zhaoqi He Caijun Zhao Yuhong He zhuoyu Liu Guyue fan Kun zhu Yiqi Wang Naisheng Zhang Yunhe Fu xiaoyu Hu Department of Clinical Veterinary Medicine College of Veterinary MedicineJilin UniversityChangchun 130062Jilin ProvinceChina

Background Mastitis is an inflammatory disease of the mammary gland that has serious economic impacts on the dairy industry and endangers food safety.Our previous study found that the body has a gut/rumen-mammary gland axis and that disturbance of the gut/rumen microbiota could result in‘gastroenterogenic mastitis'.However,the mechanism has not been fully clarified.Recently,we found that long-term feeding of a high-concentrate diet induced mastitis in dairy cows,and the abundance of Stenotrophomonas maltophilia(S.maltophilia)was significantly increased in both the rumen and milk microbiota.Accordingly,we hypothesized that‘gastroenterogenic mastitis'can be induced by the migration of endogenous gut bacteria to the mammary gland.Therefore,this study investigated the mechanism by which enterogenic S.maltophilia induces mastitis.Results First,S.maltophilia was labelled with superfolder GFP and administered to mice via gavage.The results showed that treatment with S.maltophilia promoted the occurrence of mastitis and increased the permeability of the blood-milk barrier,leading to intestinal inflammation and intestinal leakage.Furthermore,tracking of ingested S.maltophilia revealed that S.maltophilia could migrate from the gut to the mammary gland and induce mastitis.Subsequently,mammary gland transcriptome analysis showed that the calcium and AMPK signalling pathways were significantly upregulated in mice treated with S.maltophilia.Then,using mouse mammary epithelial cells(MMECs),we verified that S.maltophilia induces mastitis through activation of the calcium-ROS-AMPK-mTOR-autophagy pathway.Conclusions In conclusion,the results showed that enterogenic S.maltophilia could migrate from the gut to the mammary gland via the gut-mammary axis and activate the calcium-ROS-AMPK-mTOR-autophagy pathway to induce mastitis.Targeting the gut-mammary gland axis may also be an effective method to treat mastitis.

关键词： Calcium-ROS-AMPK-mTOR-autophagy pathway Gut-mammary axis Mastitis S.maltophilia

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