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An update on hormonal regulation of early embryo-fallopian tube interactions: insights for improvements of assisted reproductive technology outcomes

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Reproductive and Developmental Medicine 2024年第1期8卷 39-49页

作者： Suranga P.Kodithuwakku Ernest H.Y.ng William S.B.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology LKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Human fallopian tubes(FTs)play important roles in the whole reproductive *** are the site for the final maturation of gametes,fertilization,transport of preimplantation embryos,and early embryonic development before entering the *** these functions are critical in the establishment of a successful *** the embryo is in transit through the FT,the FT microenvironment changes through endocrine,paracrine,autocrine,and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring ***,the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of *** review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal ***,we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization(IVF)treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

Master equation,design equations and runaway speed of the Kaplan turbine

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Journal of Hydrodynamics 2021年第2期33卷 282-300页

作者： zh.zh.ng zhAW Zurch University of Applied ScienceZurichSwitzerland

To make the Kaplan turbine technology comparable to both the Pelton and the Francis turbine,the master equation for the Kaplan turbine has been established by analyses similar to that-for the Francis *** analysis begins with the descriptions of free vortex flows at the runner inlet and the swirl flow at the impeller *** considering the Euler equation for specific work and by further evaluating the most significant shock and swirling losses,the first and the second energy equations in the form of hydraulic efficiency were *** master equation is then established by combining both energy *** addition,three design equations and a new design parameter are *** master equation relates the turbine hydromechanics to the geometrical design of both the runner and the guide-vane *** enables the complete hydraulic characteristics of a given Kaplan turbine to be analytically and simply computed.A computation example demonstrates the functionality and applicability of the *** the reconstructed master equation,the runaway speed of the Kaplan turbine and its dependence on the guide-vane setting can be easily and precisely *** bulb turbines with guide vanes directly ahead of the turbine runner in the same tube,all computations are also applicable using another equivalent control parameter.

关键词： Kaplan turbine master equation design equations design parameter runaway speed hydraulic efficiency shock loss swirling loss bulb turbines

Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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“如果”句功能的类型学考察

汉语学习 2024年第2期 22-32页

作者：吴炳章姜彩璨许冰中国海洋大学外国语学院山东青岛266100

“如果”句的语义结构和用法复杂多样,但学界对该结构的功能类型分析过于笼统。文章通过语料库梳理书面语中“如果”句的结构特点和语篇关系,对其进行了功能分类。从功能视角看,“如果”句在知识域、语言域和人际域中分别发挥前提限定... 详细信息

“如果”句的语义结构和用法复杂多样,但学界对该结构的功能类型分析过于笼统。文章通过语料库梳理书面语中“如果”句的结构特点和语篇关系,对其进行了功能分类。从功能视角看,“如果”句在知识域、语言域和人际域中分别发挥前提限定、语篇建构和会话修辞等功能。根据从句和主句的意义关系,“如果”句可以分为蕴含条件句和非蕴含条件句。各类“如果”句的功能各有句法语义特征。从各类“如果”句的用法分布看,“如果”句的主要功能是表达推理关系,其次是语篇关系,再次是话语修辞。

关键词： “如果”句假设条件句间接条件句

血浆热休克蛋白90α预测肝细胞肝癌介入治疗预后的临床价值

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中华肿瘤杂志 2024年第2期46卷 118-126页

作者：孙伟李肖国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院介入治疗科 100021

目的探讨血浆热休克蛋白90α(HSP90α)与肝细胞肝癌(HCC)患者经动脉化疗栓塞(TACE)治疗反应及长期预后的关系。方法收集2017年8月至2018年12月在中国医学科学院肿瘤医院介入治疗科进行TACE治疗的96例HCC患者的病历资料, 采用χ2检验分析... 详细信息

目的探讨血浆热休克蛋白90α(HSP90α)与肝细胞肝癌(HCC)患者经动脉化疗栓塞(TACE)治疗反应及长期预后的关系。方法收集2017年8月至2018年12月在中国医学科学院肿瘤医院介入治疗科进行TACE治疗的96例HCC患者的病历资料, 采用χ2检验分析TACE治疗前血浆HSP90α水平与临床病理特征的关系, TACE治疗应答的影响因素分析采用单因素和多因素logistic回归分析, TACE治疗后患者无进展生存时间(PFS)的影响因素分析采用单因素和多因素Cox回归分析。结果 96例患者TACE治疗前的血浆HSP90α水平为(99.70±66.61)ng/ml。高HSP90α组(30例)比低HSP90α组(66例)肿瘤更大、甲胎蛋白更高、血管侵犯阳性者更多、巴塞罗那临床肝癌(BCLC)分期更晚(均Png/ml和(7.20±51.94)ng/ml, 差异有统计学意义(P50%:OR=86.831, P50%:HR=0.198, P<0.001)是TACE治疗后HCC患者PFS的独立影响因素。结论血浆HSP90α作为一种新的生物标志物, 可用于预测HCC患者TACE治疗的疗效和预后。

关键词：肝细胞肝癌经动脉化疗栓塞热休克蛋白90α 治疗应答预后

Impact of undissociated volatile fatty acids on acidogenesis in a two-phase anaerobic system

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Journal of Environmental Sciences 2016年第4期28卷 196-201页

作者： Keke xiao Yan zhou Chenghong Guo Yogananda Maspolim Wun Jern ng Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research InstituteNanyang Technological University School of Civil and Environmental Engineering Nanyang Technological University

This study investigated the degradation and production of volatile fatty acids（VFAs）in the acidogenic phase reactor of a two-phase anaerobic system.20 mmol/L bromoethanesulfonic acid（BESA）was used to inhibit acidogenic methanogens（which were present in the acidogenic phase reactor）from degrading *** impact of undissociated volatile fatty acids（un VFAs）on＂net＂VFAs production in the acidogenic phase reactor was then evaluated,with the exclusion of concurrent VFAs degradation.＂Net＂VFAs production from glucose degradation was partially inhibited at high un VFAs concentrations,with 59%,37% and 60% reduction in production rates at 2190 mg chemical oxygen demand（COD）/L undissociated acetic acid（un HAc）,2130 mg COD/L undissociated propionic acid（un HPr）and 2280 mg COD/L undissociated n-butyric acid（un HBu）,*** profile of VFAs produced further indicated that while an un VFA can primarily affect its own formation,there were also un VFAs that affected the formation of other VFAs.

关键词： Anaerobic process Waste treatment Substrate inhibition Undissociated volatile fatty acids Acidogenesis

Determination of the archaeal and bacterial communities in two-phase and single-stage anaerobic systems by 454 pyrosequencing

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Journal of Environmental Sciences 2015年第10期27卷 121-129页

作者： Yogananda Maspolim Yan zhou Chenghong Guo Keke xiao Wun Jern ng Advanced Environmental Biotechnology Centre (AEBC) Nanyang Environment and Water Research Institute (NEWRI)Nanyang Technological University (NTU) School of Civil and Environmental Engineering Nanyang Technological University (NTU)

2-Phase anaerobic digestion（AD）, where the acidogenic phase was operated at 2 day hydraulic retention time（HRT） and the methanogenic phase at 10 days HRT, had been evaluated to determine if it could provide higher organic reduction and methane production than the conventional single-stage AD（also operated at 12 days HRT）. 454 pyrosequencing was performed to determine and compare the microbial communities. The acidogenic reactor of the 2-phase system yielded a unique bacterial community of the lowest richness and diversity, while bacterial profiles of the methanogenic reactor closely followed the single-stage reactor. All reactors were predominated by hydrogenotrophic methanogens, mainly Methanolinea. Unusually, the acidogenic reactor contributed up to 24%of total methane production in the 2-phase system. This could be explained by the presence of Methanosarcina and Methanobrevibacter, and their activities could also help regulate reactor alkalinity during high loading conditions through carbon dioxide production. The enrichment of hydrolytic and acidogenic Porphyromonadaceae, Prevotellaceae, Ruminococcaceae and unclassified Bacteroidetes in the acidogenic reactor would have contributed to the improved sludge volatile solids degradation, and ultimately the overall 2-phase system＇s performance. Syntrophic acetogenic microorganisms were absent in the acidogenic reactor but present in the downstream methanogenic reactor, indicating the retention of various metabolic pathways also found in a single-stage system. The determination of key microorganisms further expands our understanding of the complex biological functions in AD process.

关键词： Sewage sludge 2-Phase anaerobic digestion Microbial community 454 pyrosequencing Methanogen

胸腺肽α1联合XELOX方案治疗结直肠癌术患者的临床研究

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中国临床药理学杂志 2024年第19期40卷 2796-2800页

作者：任晓东胡震李超亿李耀平山西省人民医院结直肠肛门外科山西太原030000

目的观察胸腺肽α1注射剂联合卡培他滨和奥沙利铂(XELOX)方案对结直肠癌术患者循环肿瘤细胞(CTC)和血清癌胚抗原(CEA)、血清糖类抗原19-9(CA19-9)、CA125水平的影响。方法将接受腹腔镜结直肠癌根治手术患者按队列法分为对照组和试验组... 详细信息

目的观察胸腺肽α1注射剂联合卡培他滨和奥沙利铂(XELOX)方案对结直肠癌术患者循环肿瘤细胞(CTC)和血清癌胚抗原(CEA)、血清糖类抗原19-9(CA19-9)、CA125水平的影响。方法将接受腹腔镜结直肠癌根治手术患者按队列法分为对照组和试验组。对照组予以辅助化疗XELOX方案,第1天给予135 mg·m^(-2)奥沙利铂,静脉滴注3 h,1000 mg·m^(-2)卡培他滨片,bid,口服,连用2周、停用1周;试验组在对照组治疗的基础上,加用胸腺肽α1每次1.6 mg,qod,皮下注射。2组患者均治疗6个疗程,每个疗程3周。比较2组患者的CTC计数、血清肿瘤标志物、外周血T淋巴细胞亚群、血清炎症因子、生存质量、安全性、术后2年无进展生存率和总生存率,以及安全性。结果试验组入组56例、对照组入组50例。试验组和对照组的术后2年无进展生存率分别为87.50%(49例/56例)和70.00%(35例/50例),在统计学上差异有统计学意义(Png·L^(-1),肿瘤坏死因子-α水平分别为(43.96±4.83)和(51.83±5.97)ng·L^(-1),Karnofsky功能状态评分分别为(86.77±6.91)和(82.23±5.32)分,癌症患者生活质量核心量表评分分别为(69.12±9.76)和(75.06±9.84)分,在统计学上差异均有统计学意义(均P<0.05)。治疗期间,试验组和对照组的中性粒细胞减少率分别为48.21%和76.00%,肝功能异常率分别为10.71%和40.00%,在统计学上差异均有统计学意义(均P<0.05)。结论胸腺肽α1注射剂联合XELOX方案辅助化疗可有效降低结直肠癌术后患者血清CEA、CA19-9、CA125水平,可改善患者细胞免疫功能,提高生存质量。

关键词：胸腺肽α1注射剂结直肠癌循环肿瘤细胞癌胚抗原血清糖类抗原19-9 血清糖类抗原125

Master equation and runaway speed of the Francis turbine

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Journal of Hydrodynamics 2018年第2期30卷 203-217页

作者： zh.zh.ng Free Researcher Zurich Switzerland

The master equation of the Francis turbine is derived based on the combination of the angular momentum（Euler） and the energy laws. It relates the geometrical design of the impeller and the regulation settings（guide vane angle and rotational speed） to the discharge and the power output. The master equation, thus, enables the complete characteristics of a given Francis turbine to be easily computed. While applying the energy law, both the shock loss at the impeller inlet and the swirling loss at the impeller exit are taken into account. These are main losses which occur at both the partial load and the overloads and, thus, dominantly influence the characteristics of the Francis turbine. They also totally govern the discharge of the water through the impeller when the impeller is found in the standstill. The computations have been performed for the discharge, the hydraulic torque and the hydraulic efficiency. They were also compared with the available measurements on a model turbine. Excellent agreement has been achieved. The computations also enable the runaway speed of the Francis turbine and the related discharge to be determined as a function of the setting angle of the guide vanes.

关键词： Francis turbine master equation runaway speed hydraulic efficiency shock loss swirling loss streamline similarity method