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Intestinal barrier in inflammatory bowel disease:A bibliometric analysis

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World Journal of Gastroenterology 2023年第45期29卷 6017-6021页

作者： Wen-Yu Luan Zhe Yang xiao-dong chen Tong-Tong Zhang Fang Zhang Yan-dong Miao Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2^(nd)Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

The primary objective of this investigation was to examine the evolving trajectories and pivotal focal points within the domain of research on intestinal barriers with regard to inflammatory bowel disease(IBD).Publications germane to the intestinal barrier in the context of IBD were procured from the Science Citation Index Expanded within the Web of Science Core Collection *** scrutiny and visualization were executed employing the R package"bibliometrix"through the R software platform(version:4.3.0).A comprehensive compilation of 7344 English-language articles spanning from January 1,2001 to December 31,2021 was meticulously identified and included in the ***,China emerged as the preeminent force in the realm of intestinal barrier research in relation to *** significance of the intestinal barrier in the context of IBD has been progressively and comprehensively *** recognition has ushered in a fresh therapeutic perspective that offers the promise of enhancing the management of inflammation and prognostication.

关键词： Intestinal barrier Inflammatory bowel disease Bibliometric analysis Bibliometrix Gastroenterology

Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： Yu-Sheng Zhu Si-Rui Zhou Hui-Hui Zhang Tong Wang xiao-dong chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)***:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL *** and EGFR siRNA were used to intervene EGF *** viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,***/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot *** was also determined by immunofluorescence ***:EGF treatment for 24h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR *** suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein *** also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin ***,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin ***:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE *** inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell

Contralateral pneumothorax in the subacute phase after pacemaker implantation:lead retention and follow-up

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Journal of Geriatric Cardiology 2018年第12期15卷 744-746页

作者： xiao-dong chen Xu XU Jia-Wen JI Hai-Lei LIU Jian-Ping SHEN Department of Cardiology Affiliated Hospital of Intergrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Jiangsu Province Academy of Traditional Chinese Medicine NanjingChina Department of Radiology Affiliated Hospital of Intergrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

An 89-year-old woman[body mass index(BMI)=20.27 kg/m^2)]with hypertension underwent implantation of a dual-chamber pacemaker because of dizziness and syncope due to sick sinus *** implantation via the left subclavian approach was performed on June 3,2017.A right ventricular active lead(TendrilTM STS 2088TC,St Jude Medical,Penang,Malaysia)and an atrial active lead(OptisenseTM 1999,St Jude Medical,Penang,Malaysia)were placed in the right ventricular apex and anterior wall of the right atrium,respectively.

关键词： Atrial lead perforation Contralateral pneumothorax Pacemaker implantation

Trace determination of cobalt ion by using malic acid-malonic acid double substrate oscillating chemical system

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Chinese Chemical Letters 2008年第9期19卷 1103-1107页

作者： Jie Wang Wu Yang Jie Ren Miao Guo xiao dong chen Wen Bin Wang Jin Zhang Gao College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070 China

A novel kinetic method for determination of trace amounts of cobalt ion was proposed and validated. The method is based on adding malic acid into classical Belousov-Zhabotinskii （B-Z） oscillating chemical system to form a double substrate one. The results showed that when the concentration of cobalt ion was in the range of 5.27× 10^-8 to 5.37 × 10^-12 mol L^-1, the change of the oscillating period was directly proportional to the negative logarithm of cobalt ion concentration. The sensitivity and precision of the developed method were quite satisfactory. The limit of detection was down to 5.20 × 10^-13 mol L^-1 which was a highest sensitivity found for determination of metal ions using oscillating chemical reaction so far. Some factors influencing the determination were also examined. The method has been successfully used to determine cobalt ion in vitamin B12 injection.

关键词： Two substrate oscillating chemical system Malic acid Cobalt Determination

Observation of gapless corner modes of photonic crystal slabs in synthetic translation dimensions

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Photonics Research 2024年第3期12卷 444-455页

作者： WEN-JIN ZHANG HAO-CHANG MO WEN-JIE chen xiao-dong chen JIAN-WEN dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Second-order topological photonic crystals support localized corner modes that deviate from the conventional bulk-edge ***,the frequency shift of corner modes spanning the photonic band gap has not been experimentally ***,we observe the gapless corner modes of photonic crystal slabs within a parameter space by considering translation as an additional synthetic *** corner modes,protected by topological pumping in synthetic translation dimensions,are found to exist independently of the specific corner *** gapless corner modes are experimentally imaged via the near-field scanning measurement and validated numerically by full-wave *** propose a topological rainbow with gradient translation,demonstrating the ability to extract and separate specific frequency components of light into different spatial *** work contributes to the advancement of topological photonics and provides valuable insights into the exploration of gapless corner modes in synthetic dimensions.

关键词： translation dimensions corner

Clinical efficacy and changes of serum VEGF-A,VEGF-B,and PLGF after conbercept treating neovascular agerelated macular degeneration

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1489-1494页

作者： xiao-dong chen Chan Li Guo-Long Ding Yan Suo Yu-Sheng Zhu Hui-Qin Lu Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an 710002Shaanxi ProvinceChina

AIM:To evaluate the clinical efficacy and systemic safety profile of conbercept in clinical practice on vascular endothelial growth factor(VEGF)-A,VEGF-B,and placental growth factor(PLGF)levels after intravitreal injections for the neovascular age-related macular degeneration(AMD).METHODS:Thir ty-five patients(35 eyes)with neovascular AMD received intravitreal injections of conbercept treatment with pro re nata *** visual acuity(BCVA)and central retinal thickness(CRT)were detected before the intravitreal injection and at 1,3,and 12mo after conbercept *** levels of serum VEGF-A,VEGF-B,and PLGF were measured by enzyme-linked immunosorbent assay before the injection and 1 and 12mo after conbercept ***:At baseline,the mean BCVA score was 39.89±14.64 *** mean BCVA scores were 51.03±15.78,56.71±14.38,and 52.49±10.16 letters at 1,3,and 12mo after conbercept treatment,and the BCVA improvements were all significant,respectively(P0.05).CONCLUSION:Conbercept intravitreal injection leads to BCVA and CRT improvement,however,it does not significantly affect systemic serum VEGF-A,VEGF-B,and PLGF levels at 1 and 12mo after intravitreal injection treating neovascular AMD.

关键词： conbercept vascular endothelial growth factor placental growth factor age-related macular degeneration

A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

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Chinese Journal of Polymer Science 2014年第3期32卷 321-332页

作者： Fa-ming Gong Zuo-quan Zhang xiao-dong chen Lu Zhang Xing-su Yu Qi-hua Yang Xin-tao Shuai 梁碧玲程度 PCFM Lab of Ministry of Education School of Chemistry and Chemical EngineeringSun Yat-sen University Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiology The Fifth Affiliated HospitalSun Yat-sen University Center of Biomedical Engineering Zhongshan School of MedicineSun Yat-Sen University

Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were prepared from the amphiphilic block copolymer poly（ethylene glycol）-poly（e-caprolactone）（PEG-b-PCL） with different targeting ligands cRGD and scFv-ErbB single chain antibody conjugated to the distal ends of PEG block. The breast cancer animal model was established by subcutaneous injecting the BT474 cells into the BALB/c-nu female nude mice and then employed to assess the potential of the dual ligand targeted magnetic micelles as a novel MRI contrast agent on a 1.5 T clinical MR/scanner. The T2 signal intensity of the tumor in animals receiving the dual ligand targeted magnetic micelles via tail vein decreased more significantly than the single ligand targeted and nontargeted magnetic micelles. These results indicate that the dual ligand targeted magnetic micelles, cRGD/scFv-ErbB-PEG-PCL-SPION, have great potential to act as a new type of effective nanoscale MRI contrast agent for early diagnosis of breast cancer.

关键词： Block copolymer micelle Superparamagnetic iron oxide (SPI0) Breast cancer Magnetic resonance imaging(MRI) Herceptin c(Arg-Gly-Asp-d-Phe-Lys) (cRGDfK).

Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration

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International Journal of Oral Science 2023年第2期15卷 185-203页

作者： Milos Marinkovic Olivia N.Tran Hanzhou Wang Parveez Abdul-Azees David D.Dean xiao-dong chen Chih-Ko Yeh Department of Comprehensive Dentistry University of Texas Health Science Center at San AntonioTXUSA Research Service South Texas Veterans Health Care SystemTXUSA Department of Biomedical Engineering University of Texas at San AntonioTXUSA Geriatric Research Education and Clinical CenterSouth Texas Veterans Health Care SystemTXUSA

Salivary gland(SG)dysfunction,due to radiotherapy,disease,or aging,is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of ***,the standard-of-care for this condition remains palliative.A variety of approaches have been employed to restore saliva production,but they have largely failed due to damage to both secretory cells and the extracellular matrix(niche).

关键词： salivary clinical diseases

Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes

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Light(Science & Applications) 2024年第8期13卷 1623-1630页

作者： Guo-Jing Tang xiao-dong chen Lu Sun Chao-Heng Guo Meng-Yu Li Zhong-Tao Tian Hou-Hong chen Hong-Wei Wang Qi-Yao Sun Ying-Di Pan Xin-Tao He Yi-Kai Su Jian-Wen dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

3-dB couplers,which are commonly used in photonic integrated circuits for on-chip information processing,precision measurement,and quantum computing,face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication *** address this,we introduce topological physics to nanophotonics,developing a framework for topological 3-dB *** couplers exhibit broad working wavelength range and robustness against fabrication dimensional *** leveraging valley-Hall topology and mirror symmetry,the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering *** analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 *** further propose a topological interferometer for on-chip distance measurement,which also exhibits robustness against dimensional *** extension of topological principles to the fields of interferometers,may open up new possibilities for constructing robust wavelength division multiplexing,temperature-drift-insensitive sensing,and optical coherence tomography applications.

关键词： topological splitting insensitive