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基于APB因子的开放式基金业绩评价研究

当代财经 2017年第8期 46-55页

作者：肖峻杨超江西财经大学金融管理国际研究院江西南昌330013 江西财经大学金融学院江西南昌330013

在中国开放式基金市场上,业绩比较基准选取不当会给投资者带来误导,同时中国基金市场投资风格趋同化使得投资者难以鉴别基金业绩的优劣。采用2004年至2015年的月度样本数据,通过构建主动型业绩比较基准组合(APB组合),将其作为描述基金... 详细信息

在中国开放式基金市场上,业绩比较基准选取不当会给投资者带来误导,同时中国基金市场投资风格趋同化使得投资者难以鉴别基金业绩的优劣。采用2004年至2015年的月度样本数据,通过构建主动型业绩比较基准组合(APB组合),将其作为描述基金风格的新基准,同时运用各APB组合构建APB因子,并加入到传统的三因子模型中,研究发现:该模型可有效控制基金投资风格趋同化带来的影响,还可提高投资者鉴别基金业绩优劣的能力;此外,加入APB因子的三因子模型产生的基金收益具有较强的持续性,对于改进现有基金业绩评价方法具有重要的参考价值。

关键词：开放式基金风格趋同化业绩比较基准

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基于元模型的多元输出仿真模型校准方法研究

北京理工大学学报 2017年第6期37卷 613-619页

作者：钱晓超李伟杨明哈尔滨工业大学控制与仿真中心黑龙江哈尔滨150080 上海机电工程研究所上海201109

为解决具有多元不同类型输出的仿真模型校准问题,提出一种基于优化和元模型的仿真模型校准方法.首先提出一种基于双层嵌套拉丁超立方抽样(LHS)的不确定性参数传播方法,获得系统同时含有认知和固有不确定性时的输出;其次,给出一种基于数... 详细信息

为解决具有多元不同类型输出的仿真模型校准问题,提出一种基于优化和元模型的仿真模型校准方法.首先提出一种基于双层嵌套拉丁超立方抽样(LHS)的不确定性参数传播方法,获得系统同时含有认知和固有不确定性时的输出;其次,给出一种基于数据特征的仿真输出一致性度量方法,实现仿真多元异类输出的一致性度量;进而,利用随机Kriging模型拟合认知不确定性抽样样本与仿真输出一致性度量结果的元模型,并在该元模型上通过遗传算法实现校准过程.最后,通过实例验证了本文所提方法的有效性.

关键词：模型校准不确定性数据一致性随机Kriging 优化

Sodium Methylate Catalyzed Michael/Cyclization Cascade Reactions of 3-Aminooxindoles with β,γ-Unsaturated α-Ketoamides for the Synthesis of Spirooxindoles

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Sodium Methylate Catalyzed Michael/Cyclization Cascade React...

Access to the Spiro Oxindoles Through the Direct Asymmetric Cascade Michael/Hemiketalization Reaction

河南省化学会2016年学术年会

作者： xiao-chao yang Yuan-Zhao Hua Min-Can Wang College of Chemistry and Molecular Engineering Zhengzhou University

Spirooxindoles are attractive heterocyclic skeletons with broad and promising activities in various therapeutic fields. As this frameworks have existed in a variety of natural products and pharmaceutical lead compounds, which exhibit important biological activities, a lot of efforts have been devoted to the construction of this useful structure by synthetic and medicinal chemists over the past *** year our laboratory reported the synthesis of spirooxindoles by Michael/Cyclization reaction ofα-hydroxyacetophenone with β,γ-unsaturated α-ketoamides via Et2 Zn. Herein, we communicate the new method to synthesis of spirooxindoles by Michael/Cyclization cascade reaction of 3-aminooxindoles with β,γ-unsaturated α-ketoamides via sodium methylate. In the prensence of 30 mol% sodium methylate, and 1.2 equivalents potassium carbonate, the reaction carried out smoothly at 25℃ in dichloromethane. The corresponding product was obtained in up to 97% yield.

关键词： spirooxindoles Michael/Cyclization cascade reaction

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Access to the Spiro Oxindoles Through the Direct Asymmetric ...

Clinical effects of phospholipase D2 in attenuating acute pancreatitis

手性中国2014学术研讨会

作者： xiao-chao yang Yuan-Zhao Hua Xi-Xi Song Min-Can Wang College of Chemistry and Molecular Engineering Zhengzhou University

＜正＞In recent years,spiro oxindoles have become a privileged skeleton given their broad and promising activities in various therapeutic areas,such as biological activities.[1,2]As the framework has existed in diverse natural products and pharmaceutical lead compounds,considerable effort has been devoted to developing efficient and selective synthetic methods to access spiro oxindoles.[3,4]Herein,we report a new

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-chao Zhang Wu Ning Hai-Bin Liu Hua yang chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

RL滤波函数的改进对卷积反投影图像重建的影响

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四川大学学报（自然科学版） 2004年第1期41卷 112-117页

作者：刘晓杨朝文四川大学物理学院成都610065

在工业无损检测中,利用X射线CT成像的算法———卷积反投影算法对图像进行重建时,滤波函数对图像重建质量影响很大.作者利用多点平均法对RL滤波函数作了改进,发现3点平均法的滤波函数对图像的重建质量有明显的改善.

关键词：滤波函数卷积反投影算法无损检测

抽样间距和投影数对卷积滤波法图像重建质量的影响

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四川大学学报（自然科学版） 2004年第3期41卷 588-593页

作者：刘晓杨朝文四川大学物理系成都610064

利用卷积反投影算法对图像进行重建时,要降低成本,提高成像效率,就必须选取合理的抽样间距和投影数.作者在分析抽样间距和投影数对图像重建质量影响时发现,在噪音比较大的情况下,抽样间距过小,会使重建图像的质量下降,而投影数的变化对... 详细信息

利用卷积反投影算法对图像进行重建时,要降低成本,提高成像效率,就必须选取合理的抽样间距和投影数.作者在分析抽样间距和投影数对图像重建质量影响时发现,在噪音比较大的情况下,抽样间距过小,会使重建图像的质量下降,而投影数的变化对重建图像质量的影响则相对较小.

关键词： CT 图像重建图像质量

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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抗生素序贯疗法治疗小儿支气管肺炎的疗效

中国现代药物应用 2019年第24期13卷 120-122页

作者：肖超扬福建省明溪县总医院

目的探讨抗生素序贯疗法治疗小儿支气管肺炎的疗效.方法110例小儿支气管肺炎患儿,依据随机数字表法分为静脉治疗组和序贯治疗组,每组55例.静脉治疗组患儿采用抗生素静脉滴注治疗,序贯治疗组患儿采用抗生素序贯疗法治疗.比较两组患儿治... 详细信息

目的探讨抗生素序贯疗法治疗小儿支气管肺炎的疗效.方法110例小儿支气管肺炎患儿,依据随机数字表法分为静脉治疗组和序贯治疗组,每组55例.静脉治疗组患儿采用抗生素静脉滴注治疗,序贯治疗组患儿采用抗生素序贯疗法治疗.比较两组患儿治疗效果;咳嗽消失时间、咳痰消失时间、呼吸音恢复清晰时间、肺阴影消失时间;治疗前后白细胞计数、C反应蛋白水平;治疗费用.结果两组患儿总有效率比较差异无统计学意义(P>0.05).治疗前,两组患儿白细胞计数、C反应蛋白水平比较差异无统计学意义(P>0.05);治疗后,两组患儿白细胞计数、C反应蛋白水平均低于本组治疗前,差异具有统计学意义(P0.05).序贯治疗组患儿咳嗽消失时间、咳痰消失时间、呼吸音恢复清晰时间、肺阴影消失时间分别为(4.10±1.24)、(5.04±1.61)、(5.09±1.21)、(6.02±1.24)d,均短于静脉治疗组的(6.61±2.92)、(7.10±2.13)、(6.13±2.59)、(7.11±2.14)d,差异具有统计学意义(P<0.05).序贯治疗组患儿治疗费用为(523.51±11.41)元,少于静脉治疗组的(684.55±32.77)元,差异具有统计学意义(P<0.05).结论抗生素序贯疗法治疗小儿支气管肺炎的疗效确切,和抗生素静脉滴注相似,均可有效降低炎症水平,但抗生素序贯疗法起效更快,可缩短症状消失时间,减少治疗费用,易于接受,具有良好的经济效益,可替代抗生素静脉滴注治疗.

关键词：抗生素序贯疗法小儿支气管肺炎疗效