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Coupled dynamic response analysis of multi-column floating offshore wind turbine with low center of gravity

Journal of Ocean Engineering and Science 2024年第1期9卷 25-39页

作者： Jie yang yan-ping He Yong-sheng Zhao xiao-yan yang Guo-rong Zhang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China

To realize the application of the floating offshore wind turbine(FOWT)from deep to relatively shallow waters,a new concept of multi-column floating wind turbine platform with low center of gravity(CG)is designed and *** multi-column low CG platform is designed to support a 6MW wind turbine class and operated at a water depth of 50m in the South China *** frequency domain software WADAM and time domain software NREL-FAST are used to simulate coupled dynamic responses of the floating wind turbine system with second-order wave loads *** dynamic behaviors of multi-column low CG FOWT system under normal operation and parked conditions are *** influence of second-order wave force on the motion responses of the multi-column platform,fore-aft force and moment of the tower base and mooring force are researched *** results demonstrate that the coupled dynamic responses at rated operating condition and extreme condition meet the normal operating requirements and extreme survival requirements of FOWT system in the shallow water(50m)of South China *** addition,it is found that,the wave frequency response gradually replaces the second-order low frequency response as the main influencing factor of the coupled dynamic response of the FOWT system with the increasing severity of the sea ***,in general,the magnitude of second-order low frequency response increases with the increasing severity of the design load ***,in the subsequent design of the shallow water FOWT system,the second-order effects should be paid enough attention.

关键词： Floating offshore wind turbine Multi-column platform Second-order wave force Concept design Coupled dynamic response

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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye yang Wu Wen Feng-Lin Chen Ying-Jie Zhang xiao-Cong Liu xiao-yan yang Shan-Shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

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World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun yang-yang Wang Lin Wan Qiu-Hong Wang Qian Lu xiao-yan yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

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Atypical Guillain-Barrésyndrome with positive anti-sulfatide,anti-GT1b,and anti-GT1a antibodies:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4372-4376页

作者： Fei-Fei Tan He-Xu Liu Xue-yan Huang Chang-Yin Yu xiao-yan yang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND The role of diverse antibodies in mediating peripheral nerve injury in Guillain-Barrésyndrome(GBS)is becoming clearer,but positivity for multiple antibodies in one case is *** our knowledge,this is the first case involving GBS with positive anti-sulfatide,anti-GT1a,and anti-GT1b *** SUMMARY A 20-year-old female patient was admitted to the hospital due to weakness of limbs for 5 d,and deterioration of the weakness and muscle aches for 1 *** patient's limbs were weak,but the tendon reflexes in the part of the limbs were *** was no comorbid peripheral nociception or deep sensory *** was diagnosed with GBS and was discharged after receiving intravenous human immunoglobulin pulse *** In this article,the clinical manifestations,neurophysiological examination,and auxiliary examination findings of a GBS patient positive for multiple antibodies were analyzed to improve the identification of the disease by clinical physicians at an early stage.

关键词： Guillain-Barré Anti-sulfatide antibody Anti-GT1b antibody Anti-GT1a antibody Case report

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In-situ deposited anti-aging TiN capping layer for Nb superconducting quantum circuits

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Chinese Physics B 2024年第9期33卷 133-137页

作者： Hao-Ran Tao Lei Du Liang-Liang Guo Yong Chen Hai-Feng Zhang xiao-yan yang Guo-Liang Xu Chi Zhang Zhi-Long Jia Peng Duan Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China

The performance of Nb superconducting quantum devices is predominantly limited by dielectric loss at the metal–air interface,where Nb2O5 is considered the main loss ***,we suppress the formation of native oxides by in-situ deposition of a TiN capping layer on the Nb *** TiN capping layers,no Nb2O5 forms on the surface of the Nb *** quality factor Qi of the Nb resonator increases from 5.6×10^(5) to 7.9×10^(5) at low input power and from 6.8×10^(6) to 1.1×10^(7)at high input ***,the TiN capping layer also shows good aging resistance in Nb resonator devices,with no significant performance fluctuations after one month of *** findings highlight the effectiveness of TiN capping layers in enhancing the performance and longevity of Nb superconducting quantum devices.

关键词： anti-aging oxidation dielectric loss Nb superconducting quantum circuits

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Correction of microwave pulse reflection by digital filters in superconducting quantum circuits

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Chinese Physics B 2024年第9期33卷 117-123页

作者： Liang-Liang Guo Peng Duan Lei Du Hai-Feng Zhang Hao-Ran Tao Yong Chen xiao-yan yang Chi Zhang Zhi-Long Jia Wei-Cheng Kong Zhao-Yun Chen Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

Reducing the control error is vital for high-fidelity digital and analog quantum *** superconducting circuits,one disagreeable error arises from the reflection of microwave signals due to impedance mismatch in the control ***,we demonstrate a reflection cancelation method when considering that there are two reflection nodes on the control *** propose to generate the pre-distortion pulse by passing the envelopes of the microwave signal through digital filters,which enables real-time reflection correction when integrated into the field-programmable gate array(FPGA).We achieve a reduction of single-qubit gate infidelity from 0.67%to 0.11%after eliminating microwave ***-time correction of microwave reflection paves the way for precise control and manipulation of the qubit state and would ultimately enhance the performance of algorithms and simulations executed on quantum processors.

关键词： reflection cancelation digital filter single-qubit gate superconducting circuit

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注射用伏立康唑在中国健康受试者中的生物等效性研究

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中国临床药理学杂志 2024年第14期40卷 2108-2112页

作者：严新杨双阳晓燕姚安崔畅阳国平黄洁中南大学湘雅药学院湖南长沙410205 中南大学湘雅三医院临床药理中心湖南长沙410205

目的评价2种注射用伏立康唑在中国健康受试者体内的生物等效性及安全性,并探索辅料磺丁基-β-环糊精的安全性。方法本试验按照单中心、单剂量、随机、开放、两制剂、两周期、双交叉给药的试验设计。在空腹条件下,共纳入18例健康受试者,... 详细信息

目的评价2种注射用伏立康唑在中国健康受试者体内的生物等效性及安全性,并探索辅料磺丁基-β-环糊精的安全性。方法本试验按照单中心、单剂量、随机、开放、两制剂、两周期、双交叉给药的试验设计。在空腹条件下,共纳入18例健康受试者,随机交叉单次静脉滴注伏立康唑受试制剂和参比制剂4 mg·kg^(-1),用高效液相色谱-串联质谱(HPLC-MS/MS)法测定血浆中伏立康唑和尿液中磺丁基-β-环糊精的浓度,用Phoenix WinNonlin 8.2软件计算血浆中伏立康唑的药代动力学(PK)参数,用SAS(9.4版本)软件计算尿液中磺丁基-β-环糊精的PK参数,并进行生物等效性评价。结果18例健康受试者空腹单次静脉滴注伏立康唑受试制剂和参比制剂后,血浆中伏立康唑主要PK参数:C_(max)分别为(2177.00±399.10)和(2265.00±378.70)ng·mL^(-1),AUC_(0-t)分别为(14612.07±8182.95)和(15144.69±7814.02)ng·h·mL^(-1),AUC_(0-∞)分别为(16217.48±10862.78)和(16863.18±10695.75)ng·h·mL^(-1),t_(max)分别为2.00和1.98 h。2种制剂的C_(max)、AUC_(0-t)和AUC_(0-∞)的几何均值比的90%置信区间均在等效范围80.00%~125.00%内。结论2种注射用伏立康唑在中国健康受试者空腹静脉滴注给药条件下具有生物等效性,且安全性良好。

关键词：注射用伏立康唑磺丁基-β-环糊精生物等效性药代动力学安全性

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论环境公益损害与私益损害司法救济机制的衔接

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河西学院学报 2024年第4期40卷 81-86页

作者：杨小雁甘肃政法大学甘肃兰州730070

环境损害司法救济是用最严格的制度最严密的法治来保护生态环境的生动司法实践。检视现有环境公益和环境私益并行救济模式的司法困境,探讨通过环境私益诉讼保护环境公益的实现路径,妥善处理环境复合型损害当中公益诉讼与私益诉讼竞合时... 详细信息

环境损害司法救济是用最严格的制度最严密的法治来保护生态环境的生动司法实践。检视现有环境公益和环境私益并行救济模式的司法困境,探讨通过环境私益诉讼保护环境公益的实现路径,妥善处理环境复合型损害当中公益诉讼与私益诉讼竞合时的关系,进一步厘正检察环境民事公益诉讼与行政公益诉讼的顺位。从而实现环境损害司法救济机制一体化、规范化、法治化的发展,为美丽中国建设提供良好的法治环境。

关键词：环境公益环境私益损害救济衔接

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植物配置与近代建筑色彩融合应用研究

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佛山陶瓷 2024年第1期34卷 186-188页

作者：杨小燕贵州城市职业学院贵阳550025

植物配置所营造的生活环境受建筑外部色彩明度和彩度影响较大,两者相互依托。建筑色彩的不同,植物配置营造的主体景观效果也不同,进而影响人们在城市的体验和生活。本文以贵阳市绿地系统中建筑色彩与植物搭配为研究对象,调查结果得出贵... 详细信息

植物配置所营造的生活环境受建筑外部色彩明度和彩度影响较大,两者相互依托。建筑色彩的不同,植物配置营造的主体景观效果也不同,进而影响人们在城市的体验和生活。本文以贵阳市绿地系统中建筑色彩与植物搭配为研究对象,调查结果得出贵阳市公园绿地植物配置多以常绿植物与灰色系建筑色彩相搭配,附属绿地植物配置多以彩色系植物与砖红色系建筑相搭配,其他绿地植物配置与建筑色彩搭配,色彩多以白、卡其色为主,色彩明度和彩度搭配并不合理。本文以贵阳市绿地系统中建筑色彩与植物搭配为研究对象,对各组成的模式进行分析,为今后近代建筑与植物景观的有效应用,提供参考依据。

关键词：植物配置建筑色彩 DAN 明度彩度

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生态环境检察视角下民事与行政公益诉讼的适用困境与纾解

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齐齐哈尔大学学报（哲学社会科学版） 2024年第7期 98-101页

作者：杨小雁甘肃政法大学纪委甘肃兰州730070

立法赋予了检察机关在环境行政公益诉讼和环境民事公益诉讼中的当事人资格,为检察机关依法履行生态环境检察职能供给了法律依据,有效弥补了私诉权在维护环境公益领域的不足。然而,由于生态环境案件的利益交织、责任叠加等特性,导致检察... 详细信息

立法赋予了检察机关在环境行政公益诉讼和环境民事公益诉讼中的当事人资格,为检察机关依法履行生态环境检察职能供给了法律依据,有效弥补了私诉权在维护环境公益领域的不足。然而,由于生态环境案件的利益交织、责任叠加等特性,导致检察机关在适用“两诉”过程中出现了顺位不明、关系不清、甄选困难等困境。基于生态环境检察融合履职视角,通过厘清“两诉”竞合时顺位关系,建立检察行政附带民事公益诉讼制度以及完善诉前程序运行机制,妥善处理“两诉”关系,实现制度优势互补,诉前程序与诉讼程序紧密衔接,构建融合一体的生态环境公益检察格局。

关键词：环境公益诉讼检察公益诉讼法适用困境

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