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Signalling pathways in autism spectrum disorder:mechanisms and therapeutic implications

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2863-2898页

作者： Chen-Chen Jiang Li-Shan Lin Sen Long xiao-yan ke Kohji Fukunaga Ying-Mei Lu Feng Han International Joint Laboratory for Drug Target of Critical Illnesses Key Laboratory of Cardiovascular&Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjing 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Department of Pharmacy Hangzhou Seventh People’s HospitalMental Health Center Zhejiang University School of MedicineHangzhou 310013China Child Mental Health Research Center Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China Department of CNS Drug Innovation Graduate School of Pharmaceutical SciencesTohoku UniversitySendai 980-8578Japan Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing 210029China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002China

Autism spectrum disorder(ASD)is a prevalent and complex neurodevelopmental disorder which has strong genetic *** the rapidly rising incidence of autism,little is known about its aetiology,risk factors,and disease *** are currently neither validated biomarkers for diagnostic screening nor specific medication for *** the last two decades,there have been remarkable advances in genetics,with hundreds of genes identified and validated as being associated with a high risk for *** convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of *** have been devoted to exploring the behavioural functions,key pathological mechanisms and potential treatments of ***,as we highlight in this review,emerging evidence shows that signal transduction molecular events are involved in pathological processes such as transcription,translation,synaptic transmission,epigenetics and immunoinflammatory *** involvement has important implications for the discovery of precise molecular targets for ***,we review recent insights into the mechanisms and clinical implications of signal transduction in autism from molecular,cellular,neural circuit,and neurobehavioural ***,the challenges and future perspectives are discussed with regard to novel strategies predicated on the biological features of autism.

关键词： mechanisms spectrum behaviour

Brain function differences in drug-nave first-episode auditory verbal hallucination-schizophrenia patients with versus without insight

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Chinese Medical Journal 2019年第18期132卷 2199-2205页

作者： Min Chen Chuan-Jun Zhuo Feng Ji Gong-Ying Li xiao-yan ke Department of Psychiatry School of Mental Health Jining Medical University Jining Shandong 272000 China Department of Psychiatry Nanjing Brain Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 210029 China Psychiatric-Neuroimaging-Genetics-Comorbidity Laboratory (PNGC Lab) Tianjin Mental Health Centre Mental Health Teaching Hospital of Tianjin Medical University Tianjin Anding Hospital Tianjin 300222 China

Background:Few studies have reported brain function differences in drug-na(i)ve first-episode schizophrenia patients who had auditory verbal hallucinations (AVH) with insight *** without *** study aimed to investigate brain function differences between drug-naive first-episode AVH-schizophrenia patients with and without ***:Forty first-episode drug-naive AVH-schizophrenia patients with or without insight and 40 healthy controls between December 2016 and December 2018 were recruited in this *** auditory hallucinations rating scale (AHRS) was used to assess AVH severity,while the insight and treatment attitudes questionnaire was used to distinguish *** global functional connectivity density (gFCD) between different groups was compared using a voxel-wise one-way analysis of *** relationship between gFCD and AHRS total scores were analyzed using voxel-wise multiple ***:Finally,13 first-episode drug-naive AVH-schizophrenia patients with insight,15 AVH-schizophrenia patients without insight,and 20 healthy controls were included for *** for global assessment of functioning scores,there were no significant differences in sociodemographic information between the AVH-schizophrenia and healthy groups (P > 0.05).Compared to the healthy controls,AVH-schizophrenia patients with insight demonstrated a decreased gFCD in the supramarginal gyrus within the primary auditory cortex,while those without insight demonstrated an increased gFCD in the inferior frontal gyrus and superior temporal gyrus and decreased gFCD in the supplemental motor *** to the AVH-schizophrenia patients with insight,those without insight demonstrated an increased gFCD in the supra-marginal gyrus and posterior superior temporal lobule and a decreased gFCD in the frontal *** significant correlation between gFCD and AVH severity (AHRS total score:r =0.23,P =0.590;and frequency:r =0.42,P =0.820) was found in both AVH-schizop

关键词： Auditory verbal hallucinations Schizophrenia Insight Global functional connectivity density

A neuroimaging study in 2 to 3-year-old toddlers with autism spectrum disorder

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A neuroimaging study in 2 to 3-year-old toddlers with autism...

中国神经科学学会第十届全国学术会议

作者： Zhou xiao Xiang xiao Ting xiao Fenjing LIANG Ting QIU Bing ZOU Hui FANG xiao-yan ke Child Mental Health Research Center of Nanjing Brain Hospital affiliated of Nanjing Medical University

Objective To assess total intracranial volume(TIV),global gray matter(GM) and white matter(WM)volumes,regional GM and WM alterations and the WM tract integrity between 2-year-old toddlers with autism spectrum disorder(ASD) and developmental delay(DD);to investigate the correlation between the TIV,the global GM and WM volumes and the severity of symptoms,developmental quotient(DQ) and age in children with *** Brain images of 50 toddlers with ASD and 28 age-,gender-,and developmental quotient(DQ)-matched toddlers with DD(control group) between ages 2 and 3 years were captured using a combined approach of voxel based morphometry(VBM) and voxel based analysis(VBA).Structural magnetic resonance imaging(MRI) and diffusion tensor imaging(DTI) were *** TIV,the global GM and WM volumes,and regional alterations were assessed by *** was used to investigate the white matter tract *** Autism Rating Scale(CARS) and Autism Diagnostic Interview- Revised(ADI-R) were applied to assess the severity of symptoms in children with ASD,and Bayley scales of infant development(BSID) was used to measure *** correlation research was conducted between the scores of uiose three scales and age and the TTV,the global GM and WM ***(1) Compared with DD,significant increases were observed in global GM and WM volumes in ASD(P<0.05).(2) Compared with DD,significantly more GM volumes were localized in ASD in the right superior temporal gyrus,the right Brodmann area 22 and the right Brodmann area 38(P<0.001).Conversely,significantly greater WM volumes were observed in ASD in the right superior temporal gyrus,left middle temporal gyrus,right insula,and right Heschl’s gyrus(P<0.001).Notably no significant decreases in GM and WM volumes were observed in any region between ASD and control group.(3)Compared with DD,ASD strongly exhibited higher FA in the CC,posterior cingulate cortex,and limbic lobe(P<0.001).In addition,ASD exhibited lower MD in left CC,poste

关键词： autism spectrum disorder toddler magnetic resonance imaging voxel based morphometry diffusion tensor imaging

来源： cnki会议评论

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cnki会议

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中国锰矿资源潜力分析及成矿预测

中国地质 2014年第5期41卷 1424-1437页

作者：阴江宁肖克炎中国地质科学院矿产资源研究所国土资源部成矿作用与资源评价重点实验室北京100037

锰矿是目前中国紧缺矿产,依据全国矿产资源潜力评价数据和成果,对全国锰矿资源进行了现状分析和潜力预测。中国锰矿形成的主要大地构造部位包括:"1大陆边缘浅海;2台内裂陷带(如华北地台之燕辽沉降带);3造山带中裂陷海槽等。中国锰矿以... 详细信息

锰矿是目前中国紧缺矿产,依据全国矿产资源潜力评价数据和成果,对全国锰矿资源进行了现状分析和潜力预测。中国锰矿形成的主要大地构造部位包括:"1大陆边缘浅海;2台内裂陷带(如华北地台之燕辽沉降带);3造山带中裂陷海槽等。中国锰矿以泛扬子周边地区最为发育,桂西南、湘黔渝为主要富集区。中国锰矿床的古地理展布表明,具有重大工业价值的锰矿床均形成于海相环境中,并主要为碳酸锰矿床。今后具有找矿潜力的锰矿类型主要有:海相沉积型和风化壳型,另外,海相火山岩型和陆相沉积型也有一定的潜力。依据大地构造背景与成锰盆地性质之间的关系,将中国锰矿划分为10个Ⅲ级成矿带,14个成矿远景区,对其主要含锰层位、成矿特征、主攻类型、资源潜力进行了分析,提出了重点找矿部署区建议,可为国家锰矿找矿突破提供支持。

关键词：锰矿资源潜力成矿预测中国

克隆种群的有关概念在水生植物中应用和研究进展

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水生生物学报 2008年第6期32卷 920-925页

作者：肖克炎于丹武汉大学生命科学学院水生植物实验室梁子湖湖泊生态系统国家野外科学观测研究站武汉430072

摘要: 自20世纪80年代以来,克隆植物(Clonal plants)种群生态学的研究逐渐成为国外生态学研究的热点之一,其研究成果不断发表在各种重要的国际学术刊物上 1-3 ,从而引起国内学者的关注。现已在陆生植物的多个类群中展开,但是水生植物的... 详细信息

摘要: 自20世纪80年代以来,克隆植物(Clonal plants)种群生态学的研究逐渐成为国外生态学研究的热点之一,其研究成果不断发表在各种重要的国际学术刊物上 1-3 ,从而引起国内学者的关注。现已在陆生植物的多个类群中展开,但是水生植物的克隆种群研究仍然相对较少。随着我国淡水生态系统环境的恶化,水生植物在一些水域逐渐退化甚至完全消失,淡水生态系统的功能受到了严重的破坏 4 ,与此同时很多入侵性水生植物却疯狂生长,严重影响了水生生态系统的安全与利用。克隆生长和无性繁殖在水生植物中是十分普遍的现象 5 ,因此深入开展水生植物的克隆生态学研究对水生植被的恢复及外来种的管理具有重要的意义。

关键词：水生植物克隆生长无性繁殖

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基于粒子群优化算法的自适应图像分割方法

光学技术 2006年第6期32卷 889-892页

作者：闫晓珂史彩成何佩琨北京理工大学信息科学技术学院电子工程系

提出了一种基于粒子群优化算法的图像分割新方法。粒子群优化(PSO)算法是一类随机全局优化技术,它通过粒子间的相互作用发现复杂搜索空间中的最优区域缩短了寻找阈值的时间。将PSO用于基于改进的最佳加权熵阈值法的图像分割中,试验结果... 详细信息

提出了一种基于粒子群优化算法的图像分割新方法。粒子群优化(PSO)算法是一类随机全局优化技术,它通过粒子间的相互作用发现复杂搜索空间中的最优区域缩短了寻找阈值的时间。将PSO用于基于改进的最佳加权熵阈值法的图像分割中,试验结果表明,该方法不仅能够避免陷入局部极值,而且其速度得到了明显的改善,是一种有效的图像分割新方法。

关键词：粒子群优化算法最佳熵阈值图像分割

Specific White Matter Impairments in Patients with Treatment-Refractory First-Episode Schizophrenia： A 1-Year Follow-up Pilot Study

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Chinese Medical Journal 2018年第7期131卷 879-880页

作者： Min Chen Chuan-Jun ZhUO Li-Ju Qian Bin Wang Jin-Guo Zhai Feng Ji xiao-yan ke Department of Psychiatry Nanjing Brain Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 210029 China Department of Psychiatry Jining Neuro-Psychiatric Hospital Jining Shandong 272051 China Department of Psychiatry-Neuroimaging key Laboratory Tianjin Mental Health Center Nankai University Affiliated Tianjin Anding Hospital Tianjin 300222 China Department of Psychiatry School of Mental Health Jining Medical University Jining Shandong 272067 China

To the Editor： In the last 10 years, mounting evidence has confirmed that schizophrenia is associated with white matter （WM） impairment; this impairment exists even before the occurrence of an episode of schizophrenic symptoms. Widespread WM fiber tracts were affected in patients, especially in certain key brain regions, such as the arcuate fasciculus, fasciculi longitudinalis superior, and corpus callosum. A previous study reported that although there was no more than 1% WM impairments in schizophrenic patients, it is nonetheless a stable and specific aberrant pathological feature of schizophrenia.

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镓三相点容器的研制

计量学报 2001年第4期22卷 246-248页

作者：邱萍闫小克瞿咏梅中国计量科学研究院北京100013

近年来 ,镓三相点作为新的温度固定点的研究已经得到了广泛的重视。本文介绍了镓三相点容器的制作工艺、冻制过程及复现技术。实验结果表明 ,镓三相点的温度值为 2 9 7666℃。

关键词：镓三相点真空系统复现技术镓三相点容器制作工艺温度计量国际温标定义固定点

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4种不同水源的水三相点容器的比对

计量学报 2007年第2期28卷 133-136页

作者：闫小克段宇宁马重芳北京工业大学环境与能源工程学院北京100022 中国计量科学研究院北京100013

为了研究水源对水三相点温度的影响,采用4种不同的水源并按照相同的制作工艺研制高质量的水三相点容器。同时,将这些容器进行了比对实验。比对结果表明:这些不同水源的水三相点容器复现的水三相点值在±0.02 mK范围内一致。故推断出水... 详细信息

为了研究水源对水三相点温度的影响,采用4种不同的水源并按照相同的制作工艺研制高质量的水三相点容器。同时,将这些容器进行了比对实验。比对结果表明:这些不同水源的水三相点容器复现的水三相点值在±0.02 mK范围内一致。故推断出水源对水三相点温度的影响很小。

关键词：计量学水三相点比对同位素组成水源