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Coupled dynamic response analysis of multi-column floating offshore wind turbine with low center of gravity

Journal of Ocean Engineering and Science 2024年第1期9卷 25-39页

作者： Jie yang yan-ping He Yong-sheng Zhao xiao-yan yang Guo-rong Zhang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China

To realize the application of the floating offshore wind turbine(FOWT)from deep to relatively shallow waters,a new concept of multi-column floating wind turbine platform with low center of gravity(CG)is designed and *** multi-column low CG platform is designed to support a 6MW wind turbine class and operated at a water depth of 50m in the South China *** frequency domain software WADAM and time domain software NREL-FAST are used to simulate coupled dynamic responses of the floating wind turbine system with second-order wave loads *** dynamic behaviors of multi-column low CG FOWT system under normal operation and parked conditions are *** influence of second-order wave force on the motion responses of the multi-column platform,fore-aft force and moment of the tower base and mooring force are researched *** results demonstrate that the coupled dynamic responses at rated operating condition and extreme condition meet the normal operating requirements and extreme survival requirements of FOWT system in the shallow water(50m)of South China *** addition,it is found that,the wave frequency response gradually replaces the second-order low frequency response as the main influencing factor of the coupled dynamic response of the FOWT system with the increasing severity of the sea ***,in general,the magnitude of second-order low frequency response increases with the increasing severity of the design load ***,in the subsequent design of the shallow water FOWT system,the second-order effects should be paid enough attention.

关键词： Floating offshore wind turbine Multi-column platform Second-order wave force Concept design Coupled dynamic response

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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye yang Wu Wen Feng-Lin Chen Ying-Jie Zhang xiao-Cong Liu xiao-yan yang Shan-Shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

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World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun yang-yang Wang Lin Wan Qiu-Hong Wang Qian Lu xiao-yan yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

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Atypical Guillain-Barrésyndrome with positive anti-sulfatide,anti-GT1b,and anti-GT1a antibodies:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4372-4376页

作者： Fei-Fei Tan He-Xu Liu Xue-yan Huang Chang-Yin Yu xiao-yan yang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND The role of diverse antibodies in mediating peripheral nerve injury in Guillain-Barrésyndrome(GBS)is becoming clearer,but positivity for multiple antibodies in one case is *** our knowledge,this is the first case involving GBS with positive anti-sulfatide,anti-GT1a,and anti-GT1b *** SUMMARY A 20-year-old female patient was admitted to the hospital due to weakness of limbs for 5 d,and deterioration of the weakness and muscle aches for 1 *** patient's limbs were weak,but the tendon reflexes in the part of the limbs were *** was no comorbid peripheral nociception or deep sensory *** was diagnosed with GBS and was discharged after receiving intravenous human immunoglobulin pulse *** In this article,the clinical manifestations,neurophysiological examination,and auxiliary examination findings of a GBS patient positive for multiple antibodies were analyzed to improve the identification of the disease by clinical physicians at an early stage.

关键词： Guillain-Barré Anti-sulfatide antibody Anti-GT1b antibody Anti-GT1a antibody Case report

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In-situ deposited anti-aging TiN capping layer for Nb superconducting quantum circuits

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Chinese Physics B 2024年第9期33卷 133-137页

作者： Hao-Ran Tao Lei Du Liang-Liang Guo Yong Chen Hai-Feng Zhang xiao-yan yang Guo-Liang Xu Chi Zhang Zhi-Long Jia Peng Duan Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China

The performance of Nb superconducting quantum devices is predominantly limited by dielectric loss at the metal–air interface,where Nb2O5 is considered the main loss ***,we suppress the formation of native oxides by in-situ deposition of a TiN capping layer on the Nb *** TiN capping layers,no Nb2O5 forms on the surface of the Nb *** quality factor Qi of the Nb resonator increases from 5.6×10^(5) to 7.9×10^(5) at low input power and from 6.8×10^(6) to 1.1×10^(7)at high input ***,the TiN capping layer also shows good aging resistance in Nb resonator devices,with no significant performance fluctuations after one month of *** findings highlight the effectiveness of TiN capping layers in enhancing the performance and longevity of Nb superconducting quantum devices.

关键词： anti-aging oxidation dielectric loss Nb superconducting quantum circuits

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Correction of microwave pulse reflection by digital filters in superconducting quantum circuits

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Chinese Physics B 2024年第9期33卷 117-123页

作者： Liang-Liang Guo Peng Duan Lei Du Hai-Feng Zhang Hao-Ran Tao Yong Chen xiao-yan yang Chi Zhang Zhi-Long Jia Wei-Cheng Kong Zhao-Yun Chen Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

Reducing the control error is vital for high-fidelity digital and analog quantum *** superconducting circuits,one disagreeable error arises from the reflection of microwave signals due to impedance mismatch in the control ***,we demonstrate a reflection cancelation method when considering that there are two reflection nodes on the control *** propose to generate the pre-distortion pulse by passing the envelopes of the microwave signal through digital filters,which enables real-time reflection correction when integrated into the field-programmable gate array(FPGA).We achieve a reduction of single-qubit gate infidelity from 0.67%to 0.11%after eliminating microwave ***-time correction of microwave reflection paves the way for precise control and manipulation of the qubit state and would ultimately enhance the performance of algorithms and simulations executed on quantum processors.

关键词： reflection cancelation digital filter single-qubit gate superconducting circuit

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增加革兰阴性菌外膜囊泡产量的研究进展

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生物技术通报 2024年第3期40卷 100-108页

作者：刘灿闫晓阳曾焱欧祥龙廖永洪西南大学动物医学院重庆402460 国家生猪技术创新中心重庆402460

外膜囊泡(OMVs)是由革兰阴性菌释放的一种囊泡状结构,在革兰阴性菌的生长、感染以及与周围环境交流等过程中发挥重要作用。由于OMVs无活性、不能复制且具有良好的免疫原性,被广泛应用于新型疫苗的研究。但天然OMVs产量低,无法达到规模... 详细信息

外膜囊泡(OMVs)是由革兰阴性菌释放的一种囊泡状结构,在革兰阴性菌的生长、感染以及与周围环境交流等过程中发挥重要作用。由于OMVs无活性、不能复制且具有良好的免疫原性,被广泛应用于新型疫苗的研究。但天然OMVs产量低,无法达到规模化生产的要求,OMVs产量提升是OMVs疫苗产业化要解决的关键核心技术问题。本文主要从细菌基因改造、生长培养条件优化和OMVs生产纯化工艺优化3个方面对提升OMVs产量的研究进行综述,以期为OMVs疫苗产业化研究开发提供参考。

关键词：外膜囊泡疫苗开发生物发生机制产量增加机制

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Notes on Proper Class of Triangles

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Acta Mathematica Sinica,English Series 2013年第11期29卷 2137-2154页

作者： xiao yan yang Department of Mathematics Northwest Normal University

Let T be a triangulated category and ζ a proper class of triangles. Some basics properties and diagram lemmas are proved directly from the definition of ζ.

关键词： Proper class of triangles triangulated category

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Vanishing of Tate Homology - An Application of Stable Homology for Complexes

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Acta Mathematica Sinica,English Series 2016年第7期32卷 831-844页

作者： yan Ping LIU Zhong Kui LIU xiao yan yang Department of Mathematics Northwest Normal University Lanzhou 730070 P. R. China

It has been proved that the vanishing of Tare homology is a sufficient condition for the derived depth formula to hold in [J. Pure Appl. Algebra, 219, 464-481 （2015）]. In this paper, we inves- tigate when Tate homology vanishes by studying the stable homology theory for complexes. Properties such as the balancedness and vanishing of stable homology for complexes are studied. Our results show that the vanishing of this homology can detect finiteness of homological dimensions of complexes and regularness of rings.

关键词： Tate homology stable homology complete projective resolution

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可移动自升式井口平台的立管强度和疲劳寿命分析

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船海工程 2024年第2期53卷 115-120页

作者：李行邹科陈第一周崇尧屈衍严晓扬唐霖李镜中海油能源发展装备技术有限公司湛江分公司广东湛江524057 深洋海工技术(深圳)有限公司广东深圳518110 华南理工大学海洋科学与工程学院广州511442

针对自升式海上平台中两种结构形式的WZ12-8E/W立管,考虑波浪、洋流、土壤特性、附着海生物、温度和腐蚀等综合环境,计算和分析不同设计水位工况下,两种立管在平台移动下的结构强度,并校核是否发生涡激振动,以及预测交变载荷作用下的疲... 详细信息

针对自升式海上平台中两种结构形式的WZ12-8E/W立管,考虑波浪、洋流、土壤特性、附着海生物、温度和腐蚀等综合环境,计算和分析不同设计水位工况下,两种立管在平台移动下的结构强度,并校核是否发生涡激振动,以及预测交变载荷作用下的疲劳寿命。借助ORCAFLEX有限元软件,计算两种立管在多种海况下的动态响应,并把弯矩和张力转化为应力值。利用S-N曲线、雨流计数法和Miner累积损伤准则预测其疲劳寿命,并分别累计0°、45°和90°每个方向下37个工况的疲劳损伤。计算发现两种立管在作业和极端工况下,不会发生涡激振动,强度满足设计要求;但发现疲劳损伤较大且不满足设计寿命要求的结构区域,并提出增加疲劳寿命的改进方法。

关键词：平台立管动态响应结构强度涡激振动疲劳寿命

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