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Porcine acute liver failure model established by two-phase surgery and treated with hollow fiber bioartificial liver support system

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World Journal of Gastroenterology 2005年第35期11卷 5468-5474页

作者： Yi Gao Ning Mu xiao-Ping xu Yan wang Department of Hepatobiliary Surgery Zhujiang Hospital Southern MedicalUniversity Guanzhou 510282 Guangdong Province China

AIM： To establish a highly reproducible animal model of acute liver failure （ALF）, for assessing the effect of bioartificial liver support system （BALSS）. METHODS： A two-phase complete liver devascularization procedure was performed in eight Ioco-hybrid pigs. Blood biochemical index and liver biopsy were studied every 2 h after surgery, and survival time was recorded. The BALSS constructed with high volume recirculating technique was a hollow fiber circulating system consisting of a hepatocyte reactor-hollow fiber module inoculated with microcarrieradhering hepatocytes, and a double pump, heparinized, thermostabilized, micro-capsulized activated carbonadsorbing plasmapheresis system. Twelve pigs undergoing two-phase surgery were randomized into： control group （perfused without hepatocytes, n = 6） and treatment group （perfused with hepatocytes, n = 6）. Intergroup liver biochemical indexes, survival time, and liver pathological changes were analyzed at regular intervals. RESULTS： Two-phase surgery was performed in all the experimental pigs, and there was no obvious difference between their biochemical indexes. After 3 h of phase II surgery, ammonia （Amm） increased to （269＋37）μmol/L. After 5 h of the surgery, fibrinogen （Fib） decreased to （1.5±0.2） g/L. After 7 h of the surgery, ALT, AST, Tbil and PT were （7.6±1.8） nka/L, （40±5） nka/L, （55±8）μmol/L and （17.5±1.7） nka/L respectively. After 9 h of surgery, ALB and Cr were （27±4） g/L and （87±9）μmol/L. After 13 h of surgery, BUN was （3.5±0.9） μmol/L. All the above values were different from those determined before surgery. Survival time of pigs averaged 13.5±1.4 h. ALF pigs in the other group were treated with BALSS. The comparison analysis between the treated and control animals showed the changes of Tbil, PT, AIb, BUN, Cr, Fib, and Amm （P〈0.01）, but there was no change of ALT and AST. The survival time was statistically different （P〈0.01）, and there was no significant difference in histological ***： The po

关键词： Acute liver failure Animal model Bioartificialliver Micro-capsulized activated carbon adsorbing Porcinehepatocyte

Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients

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World Journal of Clinical Cases 2021年第33期9卷 10075-10087页

作者： Yan-Fu Zheng Xin Fu xiao-xu wang xiao-Jing Sun xiao-Dan He Department of Breast Oncology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina Department of Gynecology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina

BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,resulting in hand-foot syndrome(HFS).Regional cooling can induce vasoconstriction to reduce the release of drugs in the limbs and reduce the accumulation of drugs in sweat glands;thus,decreasing the incidence and severity of *** To study the efficacy of cooling patches to prevent HFS caused by PLD in the *** This is a retrospective cohort *** breast cancer patients(n=101)who were treated with PLD in two breast wards at our department from February 2020 to February 2021 were enrolled in the study and were randomly divided into the cooling group(51 patients)and the control group(50 patients).Patients in the control group only received routine care,while the patients in the cooling group applied cooling patches,based on routine care,to the palm and back of the hands 15 min before chemotherapy infusion for 10 *** patients took a corresponding dose of dexamethasone orally one day before chemotherapy,on the day of chemotherapy,and one day after ***23.0 version was used to analyze the data in this *** occurrence and severity of HFS was analyzed by the Mann-Whitney U test,and scores were analyzed by the Student’s t test or Wilcoxon rank-sum test.A P value<0.05 was regarded as statistically *** In this study,neither group of patients developed Grade 3 *** the control group,the incidence of Grade 1 HFS and Grade 2 HFS was 38%and 2%,***,in the cooling group,only one person developed Grade 1 HFS(2%),and none of the patients developed Grade 2 *** findings showed that cooling patches can effectively reduce the frequency and severity of HFS(P<0.0001)in the *** the fourth chemotherapy cycle,although general self-efficacy scale scores in the cooling group were low,they we

关键词： The cooling patch Hand-foot syndrome Pegylated liposomal doxorubicin Breast cancer Self efficacy Quality of life

The expression of c-src gene in the carcinogenesis process of human cardia adenocarcinoma

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World Journal of Gastroenterology 1999年第6期5卷 488-491页

作者： wang Xiu Jie, YUAN Shu Lan, xiao Lin, wang xu Hua and wang Chao Jun Institute of Cancer Research First University Hospital West China University of Medical Sciences Chengdu 610041 Sichuan Province China Department of Oncology China

AIM To investigate the activation, expression of c src gene and its role in the carcinogenetic process of human cardia adenocarcinoma (CA). METHODS Fifty six cases of CA, 34 cases of normal, 36 cases of protiferative epithelia adjacent to carcinoma, and 20 cases of lymph node metastases of CA were studied for PP60 c src , the expression product of c src gene immunohistochemically by using the specific monoclonal antibody, Mab327. RESULTS The positive rates of PP60 c src in the normal epithelia, protiferative epithelia, CA and lymph node metastases were 29 4% (10/*!34), 94 4% (34/*!36), 71 4% (40/*!56) and 60 0% (12/*!20) , respectively, among them, the differences of the positive rates were statistically significant ( P <0 01) . The expression levels of PP60 c src in CA and proliferative epithelia were significantly higher than that in the normal epithelia ( P <0 01) . The PP60 c src positive rates in the papillary, tubular, poorly differentiated and mucous adenocarcinoma were 75 0% (6/*!8) , 81 8% (18/*!22) , 50 0% (10/*!20) and 100 0% (6/*!6) , respectively, whereas those of tubular and mucous adenocarcinomas were significantly higher than those of papillary and poorly differentiated adenocarcinomas ( P <0 05) , and the PP60 c src expression levels of tubular and mucous adenocarcinomas were also significantly higher than those of papillary and poorly differentiated adenocarcinomas ( P <0 01) . CONCLUSION The activation and expression of c src gene are associated with the initiation and development of human CA; the protein amount of PP60 c src increased during the process of carcinogenesis; and PP60 c src expression is also related to lymph node metastases.

关键词： c src gene expression product PP60 c src cardia adenocarcinoma carcinogenesis neoplasm metastasis immunohistochemistry

A green synthesis of dihydropyrimidinones by Biginelli reaction over Nafion-H catalyst

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Chinese Chemical Letters 2007年第5期18卷 502-504页

作者： Hai Xia Lin Qing Jie Zhao Bin xu xiao Hong wang Department of Chemistry Shanghai University Shanghai 200444 China

A Nation-H catalyzed, single step and environmentally friendly process for synthesis of dihydropyrimidinones is described. This adopted protocol for Biginelli reaction has the advantages of reusability of the catalyst... 详细信息

关键词： Nation-H Dihydropyrimidinone Biginelli reaction Catalysis

THE EFFECT OF OIL CAVITY DEPTH ON TEMPERATURE FIELD IN HEAVY HYDROSTATIC THRUST BEARING

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Journal of Hydrodynamics 2011年第5期23卷 676-680页

作者： SHAO Jun-peng DAI Chun-xi ZHANG Yan-qin YU xiao-dong xu xiao-qiu wang Yun-fei College of Mechanical and Power Engineering Harbin UniverSity of Science and Technology Harbin150080 China

For a heavy hydrostatic bearing with a high linear velocity, the results of numerical calculations often differ from practical conditions if the viscosity is considered as constant. In this article, the influence of the oil cavity depth on the temperature field in the heavy hydrostatic bearing is discussed in the context of variable viscosity. The viscosity-temperature relations for the gap oil film are first established by fitting B-Spline curves, then, numerical calculations for the temperature field in the heavy hydrostatic bearing of different oil cavity depths are carried out based on Finite Volume Method （FVM） under the same rotating speed, and the influence of the oil cavity depth on the temperature distribution in the gap oil film of the hydrostatic bearing is discussed. The results of numerical calculations provide the temperature distribution state inside the hydrostatic bearing, which would help the selection and the design of hydrostatic bearings in engineering practice.

关键词： hydrostatic thrust bearing viscosity-temperature characteristic Finite Volume Method (FVM) temperature field

First-principles calculation of Aun@(ZnS)(42)(n=6-16)hetero-nanostructure system

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Rare Metals 2020年第10期39卷 1165-1173页

作者： Han-Yue Zhao Qing Liu xiao-xu wang Jin-Rong Huo Lu Li Ping Qian Yan-Jing Su Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Department of Physics University of Science and Technology BeijingBeijing 100083China Corrosion and Protection Center Key Laboratory for Environmental Fracture(MOE)University of Science and Technology BeijingBeijing 100083China

The structure stability and electronic and optical properties of a series of Au@ZnS core-shell nanocomposites with different sizes were investigated theoretically by first-principle calculation based on density functional theory(DFT).A series of Aun@(ZnS)(42)structures with different n values from 6 to 16 were optimized and *** on the core-shell interaction energy and second-order difference of total energy of these structures,it is found that Au(13)@(ZnS)(42)turns out to be the most stable *** on the model of Au(13)@(ZnS)(42),the density of state and charge density difference were studied and provided a deeper understanding of the electronic structures of Au@*** the other hand,absorption coefficient and dielectric function were investigated to study the optical *** is found that an optical absorption peak appears in visible-light region,indicating that the photo-catalytic can be improved prominently due to the optical redshift to visible-light region when forming core-shell structure from ZnS *** the redshift phenomenon accords well with ***,the electronic structure further confirms the existence of redshift of optical absorption spectrum.

关键词： Core-shell structure Density functional theory(DFT) Electronic structure Optical properties Redshift phenomenon

Three-dimensionally ordered macroporous cross-linked polystyrene incorporating functional group via hydrophilic spacer arm

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Chinese Chemical Letters 2010年第12期21卷 1493-1496页

作者： Li Xia Yuan xiao Mei wang xu Zhang Pan Ge Liu Wei Dong Yan Institute of Polymer Science and Engineering Hebei University of Technology Tianjin 300130 China

A versatile and effective method for incorporating functional groups on the pore wall of three-dimensionally ordered macroporous cross-linked polystyrene（3DOM CLPS） by hydrophilic spacer arm has been *** 3DOM CLPS with pore size 865 nm was prepared by sacrifice template *** hydrophilic spacer arm（polyethylene glycol,molecular weight is 600） was grafted to the 3DOM CLPS via nucleophilic substitution *** other side of active hydroxyl can be further converted into a lot of other functional *** this report,the chelating ligand 2-mercaptobenzothiazole（MBZ） group was introduced on the end of the PGE chain to evidence the versatile functionalization *** functionalized ordered macroporous materials were characterized by FT-IR,element analyzer,*** results reveal that the pores were successfully bonded with 2-mercaptobenzothiazole groups via hydrophilic spacer arms and the original morphology of ordered macroporous materials were remained after *** MBZ group density is 0.052 mmol/m^*** functionalized 3DOM CLPS are expected to application as heavy metal ions adsorbent.

关键词： Three-dimensionally ordered macroporous polymer Functionalization Hydrophilic space arm Heterocyclic functional group

Characteristics of N Mineralization in Urban Soils of Hefei,East China

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Pedosphere 2010年第2期20卷 236-244页

作者： ZHANG Kai,xu xiao-Niu and wang Qin School of Forestry and Landscape Architecture,Anhui Agricultural University,Hefei 230036 (China) School of Forestry and Landscape Architecture Anhui Agricultural University Hefei 230036 (China)

Nitrogen cycling has been poorly characterized in urban *** in-situ buried bag incubation technique was used to quantify net rates of N mineralization and nitrification in soils of two urban sites,a street greening belt and a university campus,and a suburban site,a forest park,in Hefei,East *** average concentration of extractable NO 3 in the surface soil (0-10 cm) was significantly higher at the urban sites than the suburban park site,whereas extractable NH + 4 concentration was significantly higher at the suburban park site than the urban *** forest park soil had greater potential N mineralization (148.1 μg N cm 3) than the soils from the campus (138.3 μg N cm 3) and street (99.8 μg N cm 3).The net mineralization rates varied between 1.63 and 2.69 μg N cm 3 d 1 and net nitrification rates between 0.82 and 1.02 μg N cm 3 d 1 at the suburban forest park site,but the rates varied from 1.27 to 2.41 μg N cm 3 d 1 and from 1.07 to 1.49 μg N cm 3 d 1,respectively,at the urban campus *** net mineralization and nitrification rates were lower during dry *** from regression analysis indicated that net N mineralization was significantly and positively correlated with soil moisture and soil C/N ratio,and was negatively correlated with soil *** nitrification was,however,significantly and negatively correlated with soil moisture and soil C/N ratio,and was positively correlated with soil *** relative nitrification was 0.763,indicating the dominance of nitrate cycling relative to ammonium cycling at the urban *** urban soils had the great potential for N losses compared to the suburban soils.

关键词： nitrification nitrogen cycling soil properties

Preparation and Magnetic Property of La_(0.7)Sr_(0.3)MnO_3 Nanorod by Combination Sol-Gel with Molten Salt

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Chemical Research in Chinese Universities 2008年第6期24卷 672-674页

作者： QI Shu-yan FENG Jing xu xiao-dong wang Jing-ping HOU Xiang-yu ZHANG Mi-lin Key Laboratory of Superlight Materials ＆ Surface Technology of Ministry of Education Harbin Engineering University Harbin 150001 P. R. China

La0.7Sr0.3MnO3（LSMO） nanorods were synthesized by a method combining sol-gel with molten salts at 950 ℃ for 10 h, which employed KCl＋NaCl（mass ratio 4：1） as eutectic molten salts. The morphologies and magnetic properties of the resulting LSMO nanorods were investigated by X-ray diffraction（XRD）, scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, and vibrating sample magnetometer（VSM） measurements. It was found that the obtained perovskite manganite LSMO was a uniform nanorod with a diameter of about 50 nm and a length of longer than 500 rim. The Curie temperature（To） of the LSMO nanorod used here was 262 K, much lower than that of bulky single crystal LSMO（360 K）. The low Curie temperature might be a result of the great disorder near the grain boundary, which could be observed clearly from the TEM picture.

关键词： Molten salt synthesis Sol-gel processes Perovskite Nanostructured materials