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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 289-292页

作者： yan-Ni Xi xiao-yan xin Hong-Mei Ye Department of Gynecology and Obstetrics 2nd Hospital of Yulin Xijing Hospital of the Fourth Military Medical University

Objective:To analyze effects of high mobility group AT-hook 2(HMGA2)on malignant degree,invasion,metastasis,proliferation and cellular morphology of ovarian cancer ***:Three methods were applied to observe the effect on HMGA2 expression in ovarian cancer cells and ovarian epithelial ***:After the application of siRNA-HMGA2,number of T29A2-cell clones was decreased,there was significant difference compared with the negative control *** application of let-7c,number of T29A2+cell clones was decreased significantly,however,after the application of Anti-let-7,the number of clones restored,and there was no significant difference compared with the negative control *** interference,the number of T29A2-cells which passed through Matrigel polycarbonate membrane were significantly lower than the negative control *** the treatment of siRNA-HMGA2,let-7c and sh-HMGA2respectively,growth and proliferation of T29A2-,T29A2+and SKOV3 were slower,and the phenomenon was most obvious in *** interference of HMGA2 induced mesenchymalepithelial changes in the morphology of ***:HMGA2 can promote malignant transformation of ovarian cancer cells,enhance cell invasion and metastasis,and promote cell growth and proliferation of ovarian cancer cells,which can cause ovarian cancer to progress rapidly and affect the quality of life.

关键词： High mobility group AT-hook 2 Ovarian cancer invasion Proliferation Morphology

Nodular liver lesions involving multiple myeloma: A case report and literature review

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World Journal of Gastroenterology 2009年第8期15卷 1014-1017页

作者： xiao-Ning Wu xin-yan Zhao Ji-Dong Jia Liver Research Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China

We report a case of a 62-year old woman admitted to our hospital for multiple nodular metastatic liver lesions found by ultrasonography in a regular medical examination. Routine laboratory tests were normal. PET-CT showed multiple bone lesions and nodular liver lesions. Liver biopsy revealed nodular infiltration of multiple myeloma with positive staining of kappa light chain. Further investigation of bone marrow aspiration, immunofixation and immunoelectrophoresis of serum protein, urine test for Bence-Jones protein, 132-microglobulin in serum and urine confirmed the diagnosis. The patient also coinfected with hepatitis C virus （HCV）. With six cycles of chemotherapy with VAD schedule, she achieved complete remission. In this report, a literature review of liver lesions involving multiple myeloma is also provided.

关键词： Nodular lesions Liver Multiple myeloma IgA kappa light chain Hepatitis C virus

Gauge Transformation and Constraint Induced Operator Ordering for Charged Rigid Planar Rotator in Uniform Magnetic Field

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Communications in Theoretical Physics 2006年第5X期46卷 843-844页

作者： LAI Mei-Mei WANG xin xiao yan-Ping LIU Quan-Hui School for Theoretical Physics and Department of Applied Physics Hunan University Changsha 410082 China

When the motion of a particle is constrained, excess terms exist using hermitian form of Cartesian momentum pi （i=1, 2,3） in usual kinetic energy （1/2/μ）∑ pi^2 , and the correct kinetic energy turns out to be （1/2μ） ∑1/ fipi f ipi, where fi are dummy factors in classical mechanics and nontrivial in quantum mechanics. In this paper the explicit form of the dummy functions fi is given for a charged rigid planar rotator in the uniform magnetic field with different gauge chosen. Under different gauges, we have different sets of dummy factors. It means that these factors do not have direct observable effect.

关键词： operator ordering gauge transformation quantum mechanics

Progress in Human Brain Banking in China

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Neuroscience Bulletin 2019年第2期35卷 179-182页

作者： Chao Ma Ai-Min Bao xiao-xin yan Dick F. Swaab Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Human Anatomy Histol-ogy and Embryology Neuroscience Center Joint Laboratory of Anesthesia and Pain School of Basic Medicine Peking Union Medical College Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital Institute of Neuroscience NHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang University School of Medicine Department of Anatomy and Neurobiology Central South University School of Basic Medical Science Department Neuropsychiatric Disorders Netherlands Insti-tute for Neuroscience an Institute of the Royal Netherlands Academy of Arts and Sciences

Human brain banks collect,preserve,and distribute postmortem and biopsied brain samples for histological,pathological,and molecular *** from the western countries,human brain banking in China has remained preliminary over ***,joint efforts during the past few years have substantially promoted this key frontier of neuroscience in *** special topic brings together review and perspective articles on the ethical,administrative,and practical issues of brain *** original studies report molecular and pathological characterizations based on banked human brain samples.

关键词： collect Progress Banking

Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion

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Neural Regeneration Research 2015年第9期10卷 1450-1456页

作者： Xu He Feng-jun Deng Jin-wen Ge xiao-xin yan Ai-hua Pan Zhi-yuan Li Department of Anatomy and Neurobiology School of Basic Medical Sciences Central South University Department of Anatomy Yiyang Medical College Department of Pharmacy Yiyang Medical College Department of Integrated Traditional and Western Medicine Hunan University of Traditional Chinese Medicine

The main active components extracted from Panax notoginseng are total saponins. They have been shown to inhibit platelet aggregation, increase cerebral blood flow, improve neurological behavior, decrease infarct volume and promote proliferation and differentiation of neural stem cells in the hippocampus and lateral ventricles. However, there is a lack of studies on whether total saponins of Panax notoginsertg have potential benefits on immature neuroblasts in the olfactory bulb following ischemia and reperfusion. This study established a rat model of global cerebral ischemia and reperfusion using four-vessel occlusion. Rats were administered total sa- ponins of Panax notoginseng at 75 mg/kg intraperitoneally 30 minutes after ischemia then once a day, for either 7 or 14 days. Total saponins of Panax notoginseng enhanced the number of dou- blecortin （DCX）＋ neural progenitor ceils and increased co-localization of DCX with neuronal nuclei and phosphorylated cAMP response element-binding/DCX＋ neural progenitor cells in the olfactory bulb at 7 and 14 days post ischemia. These findings indicate that following global brain ischemia/reperfusion, total saponins of Panax notoginseng promote differentiation of DCX＋ cells expressing immature neuroblasts in the olfactory bulb and the underlying mechanism is related to the activation of the signaling pathway of cyclic adenosine monophosphate response element binding protein.

关键词： nerve regeneration total saponins of Panax notoginseng cerebral ischemia/reperfusion immature neurons neurogenesis doublecortin olfactory bulb neural regeneration

I_(2)-Mediated[3+2]annulation of methyl-azaarenes with alkyl_(2)-isocyanoacetates or amino acid ester hydrochlorides:selective synthesis of iodine-func-tionalized and non-iodine-functionalized fused imidazoles

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Organic Chemistry Frontiers 2022年第5期9卷 1403-1409页

作者： Yong-Ji Hu Yu Zhou Jing-Jing Gao Han Zhang Kai-Rui yang Jia-Jun Li xiao-xin yan Yuan-Lin Li yan-Ping Zhu School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityShandongYantai264005P.R.China

An I_(2)-mediated[3+2]annulation of methyl-azaarenes with alkyl_(2)-isocyanoacetates or amino acid ester hydrochlorides has been *** strategy involves CuN bond cleavage of isocyanides and can selectively synthesize iodine-functionalized and non-iodine-functionalized fused ***-up experiments and arylation,alkynylation,alkenylation and selenization of iodine-functionalized products demonstrated the potential applications of this reaction.

关键词： reaction iodine fused

Advances in Alzheimer’s disease (AAD): Standing firm at its first anniversary

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Advances in Alzheimer's Disease 2013年第2期2卷 49-50页

作者： xiao-xin yan Department of Anatomy and Neurobiology Central South University Xiangya School of Medicine Changsha China

Editorial: Advances in Alzheimer’s disease (AAD): Standing firm at its first

关键词： Editorial AAD

Cultural Dislocation and Humanity Lost:A Post-Colonial Analysis of Alice Walker’s“Everyday Use”

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Journal of Literature and Art Studies 2023年第8期13卷 580-584页

作者： xiao xin-yan University of Shanghai Science and Technology ShanghaiChina

Alice Walker is a famous African-American female author whose short story“Everyday Use”takes the conflict between a mother and her two daughters over the final ownership of“a quilt”as the main line and creates three black women characters with bright *** paper will focus on the living conditions and spiritual world of black women,and reflects the anxiety of black women on ethnic cultural heritage within the white world and reveals the suppression of the strong culture to the weak culture,and the self-preservation of the weak culture from the perspective of post-colonialism.

关键词： “Everyday use” post-colonialism black women cultural dislocation

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

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Protein & Cell 2022年第1期13卷 26-46页

作者： Weili yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han yanting Liu Sen yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang xin Xiong Huiming yang Peng Yin Huida Wan xingxing Chen Jifeng Guo xiao-xin yan Lujian Liao Shihua Li xiao-Jiang Li Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510632China Key Laboratory of Brain Functional Genomics of Ministry of Education Shanghai Key Laboratory of Brain Functional Genomicsand Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 100021China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Anatomy and Neurobiology Xiangya School of MedicineCentral South UniversityChangsha 410008China

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of *** we report that PINK1 kinase form is selectively expressed in the human and monkey ***/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and ***,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and *** findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD.

关键词： Parkinson's disease neurogenesis neurodegeneration mitochondria non-human primates

Ti掺杂对正极材料LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2结构和电化学性能的影响

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华南理工大学学报（自然科学版） 2012年第1期40卷 1-6页

作者：肖新颜汪冬华南理工大学化学与化工学院广东广州510640

为研究离子掺杂对锂离子正极材料LiNi1/3Co1/3Mn1/3O2的影响,采用氢氧化物共沉淀法制备了Ti4+掺杂改性的锂离子正极材料LiNi1/3-1/40Co1/3Mn1/3Ti1/40O2、LiNi1/3-Co1/3-1/40Mn1/3Ti1/40O2和LiNi1/3Co1/3Mn1/3-1/40Ti1/40O2,并运用X射线衍射仪和扫描电子显微镜对Ti掺杂改性后正极材料的晶型和微观结构进行表征,通过高精度电池性能检测系统对正极材料的电化学性能进行检测.结果表明:Ti分别取代Ni、Co和Mn对三元复合正极材料进行掺杂改性后,改性材料都保持典型的α-NaFeO2层状结构,且晶型良好;LiNi1/3-Co1/3Mn1/3-1/40Ti1/40O2轮廓最分明,且形貌均一;3种改性材料的电化学性能均有一定程度的提高,其中LiNi1/3Co1/3Mn1/3-1/40Ti1/40O2提高最为明显,在0.1 C、1.0 C和2.0 C倍率下其首次放电比容量分别为145.35、140.79和125.60 mA.h/g,1.0 C倍率下循环30次后的容量保持率为88.06%.

关键词：正极材料 LiNi1/3Co1/3Mn1/3O2 钛掺杂改性微观结构电化学性能