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Waist subcutaneous soft tissue metastasis of rectal mucinous adenocarcinoma: A case report

World Journal of Clinical Cases 2024年第14期12卷 2412-2419页

作者： Zi-Xing Gong Guo-Lei li Wen-Min Dong Zhao Xu Rui li Wen-Xia Lv Jing Yang Zhong-Xin li Wei Xing Department of General Surgery Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Medical Imaging Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Pathology Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Gastroendoscopy Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Gastrointestinal Disease Diagnosis and Treatment Center The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Rectal mucinous adenocarcinoma(MAC)is a rare pathological type of rectal can-cer with unique pathological features and a poor *** is difficult to diag-nose and treat early because of the lack of specific manifestations in some aspects of the *** common metastatic organs of rectal cancer are the liver and lung;however,rectal carcinoma with metastasis to subcutaneous soft tissue is a rare *** SUMMARY In this report,the clinical data,diagnosis and treatment process,and postope-rative pathological features of a patient with left waist subcutaneous soft tissue masses were retrospectively *** patient underwent surgical treatment after admission and recovered well after *** final pathological diagnosis was rectal MAC with left waist subcutaneous soft tissue *** Subcutaneous soft tissue metastasis of rectal MAC is rare,and it can suggest that the tumor is disseminated,and it can appear even earlier than the primary ma-lignant tumor,which is occult and leads to a missed diagnosis and misdiagnosis *** a subcutaneous soft tissue mass of unknown origin appears in a patient with rectal cancer,a ma-lignant tumor should be considered.

关键词： Colorectal cancer Rectal mucinous adenocarcinoma Cancer metastasis Subcutaneous soft tissue Hematogenous Case report

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Quantifying Uncertainty in Dielectric Solids’ Mechanical Properties Using Isogeometric Analysis and Conditional Generative Adversarial Networks

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2587-2611页

作者： Shuai li xiaodong Zhao Jinghu Zhou Xiyue Wang College of Civil Engineering&Architecture Dalian UniversityDalian116622China Research Center for Geotechnical and Structural Engineering Technology of liaoning Province Dalian UniversityDalian116622China

Accurate quantification of the uncertainty in the mechanical characteristics of dielectric solids is crucial for advancing their application in high-precision technological domains,necessitating the development of robust com-putational *** paper introduces a Conditional Generation Adversarial Network Isogeometric Analysis(CGAN-IGA)to assess the uncertainty of dielectric solids’mechanical *** is utilized for the precise computation of electric potentials in dielectric,piezoelectric,and flexoelectric materials,leveraging its advantage of integrating seamlessly with Computer-Aided Design(CAD)models to maintain exact geometrical *** CGAN method is highly efficient in generating models for piezoelectric and flexoelectric materials,specifically adapting to targeted design requirements and ***,the CGAN-IGA is adopted to calculate the electric potential of optimum models with different parameters to accelerate uncertainty quantification *** accuracy and feasibility of this method are verified through numerical experiments presented herein.

关键词： Dielectric solid isogeometric finite element method surrogate model generative adversarial

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Poly(arylene ether nitrile)Dielectric Film Modified by Bi_(2)S_(3)/rGO-CN Fillers for High Temperature Resistant Electronics Fields

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Chinese Journal of Polymer Science 2022年第11期40卷 1441-1450页

作者： li-Fen tong liang He Chen-Hao Zhan Yun-Qing Xia xiao-Bo liu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu610054China Sichuan Province Engineering Technology Research Center of Novel CN Polymeric Materials Chengdu610054China

High-quality film capacitors are widely used in many fields such as new energy vehicles,electronic communications,etc.,due to their advantages in wide frequency response and low dielectric *** dielectric film is a crucial part of the film capacitor,and its properties have an important impact on the performance and use conditions of the film *** this work,a novel high-temperature-resistant dielectric film was ***,the Bi_(2)S_(3)/rGO-CN fillers were prepared by hydrothermal method combined with cyanation treatment,and then added to the poly(arylene ether nitrile)(PEN)matrix to prepare the dielectric film materials(PEN/Bi_(2)S_(3)/rGO-CN).After high temperature treatment,the fillers Bi_(2)S_(3)/rGO-CN reacted with the PEN matrix,and the composites materials transformed into a thermosetting hybrid film(PEN-Bi_(2)S_(3)/rGO)with gel content of 97.88%.The prepared hybrid dielectric films did not decompose significantly before 400℃,and showed a glass transition temperature(Tg)of up to 252.4℃,which could increase the effective use temperature of the *** with the composite films without heat treatment,they exhibit better mechanical properties,with further improvement in tensile strength and elastic modulus,and a decrease in elongation at *** dielectric constant of the hybrid films can be up to 6.8 while the dielectric loss is only about 0.02 at 1 ***,the hybrid films showed excellent dielectric stability during temperature changes,and remain relatively stable before 250℃,which is suitable as a high-temperature-resistant high-dielectric material and is more advantageous for practical applications.

关键词： Poly(arylene ether nitrile) Bismuth sulfide Graphene oxide High-temperature-resistant Dielectric properties

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Electrochemical reconstruction: a new perspective on Sn metal-organic complex microbelts as robust anode for lithium storage

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Rare Metals 2024年第1期43卷 76-86页

作者： Jin-Ke Shen Nai-Teng Wu li-Yuan Wang Gang Jiang Dong-Lei Guo Jin li Gui-Long liu Hong-Yu Mi Huan Pang Xian-Ming liu Key Laboratory of Function-oriented Porous Materials of Henan Province College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources School of Chemical Engineering and TechnologyXinjiang UniversityUrumqi 830046China School of Chemistry and Chemical Engineering Institute for Innovative Materials and EnergyYangzhou UniversityYangzhou 225009JiangsuChina

Tin-based materials with high theoretical capacity and suitable working voltage are ideal anode materials for lithium-ion batteries(liBs). However, to overcome their shortcomings(volume expansion and inferior stability), the preparation processes are usually complicated and expensive. Herein, a tin-based metal-organic complex(tin 1,2-benzenedicarboxylic acid, Sn-BDC)with one-dimensional microbelt morphology is synthesized by a facile, rapid and low-cost co-precipitation method, and served as anode material for liBs without any post-treatment. Sn-BDC exhibits a high reversible capacity with609/440 m Ah·g^(-1) at 50/2000 m A·g^(-1), and robust cycling stability of 856 m Ah·g^(-1) after 200 cycles at 200 m A·g^(-1),which are obviously superior to that of the Sn Ox/C counterparts. Moreover, an electrochemical reconstruction perspective on the lithium storage mechanism of Sn-BDC is proposed by systematic ex-situ characterizations. The reconstructed SnO_(2) replaces Sn-BDC and becomes the active material in the subsequent cycles. As the by-product of the lithiation reaction, the formed li-based metal-organic complex(li-BDC, wrapped around the reconstructed SnO_(2)) plays an important role in alleviating volume expansion and accelerating the charge transfer *** work is beneficial to design and construct the new electrode materials based on the electrochemical reconstruction for advanced liBs.

关键词： Electrochemical reconstruction Metal-organic complex Anode lithium storage mechanism lithium-ion batteries

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Male reproductive function before and after the adjustment of the COVID-19 prevention policy:a multicenter study in China

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Asian Journal of Andrology 2024年第3期26卷 308-314页

作者： Jian-Zheng li Han Wu li Wang Yun-Shan Wang Feng Kong Long-Qiao Cao Ming liang Xiong Wang Ming-Zhen Yuan Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250000China Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China Engineering Laboratory of Urinary Organ and Functional Reconstruction of Shandong Province Jinan 250000China The First People’sHospital of Jining Jining 272000China Department of Reproductive Medicine The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public *** compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in China,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different *** were divided into five groups according tothe timeline of the policy *** data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square *** total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone *** showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy *** comparison revealed an initial decrease and gradual recovery in progressive motility *** morphology analysisshowed increased neck and tail abnormalities after the policy *** significant change in hormone levels was *** the adjustment of the COVID-19 prevention policy in China,a decline in sperm motility and morphology was *** trend may gradually recover over 2 *** the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.

关键词： COVID-19 multicenter study reproduction SARS-CoV-2 semen analysis

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Thymoquinone affects hypoxia-inducible factor-1αexpression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways

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World Journal of Gastroenterology 2024年第21期30卷 2793-2816页

作者： Zhan-Xue Zhao Shuai li lin-Xun liu Department of General Surgery Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of Clinical Pharmacy The Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

BACKGROUND Pancreatic cancer(PC)is associated with some of the worst prognoses of all major ***(TQ)has a long history in traditional medical practice and is known for its anti-cancer,anti-inflammatory,anti-fibrosis and antioxidant pharmacological *** studies on hypoxia-inducible factor-1α(HIF-1α)and PC have shown that HIF-1αaffects the occurrence and development of PC in many *** addition,TQ could inhibit the development of renal cancer by decreasing the expression of HIF-1α.Therefore,we speculate whether TQ affects HIF-1αexpression in PC cells and explore the *** To elucidate the effect of TQ in PC cells and the regulatory mechanism of HIF-1α*** Cell counting kit-8 assay,Transwell assay and flow cytometry were performed to detect the effects of TQ on the proliferative activity,migration and invasion ability and apoptosis of PANC-1 cells and normal pancreatic duct epithelial(hTERTHPNE)*** real-time polymerase chain reaction and western blot assay were performed to detect the expression of HIF-1αmRNA and protein in PC *** effects of TQ on the HIF-1αprotein initial expression pathway and ubiquitination degradation in PANC-1 cells were examined by western blot assay and *** TQ significantly inhibited proliferative activity,migration,and invasion ability and promoted apoptosis of PANC-1 cells;however,no significant effects on hTERT-HPNE cells were *** significantly reduced the mRNA and protein expression levels of HIF-1αin PANC-1,AsPC-1,and BxPC-3 *** significantly inhibited the expression of the HIF-1αinitial expression pathway(PI3K/AKT/mTOR)related proteins,and promoted the ubiquitination degradation of the HIF-1αprotein in PANC-1 *** had no effect on the hydroxylation and von Hippel lindau protein mediated ubiquitination degradation of the HIF-1αprotein but affected the stability of the HIF-1αprotein by inhibiting the interaction between HI

关键词： Thymoquinone Pancreatic cancer Hypoxia-inducible factor-1α PI3K/AKT/mTOR HSP90

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Data-driven diagnosis of high temperature PEM fuel cells based on the electrochemical impedance spectroscopy: Robustness improvement and evaluation

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Journal of Energy Chemistry 2024年第9期96卷 544-558页

作者： Dan Yu Xingjun li Samuel Simon Araya Simon Lennart Sahlin Vincenzo liso Department of Energy Aalborg UniversityAalborg 9220Denmark Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA Materials Research and Technology Development Luxembourg Institute of Science and Technology(LIST)4422 BelvauxLuxembourg

Utilizing machine learning techniques for data-driven diagnosis of high temperature PEM fuel cells is beneficial and meaningful to the system durability. Nevertheless, ensuring the robustness of diagnosis remains a critical and challenging task in real application. To enhance the robustness of diagnosis and achieve a more thorough evaluation of diagnostic performance, a robust diagnostic procedure based on electrochemical impedance spectroscopy (EIS) and a new method for evaluation of the diagnosis robustness was proposed and investigated in this work. To improve the diagnosis robustness: (1) the degradation mechanism of different faults in the high temperature PEM fuel cell was first analyzed via the distribution of relaxation time of EIS to determine the equivalent circuit model (ECM) with better interpretability, simplicity and accuracy;(2) the feature extraction was implemented on the identified parameters of the ECM and extra attention was paid to distinguishing between the long-term normal degradation and other faults;(3) a Siamese Network was adopted to get features with higher robustness in a new embedding. The diagnosis was conducted using 6 classic classification algorithms—support vector machine (SVM), K-nearest neighbor (KNN), logistic regression (LR), decision tree (DT), random forest (RF), and Naive Bayes employing a dataset comprising a total of 1935 collected EIS. To evaluate the robustness of trained models: (1) different levels of errors were added to the features for performance evaluation;(2) a robustness coefficient (Roubust_C) was defined for a quantified and explicit evaluation of the diagnosis robustness. The diagnostic models employing the proposed feature extraction method can not only achieve the higher performance of around 100% but also higher robustness for diagnosis models. Despite the initial performance being similar, the KNN demonstrated a superior robustness after feature selection and re-embedding by triplet-loss method, which sug

关键词： PEM fuel cell Data-driven diagnosis Robustness improvement and evaluation Electrochemical impedance spectroscopy

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RNA barcode segments for SARS-CoV-2 identification from HCoVs and SARSr-CoV-2 lineages

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Virologica Sinica 2024年第1期39卷 156-168页

作者： Changqiao You Shuai Jiang Yunyun Ding Shunxing Ye xiaoxiao Zou Hongming Zhang Zeqi li Fenglin Chen Yongliang li Xingyi Ge Xinhong Guo College of Biology Hunan UniversityChangsha410082China College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha410128China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pathogen responsible for coronavirus disease 2019(COVID-19),continues to evolve,giving rise to more variants and global *** research has demonstrated that barcode segments can effectively and cost-efficiently identify specific species within closely related *** this study,we designed and tested RNA barcode segments based on genetic evolutionary relationships to facilitate the efficient and accurate identification of SARS-CoV-2 from extensive virus samples,including human coronaviruses(HCoVs)and SARSr-CoV-2 *** sequences sourced from NCBI and GISAID were meticulously selected and curated to construct training sets,encompassing 1733 complete genome sequences of HCoVs and SARSr-CoV-2 *** genetic-level species testing,we validated the accuracy and reliability of the barcode segments for identifying ***,75 main and subordinate species-specific barcode segments for SARS-CoV-2,located in ORF1ab,S,E,ORF7a,and N coding sequences,were intercepted and screened based on single-nucleotide polymorphism sites and weighted ***-testing,these segments exhibited high recall rates(nearly 100%),specificity(almost 30%at the nucleotide level),and precision(100%)performance on *** were eventually visualized using one and two-dimensional combined barcodes and deposited in an online database(http://***/).The successful integration of barcoding technology in SARS-CoV-2 identification provides valuable insights for future studies involving complete genome sequence polymorphism ***,this cost-effective and efficient identification approach also provides valuable reference for future research endeavors related to virus surveillance.

关键词： RNA barcode segments SARS-CoV-2 variants and related lineages HCoVs Genetic tests Complete genome sequences

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加速膛参数对换能元飞片速度的影响

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含能材料 2024年第7期32卷 737-744页

作者：王蔚董晓芬王端李乾李思宇郭宇轩中北大学环境与安全工程学院山西太原030051

飞片速度是冲击片雷管能否可靠起爆的一个关键因素,为了深入研究加速膛参数对飞片速度的影响,分别通过实验和数值模拟方法对飞片速度的影响因素进行分析。采用磁控溅射技术设计制备了一种膜层厚度为0.5/0.5/2μm,尺寸为0.15 mm×0.15 mm... 详细信息

飞片速度是冲击片雷管能否可靠起爆的一个关键因素,为了深入研究加速膛参数对飞片速度的影响,分别通过实验和数值模拟方法对飞片速度的影响因素进行分析。采用磁控溅射技术设计制备了一种膜层厚度为0.5/0.5/2μm,尺寸为0.15 mm×0.15 mm的TiW/Ni/Au复合薄膜爆炸箔。在激励条件为0.1μF、1200 V下,选用密度为1.45 g·cm^(-3),厚度为25μm的聚酰亚胺飞片,利用光子多普勒速度测试技术测量了不同加速膛参数的飞片速度。研究结果显示:在相同孔径条件下,当加速膛厚度分别为0.3,0.4,0.5,0.6 mm时,随着加速膛厚度的增加,飞片速度先增后减,在厚度为0.4 mm时达到最高值;在相同厚度条件下,当加速膛孔径分别为0.15,0.23,0.3,0.35,0.45 mm时,飞片速度随孔径增加而降低,其中孔径为0.15 mm时速度最高;此外,在相同孔径和厚度下,飞片经过聚酰亚胺和陶瓷两种材质的加速膛测试得到的速度变化趋势和数值相近,而聚酰亚胺具有较高的强度和韧性,成本更低,因此可替代陶瓷作为加速膛材料。同时采用数值模拟方法重新拟合了适用于TiW/Ni/Au复合薄膜的飞片速度经验公式,验证结果表明,计算结果与实验数据的偏差均在2.5%以内。

关键词：爆炸箔光子多普勒速度测试技术(PDV) 飞片速度加速膛聚酰亚胺

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A multi-kernel-shell indium selenide@carbon nanosphere enabling high-performance lithium-ion batteries

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Journal of Energy Chemistry 2024年第9期96卷 698-708页

作者： Sihao Wang Zhuoming Jia Ying Zhao Yanhong li Xianglong Kong Yongde Yan Fei He Milin Zhang linzhi Wu Piaoping Yang Wenwu li Meilin liu Zhiliang liu College of Material Sciences1nd Chemical Engineering Harbin Engineering UniversityHarbin 150001HeilongjiangChina School of Materials Science&Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Chemical Engineering Sungkyunkwan University 2066Seobu-roJangan-guSuwon 440-746Republic of Korea College of Aerospace1nd Civil Engineering Harbin Engineering UniversityHarbin 150001HeilongjiangChina

Indium selenide has garnered significant attention for high volumetric capacities,but is currently plagued by the sluggish charge transfer kinetics,severe volume effect,and rapid capacity degradation that hinder their practical ***,we design,synthesize,and characterize a multi-kernel-shell structure comprised of indium selenide encapsulated within carbon nanospheres(referred to as m-K-S In_(2)Se_(3)@C)through an integrated approach involving a hydrothermal method followed by a gaseous selenization ***,experimental measurements and density functional theory calculations confirm that the m-K-S In_(2)Se_(3)@C not only improve the adsorption capability for li-ions but also lower the energy barrier for li-ions *** from numerous contact points,shorter diffusion distances and an improved volume buffering effect,the m-K-S In_(2)Se_(3)@C achieves an 800 mA h g^(−1)capacity over 1000 loops at 1000 mA g^(−1),a 520 mA h g^(−1)capacity at 5000 mA g^(−1)and an energy density of 270 Wh kg^(−1)when coupled with liFePO4,surpassing most related anodes reported ***,the m-K-S structure with unique nano-micro structure offers a new approach to the design of advanced anodes for liBs.

关键词： Multi-kernel-shell structure In_(2)Se_(3) Anode li-ion batteries

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