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Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults

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Journal of Geriatric Cardiology 2022年第7期19卷 522-530页

作者： Jun-Pei LI Tian-Yu CAO xiao-Yuan ZHA Yun YU Zi-Heng TAN Zai-Hua cheng Hua-Bo YING Wei ZHOU Lin-Juan ZHU Tao WANG Li-shun LIU Hui-Hui BAO xiao HUANG xiao-shu cheng Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchangChina University of California Santa BarbaraCAUSA Rancheng Community Health Service Center WuyuanChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityNan-changChina Graduate School at Shenzhen Tsinghua UniversityShenzhenChina

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(<0.9),borderline ABI(0.91-0.99)was once commonly *** study aims to explore the independent and joint effect of tHcy level and borderline ABI on all-cause death in hypertensive *** This study included 10,538 participants from China H-type Hypertension Registry *** was described into two groups:normal ABI(1.00-1.40)and borderline *** level was also divided into two groups:<15.02 and≥15.02μmo/*** groups were analyzed,using COX proportional hazard regression model,separately and pairwise to observe the independ-ent and joint effect on all-cause *** A total of 126(1.2%)deaths were observed in the 1.7 years follow-up *** ABI has a higher predicted risk of death than normal ABI(HR=1.87,95%CI:1.17-3.00)after adjusting for potential *** with tHcy level<15.02μmo/L(low tHcy),those with tHcy≥15.02μmo/L(high tHcy)had higher risk to event outcome(HR=1.99,95%CI:1.30-3.05).According to the cumulative hazard curve,group with borderline ABI and high tHcy level has significantly higher altitude and larger increasing rate over follow-up period compare to other *** those with borderline ABI,participants with high tHcy had higher death risk than those with low tHcy,nevertheless,no significant different between borderline and normal ABI among those with low tHcy *** Borderline ABI and tHcy level both have independent predictive value on all-cause *** combined group of borderline ABI and high tHcy has highest risk factor of outcomes,which suggested the mutual additive value of border-line ABI and *** attention should be given to the importance of borderline ABI in hypertensive population,especially with elevated tHcy level.

关键词： hypertensive death ankle

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Association between body mass index and the risk of bleeding in elderly patients with non-valvular atrial fibrillation taking dabigatran:a cohort study

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Journal of Geriatric Cardiology 2020年第4期17卷 193-201页

作者： Ming-Hui LI Li-Hua HU Yu-Rong XIONG Yu YU Wei ZHOU Tao WANG Ling-Juan ZHU Xi LIU Hui-Hui BAO xiao-shu cheng Department of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center of Cardiovascular Inner Mongolia People’s HospitalHohhotInner MongoliaChina

Background Uncertainty remains regarding the association between body mass index(BMI)and the risk of bleeding in patients with non-valvular atrial fibrillation(NVAF).We aimed to investigate the association between BMI and the risk of bleeding in elderly NVAF patients taking *** A total of 509 elderly NVAF patients,who were being treated at twelve centers in China from February 2015 to December 2017 and taking dabigatran,were *** exposure and outcome variables were BMI at baseline and bleeding events within the subsequent six months,*** proportional hazards regression analysis was used to evaluate the association between BMI and the risk of ***,the Cox proportional hazards regression with cubic spline functions and smooth curve fitting was *** During the six-month follow-up,50 participants experienced *** 1 kg/m^2 increase in BMI was associated with a 12%increased risk of bleeding(P=0.021).Compared to those with BMI values in Tertile 1(25.3 kg/m^2)were 2.71(95%CI:1.02–7.17)and 3.5(95%CI:1.21–8.70),*** Ptrend-value was significant in all *** adjusted smooth curve showed a linear association between BMI and *** of the stratified variables showed significant effect modification on the association between BMI and bleeding(Pinteraction>0.05).Conclusions BMI was significantly and positively associated with the risk of bleeding in elderly NVAF patients treated with dabigatran.

关键词： Atrial fibrillation Bleeding Body mass index Dabigatran

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Cross talk of NF-kappa B canonical and non-canonical pathway in human and mouse tissues

Cross talk of NF-kappa B canonical and non-canonical pathway...

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江西省第六次中西医结合心血管学术交流会

作者： xiao Huang Ren Gong xiao-feng Yang Hong Wang xiao-shu cheng Department of Cardiology Second hospital ofNanchang University Department of Pharmacology and Cardiovascular Research Center Temple University School ofMedicinePhiladelphiaPennsylvaniaUSA 19140 Department ofCardiology Second hospital ofNanchang University

＜正＞Background:Nuclear factor-kappa B（NF-κB） family are critical regulators in immunity,stress responses, apoptosis and differentiation,however,tissue NF-κB metabolism and their relevance to methylation status remain unknown. Method:We examined gene expression profiles of 5 NF-κB transcription factors,6 inhibitory IκB proteins（I-κB）, 3 IkB kinase（IKK） complex and 24 pathway components in NF-kB signaling ***-base mining of NF-κB family members and conponnets mRNA expressions are accomplished by querying GEO DataSets profiles under inflammation cytokine stimuli,hypomethylation status,and homocysteine *** analyzed correlations between gene expression,S-adenosylhomocysteine（SAH）,and S-adenosylmethion ine（SAM） levels,and SAM/SAH ratios in 7 mouse tissues. Result:Our results showed that 1) NF-kB family members and pathway components have different expression levels in different tissues,and high expression in mouse,but inactive in human in normal condition;2) Vascular system has lower response to NF-kB activity;3) Tissues can be divided into 3 tiers according to essential molecular of NF-kB canonical and non-canonical pathway expression level in normal condition;4) Canonical pathway is activated immediately after inflammatory cytokine TNF-α,IL-1 stimuli,but non-canonical pathway is up-regulated until 4 hours treatment;5) Lymphotoxin beta/LIGHT has no effect on NF-kB family members and components expressions at 4 hours;6) Scal+ subset endothelial progenitor cells has lower NF-κB family members and components expressions level than Scal-subset endothelial progenitor cells;7) Most of NF-κB family members and components expressions are down-regulated by hypomethylation status;8) Most of NF-kB family members and components expressions are down-regulated by acute homocystein treat in different cell type. Conclusion:These new results provide an insight on the roles of NF-kB family members and components in tissues and cross talk between canonical and non-canonical pa

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Independent and joint association of physical activity and sedentary behavior on all-cause mortality

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Chinese Medical Journal 2021年第23期134卷 2857-2864页

作者： Wei Zhou Wei Yan Tao Wang Ling-Juan Zhu Yan Xu Jun Zhao Ling-Ling Yu Hui-Hui Bao xiao-shu cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center NanchangJiangxi 330006China Chronic Disease Prevention and Control Institute Jiangxi Province Center for Disease Control and PreventionNanchangJiangxi 330006China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China.

Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese *** aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern ***:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 *** self-reported PA and SB were collected via the ***–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause ***:A total of 11,744 eligible participants were included in the *** an average of 5.4 years of follow-up,796 deaths *** risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause *** with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.

关键词： Physical activity Sedentary behavior All-cause mortality Joint association

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The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosis induced by hypoxia in rat cardiomyocyte

The effect of ROCK1 and ROCK2 silencing by ShRNA on apoptosi...

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第十三次全国心血管病学术会议

作者： SUN Guo-fang,LI Ju-xiang,DING Hao,HONG Kui, cheng xiao-shu,cheng xiao-shu Department of Cardiology,The second affiliated hospital of Nanchang university,Nanchang 330031,China

Objective It is well known that the apoptosis of cardiomyocyte involves the development of some cardiovascular diseases, such as heart failure,coronary heart disease and so ***-regulation of ROCK1(Rho—associated coiled-coil protein kinase-1) and ROCK2 could inhibit apoptosis of a variety of ***,shRNAs targeting ROCK1 and ROCK2 were transfected into rat cardiomyocytes to inhibit the expression of ROCK1 and *** effect of ROCK1 and ROCK2 on

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Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study

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Chinese Medical Journal 2019年第18期132卷 2150-2156页

作者： Wei Zhou Tao Wang Ling-Juan Zhu Ming-Hua Wen Li-Hua Hu xiao Huang Chun-Jiao You Ju-Xiang Li Yan-Qing Wu Qing-Hua Wu Hui-Hui Bao xiao-shu cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China

Background: The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran. Methods: A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Follow-up was completed by May 2018. The exposure and outcome variables were leukocyte count measured at baseline and the number of bleeding events within the subsequent 6 months. Multivariate Cox proportional hazards models were constructed to analyze independent associations, and a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (penalized spline method) was used to address nonlinearity between leukocyte count and bleeding. The inflection point was calculated using a recursive algorithm, and then a two-piecewise Cox proportional hazards model for both sides of the inflection point was constructed. Results: During 6-month follow-up, 87 participants occurred bleeding events. For every 1×10^9/L increase in leukocyte count, the risk of bleeding increased by 11%(hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 0.99–1.25). The smooth curve showed nonlinear relationship between leukocyte count and bleeding events. The inflection point of the leukocyte count was 6.75×10^9/L. For leukocyte counts < 6.75×10^9/L, the HR (95% CI) was 0.88 (0.69–1.13), and for leukocyte counts ≥ 6.75×10^9/L, the HR (95% CI) was 1.28 (1.09–1.51). Conclusion: This study found a J-shaped association between baseline leukocyte count and risk of bleeding in NVAF patients treated with dabigatran.

关键词： Peripheral leukocyte count Bleeding Nonvalvular atrial fibrillation Threshold effect

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Low deceleration capacity is associated with higher stroke risk in patients with paroxysmal atrial fibrillation

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Chinese Medical Journal 2019年第17期132卷 2046-2052页

作者： Ying Ding Zhen-Yan Xu Hua-Long Liu Jin-Zhu Hu Jing Chen Lin Huang Qi Chen Jian-Xin Hu xiao-shu cheng Kui Hong Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Jiangxi Key Laboratory of Molecular Medicine Nanchang Jiangxi 330006 China

Background: Deceleration capacity (DC) is a non-invasive marker for cardiac autonomic dysfunction;however, few studies have shown that the influence factors of cardiac autonomic dysfunction and the correlations between DC and stroke risk in paroxysmal atrial fibrillation (AF). We aimed to explore the influencing factors of abnormal DC and the relationships between DC and stroke risk in patients with paroxysmal AF. Methods: The study included hospitalized paroxysmal AF patients with DC measurements derived from 24-h Holter electrocardiography recordings taken between August 2015 and June 2016. Multivariable regression analysis was performed to evaluate the associations between correlated variables and abnormal DC values. The relationship between DC and ischemic stroke risk scores in patients with paroxysmal AF was analyzed. Results: We studied 259 hospitalized patients with paroxysmal AF (143 [55.2%] male, mean age 66.4 ± 12.0 years);38 patients of them showed abnormal DC values. In the univariate analysis, age, hypertension, heart failure, and previous stroke/transient ischemic attack (TIA) were significantly associated with abnormal DC values. Among these factors, a history of previous stroke/TIA (odds ratio = 2.861, 95% confidence interval: 1.356–6.039) were independently associated with abnormal DC values in patients with paroxysmal AF. The abnormal DC group showed a higher stroke risk with the score of congestive heart failure, hypertension, age >75 years, diabetes mellitus, previous stroke and TIA (CHADS2)(2.25 ± 1.48 vs. 1.40 ± 1.34, t =-4.907, P = 0.001) and CHA2DS2-vascular disease, age 65–74 years and female category (VASc)(3.76 ± 1.95 vs. 2.71 ± 1.87, t =-4.847, P = 0.001) scores. Correlation analysis showed that DC was negatively correlated with CHADS2 scores (r =-0.290, P 0.001). Conclusions: Lower DC is closely associated with previous stroke/TIA, and is also correlated negatively with higher stroke risk

关键词： Deceleration capacity Atrial fibrillation Stroke Cardiac autonomic

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柔性轨道下高速列车车轮谐波磨耗对轮轨滚动接触蠕滑特性的影响

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中国铁道科学 2017年第4期38卷 84-91页

作者：周新建肖乾程树杨逸航华东交通大学载运工具与装备教育部省部共建重点实验室江西南昌330013 西南交通大学牵引动力国家重点实验室四川成都610031

针对柔性轨道下因谐波磨耗车轮激励而引发钢轨和轮对振动时的轮轨蠕滑问题,在分析柔性轨道下轮轨间滚动接触振动对轮轨蠕滑特性影响机理的基础上,基于CRTS型双块式无砟轨道和CRH2型高速列车,采用ANSYS和UM软件建立柔性轨道下高速列车的... 详细信息

针对柔性轨道下因谐波磨耗车轮激励而引发钢轨和轮对振动时的轮轨蠕滑问题,在分析柔性轨道下轮轨间滚动接触振动对轮轨蠕滑特性影响机理的基础上,基于CRTS型双块式无砟轨道和CRH2型高速列车,采用ANSYS和UM软件建立柔性轨道下高速列车的动力学数值模型;选取6种典型谐波磨耗(阶数分别为1,6和11阶;对应波深分别为0.1和0.3mm)车轮,进行轮轨滚动接触振动特性、轮轨蠕滑力和蠕滑率的分析。结果表明:车轮谐波磨耗阶数和波深的增加均导致钢轨垂向加速度、轮对垂向加速度、轮轨垂向力及轮轨蠕滑力和蠕滑率的大幅增加,且与阶数的影响相比,波深对滚动接触蠕滑特性的影响更大;当车轮的谐波磨耗取11阶和0.3mm波深时,轮轨垂向力最大值、钢轨垂向加速度最大值、轮对垂向加速度最大值和平均值、纵向蠕滑率平均值、纵向蠕滑力绝对平均值、横向蠕滑力最大值、纵向蠕滑力最大值分别约为车轮无谐波磨耗时的7.27,49.6,20.35,15.18,7.8,9.064,6.7和8.57倍;考虑柔性轨道后,轮轨接触脱离时间明显增加,轮轨蠕滑率和蠕滑力也有明显增大。

关键词：柔性轨道高速列车车轮谐波磨耗滚动接触轮轨关系蠕滑率蠕滑力

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基于Mobile Agent的入侵检测系统的研究

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计算机工程与设计 2005年第3期26卷 688-690页

作者：肖书成王康唐学文后勤工程学院基础部重庆400016 重庆大学网络中心重庆400044

移动Agent 技术是在现代网络技术的基础上将软件Agent 技术与分布式计算技术相结合的产物,它具有传统分布式技术无法比拟的优势。将移动Agent 技术应用于入侵检测中,并提出了IDSBMA (Intrusion DetectionSystemBasedon Mobile Agent) ... 详细信息

移动Agent 技术是在现代网络技术的基础上将软件Agent 技术与分布式计算技术相结合的产物,它具有传统分布式技术无法比拟的优势。将移动Agent 技术应用于入侵检测中,并提出了IDSBMA (Intrusion DetectionSystemBasedon Mobile Agent) 入侵检测模型,重点阐述了模型的原理和实现机制。

关键词：入侵检测系统移动Agent技术入侵检测模型软件Agent 分布式技术分布式计算技术实现机制比拟优势网络技术

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一种基于FastICA的图像隐写提取算法

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计算机应用 2007年第5期27卷 1067-1069,1076页

作者：李祁云李建平肖书成解放军后勤工程学院研究生四队重庆400016 解放军后勤工程学院国际小波分析应用研究中心

针对隐写术的特点,提出了一种新的隐写提取算法。该算法不同于传统提取算法基于逆嵌入算法的思想,将快速独立分量分析(FastICA)引入提取算法中,进行载体图像与秘密图像的分离。隐写是在真彩色图像的小波系数上进行的,有效地将近几年来... 详细信息

针对隐写术的特点,提出了一种新的隐写提取算法。该算法不同于传统提取算法基于逆嵌入算法的思想,将快速独立分量分析(FastICA)引入提取算法中,进行载体图像与秘密图像的分离。隐写是在真彩色图像的小波系数上进行的,有效地将近几年来比较热门的隐写术、小波分析与独立分量分析结合在一起。实验验证独立分量分析技术不仅能够用于秘密信息提取而且还能够实现真正的盲提取。

关键词：隐写术快速独立分量分析小波系数阈值

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