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A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction

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Engineering 2024年第5期36卷 193-208页

作者： Xin Shao Zheng Wang Kai Wang xiaoyan Lu ping Zhang Rongfang Guo Jie Liao Penghui Yang Shusen Zheng xiao Xu xiaohui Fan Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Zhejiang University School of Medicine Hangzhou 310058China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Shulan International Medical CollegeZhejiang Shuren UniversityHangzhou 310000China Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHarbin 150023China

Liver transplantation(LT)is the standard therapy for individuals afflicted with end-stage liver *** notable advancements in LT technology,the incidence of early allograft dysfunction(EAD)remains a critical concern,exacerbating the current organ shortage and detrimentally affecting the prognosis of ***,the perplexing hepatic heterogeneity has impeded characterization of the cellular traits and molecular events that contribute to ***,we constructed a pioneering single-cell transcriptomic landscape of human transplanted livers derived from non-EAD and EAD patients,with 12 liver samples collected from 7 donors during the cold perfusion and portal reperfusion *** of the 75231 cells of non-EAD and EAD patients revealed an EAD-associated immune niche comprising mucosal-associated invariant T cells,granzyme B^(+)(GZMB^(+))granzyme K^(+)(GZMK^(+))natural killer cells,and S100 calcium binding protein A12^(+)(S100A12^(+))***,we verified this immune niche and its association with EAD occurrence in two independent *** findings elucidate the cellular characteristics of transplanted livers and the EAD-associated pathogenic immune niche at the single-cell level,thus,offering valuable insights into EAD onset.

关键词： Human liver transplantation Early allograft dysfunction Pathogenic immune niche Single-cell analysis Cell-cell communication

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Efficacy of Raw Corn Starch in Insulinoma-Related Hypoglycemia:A Promising Supportive Therapy

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Chinese Medical Sciences Journal 2024年第2期39卷 102-110页

作者： Rong-Rong Li Wei Chen Xin-Hua xiao Miao Yu Fan ping Lian Duan Department of Clinical Nutrition Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic DiseaseChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To investigate the efficacy of raw corn starch(RCS)in clinical management of insulinoma-induced *** We retrospectively collected clinical data of insulinoma patients who received RCS-supplemented diet preoperatively,and analyzed the therapeutic effects of the RCS intervention on blood glucose control,weight change,and its adverse *** The study population consisted of 24 cases of insulinoma patients,7 males and 17 females,aged 46.08±14.15 *** RCS-supplemented diet,all patients had frequent hypoglycemic episodes(2.51±3.88 times/week),concurrent with neuroglycopenia(in 83.3% of patients)and autonomic manifestations(in 75.0% of patients),with the median fasting blood glucose(FBG)of 2.70(interquartile range[IQR]:2.50-2.90)mmol/*** patients'weight increased by 0.38(IQR:0.05-0.65)kg per month,with 8(33.3%)cases developing overweight and 7(29.2%)cases developing *** patients maintained the RCS-supplemented diet until they underwent tumor resection(23 cases)and transarterial chemoembolization for liver metastases(1 case).For 19 patients receiving RCS throughout the day,the median FBG within one week of nutritional management was 4.30(IQR:3.30-5.70)mmol/L,which was a significant increase compared to pre-nutritional level[2.25(IQR:1.60-2.90)mmol/L;P<0.001].Of them,10 patients receiving RCS throughout the day for over four weeks had sustained improvement in FBG compared to pre-treatment[3.20(IQR:2.60-3.95)mmol/L vs.2.15(IQR:1.83-2.33)mmol/L;P<0.001].Five patients who received RCS only at night also had a significant increase in FBG within one week of nutritional management[3.50(IQR:2.50-3.65)mmol/L vs.2.20(IQR:1.80-2.60)mmol/L;P<0.001],but only one patient who continued to receive RCS for over four weeks did not have a significant improvement in *** improvement in weight gain was observed upon RCS *** diarrhea(2 cases)and flatulence(1 case)occurred,and were relieved by reduction of RCS ***

关键词： corn starch hypoglycemia insulinoma nutrition therapy

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The genetic basis and process of inbreeding depression in an elite hybrid rice

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Science China(Life Sciences) 2024年第8期67卷 1727-1738页

作者： xiaodong Xu Yawen Xu Jian Che Xu Han Zhengji Wang Xianmeng Wang Qinghua Zhang Xu Li Qinglu Zhang Jinghua xiao Xianghua Li Qifa Zhang Yidan ouyang National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

Inbreeding depression refers to the reduced performance arising from increased homozygosity,a phenomenon that is the reverse of heterosis and exists among plants and *** a natural self-pollinated crop with strong heterosis,the mechanism of inbreeding depression in rice is largely *** understand the genetic basis of inbreeding depression,we constructed a successive inbreeding population from the F_(2)to F_(4)generation and observed inbreeding depression of all heterotic traits in the progeny along with the decay of heterozygosity in each *** expected depression effect was largely explained by 13 QTLs showing dominant effects for spikelets per panicle,11 for primary branches,and 12 for secondary branches,and these loci constitute the main correlation between heterosis and inbreeding ***,the genetic basis of inbreeding depression is also distinct from that of heterosis,such that a biased transmission ratio of alleles for QTLs with either dominant or additive effects in four segregation distortion regions would result in minor effects in expected ***,two-locus interactions may change the extent and direction of the depression effects of the target loci,and overall interactions would promote inbreeding depression among *** an F_(2:3)variation population,the actual performance of the loci showing expected depression was evaluated considering the heterozygosity decay in the background after *** found inconsistent or various degrees of background depression from the F_(2)to F_(3)generation assuming different genotypes of the target locus,which may affect the actual depression effect of the locus due to *** results suggest that the genetic architecture of inbreeding depression and heterosis is closely linked but also differs in their intrinsic mechanisms,which expand our understanding of the whole-genome architecture of inbreeding depression.

关键词： rice inbreeding depression spikelet development dominance segregation distortion epistasis

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Ethanol-assisted synthesis of a Ni single-atom catalyst with poriferous 3D framework for efficient cascade CO2 electroreduction

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Rare Metals 2024年第9期43卷 4612-4619页

作者： Feng Wu Shi-Qi Wang Sebastian Kunze xiao-ping Gao Pei-Qun Yin Yu-En Wu Division of Life Sciences and Medicine Department of Endocrinology School of Chemistry and Materials Science The First Affiliated Hospital of USTC University of Science and Technology of China Department of Chemistry Seoul National University School of Biomedical Engineering Anhui Medical University

The electroreduction of carbon dioxide to generate multicarbon products is significant for achieving a carbon-neutral economy. However, the selectivity for multi-carbon products faces several challenges, such as the intricate nature of the multistep hydrogenation processes, slow reaction kinetics and the bicarbonate precipitate issue caused by alkaline conditions. These factors hinder the extensive utilization of this reaction. Herein, we successfully developed and implemented a tandem electrolyzer cascade to separate and optimize the complex elementary reactions involved in the process of multi-carbon production. This approach enables us to enhance the Faradaic efficiency (FE) of each step, consequently improving the overall performance of the system. An ethanol-assisted ionic-exchange method was utilized to synthesize a Ni

关键词： ELECTROCHEMICAL REDUCTION CARBON-DIOXIDE ARTIFICIAL PHOTOSYNTHESIS OXYGEN REDUCTION ENERGY HYDROCARBONS COORDINATION CHALLENGES HYDROGEN ETHYLENE

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Different concentrations of hyaluronic acid eye drops for dry eye syndrome: a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1110-1119页

作者： xiao-Wei ouyang Sheng Fang Yun-Min Yi Shi-Peng Zou Qi-Yu Hu Zi-Xuan Huang Qing-Xia Li Jin-Yan Luo Department of Ophthalmology Nanchang Hongdu Hospital of Traditional Chinese MedicineNanchang 330000Jiangxi ProvinceChina Department of Ophthalmology Jiangxi Hospital of Integrated Traditional Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Cataract Nanchang University Affiliated Eye HospitalNanchang 330000Jiangxi ProvinceChina Department of Neuro-ophthalmology Nanchang University Affiliated Eye HospitalNanchang 330000Jiangxi ProvinceChina

AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web of Science,Cochrane,SinoMed,CNKI,Wanfang Database,CQVIP,and Chinese journals databases between inception and July *** standardized mean differences(SMD)or weighted mean difference(WMD)with 95%confidence intervals(CI)from RCTs evaluating Schirmer’s I test(SIT),corneal fluorescein staining score(CFS),tear breakup time(TBUT),DES score(DESS),and Ocular Surface Disease Index(OSDI)were *** analysis,Egger’s test and Meta-regression analysis were performed for all ***:We conducted a Meta-analysis of 10 RCTs that met the inclusion criteria,involving 1796 ***-concentrations group significantly improved the outcome of CFS according to random effects modelling(SMD,-3.37;95%CI,-5.25 to-1.48;P=0.0005).The rest of the results were not statistically significant,including indicators such as SIT,TBUT,DESS and ***:For dry eyes with positive corneal staining,a high concentration of HY is recommended,whereas in other cases,a high concentration of HY does not offer a more pronounced advantage over a low concentration of HY in the treatment of dry eyes.

关键词： dry eye hyaluronic acid concentration Meta-analysis

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Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study

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International Journal of Dermatology and Venereology 2024年第2期7卷 78-83页

作者： Jin Zhang xiao-Yu Zhu Jing-Wei Liu Yue-ping Yin Shao-Chun Chen Reference Laboratory for STD Control Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNanjingJiangsu 210042China National Center for STD Control Chinese Center for Disease Control and PreventionNanjingJiangsu 210042China

Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and *** multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant *** results are described as ***:Seventy-four(3.6%)cephalosporin-resistant isolates were ***_(ST7363)was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLST_(ST7365)(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)***-R strains were mainly associated with penA-X(n=27,44.3%),penA-XIII(n=6,9.8%),penA-XVIII(n=5,8.2%),and CRO-R strains were mainly related to penA-XVIII(n=10,25.6%),penA-43(n=9,23.1%),penA-XIII(n=7,17.9%).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported *** CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are *** the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.

关键词： gonorrhea resistance cephalosporin cefixime ceftriaxone

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Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study

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World Journal of Pediatrics 2024年第6期20卷 621-632页

作者： Huan Wang Yan-ping Ruan Sheng Ma Ya-Qi Wang xiao-Yu Wan Yi-Hua He Jing Li Zhi-Yong Zou Institute of Child and Adolescent Health School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthPeking UniversityNo.38 Xueyuan RdHaidian DistrictBeijing 100191China Echocardiography Medical Center Beijing Anzhen Hospital.Capital Medical UniversityMaternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalNo.2 Anzhen RdChaoyang DistrictBeijing 100029China

Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this *** Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this *** was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using *** regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with *** 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),*** smoking cessation seemingly mitigated the increased risk of *** Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关键词： Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking

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Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2697-2715页

作者： Ze Dai Kai-Li Deng xiao-Mei Wang Dong-Xue Yang Chun-Lan Tang Yu-ping Zhou Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Institute of Digestive Disease of Ningbo University Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ningbo Key Laboratory of Translational Medicine Research on Gastroenterology and Hepatology Ningbo Key LaboratoryNingbo 315020Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)has a high incidence and *** studies have shown that indole derivatives involved in gut microbiota metabolism can impact the tumorigenesis,progression,and metastasis of *** To investigate the effect of indole-3-acetaldehyde(IAAD)on *** The effect of IAAD was evaluated in a syngeneic mouse model of CRC and CRC cell lines(HCT116 and DLD-1).Cell proliferation was assessed by Ki-67 fluorescence staining and cytotoxicity *** apoptosis was analysed by flow cytometry after staining with Annexin V-fluorescein isothiocyanate and propidium *** was investigated using the transwell *** blotting and real-time fluorescence quantitative polymerase chain reaction were performed to evaluate the expression of epithelial-mesenchymal transition related genes and aryl hydrocarbon receptor(AhR)downstream *** PharmMapper,SEA,and SWISS databases were used to screen for potential target proteins of IAAD,and the core proteins were identified through the String *** IAAD reduced tumorigenesis in a syngeneic mouse *** CRC cell lines HCT116 and DLD1,IAAD exhibited cytotoxicity starting at 24 h of treatment,while it reduced Ki67 expression in the *** results of flow cytometry showed that IAAD induced apoptosis in HCT116 cells but had no effect on DLD1 cells,which may be related to the activation of *** can also increase the invasiveness and epithelial-mesenchymal transition of HCT116 and DLD1 *** low concentrations(<12.5μmol/L),IAAD only exhibited cytotoxic effects without promoting cell *** addition,predictions based on online databases,protein-protein interaction analysis,and molecular docking showed that IAAD can bind to matrix metalloproteinase-9(MMP9),angiotensin converting enzyme(ACE),poly(ADP-ribose)polymerase-1(PARP1),matrix metalloproteinase-2(MMP2),and myeloperoxidase(MPO).CONCLUSION Indole-3-aldehyde can induce cell apoptosis and inhibit cell prol

关键词： Indole-3-acetaldehyde Colorectal cancer Tryptophan metabolism Apoptosis Epithelial-mesenchymal transition

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Re-evaluating the necessity of routine laboratory monitoring during isotretinoin therapy for acne

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World Journal of Clinical Cases 2024年第28期12卷 6237-6240页

作者： Yun-Xia Zhu Liang Wu Sheng-Cai Zhu Xiu-ping Wang Deng Zhang Yan-ping Tan xiao-Liang ouyang Chun-Ming Li Department of Dermatology The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Dermatology Jiangxi Provincial Maternal and Child Health HospitalNanchang 330000Jiangxi ProvinceChina Department of Plastic Surgery The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

In this letter,we discuss the topic of necessity of routine laboratory monitoring during isotretinoin treatment for *** to Park and colleagues,it is advisable to monitor the levels of triglycerides,alanine aminotransferase,and aspartate aminotransferase every 5 to 6 ***,the levels of total cholesterol and low-density lipoprotein should be checked within the first two months of *** is a commonly prescribed agent mainly used to treat *** its high effectiveness,it necessitates regular monitoring of laboratory parameters due to its side effect ***,there remains a lack of consensus on the appropriate frequency for monitoring these parameters during treatment with *** letter will provide insight into this complex and controversial *** on existing literature,we concluded that the incidence of changes in lipid and liver aminotransferase levels during isotretinoin treatment for acne was low and likely clinically *** generally healthy people,we recommend testing lipid and liver profiles once at baseline and a second time at the peak ***,frequent testing might still be beneficial in certain populations of patients.

关键词： Acne Isotretinoin Laboratory monitoring Liver function Blood lipids

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Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

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Chinese Chemical Letters 2024年第8期35卷 205-210页

作者： Zhe Li ping-Zhao Liang Li Xu Fei-Yu Yang Tian-Bing Ren Lin Yuan Xia Yin xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Photodynamic therapy(PDT)has emerged as a significant cancer therapy ***,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after ***,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some ***,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor ***,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor ***,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.

关键词： Water-soluble Three positive charge Photosensitizer Nonapoptotic Tumor therapy

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