检索结果-南通市图书馆

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

党为人民美好生活奋斗的历史逻辑及启示

山西大同大学学报（社会科学版） 2024年第1期38卷 5-10页

作者：李晓元熊玲闽南师范大学马克思主义学院漳州363000

中国共产党为人民美好生活奋斗的历史逻辑是,从为人民站起来、富起来的美好生活奋斗到为人民强起来的美好生活奋斗。党为人民站起来的美好生活奋斗贯穿于新民主主义革命以及社会主义革命和建设的始终,使人民实现了政治上和经济上的独立... 详细信息

中国共产党为人民美好生活奋斗的历史逻辑是,从为人民站起来、富起来的美好生活奋斗到为人民强起来的美好生活奋斗。党为人民站起来的美好生活奋斗贯穿于新民主主义革命以及社会主义革命和建设的始终,使人民实现了政治上和经济上的独立自主。党为人民富起来的美好生活奋斗,使人民实现了从温饱到总体小康再到全面小康的目标。党为人民强起来的美好生活奋斗是新时代新发展阶段的奋斗历程,使人民向着以高质量发展为基础的高品质生活目标迈进。这一历史逻辑具有重要的启示意义:为人民美好生活奋斗具有历史性,要在联系和发展中把握美好生活的内涵和目标;其本质是为社会主义和共产主义生活而奋斗,要在社会实践中把握美好生活的真谛;要汇聚党、人民、英雄、社会主义制度和马克思主义理论的合力,才能创造和实现美好生活。

关键词：中国共产党人民美好生活历史逻辑启示

Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第4期27卷 708-711页

作者： WU li-li li xiao-ran li Hua yuan xiao-yan Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300072 P.R. China

In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly（L-lactide-co-glycolide）（PLGA）,hybrid PLGA and chitosan（H-PLGA/CS）,and core/shell PLGA/CS （C-PLGA/CS）,were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,*** serum albumin（BSA） was selected as a model *** loading efficiency of BSA in the PLGA membrane was 1.56%,lower than those of H-PLGA/CS（5.98%） and C-PLGA/CS（4.80%）.BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 *** releases at the end of the releasing period,28 d,from the above three membranes were nearly 63%,88% and 94%,respectively,indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release *** addition,all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.

关键词： Controlled release Bovine serum albumin Electrospun membrane Poly(L-lactide-co-glycolide) Chitosan

Concentration-dependent crystal structure, elastic constants and electronic structure of ZrxTi1-x alloys under high pressure

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2014年第2期9卷 219-225页

作者： xiao-li yuan Mi-An Xue Wen Chen Tian-Qing An College of Mechanics and Materials Hohai University Nanjing 210098 China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 China College of Harbour Coastal and Offshore Engineering Hohai University Nanjing 210098 China College of Science Hohai University Nanjing 210098 China

The physical properties of ZrxTi1-x（x=0.0, 0.33, 0.5, 0.67, 0.75 and 1.00） alloys were sinmlated by virtual crystal approximation （VCA） methods which is generally used for disordered solid solutions modeling. The elastic constant, electronic structure and thermal Equation of state （EOS） of disor- dered ZrxTi1-x alloys under pressure are investigated by plane-wave pseudo-potentia1 method. Our simulations reveal increasement of variations of the calculated equilibrium volumes and decrease- ment of Bulk modulus as a function of the alloy compositions. Lattice parameters a and c of alloys with differentZr concentrations decrease linearly with pressure increasing, but the c/avalues are increasing as pressure increases, indicating no phase transitions under pressure from 0 GPa to 100 GPa. The elastic constants and the Bulk modulus to the Shear modulus ratios （B/G） indicate good ductility of Zr, Zr0.33 Ti0.67 Zr0.5Ti0.5, Zr0.75Ti0.25 and Ti, but the Zr0.67Ti0.33 alloy is brittle under 0 K and 0 GPa. The metallic behavior of these alloys was also proved by analyzing partial and total DOS.

关键词： dalloy density functional theory virtual crystal approximation (VCA) mechanics,elastic properties

在线全文

学校读者我要写书评

暂无评论

预制剪力墙震损修复抗震性能试验研究

工程力学 2024年第10期41卷 24-32页

作者：王心宇杨参天李爱群李晓园刘谦敏程庆乐北京建筑大学土木与交通工程学院北京100044 北京建筑大学大型多功能振动台阵实验室北京102616 北京市建筑设计研究院有限公司北京100045

中国现阶段以及未来将存在较大数量的装配式建筑,装配式建筑的抗震韧性成为研究热点。该研究针对抗震韧性中的震损修复问题展开研究,以灌浆套筒连接预制剪力墙为研究对象,参照现有现浇构件的震损修复方法,考虑初始灌浆缺陷对预制剪力墙... 详细信息

中国现阶段以及未来将存在较大数量的装配式建筑,装配式建筑的抗震韧性成为研究热点。该研究针对抗震韧性中的震损修复问题展开研究,以灌浆套筒连接预制剪力墙为研究对象,参照现有现浇构件的震损修复方法,考虑初始灌浆缺陷对预制剪力墙震损特征的影响,对两个震损预制剪力墙进行了严重损伤状态下的修复。随后进行了拟静力试验,并与现浇剪力墙的抗震性能进行了对比。试验结果表明:现浇构件中常用的置换混凝土加固法同样适用于震损预制剪力墙构件,尽管钢筋屈服前混凝土的裂缝开展与现浇试件存在一定差别,但修复后的试件也呈现出了弯曲破坏模式;修复后试件的承载力、变形能力和耗能能力与现浇试件基本一致,灌浆缺陷虽然会影响预制剪力墙构件的震损模式,但对震损修复后的试件的抗震性能影响较小;采用现有置换混凝土加固法修复震损预制剪力墙,基本可实现与现浇剪力墙构件一致的抗震性能。该研究的成果可为灌浆套筒剪力墙构件的损失后果函数研究以及该类结构的抗震韧性设计方法研究提供重要参考。

关键词：预制剪力墙震损修复抗震性能拟静力试验灌浆缺陷

De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第43期17卷 4804-4809页

作者： xiao-Hong Fan Jian-Zhang Geng li-Fen Wang Ying-Ying Zheng Hai-Ying Lu Jing li xiao-yuan Xu Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated ***:Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the *** of the patients were given 48 wk combination therapy with lamivudine(LAM) and adefovir dipivoxil(ADV) .Briefly,10 patients were given the de novo combination therapy with LAM and ADV,whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus(HBV) genetic ***:Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4,12,24 and 48 wk after *** albumin was also improved at 24 and 48 wk after combination therapy in both *** serum HBV DNA level wasstill detectable in every patient in the two groups at 4 and 12 wk after combination ***,in the de novo combination group,serum HBV DNA levels in 4(40%) and 9(90%) patients was decreased to below 1×10 3 copies/mL at 24 and 48 wk after the combination treatment,*** parallel,serum HBV DNA levels in 2(20%) and 8(40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment,***,6(60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment,whereas only 4(20%) patients in the add-on combination group achieved ***-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk ***,patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell ***:De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score,virus inhibition and renal function.

关键词： Hepatitis B Chronic Cirrhosis Decompensated De novo combination Lamivudine Adefovir dipivoxil

Protective effect of extracorporeal membrane pulmonary oxygenation combined with cardiopulmonary resuscitation on post-resuscitation lung injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2021年第4期12卷 303-308页

作者： Ji-yang ling Chun-sheng li Yun Zhang xiao-li yuan Bo liu Yong liang Qiang Zhang Department of Emergency Medicine Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND: Cardiac arrest(CA) is a critical condition that is a concern to healthcare workers. Comparative studies on extracorporeal cardiopulmonary resuscitation(ECPR) and conventional cardiopulmonary resuscitation(CCPR) technologies have shown that ECPR is superior to CCPR. However, there is a lack of studies that compare the protective effects of these two resuscitative methods on organs. Therefore, we aim to perform experiments in swine models of ventricular fibrillation-induced CA to study whether the early application of ECPR has advantages over CCPR in the lung injury and to explore the protective mechanism of ECPR on the post-resuscitation pulmonary ***: Sixteen male swine were randomized to CCPR(CCPR;n=8;CCPR alone) and ECPR(ECPR;n=8;extracorporeal membrane oxygenation with CCPR) groups, with the restoration of spontaneous circulation at 6 hours as an endpoint. RESULTS: For the two groups, the survival rates between the two groups were not statistically significant(P>0.05), the blood and lung biomarkers were statistically significant(Plity index were statistically significant(P<0.01). Compared with the ECPR group, electron microscopy revealed mostly vacuolated intracellular alveolar type II lamellar bodies and a fuzzy lamellar structure with widening and blurring of the blood-gas barrier in the CCPR ***: ECPR may have pulmonary protective effects, possibly related to the regulation of alveolar surface-active proteins and mitigated oxidative stress response postresuscitation.

关键词： Cardiac arrest Swine Alveolar surface-active protein Oxidative stress injury Pulmonary edema

Preparation of Poly（serine ester）s by Ring-opening Polymerization of N-Trityl Serine Lactone Under Catalysis of ZnEt2

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2013年第1期29卷 177-182页

作者： WEI Ying li xiao-yuan JING Xia-bin CHEN Xue-si HUANG Yu-bin State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Graduate School of Chinese Academy of Sciences Beijing 100039 P. R. China

Poly（N-trityl serine lactone）（PTSL） and mPEG-block-poly（N-trityl serine lactone）（mPEG-b-PTSL, PEG= polyethylene glycol） were synthesized via the ring-opening polymerization of N-trityl serine lactone（TSL） with diethyl zinc（ZnEt2） as catalyst. The structures of these polymers were confirmed with hydrogen nuclear magnetic resonance（IH NMR） spectroscopy, carbon nuclear magnetic resonance（13C NMR） spectroscopy and infrared（IR） spectrometer. The thermal decomposition temperature and glass transition temperature of PTSL were 241 and 161 ℃, respectively. A series of mPEG-b-PTSL with different molecular weights（Mn＇s from 7000 to 32000） was obtained by tuning the TSL/mPEG feed ratio. After the removal of the trityl groups, mPEG-block-poly（serine lactone）（mPEG- b-PSL） was obtained as a new kind of cationic block copolymer. Low cytotoxicity of these polymers to L929 cells was confirmed via 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） assay.

关键词： Diethyl zinc catalyst Poly(serine lactone) Pseudopoly(amino acid) Ring-opening polymerization Diethylzinc(ZnEh)

Hot working process optimization of Fe-20Mn-19Cr-0.5C-0.6N steel by activation energy, power dissipation and microstructural evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2019年第8期26卷 856-865页

作者： Meng-du Peng Jie Shi Wen-chao Yu Bing Cui Ting Sun xiao-yuan li Mao-qiu Wang Institute for Special Steels Central Iron and Steel Research Institute Beijing 100081 China Technology Center Ma'anshan Iron and Steel Co. Ltd. Ma'anshan 243000 Anhui China School of Materials Science and Engineering Anhui University of Technology Ma'anshan 243000 Anhui China

Hot deformation behavior of an Fe-20Mn-19Cr-0.5C-0.6N high-nitrogen austenitic steel has been studied by isothermal compression tests in deformation temperature range of 800-1200℃ and strain rate range of 0.01-10 s^-1. Results indicate that the Fe-20Mn-19Cr-0.5C-0.6N steel has high deformation resistance due to strong hindering effect on dislocation moving by nitrogen-induced lattice misfit. The twinning-induced plasticity effect is gradually suppressed with the increase in deformation temperature, and high-temperature plastic deformation mechanism by twinning is gradually replaced by dislocation planar slip. The deformation resistance is up to 343 MPa at deformation conditions of (1000 ℃, 0.01 s^-1), which is over 100 MPa higher than that in martensitic steel and 50 MPa higher than that in austenitic steel. Besides, value of deformation activation energy for the Fe-20Mn-19Cr-0.6N steel is up to 784 kJ mol^-1. Power dissipation efficiency is lower than 0.13, while hot processing map exhibits a very wide range of working area. The optimum hot working process obtains at deformation temperature range of 950-1200℃ and strain rate range of 0.01-10 s^-1, when deformation acti-vation energy is less than 662.6 kJ mol^-1, power dissipation efficiency exceeds 0.22, dynamic recrystallization fraction is over 46.1% and microstructures are without instable characteristics.

关键词： High-nitrogen austenitic steel Flow behavior Constitutive equation Deformation resistance Deformation activation energy Hot processing map

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第5期88卷 282-289页

作者： Feng li yuan Yang Hua Yue Shuang Wang xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery