Preparation of Poly（serine ester）s by Ring-opening Polymerization of N-Trityl Serine Lactone Under Catalysis of ZnEt2
Preparation of Poly（serine ester）s by Ring-opening Polymerization of N-Trityl Serine Lactone Under Catalysis of ZnEt2作者机构：State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Graduate School of Chinese Academy of Sciences Beijing 100039 P. R. China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2013年第29卷第1期
页 面：177-182页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China(No s.51021003 21174143)
主 题：Diethyl zinc catalyst Poly(serine lactone) Pseudopoly(amino acid) Ring-opening polymerization Diethylzinc(ZnEh)
摘 要：Poly（N-trityl serine lactone）（PTSL） and mPEG-block-poly（N-trityl serine lactone）（mPEG-b-PTSL, PEG= polyethylene glycol） were synthesized via the ring-opening polymerization of N-trityl serine lactone（TSL） with diethyl zinc（ZnEt2） as catalyst. The structures of these polymers were confirmed with hydrogen nuclear magnetic resonance（IH NMR） spectroscopy, carbon nuclear magnetic resonance（13C NMR） spectroscopy and infrared（IR） spectrometer. The thermal decomposition temperature and glass transition temperature of PTSL were 241 and 161 ℃, respectively. A series of mPEG-b-PTSL with different molecular weights（Mn＇s from 7000 to 32000） was obtained by tuning the TSL/mPEG feed ratio. After the removal of the trityl groups, mPEG-block-poly（serine lactone）（mPEG- b-PSL） was obtained as a new kind of cationic block copolymer. Low cytotoxicity of these polymers to L929 cells was confirmed via 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） assay.
维普期刊数据库