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Endophenotype strategies for the study of neuropsychiatric disorders: A quest

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Chinese Science Bulletin 2011年第32期56卷 3359-3360页

作者： CHAN~Raymoncl Chor-kiu GOTTESMAN Irving. I fu xiao-lan Neuropsychology and Applied Cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China Departments of Psychology and Psychiatry University of Minnesota Minneapolis United States of America Institute of Psychology Chinese Academy of Sciences Beijing 1 O0101 China

The identification of genes that contribute to the susceptibilities to complex neuropsychiatric disorders such as schizophrenia, major depression and bipolar disorders has not been as successful using conventional genetic approaches as had been hoped. There are several problems associated with the conventional approaches, including the validity of psychiatric diagnosis itself, excluding carriers of relevant genes who cannot be identified in the absence of manifest symptoms, and the heterogeneity

关键词：神经行为精神障碍表型相关基因精神分裂症精神疾病临床症状遗传方法

HIGH RESOLUTION,REAL-TIME LINE-FIELD FOURIER-DOMAIN INTERFEROMETRY

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Journal of Innovative Optical Health Sciences 2012年第2期5卷 41-48页

作者： QING xiao LING fu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology 1037 Luoyu Rd. Wuhan 430074P.R.China Key Laboratory of Biomedical Photonics of Ministry of Education Huazhong University of Science and Technology 1037 Luoyu Rd. Wuhan 430074P.R.China

To increase the application potential in manufacturing process,such as monitoring the processing performance,the profile measurement should be provided in real-time display and with high resolution *** propose a line-field Fourier-domain interferometric method(LFI),which combines the line-field microscope with spectral interferometer,for the surface cross-sectional profile measurement with no scan *** white light and objectives are employed to offer high axial and lateral resolution,*** our system setup,the measurement could be implemented in real-time display of 10 frame/s,and the resolutions of the LFI system in X;Y,and Z directions are~8μm,~3.2μm,and~1.4μm,*** a demonstration,the cross-sectional profiles of a microfluidic chip are *** graphics processing unit is also used to accelerate the reconstruction algorithm to achieve the real-time display of the cross-sectional profiles.

关键词： Line-field Fourier-domain interferometry cross-sectional profile real-time

Neutron Star Structure in a Nonlinear Realization of Chiral SU（3）.Spontaneous Breaking Model

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Communications in Theoretical Physics 2004年第3期41卷 447-453页

作者： CHENHan Lüxiao-fu DepartmentofPhysics SichuanUniversityChengdu610064China CCAST（WorldLaboratory） P.O.Box8730Beijing100080ChinaInstituteofTheoreticalPhysicsAcademiaSinicaP.O.Box2735Beijing100080China

We investigate neutron star properties by constructing a chiral SU(3) spontaneous breaking Lagrangian and using relativistic mean-field approximation. The results show that condensate appears at some baryon densities, and hyperons and exist in neutron star matter at high density. In this model, neutron star's maximum mass is with corresponding radius about 8 km.

关键词： chiral SU(3) spontaneous breaking beta stable Oppenheimer-Volkoff equations

Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis:a regional 20-city,5-year study in Northeast China

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Light(Science & Applications) 2021年第11期10卷 2128-2142页

作者： Cheng-Wei Lu Jing fu Xiu-Fen Liu Wei-Wei Chen Ji-Long Hao xiao-lan Li Om Prakash Pant The Department of Ophthalmology The First Hospital of Jilin UniversityChangchun130021China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China Institute of Atmospheric Environment China Meteorological AdministrationShenyang110166China Dhangadhi Netralaya Eye Hospital Dhangadhi3KailaliNepal

This study is the first to explore the potential associations among allergic conjunctivitis(AC),air pollution,and meteorological conditions in Northeast *** of meteorology,ambient atmospheric pollutants,and the incidence of allergic conjunctivitis(IAC)in prefecture-level cities between the years 2014 and 2018 are *** results show an increasing trend in the AC of average growth rate per annum 7.6%,with the highest incidence in the provincial *** IAC is positively correlated with atmospheric pollutants(i.e.,PM_(2.5),PM_(10),CO,SO_(2),NO_(2),and O_(3))and meteorological factors(i.e.,air temperature and wind speed),but negatively correlated with relative *** results suggest that the IAC is directly proportional to pollution level and climatic conditions,and also the precedence of air *** have further obtained the threshold values of atmospheric pollutants concentration and meteorological factors,a turning point above which more AC may be *** with the air quality standard advised by China and the World Health Organization(WHO),both thresholds of PM_(10)(70μg m^(-3))and PM_(2.5)(45μg m^(-3))are higher than current standards and pose a less environmental risk for the ***_(2) threshold(23μg m^(-3))is comparable to the WHO standard and significantly lower than that of China’s,indicating greater environmental risks in *** thresholds of NO_(2)(27μg m^(-3))and O_(3)(88μg m^(-3))are below current standards,indicating that they are major environmental risk factors for the *** findings highlight the importance of atmospheric environmental protection and reference for health-based amendment.

关键词： allergic meteorological pollution

Double negative optical metamaterial with all-dielectric fishnet structure

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Double negative optical metamaterial with all-dielectric fis...

A low prevalence of H pylori and endoscopic findings in HIV-positive Chinese patients with gastrointestinal symptoms

第八届中国功能材料及其应用学术会议

作者： lan Chu-wen fu xiao-jian LIU xiao-ming LI Bo ZHOU Ji State Key Lab of New Ceramics and Fine Processing School of Materials Scienceand EngineeringTsinghua University Advanced Materials Institute Shenzhen Graduate SchoolTsinghua University

ISBN: (纸本)9783037859698

An all-dielectric fishnet metamaterial(DFM) composed ofmultilayer dielectric structure with periodically patterned holes is proposed to generate left-handed behavior in optical frequency *** from the metallic fishnet negative index metamaterial realized by coupling the neighbouring functional layersalong the propagation direction,this DFM owes its simultaneous negative permeability and permittivity to the hybrid coupled resonances in the same *** on this configration,a wide-band and polarization-independent negative refraction with maximumfigure of merit as large as 13.85 is obtained by a silicon-based DFM at 450 nm *** and easy to fabricate,this concept is believed to provide an alternative route to realize high-performance negative index metamateirals at optical frequencies.

关键词： left-handed metamaterial all-dielectric fishnet coupling effect negative refraction backward wave propagation

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World Journal of Gastroenterology 2007年第41期13卷 5492-5496页

作者： fu-Jing Lv xiao-lan Luo Xin Meng Rui Jin Hui-Guo Ding Shu-Tian Zhang Department of Digestive Diseases Beijing You'an Hospital Capital Medical University Beijing 100069 China Pathology Department Beijing You'an Hospital Capital Medical University Beijing 100069 China Department of Digestive Diseases Beijing Friendship Hospital Capital Medical University Beijing 100050 China

AIM： To compare the prevalence of H pylori infection, peptic ulcer, cytomegalovirus （CNV） infection and Candida esophagitis in human immunodeficiency virus （HIV）- positive and HIV-negative patients, and evaluate the impact of CD4 lymphocyte on H pylori and opportunistic infections. METHODS： A total of 151 patients （122 HIV-positive and 29 HIV-negative） with gastrointestinal symptoms were examined by upper endoscopy and biopsy. Samples were assessed to determine the prevalence of Hpylori infection, CMV, candida esophagitis and histologic chronic gastritis. RESULTS： The prevalence of Hpylori was less common in HIV-positive patients （22.1%） than in HIV-negative controls （44.8%; P 〈 0.05）, and the prevalence of H pylori displayed a direct correlation with CD4 count stratification in HIV-positive patients. In comparison with HIV-negative group, HIV-positive patients had a lower incidence of peptic ulcer （20.7% vs 4.1%; P 〈 0.01）, but a higher prevalence of chronic atrophy gastritis （6.9% vs 24.6%; P 〈 0.05）, Candida esophagitis and CMV infection. Unlike HIV-negative group, H pylori infection had a close relationship to chronic active gastritis （P 〈 0.05）. In HIV-positive patients, chronic active gastritis was not significantly different between those with Hpylori infection and those without. CONCLUSION： The lower prevalence of H pylori infection and peptic ulcer in HIV-positive patients with gastrointestinal symptoms suggests a different mechanism of peptic ulcerogenesis and a different role of H pylori infection in chronic active gastritis and peptic ulcer. The pathogen of chronic active gastritis in HIV-positive patients may be different from the general population that is closely related to Hpylori infection.

关键词： Human immunodeficiency virus Endoscopy Cytomegalovirus Candida esophagitis H pylori Peptic ulcer Chronic gastritis

Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway

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Journal of Integrative Medicine 2021年第5期19卷 418-427页

作者： Tong Zhao Bing-jie Guo Chu-lan xiao Jiao-jiao Chen Can Lü Fan-fu Fang Bai Li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Nanjing University of Chinese Medicine.Nanjing 210023 Jiangsu ProvinceChina

Objective: Exercise, as a common non-drug intervention, is one of several lifestyle choices known to reduce the risk of cancer. Mitochondrial division has been reported to play a key role in the occurrence and transformation of hepatocellular carcinoma(HCC). This study investigated whether exercise could regulate the occurrence and development of HCC through ***: Bioinformatics technology was used to analyze the expression level of dynamin-related protein1(DRP1), a key protein of mitochondrial division. The effects of DRP1 and DRP1 inhibitor(mdivi-1) on the proliferation and migration of liver cancer cells BEL-7402 were observed using cell counting kit-8, plate colony formation, transwell cell migration, and scratch experiments. Enzyme-linked immunosorbent assay, Western blot and real-time polymerase chain reaction were used to detect the expression of DRP1 and its downstream phosphoinositide 3-kinase(PI3 K)/protein kinase B(AKT) pathway. A treadmill exercise intervention was tested in a nude mouse human liver cancer subcutaneous tumor model expressing different levels of DRP1. The size and weight of subcutaneous tumors in mice were detected before and after ***: The expression of DRP1 in liver cancer tissues was significantly upregulated compared with normal liver tissues(P<0.001). The proliferation rate and the migration of BEL-7402 cells in the DRP1 overexpression group were higher than that in the control group. The mdivi-1 group showed an inhibitory effect on the proliferation and migration of BEL-7402 cells at 50 lmol/L. Aerobic exercise was able to inhibit the expression of DRP1 and decrease the size and weight of subcutaneous tumors. Moreover,the expression of phosphorylated PI3 K(p-PI3 K) and phosphorylated AKT(p-AKT) decreased in the exercise group. However, exercise could not change p-PI3 K and p-AKT levels after knocking down DRP1 or using mdivi-1 on subcutaneous ***: Aerobic exercise can suppress the development of

关键词： Aerobic exercise Hepatocellular carcinoma Dynamin-related protein PI3K/AKT pathway

Remote Sensing Image Registration Based on Improved KAZE and BRIEF Descriptor

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International Journal of Automation and computing 2020年第4期17卷 588-598页

作者： Huan Liu Gen-fu xiao College of Electronic and Information Engineering Jinggangshan University&Jiangxi Engineering Laboratory of Internet of Things(IoT)Technologies for Crop GrowthJi'an 343009China College of Mechanical and Electronic Jinggangshan UniversityJi'an 343009China

Remote sensing image registration is still a challenging task owing to the significant influence of nonlinear differences between remote sensing *** solve this problem,this paper proposes a novel approach with regard to feature-based remote sensing image *** are two key contributions:1)we bring forward an improved strategy of composite nonlinear diffusion filtering according to the scale factors in multi-scale space and 2)we design a gradually decreasing resolution of multi-scale pyramid *** a binary code string is served as feature descriptors to improve matching *** experiments of different categories of remote image datasets on feature extraction and feature registration are *** experimental results demonstrate the superiority of our proposed scheme compared with other classical algorithms in terms of correct matching ratio,accuracy and computation efficiency.

关键词： Remote sensing image image registration composite nonlinear diffusion filter binary code string multi-scale pyramid space

High order symplectic conservative perturbation method for time-varying Hamiltonian system

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Acta Mechanica Sinica 2012年第3期28卷 885-890页

作者： Ming-Hui fu Ke-lang Lu Lin-Hua lan Department of Applied Mechanics and Engineering Sun Yat-sen University510275 GuangzhouChina

This paper presents a high order symplectic con- servative perturbation method for linear time-varying Hamil- tonian system. Firstly, the dynamic equation of Hamilto- nian system is gradually changed into a high order pertur- bation equation, which is solved approximately by resolv- ing the Hamiltonian coefficient matrix into a ＂major compo- nent＂ and a ＂high order small quantity＂ and using perturba- tion transformation technique, then the solution to the orig- inal equation of Hamiltonian system is determined through a series of inverse transform. Because the transfer matrix determined by the method in this paper is the product of a series of exponential matrixes, the transfer matrix is a sym- plectic matrix; furthermore, the exponential matrices can be calculated accurately by the precise time integration method, so the method presented in this paper has fine accuracy, ef- ficiency and stability. The examples show that the proposed method can also give good results even though a large time step is selected, and with the increase of the perturbation or- der, the perturbation solutions tend to exact solutions rapidly.

关键词： Time-varying Hamiltonian system High ordermultiplicative perturbation Symplectic conservation expo-nential matrix Precise time integration method