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Angiotensin H Induces Mesenchymal Stem Cells Proliferation in vitro

中国药理通讯 2008年第2期25卷 39-40页

作者： xiao-jun wang xiao-hua zhong rui-zhen shi ji-chang wang song-hua huang qing-ping li Department of Pharmacology Nanjing Medical University Nanjing 210029

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Angiotensin Ⅱ Induces Mesenchymal Stem Cells Proliferation in vitro

Angiotensin Ⅱ Induces Mesenchymal Stem Cells Proliferation ...

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2008心血管药理学术研讨会

作者： xiao-jun wang xiao-hua zhong rui-zhen shi ji-chang wang song-hua huang qing-ping li Department of Pharmacology,Nanjing Medical University,Nanjing,210029

It has been suggested that all components of the renin-angiotensin system are present in mesenchymal stem cells(MSCs)and may be a potential regulator in the control of adipogenesis of ***,little is known about whether...

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AIWW:a new nutrition-screening tool for the oncologic population

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Science China(life Sciences) 2023年第8期66卷 1831-1840页

作者： Yi-zhong Ge zhen-Ming Fu Qi Zhang Meng-Meng song Guo-Tian Ruan Xi Zhang xiao-Wei Zhang Xiang-rui li Kang-ping Zhang Meng Tang xiao-Yue liu Ming Yang Tong liu Hai-Lun Xie He-Yang Zhang Zi-Wen wang Chun-Lei Hu shi-Qi lin rui Zhang Hong-Xia Xu Wei li Chun-hua song Ming liu jun-Qiang Chen Kun-hua wang li Bo Ming-hua Cong Zeng-Ning li Zeng-Qin Guo xiao-Bin wang Bin-Yan wang Benjamin Xu Xian-Hui Qin Xi-ping Xu Rocco Barazzoni qing-hua Yao Min Weng Xian Shen Han-ping shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Gastrointestinal Surgery/Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou 325000China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing 100038China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Colorectal Surgery Cancer Hospital of University of Chinese Academy of SciencesZhejiang Cancer HospitalHangzhou 310022China Department of Clinical Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Cancer Center of the First Hospital of jilin University Changchun 130021China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou450001China Department of Colorectal Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal Surgery First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Yunnan University Kunming 650091China General Surgery Clinical Medical Center of Yunnan Province Kunming 650032China Affiliated Hospital of Yunnan University Kunming 650091China Comprehensive Oncology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031China Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore MD 21228USA Shenzhen Evergreen Medical Institute Shenzhen 518052China Department of Epid

Malnutrition is a common comorbidity among patients with ***,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is *** on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each *** to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on *** on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,*** sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and *** Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,*** area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,*** IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with *** missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,*** showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool

关键词： nutrition-screening AIWW NRS-2002 MST cancer

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan CHEN Ren Bo shi Nan Nan liU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI jiang Feng CHEN Hong CHEN li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU xiao Mei HU Yun Hong huang jin huang Qiu hua huang Shao zhen ji liang jiN Hai Hao LEI xiao li Chun Yan li Min qing li Qun Tang li Xian Yong liU Hong De liU jin ping liU Zhang MA Yu Ting MAO Ya MO liu Fen NA Hui wang jing Wei song Fang li SUN Sheng wang Dong Ting wang Ming Xuan wang xiao Yan wang Yin zhen wang Yu Dong WU Wei WU Lan ping xiao Yan hua XIE Hai jun XU Hong Ming XU Shou Fang XUE rui Xia YANG Chun YANG Kai jun YUAN Sheng li ZHANG Gong Qi ZHANG jin Bo ZHANG lin song ZHAO Shu Sen ZHAO Wan Ying zhenG Kai ZHOU Ying Chun ZHU jun Teng ZHU Tian qing ZHANG hua Min wang Yan ping wang Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： xiao-Dong song Fei Yang hua-Yong Wu jing Zhang De-Cheng li Feng liu Yu-Guo Zhao jin-ling Yang Bing Ju Chong-Fa Cai Biao huang huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing wang Ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang Zhou shi Wan-Zhu Ma Gang Xin Zhi-ping Qi qing-rui chang En Ci Da-Gang Yuan Yang-Zhu Zhang jun-ping Bai jia-Ying Chen jie Chen Yin-jun Chen Yun-zhong Dong Chun-Lan Han ling li li-Ming liu jian-jun Pan Fu-Peng song Fu-jun Sun Deng-Feng wang Tian-Wei wang Xiang-hua Wei Hong-Qi Wu Xia Zhao qing Zhou Gan-lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-lin Xiong Xiang-Yang Wen Xin-Qiao li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng Dong-Ya Guo zheng-hua An Ke Gong jin-Yuan liao Yan-Qiu Zhang Yue huang Lu li Xing Wen Fei Zhang jing Duan Chen-Wei wang Dong-li shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-Bing Xu xiao-hua liang Ya-qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen huan-Yu wang Sheng Yang xiao-jing liu Min Gao Mao-Shun li jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao zheng jia-Cong liu Xing-Bo Han jin-ling Qi jia huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-jie Hou Yu-Sa wang rui Qiao Xiang Ma xiao-Bo li ping wang Xin-Ying song li-Ming song shi-jie zheng Bing li Hong-Mei Zhang Yue Zhu Wei Chen jian-jian He zhen Zhang jin Hou Hong-jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan Yang Zhi-Long Wen Zhi chang Yuan-Yuan Du rui Gao xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-jun Lu Hong Lu Bin Meng Feng shi Hui wang Hui-zhen wang Yu-Peng Xu jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-ping li Yao-Quan Chu jian-Rong shi Gang wang jian-Nan Zhang zhong-rui Bai xiao-Yan Chen Feng-Fei wang Yan-Xin Guo jian-jun Chen Bing Du xiao Kong Ya-Juan Lei Yin-Bi li Yi-Han song Yue Wu Yan-Xia Zhang Xin-lin Zhou Fang Zuo Peng Du lin He Wen Hou Yi-Qiao Dong jian li Guang-Wei li Shuang li jing song Yuan Tian Meng-Xin wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu zhong-Wen Hu Lei jia Fang-hua jiang Xiang jiang Zi-Bo jiang Ge jin Ai-hua li Qi li Yin-Dun Mao zheng-Hong Tang qing-Sheng Tao liang-ping Tu Da-qing wang Dan wang jian-ping wang Lei wang Shou-Guan wang Shu-qing wang Ya-Nan wang You wang Yue-Fei wang Ming-Zhi Wei Xiang-Xiang Xue xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu De-hua Yang shi-Hai Yang zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng Zhang jing Zhang li-ping Zhang WeiZhang Yong Zhang zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang li Ming-Sheng huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan zhong jun-Hui Sun Zhi-Cheng jin jian-jian Chen Nai-jian Ge Wen-Bin Ding Wen-Hui li jin-hua huang Wei Mu Shan-Zhi Gu jia-ping li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng song Chun-wang Yuan Wei-Dong wang Ming huang Wei Zhao jian-Bing Wu song wang Xu Zhu jian-jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi wang jin-Wei Zhao Ai-Bing Xu jian Xu qing-hua Wu huan-Zhang Niu jian wang Feng Dai Dui-ping Feng qing-Dong li Rong-Shu shi jia-rui li Guang Yang Hai-Bin shi jian-song ji Yu-E liu zheng Cai Po Yang Yang Zhao xiao-li Zhu li-Gong Lu Gao-jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei rui wang chang-Ku jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-shi Fang Nan jiang Kun Zhang Zhao-jie Su Zhi-Hai Peng Ren Lang Tao jiang Qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-jun Ye Qi-Fa Ye Min Tian jian-hua shi Bo wang jiang liu Qian Lu Wei Rao jin-zhen Cai Tao Lv jia-Yin Yang Pu-Sen wang lin zhong jing-Sheng Ma Qi-Gen li Sheng-Dong Wu chang-jiang Lu Cai-De Lu Dong-hua Zhang Xuan wang Zi-Qiang li Mu-jian Teng jun-jie li Wen-Tao jiang jian-hua li Quan-Bao Zhang Ning-Qi Zhu zheng-Xin wang Kang He Qiang Xia Shao-hua song Zhi-Ren Fu Wei Qiu Guo-Yue Lv rui-Peng song ji-Zhou wang zheng wang jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-jie Luo zhong-Zhou Si Bin Xie xiao-Shun He Zhi-Yong Guo Shu-Sen zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng xiao-Wei liu Yi-Peng jing Gang wang Hao-Tong Zhang jian-Rong shi Xiang-Qun Cui Yao-Quan Chu Guo-ping li zhong-rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-jun Chen Kun-Xin Chen li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu zhong-Wen Hu Zhi-Ying Huo Lei jia Fang-hua jiang Xiang jiang Zhi-Bo jiang Ge jin xiao Kong Xu Kong Ya-Juan Lei Ai-hua li chang-hua li Guang-Wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg ji-jun Ni Zhao-Xiang Qi Yong-jun Qi shi-Yin Shen Huo-Ming shi jing song Yi-Han song Ding-Qiang Su Hong-jun Su zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang jia-Ning wang jian-ling wang jian-ping wang jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-zhong Wu xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang hua-Wei Zhang jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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