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Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients

World Journal of Gastroenterology 2021年第19期27卷 2376-2393页

作者： xiao-Juan yang Dan Liu Hong-Yan Ren xiao-Ya Zhang jun Zhang xiao-jun yang Department of Critical Care Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Critical Care Medicine Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Shanghai Mobio Biomedical Technology Co. Shanghai 201318China

BACKGROUND Sepsis is a common disease in intensive care units,with high morbidity and *** microecology plays a vital part in the development and progression of this disease,possibly because sepsis and its treatment cause specific changes in the composition of the intestinal *** To investigate the characteristics of intestinal flora disturbance in sepsis patients treated with *** In this prospective comparative study,we enrolled ten patients with sepsis(sepsis group),hospitalized in the Department of Critical Care Medicine of the General Hospital,Ningxia Medical University,China(a class IIIa general hospital)from February 2017 to june 2017;ten patients without sepsis hospitalized in the same period(non-sepsis group)and ten healthy individuals(control group)were also *** samples collected from the three groups were subjected to 16S rRNA gene sequencing and the intestinal flora diversity,structure,and composition were ***,the dynamics of the intestinal flora diversity,structure,and composition in sepsis patients were investigated via 16S rRNA gene sequencing of samples collected 0 d,3 d,and 7 d after admittance to the intensive care *** between the serum levels of procalcitonin,endotoxin,diamine oxidase,and D-lactic acid and the intestinal flora composition of sepsis patients were also *** Compared with the healthy control group,sepsis and non-sepsis patients showed reduced intestinal floraα-diversity and a distinct flora structure,with Firmicutes as the dominant phylum,and significantly decreased proportions of Bacteroidetes,as well as Prevotella and Lachnospira,among other *** note,the proportion of Enterococcus was significantly increased in the intestinal tract of sepsis ***,theα-diversity in the sepsis group decreased gradually,from days 1 to 7 of ***,pairwise comparisons showed that both the diversity and structure of the int

关键词： Sepsis Intestinal flora 16S rRNA gene sequencing Dynamic changes Intestinal barrier index Procalcitonin

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Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life

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World Journal of Gastroenterology 2015年第14期21卷 4302-4309页

作者： xiao-jun yang Hong-Mei Jiang xiao-Hua Hou jun Song Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Gastroenterology Chongqing Hospital of Traditional Chinese Medicine

AIM: To explore the role of psychological factors in gastroesophageal reflux disease(GERD) and their effect on quality of life(Qo L) of GERD ***: A total of 279 consecutive patients with typical symptoms and 100 healthy controls were enrolled in the *** of the participants wereevaluated with the Zung Self-Rating Anxiety Scale(ZSAS), the Zung Self-Rating Depression Scale(ZSDS) and the SF-36 *** scores for anxiety, depression and Qo L of the two groups were *** correlation between psychological factors and Qo L was also ***: Compared with healthy controls(34.70 ± 8.00), the scores of ZSAS in the non-erosive reflux disease( N E R D) group(48.27±10.34) and the reflux esophagitis(RE) group(45.38 ± 10.27) were significantly higher(P < 0.001).The mean ZSAS score of the NERD group was significantly higher than that of the RE group(P = 0.01).Compared with healthy controls(37.61 ± 8.44), the mean ZSDS scores were significantly higher in the NERD group(49.65 ± 11.09, P < 0.001) and the RE group(46.76 ± 11.83, P < 0.001).All dimensions of the SF-36 form were negatively correlated with the SAS and SDS scores in patients with NERD and RE(P < 0.05).According to the S F- 3 6 form, vitality, mentalhealth and social functioning were significantly correlated with symptoms of depression in patients with NERD and *** health was obviously affected by symptoms of depression in patients with NERD(P < 0.05).CONCLUSION: Anxiety and depression may play an important role in the occurrence of GERD and especially that of *** Qo L of patients with GERD is reduced by anxiety and depression.

关键词： Anxiety Depression Gastroesophageal reflux disease

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SYNTHESIS AND CHARACTERIZATION OF BENZOCYCLOBUTEN-4-YL ACRYLATE MONOMER AND ITS RADICAL POLYMERIZATION

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Chinese Journal of Polymer Science 2010年第6期28卷 877-885页

作者： Li-qin Xie jun-xiao yang Fang-hua Zhu Hai-jun yang Cai-lin Liu Lin zhang School of Materials Science and Engineering Southwest University of Science and Technology Mianyang 621010 China Research Center of Laser Fusion China Academy of Engineering Physics Mianyang 621900 China

A benzocyclobuten-4-yl acrylate（1） monomer was prepared by esterification of 4-hydroxybenzocyclobutene with acryloyl *** radical homopolymerization of 1 and copolymerization of 1 with styrene or n-butyl acrylate were carried out to produce linear polymers 2a,2b and *** of these linear polymers under thermal initiation gave corresponding cross-linked polymers 3a,3b and *** ring-opening reaction in the cross-linking process was confirmed by on-line infrared *** scanning calorimetry showed that the glass transition temperatures of linear polymers 2a and 2b were 83.2℃and 68.1℃,*** analysis of the cross-linked polymers showed that they all exhibited good thermal stability.

关键词： Benzocyclobuten-4-yl acrylate Polymerization Cross-linking Thermal stability

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A Novel Zn(Ⅱ)Complex with 1D Supramolecular Water Tape Formed by Cyclic Tetrameric Water Clusters

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1103-1107页

作者： LIU Kai-Sheng yang You-Li ZHAO xiao-jun yang En-Cui College of Chemistry Tianjin Key Laboratory of Structure and Performance for Functional Molecule Tianjin Normal University Tianjin 300387 China

A new mixed-ligand Zn（II） complex, [Zn（4,4′-bipy）2（H2O）4]-2ANS·6H2O （1, 4,4′- bipy = 4,4′-bipyridine, HANS = 2-aminonaphthalene-l-sulfonic acid）, has been isolated and structurally characterized by single-crystal X-ray diffwaction, FT-IR spectrum, TG and elemental analysis. It crystallizes in the monoclinic system, space group P2 1/c with a = 12.4852（8）, b = 18.3163（12）, c = 10.9707（7） A, β = 114.2600（10）°, V= 2287.3（3） A3, Dc = 1.455 g/cm3, Mr = 1002.37, Z = 2, F（000） = 1048,μ = 0.704 mm＂1, the final R = 0.0408 and wR = 0.962 for 4029 observed reflections with I 〉 2σ（I）. Interestingly, an unusual one-dimensional （1D） water tape with cyclic tetrameric water clusters can be observed in 1, which are further trapped via Zn-O coordination bonds exhibiting a 2D Zn（Ⅱ）-water layer. These 2D Zn（Ⅱ）-water layers are stacked together into a 3D interdigitated supramolecular architecture via weak π…π interactions, in which free ANS anions are tightly filled by hydrogen-bonding interactions. Thus, π…π and classical hydrogen-bonding interactions are fotmd as main driving forces to stabilize the 2D Zn（Ⅱ）-water layers.

关键词： water tape tetrameric water cluster π…π interaction hydrogen bond

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Exploring choices of early nutritional support for patients with sepsis based on changes in intestinal microecology

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World Journal of Gastroenterology 2023年第13期29卷 2034-2049页

作者： xiao-Juan yang xiao-Hong Wang Ming-Yue yang Hong-Yan Ren Hui Chen xiao-Ya Zhang Qin-Fu Liu Ge yang Yi yang xiao-jun yang Department of Critical Care Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Emergency Medicine Affiliated Hospital of Jining Medical UniversityJining 272030Shandong ProvinceChina Shanghai Mobio Biomedical Technology Co. Ltd.Shanghai 201318China Department of Critical Care Medicine Southeast University School of MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Sepsis exacerbates intestinal microecological disorders leading to poor *** modalities of nutritional support can improve nutrition,immunity,and intestinal *** To identify the optimal modality of early nutritional support for patients with sepsis from the perspective of intestinal *** Thirty patients with sepsis admitted to the intensive care unit of the General Hospital of Ningxia Medical University,China,between 2019 and 2021 with indications for nutritional support,were randomly assigned to one of three different modalities of nutritional support for a total of 5 d:Total enteral nutrition(TEN group),total parenteral nutrition(TPN group),and supplemental parenteral nutrition(SPN group).Blood and stool specimens were collected before and after nutritional support,and changes in gut microbiota,short-chain fatty acids(SCFAs),and immune and nutritional indicators were detected and compared among the three *** In comparison with before nutritional support,the three groups after nutritional support presented:(1)Differences in the gut bacteria(Enterococcus increased in the TEN group,Campylobacter decreased in the TPN group,and Dialister decreased in the SPN group;all P<0.05);(2)different trends in SCFAs(the TEN group showed improvement except for Caproic acid,the TPN group showed improvement only for acetic and propionic acid,and the SPN group showed a decreasing trend);(3)significant improvement of the nutritional and immunological indicators in the TEN and SPN groups,while only immunoglobulin G improved in the TPN group(all P<0.05);and(4)a significant correlation was found between the gut bacteria,SCFAs,and nutritional and immunological indicators(all P<0.05).CONCLUSION TEN is recommended as the preferred mode of early nutritional support in sepsis based on clinical nutritional and immunological indicators,as well as changes in intestinal microecology.

关键词： Sepsis Nutritional support Intestinal microecology Short-chain fatty acids Nutritional and immunological indicators Total enteral nutrition Total parenteral nutrition Supplemental parenteral nutrition

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Resonant multiple wave solutions to some integrable soliton equations

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Chinese Physics B 2019年第11期28卷 92-98页

作者： Jian-Gen Liu xiao-jun yang Yi-Ying Feng School of Mathematics China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China

To transform the exponential traveling wave solutions to bilinear differential equations, a sufficient and necessary condition is proposed. Motivated by the condition, we extend the results to the(2+1)-dimensional Kadomtsev–Petviashvili(KP) equation, the(3+1)-dimensional generalized Kadomtsev–Petviashvili(g-KP) equation, and the B-type Kadomtsev–Petviashvili(BKP) equation. Aa a result, we obtain some new resonant multiple wave solutions through the parameterization for wave numbers and frequencies via some linear combinations of exponential traveling waves. Finally, these new resonant type solutions can be displayed in graphs to illustrate the resonant behaviors of multiple wave solutions.

关键词： linear superposition principle resonant multiple wave solutions (2+1)-dimensional Kadomtsev–Petviashvili(KP) equation (3+1)-dimensional g-KP and BKP equations

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Metabolic syndrome and acute pancreatitis:Current status and future prospects

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World Journal of Gastroenterology 2024年第45期30卷 4859-4863页

作者： Ying Quan xiao-jun yang The First Clinical Medical School Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Second Ward of General Surgery Gansu Province People HospitalLanzhou 730000Gansu ProvinceChina

Rising incidence of a complicated disorder with a multifarious etiology is acute *** numbers of cases of acute pancreatitis are linked to obesity,hyperlipidemia,hyperglycemia,hypertension,and other metabolic *** driven by better living standards and unhealthy lifestyle choices both in China and *** common diagnosis for many patients is metabolic *** the adverse effect of metabolic syndrome on the severity and prognosis of acute pancreatitis is a main focus of present clinical *** next studies seek to investigate the fundamental causes of this link and create preventative plans meant to lower the incidence of pancreatitis linked to meta-bolic syndrome and enhance the prognosis.

关键词： Metabolic syndrome Acute pancreatitis Obesity Hypertension Hyperli-pidemia Hyperglycaemia

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Primary intestinal extranodal natural killer/T-cell lymphoma, nasal type: A case report

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World Journal of Clinical Cases 2020年第1期8卷 234-241页

作者： Bao-Long Dong xiao-Hua Dong Hui-Qi Zhao Peng Gao xiao-jun yang Department of General Surgery Gansu Provincial Hospital

BACKGROUND Primary intestinal extranodal natural killer/T-cell lymphoma,nasal type(PIENKTCL)is a rare non-Hodgkin’s lymphoma(NHL)subtype,and its prognosis is extremely *** characteristics of the disease are not obvious and easily *** this case report,we describe a patient with PI-ENKTCL who presented with intermittent *** advantages of positron emission tomography/computed tomography(PET-CT)as a useful diagnostic tool and the role of surgery as an important therapy are *** SUMMARY A 45-year-old man,hospitalized due to intermittent hematochezia,underwent gastroscopy,colonoscopy,biopsy and CT,but no cause was ***,we carried out a multidisciplinary team(MDT)discussion on the causes and treatment of this patient,and it was decided to perform PET-CT imaging with a MDT discussion of the ***-CT demonstrated a diagnosis of lymphoma and it was decided to surgically resect the lesion,and a R0 resection was successfully *** pathology showed negative resection margins,and examination of the lesion confirmed the diagnosis of *** surgery,the patient underwent a follow-up period of 6 mo and received 6 cycles of gemcitabine,oxaliplatin and *** recurrence or metastasis *** PI-ENKTCL is rare,and MDT discussion is required during ***-CT can be performed for imaging *** is based on surgical resection,and the best treatment regimen is determined according to postoperative pathological results to improve prognosis and to extend survival in patients.

关键词： Primary intestinal extranodal natural killer/T-cell lymphoma Multidisciplinary team discussion Rare disease Case report

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Optical-spectrum-encoded analog-to-digital converter

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Optoelectronics Letters 2007年第3期3卷 227-230页

作者： LIAO xiao-jun yang Ya-pei School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 China

A novel optical-spectrum-encoded （OSE） analog-to-digital converter （ADC） is proposed in this letter. To simply exemplify the conversion idea, a 5-bit device structure consisted of Fabry-Perot interferometers （FPI） is analyzed and numericaly simulated. The dependence of peak-transmission wavelength on modulation voltage in an electro-optical FPI and the dependence of transmitted power on incident light wavelength in an FPI are discussed and utilized to implement OSEADC. A linearly tunable mode-locked laser, as a voltage-wavelength transformer and a sampler, and chirped grating FPIs, as an encoder array, can be used to obtain much greater sampling rate and bit-resolution.

关键词：光谱编码模/数转换器 Fabry-Perot干涉计调制电压数值模拟

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Wireless esophageal pH capsule for patients with gastroesophageal reflux disease: A multicenter clinical study

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World Journal of Gastroenterology 2014年第40期20卷 14865-14874页

作者： xiao-jun yang Tian Gan Lei Wang Zhuan Liao xiao-Hong Tao Wei Shen xiao-Yan Zhao Department of Gastroenterology Xinqiao Hospital Third Military Medical University Department of Gastroenterology Changhai Hospital Second Military Medical University Departmentof Gastroenterology First Affiliated Hospital of Chongqing Medical University Department of Gastroenterology Second Affiliated Hospital of Chongqing Medical University

AIM: To investigate the feasibility and safety of pH capsule to monitor pH in patients with gastroesophageal reflux disease (GERD).

关键词： Wireless pH capsule Feasibility Safety Conventional catheter Gastroesophageal reflux disease

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