Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life

作     者：Xiao-Jun Yang Hong-Mei Jiang Xiao-Hua Hou Jun Song 

作者机构：Division of GastroenterologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of GastroenterologyChongqing Hospital of Traditional Chinese Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第14期

页      面：4302-4309页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Anxiety Depression Gastroesophageal reflux disease 

摘      要：AIM: To explore the role of psychological factors in gastroesophageal reflux disease(GERD) and their effect on quality of life(Qo L) of GERD ***: A total of 279 consecutive patients with typical symptoms and 100 healthy controls were enrolled in the *** of the participants wereevaluated with the Zung Self-Rating Anxiety Scale(ZSAS), the Zung Self-Rating Depression Scale(ZSDS) and the SF-36 *** scores for anxiety, depression and Qo L of the two groups were *** correlation between psychological factors and Qo L was also ***: Compared with healthy controls(34.70 ± 8.00), the scores of ZSAS in the non-erosive reflux disease( N E R D) group(48.27±10.34) and the reflux esophagitis(RE) group(45.38 ± 10.27) were significantly higher(P 0.001).The mean ZSAS score of the NERD group was significantly higher than that of the RE group(P = 0.01).Compared with healthy controls(37.61 ± 8.44), the mean ZSDS scores were significantly higher in the NERD group(49.65 ± 11.09, P 0.001) and the RE group(46.76 ± 11.83, P 0.001).All dimensions of the SF-36 form were negatively correlated with the SAS and SDS scores in patients with NERD and RE(P 0.05).According to the S F- 3 6 form, vitality, mentalhealth and social functioning were significantly correlated with symptoms of depression in patients with NERD and *** health was obviously affected by symptoms of depression in patients with NERD(P 0.05).CONCLUSION: Anxiety and depression may play an important role in the occurrence of GERD and especially that of *** Qo L of patients with GERD is reduced by anxiety and depression.