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Personalized medicine in functional gastrointestinal disorders:Understanding pathogenesis to increase diagnostic and treatment efficacy

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World Journal of Gastroenterology 2019年第10期25卷 1185-1196页

作者： xiao jing wang Michael Camilleri Division of Gastroenterology and Hepatology Clinical Enteric Neuroscience Translational and Epidemiological ResearchMayo Clinic

There is overwhelming evidence that functional gastrointestinal disorders(FGIDs) are associated with specific mechanisms that constitute important targets for personalized treatment. There are specific mechanisms in patients presenting with functional upper gastrointestinal symptoms(UGI Sx). Among patients with UGI Sx, approximately equal proportions(25%) of patients have delayed gastric emptying(GE), reduced gastric accommodation(GA), both impaired GE and GA,or neither, presumably due to increased gastric or duodenal *** targeted to the underlying pathophysiology utilize prokinetics,gastric relaxants, or central neuromodulators. Similarly, specific mechanisms in patients presenting with functional lower gastrointestinal symptoms, especially with diarrhea or constipation, are recognized, including at least 30% of patients with functional constipation pelvic floor dyssynergia and 5% has colonic inertia(with neural or interstitial cells of Cajal loss in myenteric plexus); 25% of patients with diarrhea-predominant irritable bowel syndrome(IBSD) has evidence of bile acid diarrhea; and, depending on ethnicity, a varying proportion of patients has disaccharidase deficiency, and less often sucrose-isomaltase deficiency. Among patients with predominant pain or bloating, the role of fermentable oligosaccharides, disaccharides, monosaccharides and polyols should be considered. Personalization is applied through pharmacogenomics related to drug pharmacokinetics, specifically the role of CYP2 D6, 2 C19 and 3 A4 in the use of drugs for treatment of patients with FGIDs. Single mutations or multiple genetic variants are relatively rare, with limited impact to date on the understanding or treatment of FGIDs. The role of mucosal gene expression in FGIDs, particularly in IBS-D, is the subject of ongoing research. In summary, the time for personalization of FGIDs, based on deep phenotyping, is here;pharmacogenomics is relevant in the use of central neuromodulators.

关键词： Gastrointestinal symptoms Gastric emptying Gastric accommodation Diarrhea Constipation Irritable bowel syndrome Bile acid diarrhea Phenotypes Pharmacogenomics Prokinetics Neuromodulators

Global Stability of a Mumps Transmission Model with Quarantine Measure

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Acta Mathematicae Applicatae Sinica 2021年第4期37卷 665-672页

作者： Yu-zhen BAI xiao-jing wang Song-bai GUO School of Science Beijing University of Civil Engineering and ArchitectureBeijing102616China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China

In this paper,a model of mumps transmission with quarantine measure is proposed and then the control reproduction number Rc of the model is *** model admits a unique endemic equilibrium P*if and only if Rc>1,while the disease-free equilibrium P0 always *** using the technique of constructing Lyapunov functions and the generalized Lyapunov-LaSalle theorem,we first show that the equilibrium P0 is globally asymptotically stable(GAS)if Rc≤1;second,we prove that the equilibrium P*is GAS if Rc>*** results reveal that mumps can be eliminated from the community for Rc≤1 and it will be persistent for Rc>1,and quarantine measure can also effectively control the mumps transmission.

关键词： mumps transmission model control reproduction number quarantine measure global stability

Hydrothermal Synthesis and Structure Analysis of a Chromium Complex [Cr(aea)]_2(OH)_2(aea =N-(2-Aminoethyl)aspartate)

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Chinese Journal of Structural Chemistry 2008年第2期27卷 225-229页

作者： DANG Dong-Bin JIN Ya-Nan BAI Yan PAN xiao-jing wang jing-Ping Institute of Molecular and Crystal Engineering School of Chemistryand Chemical Engineering Henan University Kaifeng 475001 China

A dimeric chromium compound has been synthesized by hydrothermal method and characterized by IR, EPR spectra and TG-DTA technique. The title compound [Cr（aea）]2（OH）2 （aea = N-（2-aminoethyl）aspartate） crystallizes in monoclinic, space group P21/c with a = 8.9393（10）, b = 6.7198（7）, c = 14.6791（16） A, β = 91.0580（10）°, V= 881.63（17） A3, Z= 2, Mr = 486.34, De= 1.832 g/cm3, F（000） = 500,μ = 1.296 mm-1, R = 0.0271 and wR = 0.0756. Single-crystal X-ray structural analysis indicates that the title compound consists of two Cr（aea） units linked by two bridging hydroxyl groups. The geometry around each chromium center is approximately octahedral and completed by two hydroxyls and a quadridentate ligand which is formed when ethylenediamine reacts with maleic acid.

关键词： chromium compound hydrothermal synthesis crystal structure

Microstructure and shear properties evolution of Mn-doped SAC solder joint under isothermal aging

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Journal of Iron and Steel Research International 2023年第8期30卷 1650-1660页

作者： Cheng-ming Li Shu-jin Chen Shan-shan Cai Ju-bo Peng xiao-jing wang Ying-wu wang School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina R&D Center Yunnan Tin Group(Holding)Co.Ltd.Kunming 650000YunnanChina Modern School of Engineering Yunnan UniversityKunming 650091YunnanChina

The effects of Mn addition(0.005,0.01,0.03,0.05,and 0.07 wt.%)on microstructure,shear mechanical behavior,and interfacial thermal stabilities of SAC305 joints were investigated under isothermal aging temperatures of 170 C with different aging time(0,250,500,and 750 h).It is found that Mn addition can increase fracture energy of joints without decreasing the shear *** the microstructures have transformed from the eutectic net-like structure in SAC305 solder joints into the structures based onβ-Sn matrix with intermetallic compounds(IMCs)*** doping 0.07 wt.%Mn,the Cu_(6)Sn_(5) growth along the SAC305/Cu interface during thermal aging can be inhibited to some *** isothermal aging at 170°C,the maximum shear force of solder joint decreases continuously with aging time increasing,while the fracture energy rises first and then decreases,reaching the maximum at 500 h compared by that with the microstructure ***_(3)Sn growth between Cu_(3)Sn_(5)/Cu interface has been retarded most at the aging time of 250 h with 0.07 wt.%Mn-doped *** the aging time prolonging,the inhibition effect of Mn on CusSn IMC layer becomes *** strengthening effect of Mn can be explained by precipitation strengthening,and its mechanical behavior can be predicted by particle strengthening model proposed by Orowan.

关键词： SAC305 solder Mn doping Shear mechanical behavior Isothermal aging Interfacial intermetallic compound

Anthocyanin Accumulation Mediated by Blue Light and Cytokinin in Arabidopsis Seedlings

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Journal of Integrative Plant Biology 2006年第4期48卷 420-425页

作者： Da-Qing Chen Zhi-Yang Li Rui-Chi Pan xiao-jing wang College of Life Sciences South China Normal University Guangdong Key Laboratory of Biotechnology for Plant Development Guangzhou 510631 China

It has been reported that pigmentation In plants Is stimulated by light and cytoklnln （CTK）; however, the signaling pathways and the relationship between light and CTK Involved In the regulation of anthocyanln accumulation remain to be elucidated. We Investigated （i） the role of blue light （BL） and CTK In anthocyanln accumulation ; and （ii） the relationship between BL and CTK In wild type （WT） and by4 mutants of Arabidopsis thaiiana. Two-d-old seedlings grown on medium with or without klnetln （KT） or zeatln （ZT） In darkness were Irradiated using BL at different fluence rates for 3 d before the anthocyanln content was determined using a spectrophotometrlc method. Anthocyanln accumulation was strongly Induced by BL In WT seedlings but not In hy4 seedlings, which demonstrated that CRY1 Is the main photoreceptor for BL. Both KT and ZT enhanced the response of the WT seedlings to BL In a dose-dependent manner, whereas they were not sufficient to promote anthocyanln eccumulatlon In darkness. In addition, data from experiments using the hy4 mutant showed that the CTK effect of BL was also CRYl-dependent. The results from experiments with three different treatment programs showed that the relationship between BL and KT In anthocyanln accumulation of Arabidopsis seedlings seems neither muItlpllcatlve nor additive coactlon, but rather Interaction. BL Is necessary for anthocyanln accumulation, and KT might be Involved In the BL signaling pathway.

关键词： anthocyanin Arabidopsis blue light cytokinin by4 mutant.

Long-term follow-up study of elderly patients with covered stent implantation after coronary perforation

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Journal of Geriatric Cardiology 2014年第3期11卷 218-221页

作者： Geng wang Ya-Ling HAN Quan-Min jing xiao-Zeng wang Ying-Yan MA Bin wang Department of Cardiology Shenyang Northern Hospital Shenyang 110016 Liaoning Province China

ObjectiveTo evaluate the long-term efficacy of covered stent implantation in the treatment of elderly patients with coronary perforation while undergoing percutaneous coronary intervention （PCI）.MethodsFrom June 2004 to June 2012, our center has followed ten elderly patients （age≥ 60 years） who sustained coronary perforation during PCI. The major adverse cardiac events （MACE） were observed as well. The patients were advised to take 75 mg/day Clopidogrel for two years, and indefinite use of 100 mg/day enteric-coated *** out of the 10 patients aged from 60 to 76 years old （mean 68.6 ± 5.2 years） were male, four were female. The average diameter of the implanted stents was 3.3 ± 0.3 mm, and the average length was 22.1 ± 3.7 mm. All the ruptures were successfully sealed without intra-procedural death. The follow-up duration ranged from 0.6 to 67 months （mean 31.7 ± 24.5 months）. One patient died of multiple organ failure due to lung infection in 19 days after PCI; one died of cardiac sudden death in 13 months after PCI; one had angina pectoris in 53 months after PCI; one underwent multi-slice CT examination in six months after PCI, and no in-stent restenosis was found. The other four patients received angiography follow-up, and the results showed that three patients had no intra-stent restenosis, while one had left anterior descending （LAD） restenosis in the covered stent in 67 months after PCI. The in-hospital mortality was 10% （1/10）. The MACE rate in 12 months after PCI was 10% （1/10）. During the entire followed-up period, the restenosis rate in target vessels was 20% （1/5）, mortality was 20% （2/10）, and the MACE rate was 40% （4/10）.ConclusionTreatment of coronary perforation by using covered stents can achieve favorable long-term results; a two-year dual antiplatelet therapy （DAPT） after PCI can effectively prevent intra-stent thrombosis.

关键词： Coronary perforation Percutaneous coronary intervention Covered stent

Preparation and Magnetic Property of La_(0.7)Sr_(0.3)MnO_3 Nanorod by Combination Sol-Gel with Molten Salt

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Chemical Research in Chinese Universities 2008年第6期24卷 672-674页

作者： QI Shu-yan FENG jing XU xiao-dong wang jing-ping HOU Xiang-yu ZHANG Mi-lin Key Laboratory of Superlight Materials ＆ Surface Technology of Ministry of Education Harbin Engineering University Harbin 150001 P. R. China

La0.7Sr0.3MnO3（LSMO） nanorods were synthesized by a method combining sol-gel with molten salts at 950 ℃ for 10 h, which employed KCl＋NaCl（mass ratio 4：1） as eutectic molten salts. The morphologies and magnetic properties of the resulting LSMO nanorods were investigated by X-ray diffraction（XRD）, scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, and vibrating sample magnetometer（VSM） measurements. It was found that the obtained perovskite manganite LSMO was a uniform nanorod with a diameter of about 50 nm and a length of longer than 500 rim. The Curie temperature（To） of the LSMO nanorod used here was 262 K, much lower than that of bulky single crystal LSMO（360 K）. The low Curie temperature might be a result of the great disorder near the grain boundary, which could be observed clearly from the TEM picture.

关键词： Molten salt synthesis Sol-gel processes Perovskite Nanostructured materials

The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer

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Chinese Journal of Cancer 2016年第7期35卷 374-381页

作者： xiao-jing wang Ying Xiong Ze-Biao Ma Jian-Chuan Xia Yan-Fang Li Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer Medicine Guangzhou 510060Guangdong P.R.China Department of Gynecologic Oncology Sun Yat-Sen University Cancer CenterGuangzhou 510060GuangdongP.R. China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhou 510060GuangdongP.R. China

Background:Protein tyrosine kinase 6(PTK6) is overexpressed in many epithelial tumors and predicts poor ***,PTK6 expression status and its role in cervical squamous cell cancer are *** study aimed to investigate the expression level and clinical significance of PTK6 in early-stage cervical squamous cell ***:Quantitative reverse transcription-polymerase chain reaction(qRT-PCR) and western blotting analysis were performed to detect PTK6 mRNA and protein expression levels in 10 freshly frozen,early-stage cervical squamous cell cancer specimens and adjacent non-tumorous cervical *** expression of PTK6 was detected using immunohistochemical staining in 150 formalin-fixed,paraffin-embedded,early-stage cervical squamous cell cancer sections and 10 normal cervical tissue ***:The mRNA and protein levels of PTK6 in cancer tissues were higher than those in adjacent non-tumorous cervical *** analysis showed that PTK6 was not expressed in normal cervical tissues but was overexpressed in the cytoplasm of cervical squamous cell cancer *** level of PTK6 expression was significantly associated with tumor grade(P = 0.020).The 5-year overall survival rate of patients with high PTK6 expression was lower than that of patients with low PTK6 expression(81.3%vs.96.2%,P = 0.008).Multivariate Cox regression analysis showed that the expression level of PTK6 in cervical squamous cell cancer was an independent prognostic factor for patient survival(hazard ratio = 5.999,95%confidence interval 1.622-22.191,P< 0.05).Conclusions:PTK6 is overexpressed in cervical squamous ceil *** PTK6 expression is associated with reduced 5-year overall ***6 expression is an independent prognostic predictor for cervical cancer.

关键词：蛋白酪氨酸激酶鳞状细胞癌子宫颈预后早期反转录聚合酶链反应免疫组化染色组织切片

The role of Smad7 in oral mucositis

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Protein & Cell 2015年第3期6卷 160-169页

作者： Li Bian Gangwen Han Carolyn W. Zhao Pamela J. Garl xiao-jing wang Department of Pathology The First Affiliated Hospital of Kunming Medical University Kunming 650032 China Department of Pathology University of Colorado Anschutz. Medical Campus Aurora CO 80203 USA Department of Dermatology The Second Hospital of Shandong University Jinan 250033 China

Oral mucositis, a severe oral ulceration, is a common toxic effect of radioor chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body radiation, develop oral mucositis. To date, there is no FDA approved drug to treat oral mucositis in cancer patients. The key challenges for oral mucositis treatment are to repair and protect ulcerated oral mucosa without promoting cancer cell growth. Oral mucositis is the result of complex, multifaceted pathobiology, involving a series of signaling pathways and a chain of interactions between the epithelium and submucosa. Among those pathways and interactions, the activation of nuclear factor-kappa B （NF-KB） is critical to the inflamma- tion process of oral mucositis. We recently found that activation of TGFβ （transforming growth factor β） signaling is associated with the development of oral mucositis. Smad7, the negative regulator of TGFβ signaling, inhibits both NF-KB and TGFβ activation and thus plays a pivotal role in the prevention and treatment of oral mucositis by attenuating growth inhibition, apoptosis, and inflammation while promoting epithelial migration. The major objective of this review is to evaluate the known functions of Smad7, with a particular focus on its molecular mechanisms and its function in blocking multiple pathological processes in oral mucositis.

关键词： Smad7 oral mucositis cancer TGFβ,NF-κB