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Expert Consensus on the Treat-to-Target Strategy for Psoriasis With Biological Agents in China(Simplified Edition)

International Journal of Dermatology and Venereology 2024年第2期7卷 61-69页

作者： Ai-Jun Chen Da-Xing Cai Xiang Chen Yong Cui Yan Ding Heng Gu Xing-Hua Gao Chao Ji xiao-jing kang Ye-Hong Kuang Cheng-Zhi Lyu Min Li Wei Li Xia Li Yu-Zhen Li xiao-Yong Man Jian-Jun Qiao Juan Su Liang-Dan Sun Yu-Ling Shi Juan Tao Jian-Xin Xia Rong xiao Bin Yang Wu Zhu Xue-Jun Zhang Committee on Psoriasis Dermatology and Venereology Branch of the Chinese Medical Association Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Dermatology Qilu HospitalShandong UniversityJinanShandong 250100China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology China-Japan Friendship HospitalBeijing 100192China Department of Dermatology Hainan Provincial Hospital of Skin DiseaseHaikouHainan 570311China Department of Dermatology Hospital for Skin DiseasesChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110002China Department of Dermatology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uyghur Autonomous Region 830001China Department of Dermatology Dalian Dermatosis HospitalDalianLiaoning 116021China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhouJiangsu 215127China Department of Dermatology West China Hospital of Sichuan UniversityChengduSichuan 610044China Department of Dermatology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200093China Department of Dermatology The Union Hospital of Tongji Medical CollegeHuazhong University of Science and Te

Psoriasis is a chronic,recurrent,inflammatory systemic disease that is not only characterized by skin manifestations but may also be accompanied by various comorbidities,imposing a heavy burden on patients’physical and mental health and affecting their quality of *** the continuous approval of various biological agents for clinical use has provided more effective treatment options to patients with psoriasis,no consensus on the evaluation of comprehensive treatment goals has yet been *** treat-to-target(T2T)strategy requires consideration of multiple dimensions of treatment outcomes,the development of long-term management goals,and regular assessments of treatment conditions,which are often used in the management of chronic ***,based on the latest consensuses and guidelines,research data,and clinical experience as well as the combination of survey results and expert group discussions,the present consensus focuses on 4 dimensions of short-and long-term integrated management goals for biological agents:alleviating skin lesions,improving quality of life,screening and managing psoriasis comorbidities,and ensuring drug *** implementation methods,evaluation time,treatment monitoring,and program adjustments are also herein described to achieve comprehensive management of psoriasis to the maximum *** consensus provides a reference for clinical practice.

关键词： psoriasis biological agents treat-to-target comorbidity consensus

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Analysis of Clinical Features of Patients With Psoriasis and Metabolic Syndrome in Xinjiang,China:A Cross-Sectional Study

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International Journal of Dermatology and Venereology 2023年第4期6卷 195-200页

作者： Man-Man Duan Yun-Xia Ma jing-Zhan Zhang Dong Luo Shi-Rong Yu xiao-jing kang Yuan Ding Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China Xinjiang Clinical Research Center for Dermatologic Diseases UrumqiXinjiang Uygur Autonomous Region 830001China Xinjiang Key Laboratory of Dermatology Research UrumqiXinjiang Uygur Autonomous Region 830001China Graduate School Xinjiang Medical UniversityUrumqiXinjiang Uygur Autonomous Region 830001China

Objective:Psoriasis is often closely related to metabolic syndrome (MS),herein we conducted this study to investigate the clinical characteristics of a large sample of psoriasis patients with MS in Xinjiang,***:The prevalence of MS,age,height,weight,body mass index (BMI),red blood cell count,white blood cell count,platelet count,aspartate aminotransferase level,alanine aminotransferase level,and other clinical data were analyzed in 2,492 patients with *** patients were divided into 2 groups based on the presence of MS and their clinical features were *** test was used for independent samples,and the chi-square test was used for count ***:Among the 2,492 patients,349 had MS and 1,269 were considered overweight/*** were significant differences in sex,age,disease course,age at onset,BMI,systolic blood pressure (SBP),and diastolic blood pressure (DBP) between the patients with MS and those without (allP 0.05).Binary logistic regression analysis showed that sex,age,BMI,SBP,DBP,and fasting plasma glucose were independent risk factors for MS in patients with psoriasis,and high-density lipoprotein cholesterol was considered a protective factor for these ***:The prevalence of MS in patients with psoriasis is *** sex,age,BMI,SBP,DBP,and fasting plasma glucose may be risk factors for psorias

关键词： psoriasis metabolic syndrome obesity logistic regression analysis

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Bullous Pemphigoid With Nail Damage Associated With Kaposi Sarcoma:A Case Report

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International Journal of Dermatology and Venereology 2023年第4期6卷 233-235页

作者： Feng-Xia Hu Jun-Qin Liang Dilinuer Abudoureyimu Cao-Ying Wu xiao-jing kang Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China.

Introduction:Bullous pemphigoid is an acquired autoimmune bullous skin disease that occurs in the elderly,and nail involvement is relatively *** sarcoma(KS) is a rare opportunistic tumor in patients with iatrogenic immunosuppression and is rarely associated with autoimmune bullotic *** presentation:The patient was diagnosed with bullous pemphigoid based on her history,bullous pemphigoid antibody,and skin pathological *** nail involvement occurred 20 days prior to the recurrence of the ***,KS occurred during high-dose glucocorticoid therapy in this ***:The patient was admitted to hospital because of a five-month history of erythema and blisters and a one-month history of nodules and *** diagnosis of bullous pemphigoid was followed by treatment with glucocorticoids and intravenous gamma *** treatment,the disease recurred due to discontinuation of *** were erythema and blisters all over the body,and purple nodules,plaques appeared in the base of some *** examination of nodules was consistent with *** addition,nail involvement occurred 20 days before *** particularity of this case lies in the simultaneous occurrence of nail involvement,bullous pemphigoid,and ***:Patients with autoimmune bullous skin disease may suddenly develop abnormal nails,and such patients should be vigilant about recurrence of the *** should be aware of the possibility of KS when rapidly progressing purplish red plaques or nodules appear in patients receiving high doses of corticosteroids or immunosuppressants.

关键词： bullous pemphigoid nail damage Kaposi sarcoma tumor blister

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An Analysis of HPV Infection and Distribution in Cervical and Genital Samples With Condyloma Acuminatum:A Retrospective Study

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International Journal of Dermatology and Venereology 2023年第1期6卷 35-39页

作者： Wen Hu Yan Shi Meng-Meng Guan Xiang-Yue Zhang jing-Zhan Zhang Peng Wang Xin-Mei Liu xiao-jing kang Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Xinjiang Key Laboratory of Dermatology Research(XJYS1707) Xinjiang Clinical Research Center for Dermatologic DiseasesUrumqiXinjiang 830001China

Objective:Human papillomavirus(HPV)causes condyloma acuminata,which is one of the most widespread sexually transmitted *** study was aimed to evaluate the prevalence of HPV infection and HPV genotype distribution in patients with condyloma acuminatum in Urumqi,***:A total of 835 cervical and genital samples were collected from outpatients treated for condyloma acuminatum between December 2016 and December *** genotyping was performed with the HPV Genotyping Real-time PCR Kit for 23 different HPV *** analysis was conducted using the chi-square ***:The total prevalence of HPV infection was 80.72%(674/835)in patients with condyloma acuminatum in *** HPV genotypes were HPV-6(372/835,44.55%),HPV-11(180/835,21.56%),HPV-16(91/835,10.90%),HPV-43(65/835,7.78%),HPV-42(56/835,6.71%),and HPV-58(53/835,6.35%).Among HPV-infected individuals,49.11%(331/674)were infected by a single HPV subtype,while 50.89%(343/674)were infected by multiple HPV *** prevalence of HPV infection was higher in females(82.14%,276/336)than in males(79.76%,398/499)(χ^(2)=0.73,P=0.39),and higher in other ethnicities(86.36%,133/154)than in people of Han ethnicity(79.76%,541/681)(χ^(2)=3.866,P=0.049).The peak prevalence of HPV infection was observed in the age groups of 20-29 years and 30-39 ***:HPV infection was detected in most patients with condyloma acuminatum in Urumqi with prevalence of 80.72%,and the most common HPV types were HPV-6,-11,-16,-43,-42,*** detection of HPV genotypes is very important to monitor HPV infection so that effective treatment is administered to patients with condyloma acuminatum.

关键词： condyloma acuminatum human papillomavirus prevalence genotypes infection

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Expression Changes of Serum IL-1α,CCL2,and CXCL2 in Patients With Pemphigus

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International Journal of Dermatology and Venereology 2023年第2期6卷 102-106页

作者： Li-Dan Mao Yu Zhang Jun-Qin Liang xiao-jing kang Feng-Xia Hu Fan-He Jiang Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous RegionXinjiang Clinical Research Center for Dermatologic DiseasesXinjiang Key Laboratory of Dermatology ResearchUrumqiXinjiang 830001China Department of Dermatology People’s Hospital of Xinjiang Bayingol Mongolian Autonomous PrefectureBayingol Mongolian Autonomous PrefectureXinjiang 841000China

Objective:This study was performed to explore the possible changes of the serum levels of the cytokines including interleukin 1α(IL-1α),chemokine monocyte chemotactic protein 1(also known as chemokine[C-C motif]ligand 2[CCL2]),and C-X-C motif chemokine ligand 2(CXCL2)in patients with ***:The expression levels of IL-1α,CCL2,and CXCL2 in the serum of 57 patients with pemphigus PV(including 42 patients in progressive stage and 15 patients in remission stage)and 31 healthy controls were examined by enzyme-linked immunosorbent *** indepent-samples t-test was used to compare the two *** analysis of variance was used for multiple-group comparisons,and the post-hoc least significant difference test was used to detect differences among multiple ***:The serum expression levels of CCL2 and IL-1a were all significantly higher in the patients in progressive stage than in the controls([2.69±0.23]ng/mL vs.[2.55±0.28]ng/mL,P=0.043;[0.62±0.27]ng/mL vs.[0.48±0.23]ng/mL,P=0.038,respectively).In addition,the serum expression level of CXCL2 was significantly higher in patients in progressive stage than in in the remission stage([61.70±46.38]ng/mL vs.[24.97±18.46]ng/mL,P=0.037).Sex,disease classification,disease severity,treatment,and mucosal involvement had no significant influence on the expression of IL-1α,CCL2,or CXCL2 in the serum of patients groups and controls(all P>0.05).Conclusion:IL-1α,CCL2,and CXCL2 are heavily involved in the occurrence and development of pemphigus and may be related to the activity of the disease.

关键词： pemphigus cytokines chemokine interleukin-1α chemokine(C-C motif)ligand 2 C-X-C motif chemokine ligand 2

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Regulation of insect behavior by non-coding RNAs

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Science China(Life Sciences) 2024年第6期67卷 1106-1118页

作者： jing He Le kang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Sciences Chinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071002China

The adaptation of insects to environments relies on a sophisticated set of behaviors controlled by molecular and physiological *** the past several decades,accumulating studies have unveiled the roles of non-coding RNAs(nc RNAs)in regulating insect *** RNAs assume particularly pivotal roles in the behavioral plasticity of insects by rapidly responding to environmental *** RNAs also contribute to the maintenance of homeostasis of insects by fine-tuning the expression of target ***,a comprehensive review of nc RNAs'roles in regulating insect behaviors has yet to be ***,we present the recent progress in our understanding of how nc RNAs regulate various insect behaviors,including flight and movement,social behavior,reproduction,learning and memory,and *** refine the intricate mechanisms by which nc RNAs modulate the function of neural,motor,reproductive,and other physiological systems,as well as gene expression in insects like fruit flies,social insects,locusts,and ***,we discuss potential avenues for future studies in nc RNA-mediated insect behaviors.

关键词： ncRNAs insect behavior plasticity fine-tuning environmental adaptation

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Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 248-256页

作者： Gang Huang kang-kang Wu xiao-Na Li jing-Hua Kuai Ai-Jun Zhang Department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and *** bowel tuberculosis,characterized by predominant involvement of the small intestine,is an extremely rare condition with highly atypical clinical presentations,making diagnosis even more *** SUMMARY We report three cases of small intestinal tuberculosis,two of the patients pre-sented primarily with abdominal pain,and one presented with gastrointestinal *** patients underwent blood tests and imaging *** bowel endoscopy(SBE)revealed that the main lesions in these patients were in-testinal stenosis or gastrointestinal bleeding caused by small intestinal *** patient ultimately underwent surgical *** a complex diagnostic process and comprehensive analysis,all patients were confirmed to have small intestinal tuberculosis and received standard antituberculosis treatment,leading to an improvement in their *** Patients with SBTs present with nonspecific symptoms such as abdominal pain,weight loss,and occasional gastrointestinal *** diagnosis requires a thorough evaluation of clinical symptoms and various tests to avoid misdiagno-sis and complications.

关键词： Intestinal tuberculosis Gastrointestinal hemorrhage Small bowel endoscopy Case report

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Numerical investigation on dynamic response of the screen mesh in vibrating screening through DEM-FEM co-simulation

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Particuology 2024年第4期87卷 205-217页

作者： Huan Zhang xiao Zheng Weimin jing Key Laboratory of MetallurgicalEquipment and Control Technology Ministry of EducationWuhan University of Science and TechnologyWuhan430081 China Hubei Key Laboratory of Mechanical Transmssion and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan430081China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400044China

Dynamic response of the screen mesh is of great significance in the optimum vibrating screen *** this paper,based on the DEM-FEM co-simulation method,the effect of screening parameters on the dynamic response of the screen mesh is explored and the mechanism is revealed on the particle ***,a virtual experiment on a linear vibrating screen was carried out to analyze the screening pa-rameters'effect with both impact load and sustained stress inflicted on the screen ***,the time-domain evolution regularity of the screen mesh LVA(Local Vibration Amplitude)under different particle plugging conditions was investigated based on the ***,the influence of screening parameters on LVA and its distribution was *** results show that the screening parameters can greatly affect the screen mesh LVA and its distribution by changing the movement of the granular material and the particle penetration probability,which provides an important basis for the optimal design of the screen mesh and its supporting structure.

关键词： Vibrating screen Dynamic response DEM-FEM Screening parameters Local vibration amplitude

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A Mild and Efficient Synthesis of Chiral N-Boc-a-aminoaldehydes

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Chinese Chemical Letters 2006年第9期17卷 1162-1164页

作者： Bin HU Kun xiao jing kang SHEN State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaShanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

A series of chiral N-Boc-α-aminoaldehydes were synthesized in good yields and high purity via esterification of Boc-L-amino acids followed by reduction with sodium bis （2-methoxy- ethoxy）aluminum hydride.

关键词： Aminoaldehyde reduction sodium bis(2-methoxyethoxy)aluminum hydride ester amino acid.

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Efficient removal of Cr(VI) by polydopamine-modified lignin from aqueous solution: Batch and XAFS studies

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Water Science and Engineering 2024年第1期17卷 51-61页

作者： xiao-jie Guo Wei-kang Fu jing-yuan Ma Bo-jun Xi Chen Wang Meng-yao Guan College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China College of Textile and Garment Shaoxing UniversityShaoxing 312000China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Lignocellulose has the potential to become a bio-based adsorbent due to its biodegradability and *** this study,a novel polydopamine functionalized-lignin(lignin@PDA),prepared via self-polymerization of dopamine(PDA)on lignin,was used as a bio-based adsorbent for rapid scavenging of hexavalent chromium(Cr(VI)).The morphology,functional groups,crystalline structure,and chemical composition of lignin@PDA were characterized with a scanning electron microscope-energy dispersive spectrometer,Fourier transform infrared spectroscopy,X-ray diffraction,and X-ray photoelectron *** Cr(VI)adsorption process of lignin@PDA was studied using batch experiments as a function of pH,ionic strength,adsorbent dose,and contact time at room *** adsorption rate of lignin@PDA was five times greater than that of the unmodified lignin,with a maximum adsorption capacity of 102.6 mg/g in an acidic *** adsorption of Cr(VI)on lignin@PDA fit the pseudo-secondorder equation and the Freundlich model,indicating that the adsorption process was mainly dominated by chemisorption and surface *** thermodynamic parameters showed that adsorption of Cr(VI)on lignin@PDA was an endothermic and spontaneous *** X-ray absorption fine structure results showed that sorption and reduction of Cr(VI)into Cr(II)occurred simultaneously on ***,PDA coating not only improved the reactivity of lignin but also promoted the complete reduction of Cr(VI)by *** to these results,polydopamine functionalized-lignin is a promising bio-based adsorbent for immobilization of Cr(VI)from wastewater.

关键词： Lignin Polydopamine Hexavalent chromium EXAFS Adsorption mechanism

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