Expression Changes of Serum IL-1α,CCL2,and CXCL2 in Patients With Pemphigus

作     者：Li-Dan Mao Yu Zhang Jun-Qin Liang Xiao-Jing Kang Feng-Xia Hu Fan-He Jiang Li-Dan Mao;Yu Zhang;Jun-Qin Liang;Xiao-Jing Kang;Feng-Xia Hu;Fan-He Jiang

作者机构：Department of Dermatology and VenereologyPeople’s Hospital of Xinjiang Uygur Autonomous RegionXinjiang Clinical Research Center for Dermatologic DiseasesXinjiang Key Laboratory of Dermatology ResearchUrumqiXinjiang 830001China Department of DermatologyPeople’s Hospital of Xinjiang Bayingol Mongolian Autonomous PrefectureBayingol Mongolian Autonomous PrefectureXinjiang 841000China 

出 版 物：《International Journal of Dermatology and Venereology》 (国际皮肤性病学杂志（英文）)

年 卷 期：2023年第6卷第2期

页      面：102-106页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：National Natural Science Foundation of China (No. 81960564) Xinjiang Uygur Autonomous Region Health and Family Planning Commission Youth Science and Technology Talents Special Research Project (No. WJWY-201850) 

主　　题：pemphigus cytokines chemokine interleukin-1α chemokine(C-C motif)ligand 2 C-X-C motif chemokine ligand 2 

摘      要：Objective:This study was performed to explore the possible changes of the serum levels of the cytokines including interleukin 1α(IL-1α),chemokine monocyte chemotactic protein 1(also known as chemokine[C-C motif]ligand 2[CCL2]),and C-X-C motif chemokine ligand 2(CXCL2)in patients with ***:The expression levels of IL-1α,CCL2,and CXCL2 in the serum of 57 patients with pemphigus PV(including 42 patients in progressive stage and 15 patients in remission stage)and 31 healthy controls were examined by enzyme-linked immunosorbent *** indepent-samples t-test was used to compare the two *** analysis of variance was used for multiple-group comparisons,and the post-hoc least significant difference test was used to detect differences among multiple ***:The serum expression levels of CCL2 and IL-1a were all significantly higher in the patients in progressive stage than in the controls([2.69±0.23]ng/mL vs.[2.55±0.28]ng/mL,P=0.043;[0.62±0.27]ng/mL vs.[0.48±0.23]ng/mL,P=0.038,respectively).In addition,the serum expression level of CXCL2 was significantly higher in patients in progressive stage than in in the remission stage([61.70±46.38]ng/mL vs.[24.97±18.46]ng/mL,P=0.037).Sex,disease classification,disease severity,treatment,and mucosal involvement had no significant influence on the expression of IL-1α,CCL2,or CXCL2 in the serum of patients groups and controls(all P0.05).Conclusion:IL-1α,CCL2,and CXCL2 are heavily involved in the occurrence and development of pemphigus and may be related to the activity of the disease.