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Improvement of the Injection and Transport Characteristics of Electrons in Organic Light-Emitting Diodes by Utilizing a NaC1 N-Doped Layer

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Chinese Physics Letters 2014年第4期31卷 178-181页

作者： xiao Zhi-Hui WU xiao-Ming hua yu-Lin WANG Li BI Wen-Tao BAI Juan-Juan MU Xue YIN Shou-Gen School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384Key Laboratory of Display Materials and Photoelectric Devices .Ministry of Education Tianjin 300384 Tianjin Key Laboratory of Photoelectric Materials and Devices Tianjin 300384

The injection and transport characteristics of electrons are enhanced by using sodium chloride （NaC1） as an n-type dopant doped into a 4, 7-diphnenyl-1, lO-phe-nanthroline （Bphen） electron-transporting layer, which improves the performance of organic light-emitting diodes （OLEDs）. Meanwhile, a NaCl-doped Bphen layer can effectively influence electrical characteristics of the devices, and significantly improve the current and power efficiency. The turn-on voltage and the operation voltage of the optimal device are decreased drastically from 6.5 V and 10.8 V to 3.3 V and 5 V, respectively, compared with those of the reference device. The maximum current efficiency and power efficiency of the optimal device are 7.0 cd/A and 4.4 Im/W at the current density of 16.70 mA/cm~, which are about I. 7 and 4 times higher than those of the reference device, respectively. Moreover, the enhancement of the injection and transport ability for electrons is attributed not only to the reduced energy barrier between A1 cathode and Bphen, but also to the increased mobility of electrons by the doping effect of NaCl. Therefore, both the electron injection and transport ability are enhanced, which improve the carrier balance in OLEDs and lead to the better device efficiency.

关键词： ORGANIC light emitting diodes SALT DOPING agents (Chemistry) ENERGY consumption ELECTRON mobility

Tumor necrosis factor-α： a new mechanism of ischemic ventricular fibrillation？

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Chinese Medical Journal 2008年第18期121卷 1848-1851页

作者： xiao hua LIAO yu-hua CHEN Zhi-jian Laboratory of Cardiovascular Immunology Institute of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Ventricular fibrillation （VF） in myocardial ischemia is called ＂ischemic VF＂. As a severe morbid state and a leading cause of sudden cardiac attack, ischemic VF induces approximately 3 million deaths in the United States each year. Ischemic VF is caused by ＂triggers＂ such as ventricular premature beat or ventricular tachycardia in the presence of a suitable ＂substrate＂. The triggers frequently occur at the border zone and the substrate is required for the maintenance of ischemic VE The critical factors for the initiation and maintenance of ischemic VF are obscure. Tumor necrosis factor-α （TNF-α）, an inflammatory cytokine expressed in myocardial ischemia, plays an important role in the pathophysiological process of acute myocardial infarction （AMI）. TNF-α also causes arrhythmia by action potential prolongation and abnormal Ca^2＋ handling, which also contribute to ischemic VE But the relationship between TNF-α and ischemic VF is unknown. In this article, we suggest that TNF-α may be a novel substrate of ischemic VE This may be a new mechanism for ischemic VF.

关键词： ischemic ventricular fibrillation tumor necrosis factor-alpha arrhythmias, cardiac

Inhibition of the immunoproteasome LMP_(2) ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

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Military Medical Research 2022年第4期9卷 404-418页

作者： Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao xiao-hua yu Yin-Zhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityNo.134DongjieGulou DistrictFuzhou 350001China Fujian Academy of Medical Science Fuzhou 350o01China Key Testing Laboratory of Fujian Province Fuzhou 350001China.

Background:Disruption of the blood–brain barrier(BBB)after a stroke can lead to brain injury and neurological *** work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2(LMP2)in the pathophysiology of ischemia ***,the relationship between the immunoproteasome LMP2 and the BBB remains ***:Adult male Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion(MCAO/R).Three days before MCAO,the rats were treated with lentivirus-mediated LMP2 shRNA preparations by stereotactical injection into the ipsilateral hemispheric *** rat brain microvascular endothelial cell(RBMVEC)line was exposed to oxygen–glucose deprivation/reperfusion(OGD/R)to mimic ischemic conditions in *** RNA interference-mediated knockdown of LMP2 orβ-catenin was analysed in vivo and in *** of the quantity of extravasated Evans blue(EB)and cerebral fluorescent angiography were performed to evaluate the integrity of the *** and Western blotting were employed to detect the expression of target *** migration was evaluated using a scratch migration *** results of immunofluorescence,Western blotting and cell migration were quantified using the software ImageJ(Version 1.53).Parametric data from different groups were compared using one-way ANOVA followed by the least significant difference(LSD)***:Cerebral ischemia led to lower levels of structural components of the BBB such as tight junction proteins[occludin,claudin-1 and zonula occludens(ZO-1)]in the MCAO/R group compared with the sham group(P<0.001).However,inhibition of the immunoproteasome LMP2 restored the expression of these proteins,resulting in higher levels of occludin,claudin-1 and ZO-1 in the LMP2-shRNA group compared with the control-shRNA group(P<0.001).In addition,inhibition of the immunoproteasome LMP2 contributed to higher microvascular density and decreased BBB perm

关键词： Immunoproteasome Blood–brain barrier Wnt/β-catenin pathway Oxygen–glucose deprivation/reperfusion Cerebral ischemia

Ion Selective Electrode Array Analysis Using Variable Step-Size Generalized Simulated Annealing

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Chemical Research in Chinese Universities 1993年第4期9卷 296-302页

作者： WANG Shi-hua, xiao Dan and yu Ru-qin (Department of Chemistry and Chemical Engineering,Hunan Univ. ,Changsha,410082)

A global optimum location algorithm called Variable Step-Size Generalized Simulated Annealing(VSGSA) was applied to treating the data obtained by using an array of ion-electrodes in solutions containing mixtures of Na+, K+, Ca2+. Unlike traditional optimization algorithms such as simplex procedure, VSGSA can be used to determine the model parameters without any priori information about the analytical system under investigation and overcome the disadvantage of simplex method which might converge to local extrema depending on the starting positions. The algorithm was applied to po-tentiometric determination of ions in mixture solutions.

关键词： Chemometrics Multivariate calibration Array of ion-selective electrodes,Generalized simulated annealing

Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-Tong Cui hua-Ru Xue Dian-Fang Wei xiao-yu Feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

Effects of ethanol on liver sinusoidal endothelial cells-fenestrae of rats

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 422-426页

作者： Bing-yuan Wang, xiao-hua Ju, Bao-yu Fu, Jian Zhang and Yan-Xue Cao Department of Gastroenterology, First Hospital of China Medical University, Shenyang 110001 , China Department of Gastroenterology First Hospital of China Medical University Shenyang 110001 China. wangby@***

Important advances have been made in research into the mechanism of alcoholic liver disease (ALD) over the past few years,but the role of liver sinusoidal endothelial cell (LSEC) in ALD has not been elucidated adequately. This study was undertaken to investigate the effect of ethanol on fenestrae of LSECs in rats. METHODS: A rat model of alcoholic liver disease was established by means of direct intragastric instillation of ethanol. Fifty-five rats of experimental (35 rats) and control (20) groups were sacrificed at the end of 4,8,12 weeks respectively, and also at the end of 12-week abstinence. After heart perfusion, the liver tissue was fixed and stained with hematoxylin and eosin for observation of serial changes of LSEC-fenestrae under a transmission electron microscope. RESULTS: Normal LESC was flat with a nucleus and organelles arranged regularly. The distal cytoplasm displayed as a lamina with many fenestrae, lacking the basement membrane(BM) underneath the endothelium. At the end of 4-week alcohol feeding, the number of fenestrae decreased at the distal cytoplasm in some LSECs, without the formation of the BM underneath the endothelium. At the end of 8 weeks, the number of fenestrae decreased significantly or even disappeared. The BM began to develop incompletely underneath the endothelium, while the active fibroblast appeared. At the end of 12 weeks, the number of fenestrae decreased more significantly and the complete BM could even be seen. But the changes were mostly limited in the single or adjoining sinus, and fibrosis was scarcely formed. At the end of 12-week abstinence, defenestration and formation of the endothelial BM lightened significantly. CONCLUSIONS:Defenestration and formation of the BM in LSECs develop gradually with the chronic stimulation of ethanol. Hepatic sinusoidal capillarization and fibrosis will be seen if their state is more serious. These early changes, i. e., limited and regional defenestration and capillarization may be the basi

关键词： alcoholic liver disease hepatic fibrosis liver sinusoidal endothelial cell liver sinusoidal capillarization

Moleucle action mechunisms of NM-3 on human gastric cancer SGC-7901 Cells in vivo or in vitro

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World Journal of Gastroenterology 2003年第10期9卷 2366-2369页

作者： Jin-Shui Zhu Bo Shen Jin-Lian Chen Guo-Qiang Chen xiao-Hu yu hua-Fang yu Zu-Ming Zhu, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China Guo-Qiang Chen, Shanghai Experimental Animal Center, Chinese Academy of Sciences, Shanghai 200233, China Department of Gastroenterology Affiliated Sixth People's Hospital Shanghai Jiaotong University Shanghai 200233 China. zhujs1803@***

AIM: To study the moleucle action mechunisms of NM-3 on the growth of human gastric cancer SGC-7901 cells in vivo or in ***: SGC-7901 from human non-differentiated gastric cancer cell line was cultured with NM-3 at 100 mg/ml for 24 h. We observed its inhibitory rate and the density of micro-vascular growth in grafted mice with human gastric cancer SGC-7901. The apoptosis of human gastric cancer SGC-7901 was revealed in NM-3 treatment group by using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-fluorescene nick end labeling (TUNEL)method and flow cytometry ***: The growth of SGC-7901 cells was markedly inhibited compared with control growp, which was smaller than that in normal saline control group (4.17 g±0.22 g VS 9.45 g±1.38 g, P＜0.01). The level of apoptosis of human gastric cell line SGC-7901 was obviously increased in NM-3treatment group at 1 mg.L-1 for 24 h. NM-3 inducing apoptotic index in NM-3 plus carboplatin group was 3.5 times that of carboplatin control group (TUNEL: 27.98±6.12 % VS 12.94±2.12 %, FACScan: 26.86±5.69 % VS11.86±1.09 %,P＜0.01). Western blot analysis showed that the apoptotic index of human gastric cancer was elevated for 12, 24 and 36 h with an evident time-effect relationship in groups at 100 mg.L-L. NM-3 enhanced the inhibitive effects and sensitivity of chemotherapy for human gastric cancer in nude mice. These results suggested that NM-3 played a key inhibitive role in the growth of grafted human gastric cancer in nude ***: NM-3 can inhibit the growth of human gastric cancer cell line SGC-7901, and enhance the sensitivity of carboplatin on SGC-7901 and induced its apoptosis.

关键词：胃癌分子机制 SGC-7901细胞微血管形成 TUNEL法细胞凋亡 NM-3