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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu dai Li xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Property(ω)and the Single-valued Extension Property

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Acta Mathematica Sinica,English Series 2021年第8期37卷 1254-1266页

作者： Lei dai xiao hong CAO Qi GUO School of Mathematics and Statistics Weinan Normal UniversityWeinan 714099P.R.China School of Computer Science Shaanxi Normal UniversityXi’an 710119P.R.China School of Mathematics and Information Science Shaanxi Normal UniversityXi’an 710119P.R.China

By the new spectrum originated from the single-valued extension property,we give the necessary and sufficient conditions for a bounded linear operator defined on a Banach space for which property(ω)***,the relationsh... 详细信息

关键词： Property(ω) the single-valued extension property hypercyclic property supercyclic property

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无铅Sn-Cu电镀层锡须的形成与长大

电子工艺技术 2007年第1期28卷 6-9页

作者：肖代红陈康华吴金昌中南大学粉末冶金国家重点实验室湖南长沙410083 上海达丰电脑有限公司上海201114

通过扫描电镜观察,研究不同处理工艺中电子元件引线框架表面Sn-Cu电镀层上锡须的形成与长大,结果显示,高温高湿处理易于促使锡须的形成与长大,经过一定的时间后,锡须生长速度减缓;循环热处理或室温处理对锡须的形成影响较小;当施加恒定... 详细信息

通过扫描电镜观察,研究不同处理工艺中电子元件引线框架表面Sn-Cu电镀层上锡须的形成与长大,结果显示,高温高湿处理易于促使锡须的形成与长大,经过一定的时间后,锡须生长速度减缓;循环热处理或室温处理对锡须的形成影响较小;当施加恒定外应力后进行室温处理,锡须的形成完全受到抑制。锡须的形成与长大是由于电镀层中存在压应力,压应力促使镀层中锡发生再结晶并长大成锡须。

关键词：无铅电镀锡须热处理压应力

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

On Weyl’s Theorem for Functions of Operators

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Acta Mathematica Sinica,English Series 2019年第8期35卷 1367-1376页

作者： Jiong DONG xiao hong CAO Lei dai School of Mathematics and Information Science Shaanxi Normal University Xi'an 710119 P. R. China College of Mathematics and Physics Weinan Normal University Weinan 714000 P. R. China

Let H be a complex separable infinite dimensional Hilbert space. In this paper, a variant of the Weyl spectrum is discussed. Using the new spectrum, we characterize the necessary and sufficient conditions for both T and f(T) satisfying Weyl’s theorem, where f ∈ Hol(σ(T)) and Hol(σ(T)) is defined by the set of all functions f which are analytic on a neighbourhood of σ(T) and are not constant on any component of σ(T). Also we consider the perturbations of Weyl’s theorem for f(T).

关键词： Spectrum Weyl's theorem functions of operators compact perturbation

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美国临床心理学硕士的培养方式及其优点

科教文汇 2017年第7期 71-73页

作者：李逢战杨群刘旭峰肖玮戴红第四军医大学医学心理系

本文系统介绍了美国临床心理学硕士的培养目标、培养模式及培养优点。其培养优点主要体现在教学评估方式多样、注重综合能力培养、注重与社会的结合和教学系统开放、活跃,希望能为我国临床心理学硕士的培养提供一些参考。

关键词：美国临床心理学硕士培养模式

PARAMETER IDENTIFICATION FOR MODELING RIVER NETWORK USING A GENETIC ALGORITHM

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Journal of Hydrodynamics 2010年第2期22卷 246-253页

作者： TANG hong-wu XIN xiao-kang dai Wen-hong xiao Yang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing210098 China

The simulation of a one-dimensional river network needs to solve the Saint-Venant equations,in which the variable parameters normally have a significant influence on the model accuracy.A Trial-and-Error approach is a most commonly adopted method of parameter calibration,however,this method is time-consuming and requires experience to select the appropriate values of ***,simulated results obtained via this method usually differ between *** article combines a hydrodynamic model with an intelligent model originated from the Genetic Algorithm（GA） technique,in order to provide an intelligent simulation method that can optimize the parameters *** with current approaches,the method presented in this article is simpler,its dependence on field data is lower,and the model accuracy is *** the optimized parameters are taken into the hydrodynamic numerical model,a good agreement is attained between the simulated results and the field data.

关键词： river network simulation genetic algorithm parameter identification

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Dynamics and formation of vortices collapsed from ring dark solitons in a two-dimensional spin–orbit coupled Bose–Einstein condensate

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Frontiers of physics 2022年第4期17卷 185-193页

作者： Peng-hong Lu xiao-Fei Zhang Chao-Qing dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China

We consider the dynamics and formation of vortices from ring dark solitons in a two-dimensional Bose–Einstein condensate with the Rashba spin–orbit coupling based on the time-dependent coupled Gross–Pitaevskii *** with previous results,the system exhibits complex dynamical behaviors in the presence of the spin–orbit *** the modulation of the spin–orbit coupling,not only the lifetime of ring dark solitons is greatly prolonged,but also their attenuation kinetics is significantly *** two shallow ring dark solitons with the equal strength of the spin–orbit coupling,the radius of ring dark solitons increases to a maximum value over time and then shrinks into a minimum *** to the effect of the snake instability,ring dark solitons split into a series of ring-like clusters of vortex pairs,which perform complex *** indicates that the system is strongly dependent on the presence of the spin–orbit ***,the effect of different initial modulation depths on the dynamics of ring dark solitons is investigated.

关键词： Bose–Einstein condensate Rashba spin–orbit coupling ring dark solitons vortex pairs