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Hematochezia due to rectal invasion by an internal iliac artery aneurysm: A case report

World Journal of Clinical Cases 2024年第11期12卷 1980-1989页

作者： Fang Li Bin Zhao Yong-Qiang Liu Guo-Qing Chen Rong-feng Qu Chao Xu Zhui Long Jin-Song Wu Mao Xiong Wei-Hang Liu Li Zhu xiao-ling feng Lei Zhang Department of General Surgery Chongqing General HospitalChongqing 401147China

BACKGROUND This case report presents the rare occurrence of hematochezia due to an internal iliac artery aneurysm leading to an arterioenteric fistula,expanding the differential diagnosis for gastrointestinal bleeding.It emphasizes the importance of considering vascular origins in cases of atypical hematochezia,particularly in the absence of common gastrointestinal causes,and highlights the role of imaging and multidisciplinary management in diagnosing and treating such unusual presentations.CASE SUMMARY A 75-year-old man with a history of hypertension presented with 12 d of hematochezia,experiencing bloody stools 7-8 times per day.Initial computed tomography(CT)scans revealed an aneurysmal rupture near the right internal iliac artery with suspected hematoma development.Hemoglobin levels progressively decreased to 7 g/dL.Emergency arterial angiography and iliac arterycovered stent placement were performed,followed by balloon angioplasty.Despite initial stabilization,minor rectal bleeding and abdominal pain persisted,leading to further diagnostic colonoscopy.This identified a neoplasm and potential perforation at the proximal rectum.An exploratory laparotomy confirmed the presence of a hematoma and an aneurysm invading the rectal wall,necessitating partial rectal resection,intestinal anastomosis,and ileostomy.Postoperative recovery was successful,with no further bleeding incidents and normal follow-up CT and colonoscopy results after six months.CONCLUSION In cases of unusual gastrointestinal bleeding,it is necessary to consider vascular causes for effective diagnosis and intervention.

关键词： Iliac artery aneurysm Hematoma Rectum Hematochezia Case report

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Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury:A comparative analysis with mesenchymal stem cells

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World Journal of Stem Cells 2024年第5期16卷 525-537页

作者： Fang Li Bin Zhao Lei Zhang Guo-Qing Chen Li Zhu xiao-ling feng Meng-Jia Gong Cheng-Chen Hu Yuan-Yuan Zhang Ming Li Yong-Qiang Liu Department of General Surgery Chongqing General HospitalChongqing 401147China Department of Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

BACKGROUND Acute kidney injury(AKI)is a common clinical syndrome with high morbidity and mortality rates.The use of pluripotent stem cells holds great promise for the treatment of AKI.Urine-derived stem cells(USCs)are a novel and versatile cell source in cell-based therapy and regenerative medicine that provide advantages of a noninvasive,simple,and low-cost approach and are induced with high multidifferentiation potential.Whether these cells could serve as a potential stem cell source for the treatment of AKI has not been determined.METHODS Stem cell markers with multidifferentiation potential were isolated from human amniotic fluid.AKI severe combined immune deficiency(SCID)mice models were induced by means of an intramuscular injection with glycerol.USCs isolated from human-voided urine were administered via tail veins.The functional changes in the kidney were assessed by the levels of blood urea nitrogen and serum creatinine.The histologic changes were evaluated by hematoxylin and eosin staining and transferase dUTP nick-end labeling staining.Meanwhile,we compared the regenerative potential of USCs with bone marrow-derived mesenchymal stem cells(MSCs).RESULTS Treatment with USCs significantly alleviated histological destruction and functional decline.The renal function was rapidly restored after intravenous injection of 5×105 human USCs into SCID mice with glycerol-induced AKI compared with injection of saline.Results from secretion assays conducted in vitro demonstrated that both stem cell varieties released a wide array of cytokines and growth factors.This suggests that a mixture of various mediators closely interacts with their biochemical functions.Two types of stem cells showed enhanced tubular cell prolif-eration and decreased tubular cell apoptosis,although USC treatment was not more effective than MSC treatment.We found that USC therapy significantly improved renal function and histological damage,inhibited inflammation and apoptosis processes in the kidney,and promoted tubular epithelial proliferatio

关键词： Urine-derived stem cells Regenerative medicine Acute kidney injury Renal function recovery Cell therapy

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Role of osteopontin in diet-induced brown gallstone formation in rats

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Chinese Medical Journal 2021年第9期134卷 1093-1100页

作者： Chang-Guo Jin feng-Ru Jiang Jie Zhang Jun-Ren Ma xiao-feng ling Department of General Surgery Peking University Third HospitalBeijing 100191China

Background:Although osteopontin(OPN)is expressed in the liver and pigment gallstones of patients with hepatolithiasis,its role in pigment gallstone formation remains unclear.This study aimed to explore the function of OPN in pigment gallstone formation.Methods:Rats were fed a chow diet(CD)or lithogenic diet(LD)for 10 consecutive weeks;blocking tests were then performed using an OPN antibody(OPN-Ab).Incidence of gallstones and levels of several bile components,OPN,tumor necrosis factor alpha(TNF-α),and cholesterol 7 alpha-hydroxylase(CYP7A1)were analyzed.To determine TNF-αexpression in hepatic macrophages and both CYP7A1 and bile acid(BA)expression in liver cells,recombinant rat OPN and recombinant rat TNF-αwere used to treat rat hepatic macrophages and rat liver cells,respectively.Chi-square or Fisher exact tests were used to analyze qualitative data,Student t-test or one-way analysis of variance were used to analyze qualitative data.Results:Incidence of gallstones was higher in LD-fed rats than in CD-fed rats(80%vs.10%,P<0.05).BA content significantly decreased in bile(t=-36.08,P<0.01)and liver tissue(t=-16.16,P<0.01)of LD-fed rats.Both hepatic OPN protein expression(t=9.78,P<0.01)and TNF-αlevel(t=8.83,P<0.01)distinctly increased in the LD group;what’s more,CYP7A1 mRNA and protein levels(t=-12.35,P<0.01)were markedly down-regulated in the LD group.Following OPN-Ab pretreatment,gallstone formation decreased(85%vs.25%,χ^(2)=14.55,P<0.01),liver TNF-αexpression(F=20.36,P<0.01)was down-regulated in the LD group,and CYP7A1 expression(F=17.51,P<0.01)was up-regulated.Through CD44 and integrin receptors,OPN promoted TNF-αproduction in macrophage(F=1041,P<0.01),which suppressed CYP7A1 expression(F=48.08,P<0.01)and reduced liver BA synthesis(F=119.4,P<0.01).Conclusions:We provide novel evidence of OPN involvement in pigmented gallstone pathogenesis in rats.

关键词： Pigment gallstone Rat model Osteopontin TNF-α CYP7A1

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高职工匠精神培育的探索与实践——以自动化专业执行器单元实训资源建设为例

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辽宁高职学报 2024年第7期26卷 4-7页

作者：冯晓玲辽宁石化职业技术学院辽宁锦州121001

高职教育的核心是技能培养,而具有工匠精神的高职技能型人才培养,是目前职业教育工作的重点。以自动化专业的执行器单元实训资源建设为例,对职业教育培养工匠精神、提高学生职业素养的研究路径进行探讨与分析,对促进培养高职学生爱岗敬... 详细信息

高职教育的核心是技能培养,而具有工匠精神的高职技能型人才培养,是目前职业教育工作的重点。以自动化专业的执行器单元实训资源建设为例,对职业教育培养工匠精神、提高学生职业素养的研究路径进行探讨与分析,对促进培养高职学生爱岗敬业、精益求精、勇于创新的“工匠人才”,具有一定的实用价值。

关键词：高职教育工匠精神培养路径实训资源

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蛋白琥珀酸铁口服液治疗异常子宫出血继发性贫血临床研究

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中国实用妇科与产科杂志 2024年第3期40卷 354-357页

作者：冯晓玲王士萌徐芳王炜黑龙江中医药大学附属第一医院黑龙江哈尔滨150040 黑龙江中医药大学黑龙江哈尔滨150040

目的探讨蛋白琥珀酸铁口服液治疗异常子宫出血继发性贫血的有效性及安全性。方法收集2021年4月至2022年9月在黑龙江中医药大学附属第一医院妇科被确诊为异常子宫出血继发性贫血的150例患者纳入研究,所有患者均在对症止血治疗的基础上... 详细信息

目的探讨蛋白琥珀酸铁口服液治疗异常子宫出血继发性贫血的有效性及安全性。方法收集2021年4月至2022年9月在黑龙江中医药大学附属第一医院妇科被确诊为异常子宫出血继发性贫血的150例患者纳入研究,所有患者均在对症止血治疗的基础上,采用蛋白琥珀酸铁口服溶液(盛雪元)治疗,观察治疗后第2周和第4周的临床总有效率,血红蛋白、血清铁、血清铁蛋白等疗效指标变化情况及不良反应发生情况。结果治疗后2周临床总有效率为75.3%,治疗后4周临床总有效率为90.4%,二者比较差异有统计学意义(χ^(2)=11.680,P<0.05);治疗后,血红蛋白、血清铁、血清铁蛋白水平与治疗前比均上升,差异均有统计学意义(P<0.05);总铁结合力与治疗前比下降,差异有统计学意义(P<0.05),且治疗后4周各项指标的恢复情况较治疗后2周显著。治疗后无不良反应发生。结论蛋白琥珀酸铁口服液治疗妇科异常子宫出血继发性贫血有很好的疗效并具有安全性,值得临床推广。

关键词：蛋白琥珀酸铁口服液异常子宫出血继发性贫血血红蛋白血清铁血清铁蛋白安全性

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Distribution and diversity of endophytic fungi in Gentiana rigescens and cytotoxic activities

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Chinese Herbal Medicines 2020年第3期12卷 297-302页

作者： Li-li Xu xiao-feng ling Shu-juan Zhao Ru-feng Wang Zheng-tao Wang Institute of Science Technology and HumanitiesShanghai University of Traditional Chinese MedicineShanghai 201203China MOE Key Laboratory for Standardization of Chinese Medicines SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:In the present study,Gentiana rigescens was screened for fungi communities to clarify their diversity and community assemblage in hosts.Meanwhile,the identification and activity assays of the strains were also conducted.Methods:By culture-dependent(endophytic fungi isolations from plant sections)and culture-independent(metagenomic library and cloning from plant sections)techniques,fungi communities were studied.The metagenomic library was generated using direct DNA isolation of whole plants,plant radixes,plant stems,plant leaves,plant flowers and soils around the plant.Meanwhile,endophytes were isolated from all parts ofG.rigescens plants.After fermentation of the fungi isolations,all the isolates were evaluated for their cytotoxicity against four kinds of human cancer cell lines(HCT116,BEL7404,A549,MDA-MB-231).Results:Eventually,200 strains were isolated and 103 strains were further identified through the internal transcribed spacer(ITS,ITS1 and ITS2 regions)sequence by using the universal primers ITS5 and ITS4.A total of 59,106 fungal sequences corresponding to 374 putative operational taxonomic units(OTU)were identified by 454 pyrosequencing.Through 454 pyrosequencing,the main fungal genera were Sebacina,Botrytis,Mycosphaerella,Boletus and Gibberella,and the major fungal genera which were directly isolated were Aspergillus,Fusarium,Penicillium and Alternaria.Activity assays showed strains 5-26(Aspergillus sp.)and 6-2(Fusarium avenaceum)had the outstanding cytotoxicity to all the tested cell lines with IC5o values<5μg/mL.Conclusion:This study revealed the abundance of endogenetic fungal resources and a variety of genetic information in G.rigescens by high-throughput 454 sequencing technology and fungi isolation methods.Activity assays indicated that endophytes were a promising natural source of potential anticancer agents.

关键词： cytotoxic activities endophytic fungi Gentiana rigescens Franch. ITS metagenomic library

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Two-dimensional correlation spectroscopic studies on coordination between carbonyl group of butanone and metal ions

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Chinese Chemical Letters 2015年第2期26卷 177-181页

作者： Dan-Qing Gao xiao-Pei Li Jia-Jia Shi xiao-Yan Kang Ting-Guo Kang Jin-Ming Xia xiao-feng ling Shi-Fu Weng Yi-Zhuang Xu Isao Noda Jin-Guang Wu School of Postgraduate Liaoning University of Traditional Chinese Medicine College of Chemistry and Molecular Engineering Peking University Institute of Process Engineering and Chinese Academy of Sciences College of Chemistry and Materials Hebei Normal University Two Five Eight Health Technology Co. Ltd The Third School of Clinical Medicine of Peking University Ninghai Doubly Advanced Material Co. Ltd Department of Materials Science and Engineering University of Delaware

Two dimensional asynchronous spectra were used to characterize coordination between carbonyl group of butanone and metal ions by using an approach proposed in our recent paper.Spectral variation of n-π^＊transition band of carbonyl group is used to probe the coordination even if metal ions does not possess any characteristic peak in spectra.Experimental results indicate that Ca^2＋ and Al^3＋ show considerable ability to coordinate with the carbonyl group of butanone and bring about spectral variation of the n-π-＊transition band,which is manifested by cross peaks in 2D asynchronous spectra.

关键词： Ca^2＋ Al^3＋ Butanone Coordination 2D correlation spectroscopy

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甲状腺相关激素与子痫前期的相关性

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国际生殖健康／计划生育杂志 2024年第4期43卷 348-352页

作者：柳芳蕾冯晓玲(审校) 黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院

子痫前期(preeclampsia)是一种起源于胎盘功能障碍,以母体内皮功能障碍为发病核心,以新发高血压和蛋白尿为主要症状的妊娠期疾病。甲状腺相关激素对女性的生殖代谢有重要作用,且妊娠期甲状腺疾病可导致多种不良妊娠结局。研究发现甲状... 详细信息

子痫前期(preeclampsia)是一种起源于胎盘功能障碍,以母体内皮功能障碍为发病核心,以新发高血压和蛋白尿为主要症状的妊娠期疾病。甲状腺相关激素对女性的生殖代谢有重要作用,且妊娠期甲状腺疾病可导致多种不良妊娠结局。研究发现甲状腺相关激素与子痫前期密切相关。综述甲状腺相关激素参与子痫前期发病机制的途径及妊娠期甲状腺疾病与子痫前期的相关性,探究甲状腺相关激素在子痫前期发生发展中的作用。

关键词：孕妇甲状腺素甲状腺疾病先兆子痫妊娠并发症胎盘

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Clinical application of plasma shock wave lithotripsy in treating impacted stones in the bile duct system

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World Journal of Gastroenterology 2006年第1期12卷 130-133页

作者： Zhi Xu Li-Xin Wang Neng-Wei Zhang Chun-Sheng Hou xiao-feng ling Yao Xu xiao-Si Zhou Department of Surgery ThirdHospital of Peking University 49 North Garden Road HaidianDistrict Beijing 100083 China Institute of Physics Chinese Academy of SciencesBeijing 100037 China

瞄准：为了验证血浆冲击波的安全和功效，在碎裂的碎石术(PSWL ) 在胆汁管系统影响了石头。方法：从 1988 年 9 月到 2005 年 4 月，有影响石头的 67 个病人(26 个男人和 41 个女人) 与试管经历了各种各样的胆汁的操作(或 T 试管) 排水... 详细信息

瞄准：为了验证血浆冲击波的安全和功效，在碎裂的碎石术(PSWL ) 在胆汁管系统影响了石头。方法：从 1988 年 9 月到 2005 年 4 月，有影响石头的 67 个病人(26 个男人和 41 个女人) 与试管经历了各种各样的胆汁的操作(或 T 试管) 排水。在胆管造影术在操作以后发现的胆汁管系统的残余和影响石头被 PSWL 和 choledochofiberscopy 碎裂。201 块影响石头的一个总数被为 PSWL 的每脉搏在 2-3 J 将电压放在 2.5-3.5 kV，和能排出量的 PSWL 碎裂。然后，碎裂的石头被 choledochofiberscopy 提取。PSWL 的安全和功效被观察在期间并且在过程以后。结果：在胆汁管系统的 201 块影响石头(99.0%) 中的 199 个成功地用 PSWL 被碎裂并且由 choledochofiberscopy 提取了。为病人的石头清理率是 97%(65/67 ) 。十个病人在腹部的恰好上面的象限感到了温和疼痛，并且能容忍它很好。十一个病人有从胆汁管的粘膜流血的小数量。流血在生理盐水灌溉的 2 min 以内自发地短暂、停止。没有重要复杂并发症在期间并且在过程以后。结论: PSWL 是一个安全、有效的方法因为碎裂在胆汁管系统影响了石头。

关键词：临床应用等离子体碎石术胆导管

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Interactions between pyridinium and Nd^(3+)

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Chinese Chemical Letters 2015年第2期26卷 182-186页

作者： Yu-Hai Liu Jia-Jia Shi Dan-Qing Gao Yun-Long Gao Ran Guo xiao-feng ling Shi-Fu Weng Yi-Zhuang Xu Isao Noda Jin-Guang Wu College of Chemistry and Molecular Engineering Peking University College of Chemistry and Materials Hebei Normal University School of Postgraduate Liaoning University of Traditional Chinese Medicine The third school of Clinical Medicine of Peking University Ninhai Doubly Advanced Martial Co. Ltd. Department of Materials Science and Engineering University of Delaware

In this paper,2D asynchronous spectra generated by using the DAOSD approach was utilized to probe interactions between Nd^3＋ and pyridinium dissolved in aqueous solution.A series of cross peaks in the resultant 2D asynchronous spectrum confirms the occurrence of intermolecular interaction between Nd^3＋and pyridinium.However,no coordination occurs between Nd^3＋ and pyridinium.Interaction between πelectron from aromatic system and/electron from lanthanide ions account for the appearance of cross peaks in 2D asynchronous spectra.Because of the interaction,the emission spectrum of pyridinium exhibits a significant change when neodymium perchlorate was introduced into the system.

关键词： 2D asynchronous spectrum DAOSD Nd^3＋ Intermolecular interaction

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