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Azithromycin-containing versus standard triple therapy for Helicobacter pylori eradication:A meta-analysis

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World Journal of Gastroenterology 2009年第48期15卷 6102-6110页

作者： Jie Dong xiao-feng yu Jian Zou Deoartment of Gastroenterology Huadong Hospital Fudan University Shanghai 200040 China

AIM： To evaluate whether adding azithromycin to firstline Helicobacter pylori （H pylorl） eradication improved eradication and reduced side effects. METHODS： Eligible articles were identified by searches of electronic databases. We included all randomized trials that compared azithromycin-containing with standard triple-therapy regimens for first-line treatment of H pylori infection. Statistical analysis was performed with Review Manager 5.0.10. Sub-analyses were also performed. RESULTS： We identified 14 randomized trials （1431 patients）. Pooled Hpylori eradication rates were 72.01% （95% CI： 58.09%-85.93%） and 69.78% （95% CI： 66.47%-73.09%） for patients with or without azithromycin by intention-to-treat analysis, and the odds ratio （OR） was 1.17 （95% CI： 0.64-2.14）. The occurrence of side effects differed significantly and was 15.81% （95% CI： 12.50%-19.12%） and 25.20% （95% CI： 21.44%-28.96%） for treatment with or without azithromycin, respectively, and the summary OR was 0.58 （95% CI： 0.41-0.82）. Furthermore, the azithromycin-containing group had a lower occurrence of diarrhea, nausea and taste disturbance. CONCLUSION： Our review suggests that azithromycincontaining triple-therapy regimens could be equally effective in eradication of Hpylori compared with standard first-line triple-therapy regimens.

关键词： Azithromycin He/icobacter pylori Combination drug therapy Adverse effects

Implementation of Enterprises Interoperation Based on Ontology

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International Journal of Automation and computing 2010年第3期7卷 303-309页

作者： xiao-feng Di yu-Shun Fan Department of Automation Tsinghua University Beijing 100084 PRC

The interoperation among enterprises in e-business could block the ambient semantic collaboration and cause a big problem since varying information descriptions and different data models may be used in different enterprises＇ information systems. Ontology is an important tool to overcome the above mentioned syntax and semantic misunderstanding problem. Our goal is to provide a user-friendly environment supporting syntax and neutral format data model for business information. In this paper, two scenarios are discussed and a unified description of data model is developed to solve the gap in interoperation through mapping from logical data of enterprise＇s information system. It provides the methods to realize the mapping among different types of data or information. First, database and other types of information are transformed into neutral format that are described by web ontology language （OWL）. Second, the neutral format can be mapped into the semantic entities and semantic linking through the process of extraction and annotation and added into ontology and then described in a standard format that makes the collaboration be understood easily.

关键词： Interoperation semantic ontology mapping web ontology language (OWL).

Drying and preheating processes of iron ore pellets in a traveling grate

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 535-540页

作者： Jun-xiao feng yu Zhang Hai-wei Zheng xiao-yan Xie Cai Zhang School of Mechanical Engineering University of Science and Technology B~ijing Beijing 100083 China

A mathematical model of drying and preheating processes in a traveling grate was presented based on the laws of mass, momen- tum, heat transfer, and drying semiempirical relations. A field test was systematically carried out in a traveling grate. The effects of pellet diameter, moisture, grate velocity, and inlet gas temperature on the pellet bed temperature were studied. The average relative error between actual measurements and simulations is less than 7.97%, indicating the validity of the model.

关键词： iron ores pelletizing drying preheating numerical methods field test

Reliability evaluation of wireless sensor networks using an enhanced OBDD algorithm

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The Journal of China Universities of Posts and Telecommunications 2009年第5期16卷 62-70页

作者： xiao yu-feng CHEN Shan-zhi LI Xin LI yu-hong State Key Laboratory of Networking and Switching Beijing University of Posts and Telecommunications Beijing 100876 China State Key Laboratory of Wireless Mobile Communication China Academy of Telecommunications Technology Beijing 100083 China Information Engineering School Southwest University of Science and Technology Mianyang 621000 China

An enhanced ordered binary decision diagram （EOBDD） algorithm is proposed to evaluate the reliability of wireless sensor networks （WSNs）, based on the considerations of the common cause failure （CCF） and a large number of nodes in WSNs. The EOBDD algorithm analyzes the common cause event （CCE） and the network structure when CCE takes place according to the stochastic graph and the CCF model of WSNs. After constructing the ordered binary decision diagram （OBDD） of the original network with node expansion, it uses a set of OBDD variables （SOV） to guide reliability computations along this OBDD. The two steps about OBDD can decrease the cost of OBDD constructions and storage. Furthermore, the efficient OBDD structure and Hash tables can greatly decrease redundant computations of isomorphs. The experiment results show that the EOBDD can be used to evaluate the reliability of WSN efficiently.

关键词： network reliability ordered binary decision diagram wireless sensor networks common cause failure common cause event

Fish consumption and risk of gastrointestinal cancers:A meta-analysis of cohort studies

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World Journal of Gastroenterology 2014年第41期20卷 15398-15412页

作者： xiao-feng yu Jian Zou Jie Dong Department of Gastroenterology Huadong Hospital Fudan University

AIM: To assess quantitatively the relationship between fish intake and the incidence of gastrointestinal cancers in a meta-analysis of cohort studies.

关键词： Diet Cancer prevention Fish intake Gastrointestinal cancer

miR-93 suppresses proliferation and colony formation of human colon cancer stem cells

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World Journal of Gastroenterology 2011年第42期17卷 4711-4717页

作者： xiao-feng yu Jian Zou Zhi-Jun Bao Jie Dong Department of Gastroenterology Huadong Hospital Fudan University Shanghai 200040 China

AIM： TO identify differentially expressed microRNAs （miRNAs） in human colon cancer stem cells （SW1116csc） and study their function in SW1116csc proliferation. METHODS： SW1116csc were isolated from the human colon cancer cell line, SW1116 and cultured in serum- free medium. A miRNA microarray was used to detect differential expression profiles of rniRNAs in SW1116csc and SW1116 cells. Real-time quantitative polymerase chain reaction （PCR） was performed to verify the dif- ferential expression of candidate miRNAs obtained from the microarray. Target mRNAs of differentially expressed miRNAs were predicted with target predic- tion tools, miRNA expression plasmids were transfected into SW1116csc using Lipofectamine 2000 reagent. Cell proliferation curves were generated with trypan blue staining, and the colony formation rate of transfected cells was measured with the soft agar colony formation assay. Expression of target mRNAs and proteins from differentially expressed miRNAs were detected using reverse transcription （RT）-PCR and western ***： Compared with expression in SW1116 cells, 35 miRNAs （including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa- miR-32） were upregulated more than 1.5-fold, and 11 miRNAs （including hsa-miR-93, hsa-miR-1231, hsa- miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561） were downregulated in SW1116csc. The miRNA microarray results were further validated with quantitative RT-PCR. miR-93 was downregulated, and its predicted mRNA targets included BAMBI, CCND2, CDKNIA, HDACS, KIF23, MAP3K9, MAP3K11, MYCN, PPARD, TLE4 and ZDHHCl. Overexpressed miR-93 sig- nificantly inhibited cell proliferation and colony forma- tion by SW1116csc. Furthermore, miR-93 negatively regulated the mRNA and protein levels of HDAC8 and TLE4. CONCLUSION： Some miRNAs were differentially ex- pressed during differentiation of SW1116csc into SW1116 cells, miR-93 may inhibit SW1116csc proliferation and colony formation.

关键词： miR-93 Stem cell Colon cancer Expres-sion profile

Proteome of human colon cancer stem cells:A comparative analysis

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World Journal of Gastroenterology 2011年第10期17卷 1276-1285页

作者： Jian Zou xiao-feng yu Zhi-Jun Bao Jie Dong Department of Gastroenterology Huadong Hospital Fudan UniversityShanghai 200040 China

AIM： To isolate and identify the biological characteristics of human colon cancer stem cells （SW1116 cells） and further study their proteome. METHODS： SW1116 cells were isolated and cultured with a serum-free medium （SFM）. Sphere formation was assayed to observe the formation of colon cancer stem cell spheres. SW1116 cells were inoculated into a serum-containing medium for observing their differentiation characteristics. Proliferation curve and cross-resistance of SWl116 cells to different drugs were detected by MTT. Percentage of SP cells in SW1116 cells was detected with Hoechst33342 staining. Telomerase activity in SW1116cells was checked by polymerase chain reaction （PCR）-enzyme linked immunosorbent assay. Expressions of stem cell relevant genes and proteins were detected by reverse transcription-PCR and Western blot, respectively. Total protein was isolated from SW1116 cells by two-dimensional gel electrophoresis （2-DE） and differentially expressed proteins were identified by tandem mass spectrometry （MALDI-TOF/TOF）. RESULTS： The isolated SW1116 cells presented as spheroid and suspension growths in SFM with a strong self-renewal, proliferation, differentiation and drug-resistance ability. The percentage of SP cells in SW1116 cells was 38.9%. The SW1116 cells co-expressed the CD133 and CD29 proteins. The telomerase activity in SW1116 cells was increased. The expressions of different stem cell relevant genes and proteins were detected. The proteomic analysis showed that the 26 protein spots were differently expressed in SW1116 cells and 10 protein spots were identified as ubiquitin fusion- degradation l-like protein, nuclear chloride channel protein, tubulin 13, Raichu404X, stratifin, F-actin cap- ping protein α-1 subunit, eukaryotic translation elongation factor 1 delta isoform 2, hypothetical protein, glyceraldehyde-3-phosphate dehydrogenase and guanine nucleotide binding protein 13 polypeptide 2-like 1, respectively. CONCLUSION： SW1116 cells are biologically c

关键词： Proteome Stem cell Colon cancer Isola-tion Characterization

Thermal hydraulic and mechanical analysis of CH HCSB TBM

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核聚变与等离子体物理 2006年第3期26卷 181-185页

作者： WANG xiao-yu feng Kai-ming ZHANG Guo-shu yuAN Tao Southwestern Institute of Physics Chengdu 610041

Based on the structure design and results of neutronics analysis of the CH HCSB TBM (Chinese helium cooled solid breeder test blanket module), thermal hydraulic and mechanical analyses have been carried out. Results s... 详细信息

关键词：热水力分析中子物理学分析再生区热核反应

A meta-analysis of the effects of energy intake on risk of digestive cancers

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World Journal of Gastroenterology 2012年第48期18卷 7362-7370页

作者： xiao-feng yu Yi-Qian Wang Jian Zou Jie Dong Department of Gastroenterology Huadong HospitalFudan University

AIM:To quantitatively assess the relationship between energy intake and the incidence of digestive cancers in a meta-analysis of cohort ***:We searched MEDLINE,EMBASE,Science Citation Index Expanded,and the bibliographies of retrieved *** were included if they reported relative risks(RRs) and corresponding 95% CIs of digestive cancers with respect to total energy *** RRs were not available in the published article,they were computed from the exposure *** were extracted independently by two investigators and discrepancies were resolved by discussion with a third *** performed fixed-effects meta-analyses and meta-regressions to compute the summary RR for highest versus lowest category of energy intake and for per unit energy intake and digestive cancer incidence by giving each study-specific RR a weight that was proportional to its ***:Nineteen studies consisting of 13 independent cohorts met the inclusion *** studiesincluded 995 577 participants and 5620 incident cases of digestive cancer with an average follow-up of 11.1 years.A significant inverse association was observed between energy intake and the incidence of digestive *** RR of digestive cancers for the highest compared to the lowest caloric intake category was 0.90(95% CI 0.81-0.98,P 0.05) or pancreatic(RR 0.79,95% CI 0.49-1.09,P > 0.05) *** were also similar in studies from North America and *** RR was 1.02(95% CI 0.79-1.25,P > 0.05) when considering the six studies conducted in North America

关键词： Diet Cancer prevention Energy intake Digestive cancer