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International Journal of Ophthalmology(English edition) 2011年第1期4卷 78-80页

作者： Wei xiao xiao-fang liang and Jia-Jun Sun Department of Ophthalmology Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China

AIM: To observe the central corneal thickness (CCT) changes in infants and young children who had been undergone bilateral congenital cataract surgery, and to compare the changes with normal control group which was selected from healthy population. METHODS: A cross section case-control study contained 28 cases (56 eyes) of bilateral aphakia (aphakic group) due to congenital cataract surgery combining with posterior continuous curvilinear capsulorhexis and with anterior vitrectomy during 2-6 months after birth. Fourteen children (28 eyes) of age-sex matched with the aphalic group were selected as normal control group. CCT and intraocular pressure (TOP) were measured postoperatively and the results were compared between groups. RESULTS: The mean CCT was 653.5 +/- 82.4 mu m in the aphakic group and 579.6 +/- 39.2 mu m in the control group, with a significant difference (P=0.000). The mean value of TOP in aphakic group (22.0 +/- 1.6mmHg) was greater than that of control group (16.9 +/- 2.1mmHg), P=0.023. There was a negative correlation between age and CCT in normal control group (r=-0.531, P=0.026), and there was no correlation in bilateral aphakia group (r=-0.324, P=0.165). CONCLUSION: Aphakic children due to congenital cataract surgery have a greater CCT than normal children. It is necessary to consider CCT in evaluating IOP for children after congenital cataract surgery.

关键词： congenital cataract surgery aphaka central corneal thickness introcular pressure

The Ephemeral 10β-OH Trifluoromethanesulfonates of 7-Epi Paclitaxel Analogs─A New Example for Anchimeric Assistance

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Chinese Chemical Letters 1998年第1期9卷 29-33页

作者： Wei Shuo fang Qi Cheng fang and xiao Tian liang (Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 ) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

Two rearranged products, dienone 4 and 10-oxo product 5 were obtained upon attempted 10β-OSO2SO2CF3 formation from 3. The formation of compound 5 can be explained by anchimeric assistance of 7α-OH. Reduction of 4 ... 详细信息

关键词： rearrange anchimeric assistance neighboring group participation

Preliminary Studies on Acylation of 10β-OH and 7α-OH in 7-Epi-10-deacetylpaclitaxel

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Chinese Chemical Letters 1997年第10期8卷 847-848页

作者： Wei Shuo fang Qi Cheng fang and xiao Tian liang (Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College.Beijing 100050) CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

10β-OH can be acylated cleanly when 7α-OH is also free, and thus a facile access to semisynthesis of 7-epi-paclitaxel was proposed. A 2's, 3's-oxazoline paclitaxel analog was serendipitously synthesized

关键词： OH in 7-Epi-10-deacetylpaclitaxel TES Preliminary Studies on Acylation of 10

Multiplex gene editing reduces oxalate production in primary hyperoxaluria type 1

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Zoological Research 2023年第6期44卷 993-1002页

作者： Rui Zheng De-Xin Zhang Yan-Jiao Shao xiao-liang fang Lei Yang Ya-Nan Huo Da-Li Li Hong-Quan Geng Department of Pediatric Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Division of Pediatric Urology Children’s Hospital of Fudan UniversityShanghai 201102China

Targeting key enzymes that generate oxalate precursors or substrates is an alternative strategy to eliminate primary hyperoxaluria type I(PH1),the most common and lifethreatening type of primary *** compact Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)from the Prevotella and Francisella 1(Cpf1)protein simplifies multiplex gene editing and allows for all-in-one adeno-associated virus(AAV)*** hypothesized that the multiplex capabilities of the Cpf1system could help minimize oxalate formation in PH1 by simultaneously targeting the hepatic hydroxyacid oxidase 1(Hao1)and lactate dehydrogenase A(Ldha)*** cohorts included treated PH1 rats(Agxt Q84X rats injected with AAV-AsCpf1 at 7 days of age),phosphate-buffered saline(PBS)-injected PH1 rats,untreated PH1 rats,and age-matched wild-type(WT)*** most efficient and specific CRISPR RNA(crRNA)pairs targeting the rat Hao1and Ldha genes were initially screened ex *** vivo experiments demonstrated efficient genome editing of the Hao1 and Ldha genes,primarily resulting in small *** resulted in decreased transcription and translational expression of Hao1 and *** significantly reduced urine oxalate levels,reduced kidney damage,and alleviated nephrocalcinosis in rats with *** liver toxicity,ex-liver genome editing,or obvious offtarget effects were *** demonstrated the AAVAsCpf1 system can target multiple genes and rescue the pathogenic phenotype in PH1,serving as a proof-ofconcept for the development of multiplex genome editingbased gene therapy.

关键词： Hyperoxaluria Genome editing Lactate dehydrogenase Hydroxyacid oxidase 1

Oral everolimus inhibits intimal proliferation in injured carotid artery in rats

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Chinese Medical Journal 2013年第10期126卷 1906-1912页

作者： WANG xiao-fang SHEN De-liang ZHAO xiao-yan N1NG Hong-jie FENG Ri-sheng ZHANG Jin-ying Department of Cardiology First Affiliated Hospital College ofMedicine Zhengzhou University Zhengzhou Henan 450052 China

Background Everolimus, a derivative of sirolimus, is a potent immunosuppressant that has important anti-proliferative properties. In the present study, we demonstrated the inhibiting neointimal hyperplasia in injured carotid arteries in rats by using two different doses of everolimus administrated via the oral route for a long time. Methods A rat model of carotid artery injury was established by balloon inflation. Eighty rats were randomly divided into the sham-operated group （n=20）, injury group （n=20）, low dosage of everolimus group （n=20）, and high dosage of everolimus group （n=20）. The low close of everolimus （1.5 mg/kg） was given one day before injuring the carotid artery by balloon, followed by 0.75 mg/kg per day for 28 days via intragastric gavage. High dose everolimus （2.5 mg/kg） was given one day before injuring the carotid artery by balloon, followed by 1 mg/kg per day for 28 days. Expression of eukaryotic translation initiation factor 4E （elF-4E） and phosphorylation of ribosomal proteinS6 kinase 1 （P70S6K） were determined by reverse transcription-polymerase chain reaction and Western blotting analysis. Results In the injured carotid artery, neointimal hyperplasia was normally observed four weeks after injury. Everolimus inhibited neointimal hyperplasia after balloon injury in a dose dependent manner. At the same time, the study demonstrated that everolimus reduced the expression of P-P70S6K, elF-4E, transforming growth factor （TGF）-131 and of proliferating cell nuclear antigen （PCNA）. Conclusions Everolimus significantly inhibited neointimal hyperplasia of the injured carotid artery. The effect depended on dosaqe and was associated with the reduction of phosphorylation of P70S6K and the elF-4E expression level.

关键词： everolimus ribosomal protein S6 kinase 1, eukaryotic translation initiation factor 4E

不同覆盖度下丙硫醇在Au(111)面吸附的理论研究

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物理学报 2013年第22期62卷 120-128页

作者：冉润欣范晓丽杨永良方小亮西北工业大学凝崮技术国家重点实验室西安710072

采用基于密度泛函理论的第一性原理方法研究了丙烷硫醇(C3H7SH)在Au(111)面五种覆盖度(1/16,2/16,3/16,4/16,1/3)下的未解离和解离吸附的结构、能量和吸附性质.发现丙烷硫醇的倾斜角和吸附能均受覆盖度影响,计算结果显示丙烷硫醇的倾斜... 详细信息

采用基于密度泛函理论的第一性原理方法研究了丙烷硫醇(C3H7SH)在Au(111)面五种覆盖度(1/16,2/16,3/16,4/16,1/3)下的未解离和解离吸附的结构、能量和吸附性质.发现丙烷硫醇的倾斜角和吸附能均受覆盖度影响,计算结果显示丙烷硫醇的倾斜角随着覆盖度的增大减小了6—10,吸附能随覆盖度的增大减小了0.21 eV.特别针对饱和覆盖度,研究了三种可能的表面结构:(2√3×2√3)R30,2√3×3和(3×3).发现S—H键未解离时三种表面结构的吸附构型和吸附能基本一致;S—H键解离后,(2√3×2√3)R30和2√3×3结构的吸附能比以(3×3)结构的吸附能约高0.05—0.07 eV,说明C3H7S在Au(111)面吸附时,倾向于形成(2√3×2√3)R30和2√3×3结构.此外,采用DFT-D2方法对饱和覆盖度下C3H7SH分子在Au(111)面的吸附进行了范德华修正,结果显示分子间相互作用使吸附物和Au表面的距离减小,该相互作用对吸附能的修正值为0.53 eV,修正后结果与实验结果接近.

关键词：第一性原理覆盖度表面结构范德华力

An Arc Incision Surgical Approach in Congenital Megaprepuce

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Chinese Medical Journal 2015年第4期128卷 555-557页

作者： Hou-Wei Lin Ling Zhang Hong-Quan Geng xiao-liang fang Guo-Feng Xu Mao-Sheng Xu Wei Cai Department of Pediatric Urology Xinhua Hospital Shanghai 200092 China Department of Day Ward Renji Hospital Shanghai 200001 China

INTRODUCTION Congenital megaprepuce （CMP） is considered as a congenital penile malformation, which includes phimosis and severe ballooning of the redundant inner prepuce, conferring the typical aspect of concealed p... 详细信息

关键词： Foreskin Malformation Penis Reconstruction Surgical Technique

STUDIES ON THE SYNTHESIS OF BAIMUXINOL BY CATALYTIC HYDROGENATION OF DEHYDROBAIMUXINOL

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Chinese Chemical Letters 1992年第7期3卷 495-498页

作者： Qian LIU, Ji Yu GUO, Yah Qing XU, Hong Ju fang, xiao Tian liang Institute of Materia Medica, Chinese Academy of Medal Sciences, Beijing 100050

Baimuxinol, a 4-hydroxymethyl agarofuran isolated from Aquilaria Sinensis, was synthsizd. The stereoselectivity of catalytic hydrogenation of dehydrobaimuxino and its derivatives was studied.

关键词： STUDIES ON THE SYNTHESIS OF BAIMUXINOL BY CATALYTIC HYDROGENATION OF DEHYDROBAIMUXINOL

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铜基粉末冶金摩擦材料的应用及展望

粉末冶金技术 2020年第4期38卷 313-318页

作者：方小亮郑合静合肥波林新材料股份有限公司合肥230088

铜基粉末冶金摩擦材料以其在制动方面的优越性能获得了广泛地应用。本文阐述了铜基粉末冶金摩擦材料的使用要求,系统地介绍了铜基粉末冶金摩擦材料在飞机、高速列车、风力发电和汽车等领域的应用现状,并对铜基粉末冶金摩擦材料的未来发... 详细信息

铜基粉末冶金摩擦材料以其在制动方面的优越性能获得了广泛地应用。本文阐述了铜基粉末冶金摩擦材料的使用要求,系统地介绍了铜基粉末冶金摩擦材料在飞机、高速列车、风力发电和汽车等领域的应用现状,并对铜基粉末冶金摩擦材料的未来发展进行了展望,为铜基粉末冶金摩擦材料的进一步的发展提供参考。

关键词：铜基合金粉末冶金摩擦材料摩擦因数

Expression of EphB4 receptor in human prostate cancer and their relationship with tumor lymphangiogenesis and metastasis

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Expression of EphB4 receptor in human prostate cancer and th...