The Ephemeral 10β-OH Trifluoromethanesulfonates of 7-Epi Paclitaxel Analogs─A New Example for Anchimeric Assistance

作     者：Wei Shuo FANG Qi Cheng FANG and Xiao Tian LIANG (Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 ) 

作者机构：Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：1998年第9卷第1期

页      面：29-33页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：rearrange anchimeric assistance neighboring group participation 

摘      要：Two rearranged products, dienone 4 and 10-oxo product 5 were obtained upon attempted 10β-OSO2SO2CF3 formation from 3. The formation of compound 5 can be explained by anchimeric assistance of 7α-OH. Reduction of 4 yielding a 4-deacetyl product (12) also involves neighboring group participation.