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Exosomes as potential diagnosis and treatment for liver cancer

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 334-347页

作者： xiao-cui wei Li-Juan Liu Fan Zhu State Key Laboratory of Virology Hubei Province Key Laboratory of Allergy and ImmunologyDepartment of Pathogenic BiologySchool of MedicineWuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND Liver cancer is the fourth most significant cause of cancer-related *** of early diagnosis strategy and a scarcity of efficient therapy constitute the main reasons for its ***,which contain various bioactive molecules,are characterized by high biocompatibility,low immunogenicity,and high transport *** a result,exosomes have become a research hotspot and present significant potential for cancer diagnosis biomarkers,biotherapeutics,therapy targets,drug carriers and therapeutic *** To explore the potential of exosomes in the diagnosis and treatment of liver *** We conducted a systematic literature search via PubMed and Web of *** following keywords were used:"exosomal biomarkers","exosomal therapy","exosomal therapy",and"liver cancer"or"HCC".The duplicate data were deleted by EndNote *** search focused on full-texts and references of each article were carefully *** author(xiao-cui wei)screened the literature that met the following inclusion criteria:(1)Detection of exosomes or their contents in clinical samples(body fluid or tissue);or(2)Exosomes served as drug carriers or therapeutic *** authors(xiao-cui wei and Li-Juan Liu)independently reviewed all retained literature and analyzed the *** A total of 1295 studies were identified using the systematic literature *** these,835 duplicate studies were removed.A further 402 irrelevant studies were excluded due to being irrelevant,including other diseases,review articles,the literature containing neither clinical samples nor animal experiments,exosomeindependent studies,methods for detecting exosomes,or articles in ***,58 published papers were retained and analyzed in the *** showed a list of potential exosomal biomarkers that were upregulated in the blood samples of patients with liver *** downregulated in exosomes might serve as possible *** exosomes derived

关键词： Exosomes Liver cancer Biomarker Treatment Drug delivery system

Large Dimuon Asymmetry and a Non-Universal Z′ Boson in the Bs−Bs System

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Chinese Physics Letters 2011年第8期28卷 47-50页

作者： CHANG Qin WANG Ru-Min XU Yuan-Guo cui xiao-wei Department of Physics Henan Normal UniversityXinxiang 453007 Institute of Particle Physics Huazhong Normal UniversityWuhan 430079 College of Physics and Electronic Engineering Xinyang Normal UniversityXinyang 464000

Motivated by recently observed anomalously large dimuon charge asymmetry in neutral B decays reported by the D0 collaboration,we study the effects of a family of non-universal Z′bosons for possible *** fitting results for the Z′parameters are presented under the constraints from the D0 result for asls and UTfit results for CBs andφBs in two limiting scenarios for left−and right-handed b-s-Z′*** find the couplings BsbL and BsbR are rigorously bounded but not excluded,which means that the anomalies in the Bs−Bs system could be moderated simultaneously within a non-universal Z′***,a new weak phaseφLs∼−60°(−80°)in scenario I or∼30°(10°)in scenario II is crucial to moderate the large dimuon charge asymmetry.

关键词： rigorous limiting neutral

Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第48期27卷 8302-8322页

作者： xiao-cui wei Ya-Ru Xia Ping Zhou Xing Xue Shuang Ding Li-Juan Liu Fan Zhu State Key Laboratory of Virology Hubei Province Key Laboratory of Allergy and ImmunologyDepartment of Medical MicrobiologySchool of MedicineWuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common malignant *** association of hepatitis B virus(HBV)infection with HCC is hitherto *** miRNAs contribute to cancer progression and *** X protein has been known to modulate miRNAs that facilitate cell proliferation and the process of ***,there has been no report on hepatitis B core antigen(HBc)regulating exosomal miRNAs to induce drug resistance of HCC *** To elucidate the mechanism by which HBc promotes Doxorubicin hydrochloride(Dox)resistance in *** Exosomes were isolated by *** morphology and size of exosomes were evaluated by Dynamic Light Scattering(DLS)and transmission electron microscopy(TEM).The miRNAs differentially expressed in HCC were identified using The Cancer Genome Atlas(TCGA)*** level of miR-135a-5p in patient tissue samples was detected by quantitative polymerase chain *** and luciferase assay were used to predict and prove the target gene of ***,we identified the effects of miR-135a-5p on anti-apoptosis and the proliferation of HCC in the presence or absence of Dox using flow cytometry,Cell counting kit 8(CCK-8)assay and western *** We found that HBc increased the expression of exosomal *** analysis of bioinformatics and patient samples found that miR-135a-5p was increased in HCC tissues in comparison with paracancerous *** analysis and in vitro validation identified vesicle-associated membrane protein 2(VAMP2)as a novel target gene of *** assays showed that exosomal miR-135a-5p induced apoptosis protection,cell proliferation,and chemotherapy resistance in *** addition,the rescue experiment demonstrated that VAMP2 reversed apoptosis protection,cell growth,and drug resistance by ***,HBc promoted HCC anti-apoptosis,proliferation,and drug resistance and prevented Dox-i

关键词： Hepatocellular carcinoma Exosomes miR-135a-5p Anti-apoptosis Proliferation Chemoresistance

CPEB1,a novel risk gene in recent-onset schizophrenia,contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1

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World Journal of Psychiatry 2021年第11期11卷 1075-1094页

作者： Ya-Ru Xia xiao-cui wei Wen-Shi Li Qiu-Jin Yan Xiu-Lin Wu wei Yao Xu-Hang Li Fan Zhu State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy&Immunology Department of Medical MicrobiologySchool of MedicineWuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND Schizophrenia afflicts 1%of the world *** studies suggest that schizophrenia patients may have an imbalance of mitochondrial energy metabolism via inhibition of mitochondrial complex I ***,recent studies have shown that ERVWE1 is also a risk factor for ***,there is no available literature concerning the relationship between complex I deficits and ERVWE1 in *** risk factors and blood-based biomarkers for schizophrenia may provide new guidelines for early interventions and prevention *** To address novel potential risk factors and the underlying mechanisms of mitochondrial complex I deficiency caused by ERVWE1 in *** Quantitative polymerase chain reaction(qPCR)and enzyme-linked immunosorbent assay were used to detect differentially expressed risk factors in blood *** statistical analyses were performed by median analyses and Mann-Whitney U ***’s rank correlation was applied to examine the correlation between different risk factors in blood ***,western blot analysis,and luciferase assay were performed to confirm the relationship among ERVWE1,cytoplasmic polyadenylation element-binding protein 1(CPEB1),NADH dehydrogenase ubiquinone flavoprotein 2(NDUFV2),and NDUFV2 pseudogene(NDUFV2P1).The complex I enzyme activity microplate assay was carried out to evaluate the complex I activity induced by *** Herein,we reported decreasing levels of CPEB1 and NDUFV2 in schizophrenia *** studies showed that ERVWE1 was negatively correlated with CPEB1 and NDUFV2 in ***,NDUFV2P1 was increased and demonstrated a significant positive correlation with ERVWE1 and a negative correlation with NDUFV2 in *** vitro experiments disclosed that ERVWE1 suppressed NDUFV2 expression and promoter activity by increasing NDUFV2P1 *** luciferase assay revealed that ERVWE1 could enhance the promoter

关键词： ERVWE1 CPEB1 NADH dehydrogenase ubiquinone flavoprotein 2 complex I Pseudogene

Involvement of unusual noncovalent interactions in the self-assembly of cucurbit[6]uril with [CdCl_4]^(2-) anions

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Chinese Chemical Letters 2016年第1期27卷 173-177页

作者： xiao-wei cui Shi-Yan Chen Chuan-Zeng Wang Wen-Xuan Zhao Tao Sun Xin-Long Ni Yun-Qian Zhang Zhu Tao Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou University Key Laboratory of Guizhou High Performance Computational Chemistry Guizhou University

The [CdCl_4]^（2-） anion as a structure inducer has proved to be useful in the construction of cucurbit[n]urilmetal coordination architectures and materials. In order to better understand the role and influence of the structure inducer in Q[n] systems, we report herein the self-assembly of Q[6] solely in the presence of[CdCl_4]^（2-）anions and in the presence of both a linear cationic organic guest and [CdCl_4]^（2-）anions. X-ray diffraction analysis revealed that 1D Q[6] porous channels were formed by the noncovalent interactions between Q[6] and [CdCl_4]^（2-）anions, but the ＇＇honeycomb effect＇＇ was not observed in the present ***, it seems that the ＇＇honeycomb effect＇＇ and the self-assembly of Q[6] with [CdCl_4]^（2-）anions can be significantly modified and switched in the presence of a linear cationic dibutylamine guest through some unusual noncovalent interactions.

关键词： Cucurbituril [CdCl_4]^(2-) anions Cationic guest Honeycomb effect Assembly

Effects of PM2.5 Exposure in Different Air Quality Grades on Daily Outpatient Visits for Childhood Asthma in Shijiazhuang, China

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Biomedical and Environmental Sciences 2018年第12期31卷 888-892页

作者： FU Gui Qin JIANG Yan Feng LIU Lan Ping LIU Hua Yue ZHOU Ji cui xiao wei WANG Shi Gong Hebei Provincial Meteorology Service Center and Key Laboratory for Meteorology and Ecological Environment Shijiazhuang 050021 Hebei China Shanghai Key Laboratory of Meteorology and Health Shanghai 200135 China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai 200438 China Children's Hospital of Hebei Province Shijiazhuang 050021 Hebei China Laboratory of Sichuan Province for Plateau Atmosphere and Environment College of Atmospheric Sciences Chengdu University of Information Technology Chengdu 610225 Sichuan China

Asthma is a common chronic inflammatory disorder that is more prevalent in children than in *** has seen an increasing prevalence of childhood asthma in recentdecades[1].Earlier studies have shown that air particulate matter (PM),particularly fine particulate matter(PM2.5)[2],is an important factor triggering childhood asthma. Since nationalPM2.5data were nota vailabl euntil 2013,

关键词： Effects of PM China Exposure in Different Air Quality Grades on Daily Outpatient Visits for Childhood Asthma in Shijiazhuang

A Novel Variable Shifting Code for Test Compression of SoC

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Journal of Electronic Science and Technology of China 2009年第4期7卷 375-379页

作者： xiao-Le cui Liang Yin Jin-Xi Hong Ren-Fu Zuo xiao-Xin cui wei Cheng Key Lab of Integrated Microsystems Shenzhen Graduate School of Peking University Shenzhen 518055 China

The test vector compression is a key technique to reduce IC test time and cost since the explosion of the test data of system on chip （SoC） in recent years. To reduce the bandwidth requirement between the automatic test equipment （ATE） and the CUT （circuit under test） effectively, a novel VSPTIDR （variable shifting prefix-tail identifier reverse） code for test stimulus data compression is designed. The encoding scheme is defined and analyzed in detail, and the decoder is presented and discussed. While the probability of 0 bits in the test set is greater than 0.92, the compression ratio from VSPTIDR code is better than the frequency-directed run-length （FDR） code, which can be proved by theoretical analysis and experiments. And the on-chip area overhead of VSPTIDR decoder is about 15.75 % less than the FDR decoder.

关键词： FDR code run-length code test data compression VSPTIDR code.

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中等挥发分烟煤燃烧特性研究

煤炭科学技术 2015年第5期43卷 135-138 25,25页

作者：肖翠微煤炭科学技术研究院有限公司北京100013 煤炭资源高效开采与洁净利用国家重点实验室北京100013 国家能源煤炭高效利用与节能减排技术装备重点实验室北京100013

为了明确中等挥发分烟煤的燃烧特性,利用热重分析方法对挥发分含量20%~30%的6种煤样进行热重试验,得出样品的特性参数,并根据特性参数对煤的挥发分析出指数、燃烧特性指数、燃尽特性指数进行计算。结果表明:随着挥发分含量的提高,热失... 详细信息

为了明确中等挥发分烟煤的燃烧特性,利用热重分析方法对挥发分含量20%~30%的6种煤样进行热重试验,得出样品的特性参数,并根据特性参数对煤的挥发分析出指数、燃烧特性指数、燃尽特性指数进行计算。结果表明:随着挥发分含量的提高,热失重曲线向低温方向移动,相应特征温度(着火温度、最大反应速率对应的温度、燃尽温度)随挥发分的提高而降低;煤的挥发分析出特性指数D、燃烧特性指数S、燃尽特性指数FZ可较好地反映煤的着火特性、燃烧综合特性及燃尽特性,试验煤种挥发分范围内D、S、FZ分别为(3.11~3.69)×10-5、(0.93~1.25)×10-7、2.89~5.12,且随着挥发分的增高均有增大的趋势,并可反映出其他因素的影响。

关键词：烟煤燃烧特性燃尽特性热重分析特征温度

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基于稀疏故障假设的鲁棒定位方法

浙江大学学报（工学版） 2015年第10期49卷 1924-1928页

作者：张鑫崔晓伟冯振明清华大学电子工程系北京100084

为了使接收机在多个故障伪距存在时能够提供鲁棒的定位结果,提出基于稀疏假设的故障检测与排除算法.该方法利用定位解算残差与伪距误差之间的映射关系,通过对故障观测量的个数进行稀疏约束,使用稀疏算法直接求解所有观测量的伪距误差.... 详细信息

为了使接收机在多个故障伪距存在时能够提供鲁棒的定位结果,提出基于稀疏假设的故障检测与排除算法.该方法利用定位解算残差与伪距误差之间的映射关系,通过对故障观测量的个数进行稀疏约束,使用稀疏算法直接求解所有观测量的伪距误差.利用伪距误差计算结果修正初始的定位结果,实现鲁棒定位.在不同的可见卫星数和不同的故障卫星数下进行仿真.仿真结果表明,当可见卫星数量较多时,使用该算法能够对多个故障观测量进行有效的检测,提升定位结果的准确性.

关键词：多星故障故障检测稀疏约束鲁棒定位