Exosomes as potential diagnosis and treatment for liver cancer
作者机构：State Key Laboratory of VirologyHubei Province Key Laboratory of Allergy and ImmunologyDepartment of Pathogenic BiologySchool of MedicineWuhan UniversityWuhan 430071Hubei ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2022年第14卷第1期
页 面：334-347页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China,No.81971943 and No.81772196 the Medical Science Advancement Program(Clinical Medicine)of Wuhan University,No.TFLC 2018003
主 题：Exosomes Liver cancer Biomarker Treatment Drug delivery system
摘 要：BACKGROUND Liver cancer is the fourth most significant cause of cancer-related *** of early diagnosis strategy and a scarcity of efficient therapy constitute the main reasons for its ***,which contain various bioactive molecules,are characterized by high biocompatibility,low immunogenicity,and high transport *** a result,exosomes have become a research hotspot and present significant potential for cancer diagnosis biomarkers,biotherapeutics,therapy targets,drug carriers and therapeutic *** To explore the potential of exosomes in the diagnosis and treatment of liver *** We conducted a systematic literature search via PubMed and Web of *** following keywords were used:exosomal biomarkers,exosomal therapy,exosomal therapy,andliver cancerorHCC.The duplicate data were deleted by EndNote *** search focused on full-texts and references of each article were carefully *** author(Xiao-Cui Wei)screened the literature that met the following inclusion criteria:(1)Detection of exosomes or their contents in clinical samples(body fluid or tissue);or(2)Exosomes served as drug carriers or therapeutic *** authors(Xiao-Cui Wei and Li-Juan Liu)independently reviewed all retained literature and analyzed the *** A total of 1295 studies were identified using the systematic literature *** these,835 duplicate studies were removed.A further 402 irrelevant studies were excluded due to being irrelevant,including other diseases,review articles,the literature containing neither clinical samples nor animal experiments,exosomeindependent studies,methods for detecting exosomes,or articles in ***,58 published papers were retained and analyzed in the *** showed a list of potential exosomal biomarkers that were upregulated in the blood samples of patients with liver *** downregulated in exosomes might serve as possible *** exosomes derived
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