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Maternal resveratrol improves the intestinal health and weight gain of suckling piglets during high summer temperatures: The involvement of exosome-derived microRNAs and immunoglobin in colostrum

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Animal Nutrition 2024年第2期17卷 36-48页

作者： Changming Hong Yujian Huang Guan Yang xiaolu Wen Li Wang Xuefen Yang Kaiguo Gao Zongyong Jiang hao xiao State Key Laboratory of Swine and Poultry Breeding Industry Institute of Animal ScienceGuangdong Academy of Agricultural Sciences Key Laboratory of Animal Nutrition and Feed Science in South China Ministry of Agriculture and Rural AffairsGuangdong Public Laboratory of Animal Breeding and Nutrition Guangdong Provincial Key Laboratory of Animal Nutrition Control Institute of Subtropical Animal Nutrition and FeedCollege of Animal ScienceSouth China Agricultural University Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong Kong

Previous studies have shown that maternal resveratrol improved growth performance and altered the microbial composition of suckling piglets under hot summer conditions. However, it remains unclear how maternal resveratrol improves growth performance of suckling piglets during high summer temperatures. A total of 2. sows(Landrace × Large White; three parity) were randomly assigned to 2.groups(with or without 300 mg/kg resveratrol) from d 75 of gestation to d 2. of lactation during high ambient temperatures(from 2. to 30℃). The results showed that maternal resveratrol supplementation increased total daily weight gain of piglets under hot summer conditions, which is consistent with previous studies. Furthermore, we found that maternal resveratrol improved the intestinal morphology and intestinal epithelial proliferation in suckling piglets. Dietary resveratrol supplementation affected the characteristics of exosome-derived microRNAs(miRNAs) in sow colostrum, as well as the genes targeted by differentially produced miRNAs. MiRNAs are concentrated in the tight junction pathway. As a result, the expression of intestinal tight junction proteins was increased in suckling piglets(P < 0.05).Notably, maternal resveratrol increased the intestinal secretory immunoglobulin A(sIgA) levels of suckling piglets via colostrum immunoglobin(P < 0.05), which could increase the abundance of beneficial microbiota to further increase the concentration of short chain fatty acids(SCFA) in suckling piglets' intestine(P < 0.05). Finally, our correlation analysis further demonstrated the positive associations between significantly differential intestinal microbiota, intestinal sIgA production and SCFA concentrations,as well as the positive relation between total daily weight gain and intestinal health of suckling *** together, our findings suggested that maternal resveratrol could promote intestinal health to improve piglet growth during high summer temperatures, which might be associa

关键词： Colostrum Exosome Immunoglobulin Intestinal health Resveratrol

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Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 896-903页

作者： Dan-Qi Fang Da-Wei Yang xiao-Ting Mai Carol Y Cheung hao-Yu Chen Joint Shantou International Eye Center Shantou University&the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology and Visual Sciences Chinese University of Hong KongHong Kong 999077China

AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy ***:Thir ty-three healthy subjects were *** ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning *** of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were *** repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman ***:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.2.%to 6.2.%for circumpapillary vessel ***:OCTA ONH parameters demonstrate good repeatability in healthy *** interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.

关键词： interocular correlation repeatability optic nerve head optical coherence tomography angiography vessel density

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Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?

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Journal of Animal Science and Biotechnology 2024年第2期15卷 519-534页

作者： Changming Hong Yujian Huang Shuting Cao Li Wang Xuefen Yang Shenglan Hu Kaiguo Gao Zongyong Jiang hao xiao State Key Laboratory of Swine and Poultry Breeding Industry Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South ChinaGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouChina Institute of Animal Science Guangdong Academy of Agricultural Sciences1 Dafeng 1st StreetGuangzhou 510640China

Oxidative stress has been associated with a number of physiological problems in swine,including reduced production ***,although there has been increased research into regulatory mechanisms and antioxidant strategies in relation to oxidative stress-induced pig production,it remains so far largely unsuccessful to develop accurate models and nutritional strategies for specific oxidative stress ***,we discuss the dose and dose intensity of the causes of oxidative stress involving physiological,environmental and dietary factors,recent research models and the antioxidant strategies to provide theoretical guidance for future oxidative stress research in swine.

关键词： Accurate models Dose Nutritional strategies Oxidative stress Swine

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Neuroprotective effects of acteoside in a glaucoma mouse model by targeting Serta domain-containing protein 4

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 625-637页

作者： Hui-Jie hao Ya-Hong Li Bo Yu Xun Liu Yan Zhang xiao-Li Xing Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

AIM:To explore the therapeutic effect and main molecular mechanisms of acteoside in a glaucoma model in DBA/2. ***:Proteomics was used to compare the differentially expressed proteins of C57 and DBA/2. *** acteoside administration in DBA/2. mice,anterior segment observation,intraocular pressure(IOP)monitoring,electrophysiology examination,and hematoxylin and eosin staining were used to analyze any potential ***(IHC)assays were used to verify the proteomics ***,retinal ganglion cell 5(RGC5)cell proliferation was assessed with cell counting kit-8(CCK-8)*** domain-containing protein 4(Sertad4)mRNA and protein expression levels were measured by qRT-PCR and Western blot analysis,***:Proteomics analysis suggested that Sertad4 was the most significantly differentially expressed *** with the saline group,the acteoside treatment group showed decreased IOP,improved N1-P1 wave amplitudes,thicker retina,and larger numbers of cells in the ganglion cell layer(GCL).The IHC results showed that Sertad4 expression levels in DBA/2. mice treated with acteoside were significantly lower than in the saline *** treatment could improve RGC5 cell survival and reduce the Sertad4 mRNA and protein expression levels after glutamate ***:Sertad4 is differentially expressed in DBA/2. *** can protect RGCs from damage,possibly through the downregulation of Sertad4,and has a potential use in glaucoma treatment.

关键词： glaucoma acteoside Serta domaincontaining protein 4 proteomics mice

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MoS2.as a cocatalyst applied in advanced oxidation processes for enhancing degradation of organic pollutants: a review

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Tungsten 2024年第3期6卷 473-487页

作者： Ming-hao Fan Cong-Hui Wang Xiang Yu Jun Ding Ao-Qi xiao Yue Li Wei-Ya Huang School of Material Science and Engineering Henan Polytechnic University School of Chemical and Printing-Dyeing Engineering Henan International Joint Laboratory of Rare Earth Composite Materials Henan University of Engineering School of Chemistry and Chemical Engineering Jiangxi University of Science and Technology Department of Chemical and Environmental Engineering University of Cincinnati

Fenton technology,as a typical advanced oxidation processes（AOPs）,can generate reactive oxygen species（ROS） of strong oxidation capacity to degrade organic pollutants,which has attracted wide ***,it is accompanied by the slow Fe3+/Fe2.cycle rate,easy to generate iron sludge and so ***,it has been proven that the inorganic cocatalysts represented by MoS2.an effectively solve the above ***,MoS2.an accelerate the activation of peroxy mono sulfate（PMS） and peroxodisulfate（PDS） by Fe2..In this paper,MoS2.s the cocatalyst in H2.2.Fe2.,PMS+Fe2.and PDS+Fe2.were comprehensively ***,the cycling processes of Fe3+/Fe2.in different systems,the cocatalytic effect of MoS2.y the exposed active sites,the ROS generation mechanism as well as the microscopic mechanism during the reaction were elaborated *** results indicate that the reductive active sites on the surface of MoS2.an promote the regeneration of Fe2.through the cycle between Fe3+/Fe2.and Mo4+/Mo5+/Mo6+.Thus,ROS such as ·OH,SO4·-and1O2.ith strong oxidizing property can be produced to improve the degradation efficiency of organic *** last,the challenges and developments of MoS2.ocatalysts in AOPs for practical applications were *** review contributes to a deeper understanding of the cocatalytic effect of two-dimensional metal sulfides in AOPs and facilitates their industrial application.

关键词： Cocatalyst Fenton reaction Degradation of organic pollutant Molybdenum disufide Reactive oxygen species

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ATP6AP2.a regulator of LRP6/β-catenin protein trafficking,promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner

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Bone Research 2024年第2期12卷 453-468页

作者： Lei Xiong hao-Han Guo Jin-Xiu Pan xiao Ren Daehoon Lee Li Chen Lin Mei Wen-Cheng Xiong Department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Louis Stoke VA Medical Center ClevelandOH 44106USA

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,including osteoblast(OB)differentiation and *** how Wnt/β-catenin signaling is regulated in OBs remain ***6AP2.an accessory subunit of V-ATPase,plays important roles in multiple cell types/organs and multiple signaling ***,little is known whether and how ATP6AP2.in OBs regulates Wnt/β-catenin signaling and bone *** we provide evidence for ATP6AP2.in the OB-lineage cells to promote OB-mediated bone formation and bone homeostasis selectively in the trabecular bone *** knocking out(CKO)ATP6AP2.in the OB-lineage cells(Atp6ap2.(Ocn-Cre))reduced trabecular,but not cortical,bone formation and bone *** and cellular biochemical studies revealed that LRP6 and N-cadherin were reduced in ATP6AP2.KO BMSCs and OBs,but not *** in vitro and in vivo studies revealed impairedβ-catenin signaling in ATP6AP2.KO BMSCs and OBs,but not osteocytes,under both basal and Wnt stimulated conditions,although LRP5 was decreased in ATP6AP2.KO osteocytes,but not *** cell biological studies uncovered that osteoblastic ATP6AP2.is not required for Wnt3a suppression ofβ-catenin phosphorylation,but necessary for LRP6/β-catenin and N-cadherin/β-catenin protein complex distribution at the cell membrane,thus preventing their *** of activeβ-catenin diminished the OB differentiation deficit in ATP6AP2.KO *** together,these results support the view for ATP6AP2.as a critical regulator of both LRP6 and N-cadherin protein trafficking and stability,and thus regulatingβ-catenin levels,demonstrating an un-recognized function of osteoblastic ATP6AP2.in promoting Wnt/LRP6/β-catenin signaling and trabecular bone formation.

关键词： LRP6 impaired organs

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Fast X-ray imaging beamline at SSRF

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Nuclear Science and Techniques 2024年第9期35卷 68-81页

作者： Ke Li Hong-Lan Xie Ya-Nan Fu Fei-Xiang Wang Guo-hao Du Jian-Feng ji Biao Deng Ti-Qiao xiao Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

The fast X-ray imaging beamline(BL16U2.at Shanghai Synchrotron Radiation Facility(SSRF)is a new beamline that provides X-ray micro-imaging capabilities across a wide range of time scales,spanning from 100 ps toμs and *** beamline has been specifically designed to facilitate the investigation of a wide range of rapid phenomena,such as the deformation and failure of materials subjected to intense dynamic *** addition,it enables the study of high-pressure and high-speed fuel spray processes in automotive *** light source of this beamline is a cryogenic permanent magnet undulator(CPMU)that is cooled by liquid *** CPMU can generate X-ray photons within an energy range of 8.7-30 *** beamline offers two modes of operation:monochromatic beam mode with a liquid nitrogen-cooled double-crystal monochromator(DCM)and pink beam mode with the first crystal of the DCM out of the beam *** X-ray imaging methods were implemented in BL16U2.single-pulse ultrafast X-ray imaging,microsecond-resolved X-ray dynamic imaging,millisecond-resolved X-ray dynamic micro-CT,and high-resolution quantitative ***,BL16U2.is equipped with various in situ impact loading systems,such as a split Hopkinson bar system,light gas gun,and fuel spray *** the completion of the final commissioning in 2.2. and subsequent trial operations in 2.2.,the beamline has been officially available to users from 2.2..

关键词： Multiple time-scale X ray imaging Single-pulse X ray imaging Dynamic 2. imaging Dynamic micro-CT

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Symmetry breaking of highly symmetrical nanoclusters for triggering highly optical activity

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Fundamental Research 2024年第1期4卷 63-68页

作者： xiao Wei hao Li Honglei Shen Chuanjun Zhou Shuxin Wang Xi Kang Manzhou Zhu Department of Chemistry and Centre for Atomic Engineering of Advanced Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials.Anhui UniversityHefei 230601China

Developing new approaches to fulfill the enantioseparation of nanocluster racemates and construct cluster-based nanomaterials with optical activity remains highly desired in cluster science,because it is an essential prerequisite for fundamental research and extensive applications of these *** herein propose a strategy termed“active-site exposing and partly re-protecting”to trigger the symmetry breaking of highly symmetrical nanoclusters and to render cluster crystals optically *** vertex PPh_(3)of the symmetrical Ag_(2.)(SSR)_(12.(PPh_(3))_(4)(SSR=1,3-benzenedithiol)nanocluster was firstly dissociated in the presence of counterions with large steric hindrance,and then the exposed Ag active sites of the obtained Ag_(2.)(SSR)_(12.nanocluster were partly re-protected by Ag^(+),yielding an Ag_(2.)(SSR)_(12.-Ag_(2.nanocluster with a symmetry-breaking ***_(2.)(SSR)_(12.-Ag_(2.followed a chiral crystallization mode,and its crystal displayed strong optical activity,derived from CD and CPL ***,this work presents a new approach(i.e.,active-site exposing and partly re-protecting)for the symmetry breaking of highly symmetrical nanoclusters,the enantioseparation of nanocluster racemates,and the achievement of highly optical activity.

关键词： Atomically precise nanocluster Symmetry breaking Enantioseparation Circularly polarized luminescent Photoluminescence

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Enhancing thermoelectric performance of p-type SnTe through manipulating energy band structures and decreasing electronic thermal conductivity

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Rare Metals 2024年第7期43卷 3232-3241页

作者： Xin Qian hao-Ran Guo Jia-Xin Lyu Bang-Fu Ding Xing-Yuan San xiao Zhang Jiang-Long Wang Shu-Fang Wang Hebei Key Lab of Optic-Electronic Information and Materials College of Physics Science and TechnologyHebei UniversityBaoding 071002China College of Electron and Information Engineering Hebei UniversityBaoding 071002China Research Institute for Frontier Science Beihang UniversityBeijing100191China

SnTe has received considerable attention as an environmentally friendly alternative to the representative thermoelectric material of ***,excessive hole carrier concentration in SnTe results in an extremely low Seebeck coefficient and high thermal conductivity,which makes it exhibit relatively inferior thermoelectric *** this work,the thermoelectric performance of p-type SnTe is enhanced through regulating its energy band structures and reducing its electronic thermal conductivity by combining Bi doping with CdSe ***,the carrier concentration of SnTe is successfully suppressed via Bi doping,which significantly decreases the electronic thermal ***,the convergence and flattening of the valence bands by alloying CdSe effectively improves the effective mass of SnTe while restraining its carrier ***,a maximum figure of merit(ZT) of~ 0.87 at 82. K and an average ZT of~ 0.51 at 300-82. K have been achieved in Sn_(0.96)Bi_(0.04)Te-5%*** results indicate that decreasing the electronic thermal conductivity is an effective means of improving the performance of thermoelectric materials with a high carrier concentration.

关键词： Thermoelectric materials SnTe Energy band structure Electronic thermal conductivity ZT value

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New insights in nano-copper chromite catalyzing ultrafine AP:Evaluation of dispersity and mixing uniformity

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Defence Technology（防务技术） 2024年第2期32卷 120-133页

作者： Yong Kou Peng Luo Lei xiao Yanping Xin Guangpu Zhang Yubing Hu Junqing Yang Hongxu Gao Fengqi Zhao Wei Jiang Gazi hao National Special Superfine Powder Engineering Research Center of China School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing210094China Xi'an North Huian Chemical Industry Co.Ltd Xi'an710302China Xi'an Modern Chemistry Research Institute Xi'an710065China

Improving the application of nanomaterials has always been a research hotspot in the field of energetic materials(EMs)due to their obvious catalytic effect on the EMs,especially the uniformly dispersed ***,few studies have reported the dispersion of *** this study,the dispersity and mixing uniformity of nano-CuCr_(2.O_(4)was evaluated based on the difference of solid UV light absorption between the nano-catalytic materials and *** nano-CuCr_(2.O_(4)/ultrafine AP composites with different dispersity of nano-CuCr_(2.O_(4)were prepared by manual grinding and mechanical grinding with different grinding strength and griding *** then,the absorbance of different samples at 2.2.nm was obtained by solid UV testing due to the high repeatability of the absorbance at 2.0-2.4 nm for three parallel experiments,and the dispersity of different samples was calculated through the established difference ***,the samples were characterized by XRD,IR,SEM,EDS,DSC and TG-MS,which confirmed that different mixing methods did not change the structure of the samples(XRD and IR),and the mixing uniformity improved with the increase of grinding strength and grinding time(SEM and EDS).The scientificity and feasibility of the difference equation were further verified by *** dispersity of nano-CuCr_(2.O_(4)exhibits a positive intrinsic relationship with its catalytic performance,and the uniformly dispersed nano-CuCr_(2.O_(4)significantly reduces the thermal decomposition temperature of ultrafine AP from 367.7 to 338.8℃.The TG-MS patterns show that the dispersed nano-CuCr_(2.O_(4)advanced the thermal decomposition process of ultrafine AP by about 700 s,especially in the high temperature decomposition stage,and the more concentrated energy release characteristic is beneficial to further enhance the energy performance of AP-based *** above conclusions show that the evaluation method of dispersity based on solid UV curves could pro

关键词： Nano-CuCr_(2.O_(4) Ultrafine AP Dispersity UVeVis diffuse reflectance spectroscopy Thermal decomposition

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