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Investigation on the temperature distribution and strength of flat steel ribbon wound cryogenic high-pressure vessel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 210-215页

作者： cui xiao-long CHEN Guang-ming Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China

By analyzing heat transfer on the wall of fiat steel ribbon wound vessel （FSRWV）, a numerical model of temperature distribution on the entire wall （including inner core wall, flat steel ribbons, outside cylinder of jacket and insulating layer） was established by the authors. With the model, the temperature distribution and the length change in the vessel walls and flat steel ribbons in low temperature are calculated and analyzed. The results show that the flat steel ribbon wound cryogenic high-pressure vessel is simpler in structure, safer and easier to manufacture than those of conventional ones.

关键词： Cryogenic high-pressure vessel Flat steel ribbon wound vessel (FSRWV) Temperature distribution Numerical simulation

SPT6L Encoding a Putative WG/GW-Repeat Protein Regulates Apical-Basal Polarity of Embryo in Arabidopsis

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Molecular Plant 2012年第1期5卷 249-259页

作者： xiao-Lu Gu Hua Wang Hai Huang xiao-Feng cui National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChineseAcademy of Sciences300 Fenglin RoadShanghai 200032China

In eukaryotes, a protein motif consisting of WG/GW repeats, also called the Argonaute （AGO） hook, is thought to be essential for binding AGO proteins to fulfill their functions in RNA-mediated gene silencing. Although a number of WG/GW-containing proteins have been computationally identified in Arabidopsis, their roles in plant growth and development are unknown. Here, we show that the Arabidopsis Suppressor of Ty insertion 6-like （SPT6L） gene, which encodes a protein with C-terminal WG/GW repeats, plays critical roles in embryonic development. SPT6L is evolutionarily conserved only in vascular plants, with varying numbers of C-terminal WG/GW repeats, which are plant-species specific. spt61 mutants formed embryos with an aberrant apical-basal axis, showing insufficient development of the basal domain and embryonic lethality. Expression domains of the class-Ill homeodomain-leucine zipper （HD-ZIP III） genes PHABULOSA （PHB） and PHAVOLUTA （PHV） were expanded in the spt61 embryo. In contrast, the PLETHORA1 （PLT1） gene, which acts antagonistically to the HD-ZIP III genes in specification of basal fate, was severely down-regulated in the spt61 mutant. Furthermore, the phb phv double mutations partially rescued aberrant basal development in the spt61 background and restored PLT1 expression. Collectively, our results indicate that SPT6L is essential for specification of the apical-basal axis, partly by controlling the HD-ZIP III genes in embryos.

关键词： Arabidopsis embryo HD-ZIP ill polarity SPT6L.

First synthesis of (±)-cedarmycin B

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Chinese Chemical Letters 2009年第9期20卷 1023-1024页

作者： Hai Shen Yang xiao xiao Qiao Qing cui xiao Hua Xu State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China

The synthesis of racemic cedannycin B, an antibiotic from Streptomyces sp. TP-A0456 was achieved firstly from γ- butyrolactone. The key step was a Barbier-type addition of 3-bromomethyl-5H-furan-2-one to formaldehyde mediated by zinc, which afforded the sole γ-addition product 4-hydroxymethyl-3-methylene-dihydrofuran-2-one. The final compound was confirmed by 1H NMR, 13C NMR and HRMS. 2009 xiao Hua Xu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Cedarrnycin B Antibiotic Streptomyces sp. Barbier reaction 3-Bromomethyl-5H-furan-2-one

Electroactive Shape Memory Cyanate/Polybutadiene Epoxy Composites Filled with Carbon Black

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Chinese Journal of Polymer Science 2016年第4期34卷 466-474页

作者： Kun Wang 朱光明 xiao-gang Yan Fang Ren xiao-ping cui Department of Applied Chemistry Northwestern Polytechnical UniversityXi'an 710129China

Electroactive shape memory composites were synthesized using polybutadiene epoxy （PBEP） and bisphenol A type cyanate ester （BACE） filled with different contents of carbon black （CB）. Dynamic mechanical analysis （DMA）, scanning electron microscopy （SEM）, electrical performance and electroactive shape memory behavior were systematically investigated. It is found that the volume resistivity decreased due to excellent electrical conductivity of CB, in turn resulting in good electroactive shape memory properties. The content of CB and applied voltage had significant influence on electroactive shape memory effect of developed BACE/PBEP/CB composites. Shape recovery can be observed within a few seconds with the CB content of 5 wt% and voltage of 60 V. Shape recovery time decreased with increasing content of CB and voltage. The infrared thermometer revealed that the temperature rises above the glass transition temperature faster with the increase of voltage and the decrease of resistance.

关键词： Electroactive shape memory behaviors Cyanate ester Carbon black Electrical performance.

Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus

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World Journal of Clinical Cases 2022年第20期10卷 6900-6914页

作者： xiao-Yan cui xiao Wu Dan Lu Dan Wang Hebei Institute for Drug and Medical Device Control Shijiazhuang 050011Hebei ProvinceChina Department of Basic Medical HE’s UniversityShenyang 110163Liaoning ProvinceChina College of Clinical HE’s UniversityShenyang 110163Liaoning ProvinceChina College of Human Kinesiology Shenyang Sport UniversityShenyang 110102Liaoning ProvinceChina

BACKGROUND A comprehensive literature search shows that Sanqi and Huangjing(SQHJ)can improve diabetes treatment in vivo and in vitro,***,the combined effects of SQHJ on diabetes mellitus(DM)are still *** To explore the potential mechanism of Panax notoginseng(Sanqi in Chinese)and Polygonati Rhizoma(Huangjing in Chinese)for the treatment of DM using network *** The active components of SQHJ and targets were predicted and screened by network pharmacology through oral bioavailability and drug-likeness filtration using the Traditional Chinese Medicine Systems Pharmacology Analysis Platform *** potential targets for the treatment of DM were identified according to the DisGeNET database.A comparative analysis was performed to investigate the overlapping genes between active component targets and DM treatmentrelated *** constructed networks of the active component-target and target pathways of SQHJ using Cytoscape software and then analyzed the gene *** the STRING database to perform an interaction analysis among overlapping genes and a topological analysis,the interactions between potential targets were *** Ontology(GO)function analyses and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted in *** We screened 18 active components from 157 SQHJ components,187 potential targets for active components and 115 overlapping genes for active components and *** network pharmacology analysis revealed that quercetin,beta-sitosterol,baicalein,*** the major active *** mechanism underlying the SQHJ intervention effects in DM may involve nine core targets(TP53,AKT1,CASP3,TNF,interleukin-6,PTGS2,MMP9,JUN,and MAPK1).The screening and enrichment analysis revealed that the treatment of DM using SQHJ primarily involved 16 GO enriched terms and 13 related *** SQHJ treatment for DM targets TP53,AKT1,CASP3,and TNF and participates in pathways in

关键词： Panax notoginseng(Sanqi in Chinese) Polygonati Rhizoma(Huangjing in Chinese) Diabetes mellitus Active compounds Network pharmacology Hub genes

Protective Effects of Berberine on Nonalcoholic Fatty Liver Disease in db/db Mice via AMPK/SIRT1 Pathway Activation

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Current Medical Science 2024年第5期44卷 902-911页

作者： Cheng CHEN xiao-cui LIU Bin DENG Jingzhou Hospital Affiliated to Yangtze University Jingzhou434020China Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming650201China University of Chinese Academy of Sciences Beijing100049China

Objective Berberine(BBR)has emerged as a promising therapeutic agent for nonalcoholic fatty liver disease(NAFLD).This study aims to elucidate the underlying molecular *** In this study,db/db mice were chosen as an animal model for NAFLD.A total of 10 healthy C57BL/6J mice and 30 db/db mice were randomly allocated to one of 4 groups:the normal control(NC)group,the diabetic control(DC)group,the Metformin(MET)therapy group,and the BBR therapy *** total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-c),high-density lipoprotein cholesterol(HDL-c),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)levels in the serum were *** glutathione peroxidase(GSH-Px),glutathione(GSH),malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT),interleukin(IL)-1β,tumor necrosis factor(TNF)-αand monocyte chemotactic protein 1(MCP-1)levels in liver tissue were *** and eosin(H&E),acid-Schiff(PAS)and TUNEL stanning was performed for histopathological *** blotting and immunohistochemistry were conducted to detect the expression levels of key proteins in the AMPK/SIRT1 *** BBR could improve lipid metabolism,attenuate hepatic steatosis and alleviate liver injury *** excessive oxidative stress,high levels of inflammation and abnormal apoptosis in db/db mice were reversed after BBR *** clearly changed the expression of AMP-activated protein kinase(AMPK)/Sirtuin 1(SIRT1),and their downstream *** BBR could reverse NAFLD-related liver injury,likely by activating the AMPK/SIRT1 signaling pathway to inhibit oxidative stress,inflammation and apoptosis in hepatic tissue.

关键词： nonalcoholic fatty liver disease berberine inflammation oxidative stress apoptosis

Delayed onset and fast rise of prompt optical-UV emission from gamma-ray bursts in molecular clouds

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Research in Astronomy and Astrophysics 2013年第1期13卷 57-70页

作者： xiao-Hong cui Zhuo Li Li-Ping Xin National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Kavli Institute for Astronomy and Astrophysics Peking University

Observations imply that long ＂y-ray bursts （GRBs） originate from the explo- sions of massive stars, therefore they may occur in the molecular clouds where their progenitors were born. We show that the prompt optical-UV emission from GRBs may be delayed due to dust extinction, which can explain the observed optical delayed on- set and fast rise in GRB 080319B well. The density and the size of the molecular cloud around GRB 080319B are roughly constrained to be ~ 103 cm-z and ~ 8 pc, respectively. We also investigate other GRBs with prompt optical-UV data, and find similar values of the densities and sizes of the local molecular clouds. Future obser- vations of prompt optical-UV emission from GRBs on a timescale of subseconds, e.g. by UFFO-Pathfinder and SVOM-GWAC, will provide more evidence and probes of the local environments of GRBs.

关键词： radiation mechanisms: non-thermal -- gamma-rays: bursts -- dust: ex-tinction

Hydrogen and helium shell burning during white dwarf accretion

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Research in Astronomy and Astrophysics 2018年第5期18卷 111-118页

作者： xiao cui Xiang-Cun Meng Zhan-Wen Han Yunnan Observatories Chinese Academy of Sciences Kunming 650216 China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650216 China University of Chinese Academy of Sciences Beijing 100049 China

Type Ia supernovae（SNe Ia） are believed to be thermonuclear explosions of carbon oxygen（CO） white dwarfs（WDs） with masses close to the Chandrasekhar mass limit. How a CO WD accretes matter and grows in mass to this limit is not well understood, hindering our understanding of SN Ia explosions and the reliability of using SNe Ia as a cosmological distance indicator. In this work, we employed the stellar evolution code MESA to simulate the accretion process of hydrogen-rich material onto a 1.0 M⊙CO WD at a high rate（over the Eddington limit） of 4.3 × 10^-7 M⊙yr^-1. The simulation demonstrates the characteristics of the double shell burning on top of the WD, with a hydrogen shell burning on top of a helium burning shell. The results show that helium shell burning is not steady（*** flashes）. Flashes from the helium shell are weaker than those in the case of accretion of helium-rich material onto a CO WD. The carbon to oxygen mass ratio resulting from the helium shell burning is higher than what was previously thought. Interestingly, the CO WD growing due to accretion has an outer part containing a small fraction of helium in addition to carbon and oxygen. The flashes become weaker and weaker as the accretion continues.

关键词： stars evolution - supernovae general - white dwarfs

Characterizations of Sobolev spaces in Euclidean spaces and Heisenberg groups

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Applied Mathematics(A Journal of Chinese Universities) 2013年第4期28卷 531-547页

作者： cui xiao-yue LAM Nguyen LU Guo-zhen Department of Mathematics Wayne State UniversityDetroit MI 48202 USA

Recently, many new features of Sobolev spaces W k,p ？RN ？ were studied in [4-6, 32]. This paper is devoted to giving a brief review of some known characterizations of Sobolev spaces in Euclidean spaces and describing our recent study of new characterizations of Sobolev spaces on both Heisenberg groups and Euclidean spaces obtained in [12] and [13] and outlining their proofs. Our results extend those characterizations of first order Sobolev spaces in [32] to the Heisenberg group setting. Moreover, our theorems also provide diff erent characterizations for the second order Sobolev spaces in Euclidean spaces from those in [4, 5].

关键词： characterization of Sobelev spaces Folland-Stein space Poincar′e inequalities Heisenberg group second order Sobolev space