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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu xiao-xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Theoretical Studies on the Fe-M Interactions and 31p NMR in Fe（CO）3（EtPhPpy）2MX2 （X=NCS, SCN, CI; M=Zn, Cd, Hg）

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Chinese Journal of Chemical Physics 2008年第5期21卷 438-444页

作者： xiao-xuan Huang xuan Xu Mei-xiang Xie School of Chemistry and Environment Key Lab of Technology on Electrochemical Energy Storage and Power Generation in Guangdong Universities South China Normal University Guangzhou 510006 China

To study the Fe-M interactions and their effects on 31p NMR, the structures of Fe（CO）3（EtPhPpy）2 1, Fe（CO）3（EtPhPpy）2M（NCS）2 （2： M=Zn, 3： M=Cd, 4： M=Hg） and Fe（CO）3（EtPhPpy）2CdX2 （5： X=C1, 6： X=SCN） were investigated by density functional theory （DFT） PBE0 method. The stabilities S of complexes follow S（2）〉S（3）〉S（4） and S（3）,.~S（6）〉S（5）, indicating that 6 is stable and may be synthesized. The complexes with thiocyanate are more stable than that with chloride in Fe（CO）3（EtPhPpy）2CdX2. The strength I of Fe-M interactions follows I（2）≈I（3）〈I（4）. The Fe-Cd interactions of 3 and 6, which contain thiocyanate, are stronger than that of 5 with chloride. The charge-transfer, which enhances with the increasing of Fe-M interaction strength, comes from Et, Ph, py, CO groups towards P, Fe, and M atoms. Because the delocalization of thiocyanate disperses the charge of M2＋, the charge-transfer of the complexes with thiocyanate is stronger than that with chloride. There is a a-bond between Fe and Hg atoms in 4. However, in binuclear complexes except 4, the Fe-M interactions act as nFe→nM, σP-Fe→nM and σC-Fe→nM delocalization, and the N-M interactions mainly act as nN→nM delocalization. In binuclear complexes, due to the Fe→M interactions, the strong σFe--C→σ＊Fe--p or σFe-Hg→σ＊Fe--I2 delocalization and the charge-transfer, the electron density on P nucleus is increased, and thus upfield 31p chemical shifts are caused （compared with mononuclear complex 1）.

关键词： DFT 31p NMR Metal-metal interaction Nature bond orbital

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Pt–C interactions in carbon-supported Pt-based electrocatalysts

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Frontiers of Chemical Science and Engineering 2023年第11期17卷 1677-1697页

作者： Yu-xuan xiao Jie Ying Hong-Wei Liu xiao-Yu Yang School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing&Shenzhen Research Institute&Joint Laboratory for Marine Advanced Materials in Pilot National Laboratory for Marine Science and Technology(Qingdao) Wuhan University of TechnologyWuhan 430070China

Carbon-supported Pt-based materials are highly promising *** carbon support plays an important role in the Pt-based catalysts by remarkably influencing the growth,particle size,morphology,dispersion,electronic structure,physiochemical property and function of *** review summarizes recent progress made in the development of carbon-supported Pt-based catalysts,with special emphasis being given to how activity and stability enhancements are related to Pt–C interactions in various carbon supports,including porous carbon,heteroatom doped carbon,carbon-based binary support,and their corresponding electrocatalytic ***,the current challenges and future prospects in the development of carbon-supported Pt-based catalysts are discussed.

关键词： Pt-C interactions Pt-based materials carbon support electrocatalysis

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Adaptive segmentation of digital mammograms through reinforcement learning

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光学精密工程 2005年第5期13卷 575-583页

作者： LIU Xin-yue FANG xiao-xuan HUANG Lian-qing Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of SciencesChangchun 130033 China China-Japan Union Hosptial of Jilin University Changchun 130033China

An approach based on reinfocement learning for the automated segmentation is presented. The approach consists of two modules:segmentation module and learning module. The segmentation module uses the region-growing algorithm combined with the smooth filtering and the morphological filtering to segment mammograms. The learning module uses the segmentation output as the feedback to learn to select the optimal parameter settings of the segmentation algorithm according to the image properties using reinforcement learning techniques. The approach can adapt itself to various kinds of mammograms through training and therefore obviates the tedious and error-prone tuning of parameter settings manually. Quantitative test results show that the approach is accurate for several kinds of mammograms. Compared to previously proposed approaches,the approach is more adaptable to different mammograms.

关键词：适应性分割平滑性计算机控制系统程序设计

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Disordered Fragments of Chemical Structures Based on Single-crystal X-ray Diffraction

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Chinese Journal of Structural Chemistry 2020年第4期39卷 698-708页

作者： ZHANG Jun MA xiao-Fan xuan xiao-Peng School of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei 230601China Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China Department of Chemistry The Hong Kong University of Science&TechnologyHong KongChina

For the reported chemical structures,the disordered fragments of the structure acting as hosts and guests are common and unmanageable for *** to analyze and treat such disordered assemblies is an important task for *** is often difficult for some researchers to refine the disordered structures,even to mechanically justify the refined consequence in the absence of ***,some examples of disorder refinements selected from the literature,including the disordered assemblies of nitrate,perchlorate,alkyl,aromatic assemblies,and guest solvent molecules,are summarized and discussed to provide practical advice for investigating the disorders for crystallographic researchers and *** refinement approach for these disordered assemblies is also discussed in detail,which is helpful for crystallographers.

关键词： single-crystal X-ray diffraction crystal-structure refinement disorder disordered assemblies

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Production of Transgenic Anliucheng Sweet Orange(Citrus sinensis Osbeck) with Xa21 Gene for Potential Canker Resistance

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Journal of Integrative Agriculture 2014年第11期13卷 2370-2377页

作者： LI Ding-li xiao xuan GUO Wen-wu Key Laboratory of Horticultural Plant Biology Ministry of Education/College of Horticulture & Forestry Sciences Huazhong Agricultural University College of Life and Environmental Sciences Gannan Normal University

Citrus canker, an epidemic quarantine disease caused by Xanthomonas axonopodis pv. citri, has brought a great damage in citrus production worldwide. Herein, a rice PRR （pattern recognition receptor） gene Xa21 together with GUS reporter gene and hygromycin phosphotransferase gene （HPT） was introduced into Anliucheng sweet orange （Citrus sinensis Osbeck） via Agrobacterium-mediated transformation of embryogenic callus. The transgenic calluses were screened on MT basal medium containing hygromycin （HYG） and detected by histochemical GUS staining. The transgenic plantlets were recovered through somatic embryogenesis pathway. The regenerated plantlets were accustomed to and maintained in the greenhouse. The transgene integration of recovered plantlets was identiifed by PCR and Southern blot hybridization. It showed that all the transgenic plantlets tested had undergone single copy integration, the expression of Xa21 in eight different transgenic lines detected by qRT-PCR can be divided into three grades, high for T5 and T6, middle for T4 and low for the rest. The tolerance to citrus canker disease of the three recovered transgenic lines T2, T4 and T6 was assessed by in vitro pin-puncture inoculation. The results showed that all the three transgenic lines conferred improved resistance to citrus canker bacterium infection and the T4 transgenic line displayed the highest resistance. The mechanism and feasibility of rice Xa21 in triggering innate immunity in citrus was brielfy discussed.

关键词： citrus canker Xa21 sweet orange pattern recognition receptors (PRRs)

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Anodic-Cathodic Electrocatalytic Degradation of Phenol with Oxygen Sparged in the Presence of Iron(Ⅱ)

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Chemical Research in Chinese Universities 2002年第3期18卷 262-266页

作者： ZHOU Ming hua WU Zu cheng xuan xiao dong Department of Environmental Engineering Zhejiang UniversityHangzhou 310027P.R.China

Under oxygen sparged, the synergetic effects of both anodic cathodic electrocatalysis(ACE) and ferrous ion catalyzed anodic cathodic electrocatalysis(FeACE) on phenol degradation were observed in an undivided cell composed of a β PbO 2 anode modified with fluorine resin and a nickel chromium titanium alloy net cathode. Oxygen sparging rate, ferrous concentration, and current significantly affect phenol destruction. The phenol was removed by 10%-13% increasingly under FeACE vs . ACE, and by 12%-15% under ACE vs . anodic electrocatalysis(AE). The phenol destruction was due to the formation of hydroxyl oxidant on the surface of lead oxide at the anode and the reduction of oxygen at the cathode.

关键词： Anodic cathodic electrocatalysis Phenol degradation Advanced oxidation process

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Non-line-of-sight error mitigating algorithm based on scattering models via multi-antenna system

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The Journal of China Universities of Posts and Telecommunications 2008年第1期15卷 18-22页

作者： ZHU xiao-xuan SHI Ming-yang ZHANG Jing TAO xiao-feng Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications Ministry of Education Wireless Technology Innovation Institute (WTI) Beijing 100876 China

In urban environment with serious blocking of direct paths, the non-line-of-sight （NLOS） propagation influences the location estimation accuracy. In this article, a novel algorithm is developed, which can mitigate the NLOS errors in location estimation significantly. Utilizing multiantenna array, the information of scatterers that cause the NLOS propagation is obtained. Then, we combine the information with TOA/TDOA based location algorithm to estimate the location of mobile station （MS）. The simulation results show that our method can mitigate NLOS errors and enhance the location accuracy greatly.

关键词： multi-antenna location algorithm NLOS time of arrival (TOA)

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DR5 is a Suitable System for Studying the Auxin Response in the Poncirus trifoliata-Xanthomonas axonopodis *** Interaction

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Horticultural Plant Journal 2020年第5期6卷 277-283页

作者： xuan xiao xiaoyan Li Chunli Chen Wenwu Guo College of Life Science Gannan Normal UniversityGanzhouJiangxi 341000China Key Laboratory of Horticultural Plant Biology(Ministry of Education) College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China

The local auxin distribution characteristics in the roots,stems,and leaves of stably transformed plantlets of trifoliate orange(Poncirus trifoliata)with auxin reporter system DR5::GUS-YFP were elucidated in this *** auxin response maxima could be observed in the apex of the root tip,primary phloem of the tender stem,and the margin of the young leaves according to the activity of theβ-glucuronidase(GUS)reporter gene triggered by the auxin responsive DR5 *** responses in the apex of the root tips increased when treated with synthetic auxin 1-naphthylacetic acid(NAA),but decreased when treated with the auxin polar transportation inhibitor 2,3,5-triiodobenzoic acid(TIBA).These results indicated that the DR5 reporter system worked in *** for auxin distribution and response *** orange is highly susceptible to citrus canker *** accumulation was observed visually in the invasion sites of the detached leaves inoculated with Xanthomonas axonopodis ***(Xac)by GUS staining;the upregulated expression of the YFP,GH3.1,GH3.9,and SAUR genes assessed by quantitative real-time PCR(qRT-PCR)also identified auxin accumulation in the inoculated tissues following Xac ***,these findings indicated that the plantlets of *** engineered with the auxin reporter gene provided a promising system for studying auxin responses during Xac infection.

关键词： Poncirus trifoliata DR5 auxin Xanthomonas axonopodis pv.citri

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Dual drug delivery system with flexible and controllable drug ratios for synergistic chemotherapy

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Science China Chemistry 2021年第6期64卷 1020-1030页

作者： Yalan Tu Rui Zheng Fangzhou Yu xuan xiao Maoling Jiang Youyong Yuan Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou 510006China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Engineering of Guangdong Province and Innovation Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China

Determination of whether multidrug nanocarriers can deliver and release loaded drugs at a predefined synergistic ratio to target cancer cells is *** there are many successful applications for delivery of multiple drugs,most current carriers are unable to achieve coordinated loading and release,leading to a drug release ratio that disagrees with the predefined loading *** this work,a simple dual-drug delivery system with a flexible and controllable drug release ratio was constructed to deliver two anticancer drugs,doxorubicin(DOX)and curcumin(CUR).The drug ratio of DOX and CUR can be easily tuned for an enhanced synergistic effect,and the drugs can be released at predesigned ratios due to synchronous drug activation and nanoparticle *** release at predefined ratios for synergistic anticancer therapy was demonstrated via in vitro and in vivo experiments.

关键词： nanomedicine drug delivery system combination therapy synergistic chemotherapy

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