Dual drug delivery system with flexible and controllable drug ratios for synergistic chemotherapy

作     者：Yalan Tu Rui Zheng Fangzhou Yu Xuan Xiao Maoling Jiang Youyong Yuan Yalan Tu;Rui Zheng;Fangzhou Yu;Xuan Xiao;Maoling Jiang;Youyong Yuan

作者机构：Institutes for Life SciencesSchool of MedicineSouth China University of TechnologyGuangzhou 510006China National Engineering Research Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Engineering of Guangdong Province and Innovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)Guangzhou 510005China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2021年第64卷第6期

页      面：1020-1030页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(51873072,52073101) Guangdong Provincial Pearl River Talents Program(2019QN01Y088) the Science and Technology Program of Guangzhou(202002030268,201804020060) Outstanding Scholar Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110102001) 

主　　题：nanomedicine drug delivery system combination therapy synergistic chemotherapy 

摘      要：Determination of whether multidrug nanocarriers can deliver and release loaded drugs at a predefined synergistic ratio to target cancer cells is *** there are many successful applications for delivery of multiple drugs,most current carriers are unable to achieve coordinated loading and release,leading to a drug release ratio that disagrees with the predefined loading *** this work,a simple dual-drug delivery system with a flexible and controllable drug release ratio was constructed to deliver two anticancer drugs,doxorubicin(DOX)and curcumin(CUR).The drug ratio of DOX and CUR can be easily tuned for an enhanced synergistic effect,and the drugs can be released at predesigned ratios due to synchronous drug activation and nanoparticle *** release at predefined ratios for synergistic anticancer therapy was demonstrated via in vitro and in vivo experiments.