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Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan

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Science China(Life Sciences) 2025年第2期68卷 416-430页

作者： jia-yu liu Yao wang yue Guo Run-Qi Zheng yun-Ying wang Yan-Yan Shen Yan-Hong liu Ai-ping Cao Rui-Bo wang Bo-Yang Xie Shuai jiang Qiu-Ying Han jing Chen Fang-Ting Dong Kun He Na wang Xin Pan Tao Li Tao Zhou Ai-Ling Li qing Xia wei-Na Zhang Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100850China

As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly *** an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic acid(TUDCA),a natural bile acid,offers additional health benefits beyond liver ***,we show that TUDCA extends the lifespan and healthspan of ***,oral supplementation of TUDCA improves fitness in old mice,including clinically relevant phenotypes,exercise capacity and cognitive ***,TUDCA treatment drives broad transcriptional changes correlated with anti-aging ***,we discover that TUDCA targets the chaperone HSP90 to promote its protein refolding *** collaboration further alleviates aging-induced endoplasmic reticulum(ER)stress and facilitates protein homeostasis,thus offering resistance to *** summary,our findings uncover new molecular links between an endogenous metabolite and protein homeostasis,and propose a novel anti-aging strategy that could improve both lifespan and healthspan.

关键词： tauroursodeoxycholic acid lifespan healthspan protein homeostasis

Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury

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Neural Regeneration Research 2021年第5期16卷 878-884页

作者： xiao-qing Cheng Wen-jing Xu xiao Ding Gong-Hai Han Shuai wei ping liu Hao-Ye Meng Ai-jia Shang yu wang Ai-yuan wang Institute of Orthopedics Chinese PLA General HospitalBeijingChina Beijing Key Laboratory of Regenerative Medicine in Orthopedics Chinese PLA General HospitalBeijingChina Key Lab of Musculoskeletal Trauma&War Injuries Chinese PLA General HospitalBeijingChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In our previous study,we investigated the dynamic expression of cytokines in the distal nerve stumps after peripheral nerve injury using microarray analysis,which can characterize the dynamic expression of *** the present study,we used a rat model of right sciatic nerve transection to examine changes in the expression of cytokines at 1,7,14 and 28 days after injury using protein microarray *** were increased in the distal nerve stumps at 1–14 days post nerve ***,growth factors and growth factor-related proteins were mainly upregulated in the proximal nerve *** P-values of the inflammatory response,apoptotic response and cell-cell adhesion in the distal stumps were higher than those in the proximal nerve stumps,but the opposite was observed for *** number of cytokines related to axons in the distal stumps was greater than that in the proximal stumps,while the percentage of cytokines related to axons in the distal stumps was lower than that in the proximal nerve *** of the results revealed the specific expression patterns and differences in cytokines in and between the proximal and distal nerve *** findings offer potential therapeutic targets and should help advance the development of clinical treatments for peripheral nerve *** for animal use in this study was obtained from the Animal Ethics Committee of the Chinese PLA General Hospital on September 7,2016(approval No.2016-x9-07).

关键词： cytokine distal stumps Gene Ontology Kyoto Encyclopedia of Genes and Genomes Pathway microarray microenvironment peripheral nerve injury proximal stumps

Prokineticin 2 overexpression induces spermatocyte apoptosis in varicocele in rats

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Asian Journal of Andrology 2020年第5期22卷 500-506页

作者： Ying Li Ting Zhou yu-Fang su Zhi-Yong Hu jia-jing wei wei wang Chun-Yan liu Kai Zhao Hui-ping Zhang Family Planning Research Institute/Reproductive Medicine Center Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Departm ent of Gynecology and Obstetrics Union HospitalTorigji Medical CollegeHuangzhong University of Science and TechnologyWuhan 430030China

Varicocele is one of the most important causes of male infertility,as this condition leads to a decline in sperm *** is generally believed that the presence of varicocele induces an increase in reactive oxygen species levels,leading to oxidative stress and sperm apoptosis;however,the specific pathogenic mechanisms affecting spermatogenesis remain *** 2(PK2),a secretory protein,is associated with multiple biological processes,including cell migration,proliferation,and *** the testis,PK2 is expressed in spermatocytes under normal physiological *** investigate the role of PK2 in varicocele,a rat varicocele model was established to locate and quantify the expression of PK2 and its receptor,prokineticin receptor 1(PKR1),by immunohistochemistry and quantitative real-time PCR assays(qPCR).Moreover,H2O2 was applied to mimic the oxidative stress state of varicocele through coculturing with a spermatocyte-derived cell line(GC-2)in vitro,and the apoptosis rate was detected by flow ***,we illustrated that the expression levels of PK2 and PKR1 were upregulated in the spermatocytes of the rat *** of H202 stimulated the overexpression of PK2 in *** of recombinant pCMV-HA-PK2 into GC-2 cells promoted apoptosis by upregulating cleaved-caspase-3,caspase-8,and B cell lymphoma 2-associated X;downregulating B cell lymphoma 2;and promoting the accumulation of intracellular ***,we revealed that the varicocele-induced oxidative stress stimulated the overexpression of PK2,leading to apoptosis of *** study provides new insight into the mechanisms underlying oxidative stress-associated male infertility and suggests a novel therapeutic target for male infertility.

关键词： apoptosis oxidative stress prokineticin 2 varicocele

Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n

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Nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le Yang Zhen‑Dong An wei jiang Xian‑Kai Li wei‑wei Qiu Zheng‑Fa Liao Zi‑yue Zhuang xiao‑ping Zhang Sheng‑Li Chen Chen‑Chen Guo Er‑Xi xiao xiao Fang Xin‑Xiang Li Xin‑Rong Hu Bing jiang Jin‑Cheng wang Jie Ren Wen Luo Zhi‑Chao Zhu Hao‑Yang Lan Zong‑wei Cao Xu Ma Ying‑Du liu Pu‑Sen wang Yi Yang ping su Xian‑Gai Deng Wan‑Bing He Chun‑wang Ma yu‑Ting wang Zhi‑Tao Dai Peng‑Qin He Ren‑Guang Tang Tao Zhou jing wang Han Yi yue Zhang Yong‑Hao Chen Rui‑Rui Fan Ke‑qing Gao Qiang Li Kang sun Zhi‑Xin Tan Min‑Hao Gu Han‑Tao jing jing‑yu Tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA Macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411100China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and Nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value.

关键词： Time-of-flight technique Neutron capture cross sections Maxwell average cross sections

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5919-5930页

作者： Lin wang jia-Bao Cao Bin-Bin Xia yue-Juan Li Xuan Zhang Guo-Xin Mo Rui-Juan wang Si-Qi Guo yu-qing Zhang Kun xiao Guang-Fa Zhu Peng-Fei liu Li-Cheng Song Xi-Hui Ma ping-Chao Xiang jiang wang yu-Hong liu Fei Xie Xu-Dong Zhang Xiang-Xin Li Wan-Lu sun Yan Cao Kai-Fei wang Wen-Hui Zhang wei-Chao Zhao Peng Yan Ji-Chao Chen yu-wei Yang Zhong-Kuo yu jing-Si Tang Li xiao Jie-Min Zhou Li-Xin Xie Jun wang College of Pulmonary&Critical Care Medicine 8th Medical Center of Chinese PLA General HospitalBeijing 100091China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Faculty of Biological Science and Technology Baotou Teacher’s CollegeBaotou 014030China Department of Respiratory Medicine PLA Strategic Support Force Medical CenterBeijing 100101China Department of Respiratory and Critical Care Medicine Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China Respiratory Research Institute Department of Pulmonary&Critical Care MedicineBeijing Key Laboratory of OTIRthe 8th Medical Center of Chinese PLA General HospitalBeijing 100091China Shougang hospital of Peking University Beijing 100144China Department of Respiratory Medicine Beijing Changping HospitalBeijing 102200China Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Pulmonary research institute Senior Department of Respiratory and Critical Care Medicinethe 8th medical center of Chinese PLA general hospitalBeijing 100091China College of Pulmonary&Critical Care Medicine Chinese PLA General HospitalBeijing 100853China China Aerospace Science&Industry Corporation 731 hospital Beijing 100074China Department of Respiratory and Critical Care Medicine Aerospace Center HospitalBeijing 100049China Vision Medicals Center for Infectious Diseases Guangzhou 510700China

The Omicron variant of the severe acute respiratory syndrome coronavirus 2(SARS‑CoV‑2)infected a substantial proportion of Chinese population,and understanding the factors underlying the severity of the disease and fatality is valuable for future prevention and clinical *** recruited 64 patients with invasive ventilation for COVID-19 and performed metatranscriptomic sequencing to profile host transcriptomic profiles,plus viral,bacterial,and fungal content,as well as virulence factors and examined their relationships to 28-day mortality were *** addition,the bronchoalveolar lavage fluid(BALF)samples from invasive ventilated hospital/community-acquired pneumonia patients(HAP/CAP)sampled in 2019 were included for *** analysis revealed that all Omicron strains belong to BA.5 and BF.7 sub-lineages,with no difference in 28-day mortality between *** to HAP/CAP cohort,invasive ventilated COVID-19 patients have distinct host transcriptomic and microbial signatures in the lower respiratory tract;and in the COVID-19 non-survivors,we found significantly lower gene expressions in pathways related viral processes and positive regulation of protein localization to plasma membrane,higher abundance of opportunistic pathogens including bacterial Alloprevotella,Caulobacter,Escherichia-Shigella,Ralstonia and fungal Aspergillus sydowii and Penicillium *** analysis further revealed significant associations between host immune responses and microbial compositions,besides synergy within viral,bacterial,and fungal *** study presents the relationships of lower respiratory tract microbiome and transcriptome in invasive ventilated COVID-19 patients,providing the basis for future clinical treatment and reduction of fatality.

关键词： patients mortality prevention

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan Ming He qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan jian-Ming Zhou Kang-Ning Li xiao-Fei wang jian-Cheng liu Zhao-Hua Peng Zhuo Liang Ai-Ling Li jian Zheng Qi-Wen Fan yun-Ju Li You-Bao wang Zhi-Hong Li Yang-ping Shen Ding Nan wei Nan yu-Qiang Zhang jia-Ying-Hao Li Jun-Wen Tian jiang-Lin Hou Chang-Xin Guo Zhi-Cheng Zhang Ming-Hao Zhu yu-Wen Chen yu-Chen jiang Tao Tian Jin-Long Ma Yi-Hui liu jing-yu Dong Run-Long liu Mei-yue-Nan Ma Yong-Shou Chen wei-ping liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation supernovae Chang'e-5 lunar samples

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-wei Yang Yong-Hao Chen Rong liu Bang-jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-ping Chen Zhong-wei Wen wei-Li sun Han Yi Xing-Yan liu Tao Ye jiang-Bo Bai Qi An Jie Bao yu Bao ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-wei Hu Han-Xiong Huang Xi-Ru Huang Hao-yu jiang wei jiang Zhi-Jie jiang Han-Tao jing Ling Kang Bo Li Chao Li jia-Wen Li Qiang Li xiao Li Yang Li Jie liu Shu-Bin liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang sun Zhi-jia sun Zhi-Xin Tan jing-yu Tang Xin-Yi Tang Bin-Bin Tian Li-jiao wang Peng-Cheng wang Zhao-Hui wang xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-yun Yang Li yu Tao yu Yong-Ji yu Guo-Hui Zhang Lin-Hao Zhang Qi-wei Zhang Xian-Peng Zhang yu-Liang Zhang Zhi-Yong Zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

Prediction of energy resolution in the JUNO experiment

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Chinese Physics C 2025年第1期49卷 35-59页

作者： Angel Abusleme Thomas Adam Kai Adamowicz Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Joao Pedro Athayde Marcondes de André Didier Auguste weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Marco Beretta Antonio Bergnoli Daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld Iwan Blake David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Anatael Cabrera Barbara Caccianiga Hao Cai xiao Cai Yanke Cai Zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Vanessa Cerrone Jinfan Chang yun Chang Auttakit Chatrabhuti Chao Chen Guoming Chen pingping Chen Shaomin Chen Xin Chen Yiming Chen Yixue Chen yu Chen Zelin Chen Zhangming Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng yuChin Cheng Alexander Chepurnov Alexey Chetverikov Davide Chiesa Pietro Chimenti Yen-Ting Chin Po-Lin Chou Ziliang Chu Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Marta Colomer Molla Selma Conforti Di Lorenzo Alberto Coppi Daniele Corti Simon Csakli Chenyang Cui Flavio Dal Corso Olivia Dalager Jaydeep Datta Christophe De La Taille Zhi Deng Ziyan Deng xiaoyu Ding Xuefeng Ding Yayun Ding Bayu Dirgantara Carsten Dittrich Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko jianmeng Dong Evgeny Doroshkevich wei Dou Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Katherine Dugas Stefano Dusini Hongyue Duyang Jessica Eck Timo Enqvist Andrea Fabbri Ulrike Fahrendholz Lei Fan jian Fang Wenxing Fang Dmitry Fedoseev Li-Cheng Feng Qichun Feng Federico Ferraro Amélie Fournier Fritsch Fritsch Haonan Gan Feng Gao Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong yuri Gornushkin Marco Grassi Maxim Gromov Vasily Gromov Minghao G Yerevan Physics Institute YerevanArmenia Université Libre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Millennium Institute for subAtomic Physics at the High-energy Frontier(SAPHIR) ANIDChile Pontificia Universidad Católica de Chile SantiagoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National

This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction *** determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 *** achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO *** factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction *** account for these effects,a full JUNO simulation and reconstruction approach is *** enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy *** results of this study reveal an energy resolution of 2.95% at 1 ***,this study assesses the contribution of major effects to the overall energy resolution *** analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data ***,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.

关键词： energy resolution liquid scintillator detector JUNO simulation reconstruction

Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： jing-yu Tang Qi An jiang-Bo Bai Jie Bao yu Bao ping Cao Hao-Lei Chen Qi-ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-wei Hu Han-Xiong Huang Xi-Ru Huang Hao-yu jiang wei jiang Zhi-Jie jiang Han-Tao jing Ling Kang Bo Li Chao Li jia-Wen Li Qiang Li xiao Li Yang Li Jie liu Rong liu Shu-Bin liu Xing-Yan liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang sun Zhi-jia sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-jiao wang Peng-Cheng wang Zhao-Hui wang Zhong-wei Wen xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-yun Yang Yi-wei Yang Han Yi Li yu Tao yu Yong-Ji yu Guo-Hui Zhang Lin-Hao Zhang Qi-wei Zhang Xian-Peng Zhang yu-Liang Zhang Zhi-Yong Zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications