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Role of the Anterior Cingulate Cortex in Translational Pain Research

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Neuroscience Bulletin 2021年第3期37卷 405-422页

作者： xiao xiao ming Ding Yu-Qiu Zhang Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Ministry of EducationInstitute of Science and Technology for Brain-Inspired IntelligenceBehavioral and Cognitive Neuroscience CenterFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Department of Translational NeuroscienceJing’an District Centre Hospital of ShanghaiInstitutes of Brain ScienceInstitute of Integrative MedicineFudan UniversityShanghai 200032China

As the most common symptomatic reason to seek medical consultation,pain is a complex experience that has been classified into different categories and *** pain processing,noxious stimuli may activate the anterior cingulate cortex(ACC).But the function of ACC in the different pain conditions is not well *** this review,we elaborate the commonalities and differences from accumulated evidence by a variety of pain assays for physiological pain and pathological pain including inflammatory pain,neuropathic pain,and cancer pain in the ACC,and discuss the cellular receptors and signaling molecules from animal *** further summarize the ACC as a new central neuromodulation target for invasive and non-invasive stimulation techniques in clinical pain *** comprehensive understanding of pain processing in the ACC may lead to bridging the gap in translational research between basic and clinical studies and to develop new therapies.

关键词： Anterior cingulate cortex Deep brain stimulation Transcranial magnetic stimulation Transcranial direct current stimulation Pathological pain Inflammatory pain Neuropathic pain Cancer pain

Experimental research on the contact force of the bi-directional pig in oil and gas pipeline

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Petroleum Science 2023年第1期20卷 474-481页

作者： xiao-xiao Zhu Chun-ming Fu Yu-Tao Wang Shi-ming Zhang College of Mechanical and Transportation Engineering China University of Petroleum-BeijingChangpingBeijing102249China

The migration process of the pig in oil and gas pipeline is a complex dynamic *** the pigging operation,the variation of friction force caused by the nonlinear contact between the sealing disc and the pipe wall is the key factor affecting the dynamic characteristics of the pig *** present,the existed pigging models for predicting pigging behavior regard friction as an invariant *** research indicates that the friction force of the pig varies with the contact force and the lubrication ***,the assumption that the friction force is constant cannot reflect the friction dynamic characteristics of the pig during pigging,and will also affect the accuracy of the pigging *** the variation of friction force of pig under different conditions is the basis of establishing the transient dynamic model of a *** a result,in this paper,a method of direct measurement of contact force between the pig and the pipeline is presented,the contact force,the friction force,as well as the friction coefficient of the pig are obtained from the *** results in this paper can help to establish a more accurate dynamic model of pig.

关键词： Pipeline pig Sealing disc Contact force Friction coefficient Experimental rig

GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期 145-158页

作者： Wei JU Yiyang GU Zhengyang MAO Ziyue QIAO Yifang QIN xiao LUO Hui XIONG ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

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Optimization of Electron Density and Temperature Profiles in Tokamaks via Safety Factor Profile

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Chinese Physics Letters 2001年第8期18卷 1101-1102页

作者： QIU xiao-ming PENG xiao-Dong Southwestern Institute of Physics P.O.Box 432Chengdu 610041

The turbulent particle and thermal transport scaling laws are derived by means of Lagrangian invariant of trapped electron dynamics in tokamaks,which are in good agreement with experimental *** the basis of the two scaling laws,it is proposed that the optimization of electron density and temperature profiles can be achieved by designing a desirable safety factor profile.

关键词： Electron scaling Profiles

Enhanced Reproducibility of Positive Temperature Coefficient Effect of CB/HDPE/PVDF Composites with the Addition of Ionic Liquid

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Chinese Journal of Polymer Science 2021年第2期39卷 228-236,I0008页

作者： Long Chen xiao Wu xiao-Fang Zhang Jian-ming Zhang Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plasticsQingdao University of Science&TechnologyQingdao 266042China

Developing an effective method for improving the reproducibility of positive temperature coefficient(PTC)effect is of great significance for large-scale application of polymer based PTC composites,owing to its contribution to the security and ***,we developed a carbon black(CB)/high density polyethylene(HDPE)/poly(vinylidene fluoride)(PVDF)composite with outstanding PTC reproducibility,by incorporating 1-octyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide([OMIm][NTf2])into the *** multiple repeated temperature cycles,the PTC performance of as-prepared material keeps almost unchanged and the varition of resistance at room temperature is less than 7%.Our studies revealed that[OMIm][NTf2]contributes to the improvement of PTC reproducibility in two ways:(i)it acts as an efficient plasticizer for refining the co-continuous phase morphology of HDPE/PVDE blends;(ii)it inhibits the crystallization of PVDF through the dilution effect,leading to more overlaps of the volume shrinkage process of HDPE and PVDF melt which results in the decrease of interface gap between HDPE and *** study demonstrated that ionic liquids as the multifunctional agents have great potential for improving the reproducibility in the application of the binary polymer based PTC composites.

关键词： Conductive polymer composites Reproducibility Positive temperature coefficient Ionic liquid

Distributed event-triggered adaptive control for second-order nonlinear uncertain multi-agent systems

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Chinese Journal of Aeronautics 2021年第10期34卷 237-247页

作者： ming xiao Zhitao LIU Hongye SU The State Key Laboratory of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China

In this paper,the event-triggered consensus control problem for nonlinear uncertain multi-agent systems subject to unknown parameters and external disturbances is *** dynamics of subsystems are second-order with similar structures,and the nodes are connected by undirected *** event-triggered mechanisms are not only utilized in the transmission of information from the controllers to the actuators,and from the sensors to the controllers within each agent,but also in the communication between *** on the adaptive backstepping method,extra estimators are introduced to handle the unknown parameters,and the measurement errors that occur during the event-triggered communication are well handled by designing compensating terms for the control *** presented distributed event-triggered adaptive control laws can guarantee the boundness of the consensus tracking errors and the Zeno behavior is ***,the update frequency of the controllers and the load of communication burden are vastly *** obtained control protocol is further applied to a multi-input multi-output second-order nonlinear multi-agent system,and the simulation results show the effectiveness and advantages of our proposed method.

关键词： Adaptive distributed control structure Event-triggered control Multi-agent systems Second-order nonlinear models

Proteolysis targeting chimera technology:a novel strategy for treating diseases of the central nervous system

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Neural Regeneration Research 2021年第10期16卷 1944-1949页

作者： Ke Ma xiao-xiao Han xiao-ming Yang Song-Lin Zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina College of Life Science Nantong UniversityNantongJiangsu ProvinceChina

Neurological diseases such as stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease are among the intractable diseases for which appropriate drugs and treatments are *** targeting chimera(PROTAC)technology is a novel strategy to solve this *** technology uses the ubiquitin-protease system to eliminate mutated,denatured,and harmful proteins in *** can be reused,and utilizes the protein destruction mechanism of the cells,thus making up for the deficiencies of traditional protein degradation *** can effectively target and degrade proteins,including proteins that are difficult to identify and ***,it has extremely important implications for drug development and the treatment of neurological *** present,the targeted degradation of mutant BTK,mHTT,Tau,EGFR,and other proteins using PROTAC technology is gaining *** is expected that corresponding treatment of nervous system diseases can be *** review first focuses on the recent developments in PROTAC technology in terms of protein degradation,drug production,and treatment of central nervous system diseases,and then discusses its *** review will provide a brief overview of the recent application of PROTAC technology in the treatment of central nervous system diseases.

关键词： Alzheimer’s disease disease treatment drug development Huntington’s disease proteolysis targeting chimera stroke targeted degradation

Local Cooling Effect of Rotation and Formation of Thermal Transport Barrier in Tokamaks

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Chinese Physics Letters 1996年第9期13卷 682-684页

作者： QIU xiao-ming DING Ning Southwestern Institute of Physics P.O.Box 432Chengdu 610041

A simple model,rotation-inducing local cooling,for the mechanism on the formation of thermal transport barrier and the increase in rotation velocity is *** is shown that the sheared rotation can make electron temperature profile T_(e)(r)steepen near the rotation layer and▽T_(e)>0 on some location inside it,in agreement with the experimental observations in tokamaks,such as JT-60U with(poloidal or toroidal)sheared rotation and HL-1M with a biased *** temperature profile can remarkably improve the energy confinement in tokamaks.

关键词： tokamak rotation transport

Positive Solutions for a Class of Fractional p-Laplacian Equation with Critical Sobolev Exponent and Decaying Potentials

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 463-483页

作者： Na LI xiao-ming HE College of Science Minzu University of ChinaBeijing 100081China

In this paper,we study the existence of positive solution for the p-Laplacian equations with frac-tional critical nonlinearity{-Δ)_(p)^(s)u+V(x)|u|^(p-2)u=K(x)f(u)+P(x)|u|p_(s)^(*)-^(2)u,x∈R^(N),u∈Ds,p(RN),where s∈(0,1),p_(s)^(*)=Np/N-sp,N>sp,p>1 and V(x),K(x)are positive continuous functions which vanish at infinity,f is a function with a subcritical growth,and P(x)is bounded,nonnegative continuous *** using variational method in the weighted spaces,we prove the above problem has at least one positive solution.

关键词： Fractional p-Laplacian Variational methods Mountain Pass Theorem Critical growth Vanishing potential