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Correlation between Hemagglutination Inhibition Titer and Protection against Infectious Bronchitis Virus Challenge in SPF Layers

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Animal Husbandry and Feed Science 2010年第5期2卷 34-36,40页

作者： JING xiao-dong zhang Zhen-hua LI Lin zhang Jian-wei JIANG Bei-yu Institute of Animal Husbandry and Veterinary Medicine Beijing Academy of Agriculture and Forestry Sciences Beijing 100097 China

[ Objective] To study the correlation between HI titer and protection against IBV challenge in SPF layers. [ Method ] SPF layers were randomly divided into four groups, namely group A1, A2, B1 and B2. The group A1 was immunized with H120 live vaccine. The group A2 was first immunized with H120 live vaccine and later boosted with ND-IB-EDS trivalent inactivated vaccine. The group B1 was used as unimmunized chal- lenge control. The group B2 was kept as unimmunized unchallenged control. The blood samples were taken prior and post-vaccination at intervals and HI tests were conducted. At the laying peak, the group A1, A2 and B1 were challenged with IBV M4t virulent strain. The clinical features and egg production of layers were monitored and recorded. [Result] After 30 d post vaccination with H120 live vaccine, the HI titer reached 4.45 log2; after 30 days boosting with ND-IB-EDS trivalent inactivated vaccine, the HI titer reached to 7.35 log2. Before challenge, HI antibody titer in group A1, A2, B1 and B2 were respectively 4.24 log2, 7.40 Iog2, 2.10 log2 and 2.10 log2. After challenge, chickens in unimmunized challenge control group B1 showed respiratory symptoms, egg production dropped by 30.9%, and they produced more soft-shelled, no-shelled or abnormal eggs. In the group A1, some chickens had light respiratory symptoms and egg production dropped by 11.7%. In the group A2, the egg production of all chickens was as normal as the group B2. [ Conclusion] When the HI titer was over 6 log2, challenge by virulent virus had no impact on egg produc- tion; when the HI titer was 5 log2, 4 log2 and less 3 log2, egg production dropped by 6.0%, 11.3% and 29.6%, respectively. Thus, the HI anti- body level in chickens has close correlation with protection against IBV challenge.

关键词： Infectious bronchitis Hemagglutination inhibition titer Protection rate against challenge

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CysLT1 receptor antagonist praniukast protects mice from traumatic brain cryoinjury

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中国药理通讯 2005年第4期22卷 33-34页

作者： xiao - dong Qian Lei zhang Meng - Ling Wang Wei - Ping zhang Er- Qing Wei Department of Pharmacology School of Medicine Zhejiang University Hangzhou 310031

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Over-expressing root-specific β-amyrin synthase gene increases glycyrrhizic acid content in hairy roots of glycyrrhiza uralensis

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Chinese Herbal Medicines 2019年第2期11卷 192-199页

作者： Yan-chao Yin xiao-dong zhang Zhi-qiang Gao Ting Hu Lin Yang Zhi-xin zhang Wen-dong Li Ying Liu School of Life Sciences Beijing University of Chinese Medicine Beijing 102401 China Department of Antibiotic Beijing Institute for Drug Control Beijing 102206 China

Objsective: Glycyrrhizia uralensis, one of the most widely-used traditional Chinese medicines, is mainly cropped in China. However, many cultivars are less in glycyrrhizic acid than Chinese Pharmacopoeia requires. In this paper, we improved glycyrrhizic acid by regulating β-amyrin synthase gene(GuBAS).Methods: Tobacco root-specific promoter TobRB7 and Gu BAS c DNA were obtained and combined with linearized pCAMBIA1305.1 to construct root-specific plant expression vector which was later transformed into Agrobacterium rhizogenes ACCC10060 by electrotransformation. The cotyledons and hypocotyls of *** were infected by the recombinant A. rhizogenes ACCC10060 to induce hairy roots. The GA content was quantified by ***: The PCR and sequencing results both showed that three transgenic hairy root lines were obtained. The copy number of Gu BAS in these transgenic hairy roots was intended by q RT-PCR to be 3, 7,and 4. GA was detected by HPLC, and the results showed that GA was present in the three transgenic hairy roots, while absent in wild hairy ***: Over-expressing Gu BAS root-specifically in hairy roots of G. uralensis enhanced GA accumulation.

关键词： β-amyrin synthase Glycyrrhiza uralensis Fisch. hairy roots root-specific over-expression

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Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3445-3456页

作者： Fan Zeng Da-Ya zhang Shi-Ju Chen Run-Xiang Chen Chen Chen Shi-Mei Huang Da Li xiao-dong zhang Jia-Jia Chen Cui-Yi Mo Lei Gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology Qionghai People’s HospitalQionghai 571400Hainan ProvinceChina Department of Gastroenterology Sanya Central HospitalSanya 572022Hainan ProvinceChina Department of Gastroenterology Hainan Second People’s HospitalWuzhishang 572299Hainan ProvinceChina Department of Gastroenterology Dongfang People’s HospitalDongfang 572699Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina The Gastroenterology Clinical Medical Center of Hainan Province Haikou 570216Hainan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage *** highlights the significance of early detection and prevention measures to enhance survival *** immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in *** To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT *** This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan *** study was conducted from August 2022 to April 2023,employing a stratified sampling method to select *** with positive FIT results subsequently underwent *** predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic *** A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT *** overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),*** associations were found between age,dietary habits,and positive FIT *** of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance *** them,10 had a clean

关键词： Fecal immunochemical test Colorectal cancer Adenoma Screening Hainan Province

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The Clustering Coefficient and the Diameter of Small-world Networks

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数学学报(中文版) 2013年第2期 292-292页

作者： Lei GU Hui Lin HUANG xiao dong zhang

The small-world network,proposed by Watts and Strogatz,has been extensively studied for the past over ten *** this paper,a generalized small-world network is proposed, which extends several small-world network ***,some properties of a special type of generalized small-world network with given expectation of edge numbers have been investigated, such as the degree distribution and the isoperimetric *** results are used to present a lower and an upper bounds for the clustering coefficient and the diameter of the given edge number expectation generalized small-world network,*** other words,we prove mathematically that the given edge number expectation generalized small-world network possesses large clustering coefficient and small diameter.

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大型往复压缩机管道系统气流脉动的计算

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工程热物理学报 2017年第10期38卷 2119-2124页

作者：熊怡君张晓青张栋侯小兵叶君超华中科技大学能源与动力工程学院武汉430074 中石化石油机械股份有限公司压缩机分公司武汉430041

针对某大型往复活塞压缩机管系结构,进行了气流脉动的计算与分析。以平面波动理论为基础,采用网络传递矩阵方法,建立了该复杂管系气流脉动的网络分析模型,并开发了相应的分析软件程序代码。计算了该管道系统气柱的前十阶固有频率,并判... 详细信息

针对某大型往复活塞压缩机管系结构,进行了气流脉动的计算与分析。以平面波动理论为基础,采用网络传递矩阵方法,建立了该复杂管系气流脉动的网络分析模型,并开发了相应的分析软件程序代码。计算了该管道系统气柱的前十阶固有频率,并判断管系是否共振,同时,计算了管道系统中各节点的脉动压力,计算结果满足API 618标准的要求。复杂管系气流脉动的研究,将为管系的设计、气流脉动与管道振动的拟制与消除提供理论依据。

关键词：往复压缩机平面波动理论网络传递矩阵气柱固有频率脉动压力

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Early enteral and parenteral nutritional support in patients with cirrhotic portal hypertension after pericardial devascularization

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 55-59页

作者： Ke zhang, Weng-Bing Sun, Hui-Feng Wang, Zhi-Wei Li, xiao-dong zhang, Hong-Bo Wang and Xu Ji Beijing, China Department of Hepatobiliary Surgery, The 302nd Hospital of PLA, Beijing 100039, China Department of Hepatobiliary Surgery The 302nd Hospital of PLA Beijing 100039 China. zhangke@***

BACKGROUND: The abnormal metabolism caused by cir- rhosis always results in a complex problem about nutritional support, which will be more intricate while patients with portal hypertension are treated with pericardial devasculari- zation. Comparing the effects of early enteral and parente- ral nutritional support in patients with cirrhotic portal hy- pertension after pericardial devascularization, we try to rea lize the advantages and disadvantages of the two nutritional therapies and to guide our clinical practice. METHODS: After pericardial devascularization,40 patients with cirrhotic portal hypertension were divided randomly into 2 groups; enteral and parenteral nutritional support, respectively. The general nutritional condition, capability of producing protein, liver function, blood velocity of the portal vein, gut function, bowel bacterial translocation, mortality, complication rate, stay in ICU, duration of hos- pitalization and costs of treatment were determined in all the patients and compared between the 2 groups. RESULTS; Both enteral and parenteral nutritional supports could improve the general nutrition condition of the pa- tients; but patients receiving enteral nutritional support had fewer complications. Enteral nutrition was more ef- fective than parenteral nutrition in increasing the blood ve- locity of the portal vein, stimulating gut motion, preven- ting bowel bacterial translocation, shortening the stay in ICU and the duration of hospitalization, and saving costs of treatment. CONCLUSION: After pericardial devascularization, pa- tients with cirrhotic portal hypertension should be treated with enteral nutritional support as early as possible.

关键词： hypertension, portal liver cirrhosis

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Successful Renal Transplantation in a Patient with Atypical Hemolytic Uremic Syndrome Treated with Eculizumab in China

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Chinese Medical Journal 2016年第11期129卷 1379-1381页

作者： Ze-Jia Sun Xin Du Lu-Lu Su xiao-dong zhang Yong Wang Liang Ren Wei Wang Department of Urology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Hemolytic uremic syndrome （HUS） is a rare disease characterized by thrombocytopenia and acute renal failure. Atypical HUS （aHUS） accounts for approximately 10% of all HUS cases. The pathogenesis of aHUS is mainly associated with gene mutations in complement factor H, complement factor I, and membrane cofactor protein （MCP）. The prognosis of aHUS is generally poor.

关键词： Atypical Hemolytic Uremic Syndrome Complement Eculizumab Kidney Transplantation

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Synthesis and anti-bacterial and-tumor activities of N,N-di-substituted Schiff bases in vitro

Synthesis and anti-bacterial and-tumor activities of N,N-di-...

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中国化学会第十届全国天然有机化学学术会议

作者： Heng Luo Yu-Fen Xia Lei Xia Yan Chen Hua-Yong Lou xiao xiao Tang-Jingjun Liu Wei-dong Pan xiao-dong zhang Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Capital medical university Guizhou University

＜正＞Schiff bases（aldehyde or ketone-like compounds）exhibited intense antibacterial and antitumor characteristics,and are therefore,promising candidates as antibacterial and antitumor *** investigate the mechanism of action of newly synthesized N,N-di-substituted Schiff bases,we synthesized three high-yielding benzaldehyde Schiff bases based on the reaction between

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机会不平等如何影响技术效率——基于社会资本视角

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当代财经 2018年第5期 3-14页

作者：陈晓东张卫东华中科技大学经济学院湖北武汉430074

在对我国省级层面的技术效率和机会不平等程度定量测度的基础上,从社会资本的视角探究机会不平等对技术效率的影响。结果表明,机会不平等对技术效率具有显著的负向影响。此外,对机会不平等与社会资本之间的关系进行检验后发现,机会不平... 详细信息

在对我国省级层面的技术效率和机会不平等程度定量测度的基础上,从社会资本的视角探究机会不平等对技术效率的影响。结果表明,机会不平等对技术效率具有显著的负向影响。此外,对机会不平等与社会资本之间的关系进行检验后发现,机会不平等对社会公平感有显著的负效应,且主要体现在家庭背景条件较差和当前个人收入水平较高的群体之中;机会不平等对社会信任感的负效应主要体现在当前个人收入水平较高的群体之中;机会不平等对地区犯罪率并无显著影响。进一步研究显示,社会资本正向作用于技术效率。这证实了社会资本在机会不平等影响技术效率中的中介作用。

关键词：机会不平等技术效率社会资本中介效应

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