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Advances in Atmospheric Sciences 2024年第11期41卷 2245-2258页

作者： Suguo ZHANG Qin HU Xianhong MENG Yaqiong LÜ xianyu YANG School of Atmospheric Sciences/Plateau Atmosphere and Environment Key Laboratory of Sichuan Province Chengdu University of Information TechnologyChengdu 610225China Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Earth System Modelling School of Engineering and DesignTechnical University of MunichMunich 85521Germany

The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway(SSP) scenarios for the near,middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal:(1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR,FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI-ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau.(2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large.(3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future.

关键词： Tibetan Plateau CMIP6 models diurnal temperature range model assessment historical period future projection

Large Eddy Simulation of Vertical Structure and Size Density of Deep Layer Clouds

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Advances in Atmospheric Sciences 2024年第8期41卷 1629-1642,1668-1670页

作者： Bangjun CAO xianyu YANG Jun WEN Qin HU Ziyuan ZHU School of Atmospheric Sciences Chengdu University of Information TechnologyChengdu 610225China Institute for Geophysics and Meteorology University of CologneCologne 50923Germany

In a convective scheme featuring a discretized cloud size density, the assumed lateral mixing rate is inversely proportional to the exponential coefficient of plume size. This follows a typical assumption of-1, but it has unveiled inherent uncertainties, especially for deep layer clouds. Addressing this knowledge gap, we conducted comprehensive large eddy simulations and comparative analyses focused on terrestrial regions. Our investigation revealed that cloud formation adheres to the tenets of Bernoulli trials, illustrating power-law scaling that remains consistent regardless of the inherent deep layer cloud attributes existing between cloud size and the number of clouds. This scaling paradigm encompasses liquid, ice, and mixed phases in deep layer clouds. The exponent characterizing the interplay between cloud scale and number in the deep layer cloud, specifically for liquid, ice, or mixed-phase clouds, resembles that of shallow convection,but converges closely to zero. This convergence signifies a propensity for diminished cloud numbers and sizes within deep layer clouds. Notably, the infusion of abundant moisture and the release of latent heat by condensation within the lower atmospheric strata make substantial contributions. However, this role in ice phase formation is limited. The emergence of liquid and ice phases in deep layer clouds is facilitated by the latent heat and influenced by the wind shear inherent in the middle levels. These interrelationships hold potential applications in formulating parameterizations and post-processing model outcomes.

关键词： deep layer cloud cloud spatial structure cloud size density large eddy simulation

Poly(ferulic acid)nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages

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Chinese Chemical Letters 2024年第9期35卷 289-295页

作者： Weijian Zhang xianyu Deng Liying Wang Jian Wang Xiuting Guo Lianggui Huang Xinyi Wang Jun Wu Linjia Jiang Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Otolaryngology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hematology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of Pediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SAR 999077China

Macrophages,as a subset of innate immune cells,play a pivotal role in the initiation,maintenance,and resolution of inflammatory responses during tissue damage repair,defense against infections,and tumor ***,the mechanisms by which macrophages regulate inflammation in acute myeloid leukemia(AML)and their involvement in the chemotherapeutic effect remain *** this study,we have identified that AML cells stimulate macrophage expansion by activating the colony-stimulating factor 1 receptor(CSF1R)*** expanded macrophages activate nuclear factor kappa-B(NFκB)to induce the expression of inflammatory factors,thereby maintaining leukemic cell quiescence and promoting cell survival following ***,we have successfully utilized a poly(ferulic acid)nanocarrier to selectively target macrophages for inhibiting the NFκB-mediated inflammation,ultimately enhancing chemotherapy efficacy against *** together,our findings highlight the crucial role of macrophage-induced inflammation in conferring chemoresistance to AML,and demonstrate the potential of a targeted nanocarrier specifically designed for inflammatory macrophages to improve the AML chemotherapeutic outcomes.

关键词： Acute myeloid leukemia Chemoresistance Macrophage Inflammation NFκB

Development of a rapid and efficient system for CR genes identification based on hairy root transformation in Brassicaceae

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Horticultural Plant Journal 2024年第4期10卷 1049-1060页

作者： Wenlin Yu Lu Yang Yuanyuan Xiang Rongde Li Xueqing Zhou Longcai Gan xianyu Xiang Yunyun Zhang Lei Yuan Yanqing Luo Genze Li Youning Wang Yinhua Chen Peng Chen Chunyu Zhang National Key Laboratory of Crop Genetic Improvement and College of Plant Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China National Key Laboratory for Tropical Crop Breeding Sanya Nanfan Research InstituteHainan UniversitySanyaHainan 572025China National Agro-Tech Extension and Service Center Beijing 100125China Industrial Crops Research Institute Yunnan Academy of Agricultural SciencesKunmingYunnan 650221China College ofAgronomy NorthwestA&F UniversityYanglingShaanxi712100China

Many economically important crops and vegetables belonging to the cruciferous family are heavily endangered by clubroot disease caused by Plasmodiophora brassicae *** of clubroot resistant cultivars based on mapping and cloning of resistant genes is commonly regarded as the most cost-effective and efficient way to fight against this *** traditional way of R gene functional validation requires stable transformation that is both time-and *** this study,a rapid and efficient hairy-root transgenic protocol mediated by Agrobacterium rhizogenes was *** transformation positive rate was over 80%in Brassica napus showed by GUS reporter gene and this transformation only took 1/6 of the time compared with stable *** system was applicable to different *** varieties and other cruciferous crops including Brassica rapa and Brassica *** particular,two known CR genes,CRA3.7.1 and CRA8.2.4 were used respectively,as example to show that the system works well for CR gene study combined with subsequent *** infection in *** importantly,it works both in over-expression that led to disease resistance,as well as in RNAi which led to disease susceptible ***,this system can be used in batch-wise identification of CR genes,and also offered the possibility of manipulating key genes within the *** genome that could improve our knowledge on host-pathogen interaction.

关键词： Brassicaceae Agrobacterium rhizogenes Hairy root transformation Clubroot Gene function

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无人机通信中的资源分配及部署位置联合优化

西南交通大学学报 2024年第4期59卷 917-924页

作者：张先玉陈勇张余杨华国防科技大学第六十三研究所江苏南京210003 解放军75841部队湖南长沙410000 陆军工程大学通信工程学院江苏南京210003 军事科学院战争研究院北京100091

为提升基于正交频分多址接入模式无人机辅助无线通信系统的网络性能,首先,以提升用户的公平性为系统方案设计指标,将包括子信道分配、调制模式选择、功率分配等通信资源和无人机位置联合建模为一个混合整数非线性优化问题;进一步,利用... 详细信息

为提升基于正交频分多址接入模式无人机辅助无线通信系统的网络性能,首先,以提升用户的公平性为系统方案设计指标,将包括子信道分配、调制模式选择、功率分配等通信资源和无人机位置联合建模为一个混合整数非线性优化问题;进一步,利用迭代优化的方式解决变量耦合性及非凸性等问题,将最大-最小问题转换为两个子问题:子信道分配和调制方式选择联合优化、无人机位置和子信道功率联合优化;然后,通过适当变换将子信道分配和调制方式选择联合优化建模为0-1线性优化问题进行求解,而无人机位置和子信道功率联合优化建模为凸优化问题求解;最后,进行实验仿真验证.研究结果表明,所提联合优化算法相比基本方案可有效提升网络用户的公平性.

关键词：无人机正交频分多址子信道分配功率控制调制模式混合整数非线性规划

2016年冬季四川盆地一次重度灰霾事件形成机制研究

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高原气象 2024年第3期43卷 775-789页

作者：任鑫冰杨显玉文军王式功成都信息工程大学大气科学学院/高原大气与环境四川省重点实验室四川成都610225 成都平原城市气象与环境四川省野外科学观测研究站四川成都610225 中国科学院大气物理研究所大气边界层物理和大气化学国家重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049

深入理解重度灰霾污染事件的形成和演化机制对于区域尺度空气质量的管控以及霾污染防治政策的制定具有重要的意义。本文应用中尺度气象模式WRF和区域空气质量模型CMAQ,结合实际观测数据,研究了2016年12月23日至2017年1月7日发生在四川... 详细信息

深入理解重度灰霾污染事件的形成和演化机制对于区域尺度空气质量的管控以及霾污染防治政策的制定具有重要的意义。本文应用中尺度气象模式WRF和区域空气质量模型CMAQ,结合实际观测数据,研究了2016年12月23日至2017年1月7日发生在四川盆地成都地区的一次重度灰霾事件。主要分析了在此污染期间气象要素场的时间变化,PM_(2.5)浓度和通风系数的时空变化,量化了各个物理化学过程对PM_(2.5)的相对贡献以及污染源区的分布,以研究此次重污染霾事件的形成和演化机制。研究表明:(1)霾事件期间低温和低风速的环境条件为污染物的积累创造了有利条件。(2)盆地北侧的偏北气流和南侧的偏西南气流以及较低的通风系数(大气的湍流扩散能力弱)是污染物积累的主要原因,成都地区PM_(2.5)浓度在东北气流的作用下达到峰值。污染物的消散主要是因为偏北气流的加强和较高的通风系数(大气的湍流扩散能力强)。(3)此次霾事件中气溶胶过程和排放源的正贡献加强,PM_(2.5)的增加主要在夜间(平流过程和扩散过程的负贡献减弱)且增加幅度更大,使得PM_(2.5)总体上逐渐增加。(4)PSCF和CWT分析表明,在此次霾事件期间,致使成都地区PM_(2.5)浓度升高的主要气流为其东北方向和西南方向的气流,潜在的污染源区在总体上呈东北-西南向的分布状态。

关键词：霾事件 CMAQ PM_(2.5) 成都四川盆地

氯化胆碱/乳酸/愈创木酚三元共熔溶剂提取灵芝多糖的工艺及其抗氧化活性研究

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食品工业科技 2024年第14期45卷 34-41页

作者：何仙玉李镕基李小艳刘贵江永州师范高等专科学校湖南永州425100 北京化工大学生命科学与技术学院北京100029

本研究采用氯化胆碱/乳酸/愈创木酚三元共熔溶剂(DES)来提取灵芝多糖(GLPs),优化DES溶剂提取灵芝多糖的工艺参数,采用傅里叶变换红外光谱(Fourier Transform Infrared Spectroscopy,FT-IR)和凝胶渗透色谱(Gel Permeation Chromatography,GPC)对GLPs结构进行了表征,并研究其体外抗氧化活性,最后,采用密度泛函理论初步研究了DES提取GLPs的分子机制。结果表明,在含水量为50%、提取温度为80℃、提取时间为1 h、料液质量体积比为1:30 g/mL的条件下,GLPs得率达9.20%±0.27%。FT-IR和GPC分析表明,4000~500 cm-1区域GLPs具有典型的多糖结构,GLPs的数均分子量为8057 Da,多分散系数为1.6。体外抗氧化活性测试显示,当GLPs质量浓度为5 mg/mL时,其总还原力为0.67±0.04。此外,GLPs对DPPH、OH和ABTS+自由基的清除能力的IC50值分别为2.366、6.179和2.440 mg/mL。密度泛函理论模拟分析表明,DES与葡萄糖之间的结合能为65.29 kcal/mol,远高于水与葡萄糖之间的结合能(20.38 kcal/mol),DES提取多糖是通过三重氢键相互作用来实现的。研究成果从分子水平上阐明了DES提取GLPs效果优于传统热水提取方法的内在机制。

关键词：深共熔溶剂氯化胆碱/乳酸/愈创木酚灵芝多糖抗氧化活性密度泛函理论

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基于SciBERT-BiLSTM-CRF-wordMixup的软件实体识别研究

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现代情报 2024年第10期44卷 75-85页

作者：潘雪莲钱雨菲王宪雨南京大学信息管理学院江苏南京210023

[目的/意义]软件在现代科学研究中发挥着重要作用,高效识别学术文献中的软件实体对深入认识软件的学术价值、促进软件可持续发展和学术生态体系均衡发展具有重要意义。[方法/过程]本研究首先对软件实体进行定义;然后基于小型知识库的程... 详细信息

[目的/意义]软件在现代科学研究中发挥着重要作用,高效识别学术文献中的软件实体对深入认识软件的学术价值、促进软件可持续发展和学术生态体系均衡发展具有重要意义。[方法/过程]本研究首先对软件实体进行定义;然后基于小型知识库的程序辅助标注方案,构建软件实体识别领域语料库;在此基础上,提出改进的SciBERT-BiLSTM-CRF-wordMixup模型并对该模型的识别效果进行评估。[结果/结论]实验结果显示,本研究提出的改进模型SciBERT-BiLSTM-CRF-wordMixup在软件实体识别任务中表现最优,其整体F1值达到87.5%,说明该模型能够有效地从学术论文文本中识别出软件及其相关信息实体。

关键词：软件实体识别命名实体识别深度学习数据增强 SciBERT

深绿色、青白色和粉色印章石材料的宝石学和矿物学特征

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宝石和宝石学杂志（中英文） 2024年第3期26卷 21-29页

作者：杨天畅徐娅芬刘衔宇上海建桥学院珠宝学院上海201306

近年来,我国珠宝市场上各类印章石材料层出不穷,有些被当作寿山石或青田石高价售卖。选取深绿色、青白色和粉色三种颜色的印章石材料作为研究对象,采用常规宝石学测试仪器、傅里叶变换红外光谱仪、紫外-可见光分光光度计、共聚焦激光显... 详细信息

近年来,我国珠宝市场上各类印章石材料层出不穷,有些被当作寿山石或青田石高价售卖。选取深绿色、青白色和粉色三种颜色的印章石材料作为研究对象,采用常规宝石学测试仪器、傅里叶变换红外光谱仪、紫外-可见光分光光度计、共聚焦激光显微拉曼光谱仪、X射线粉末衍射仪、电感耦合等离子体质谱仪以及扫描电子显微镜等测试仪器对其宝石学特征、矿物组成、化学成分和形貌特征进行分析。结果表明,三种颜色印章石样品中的矿物均呈薄片状不定向分布,宝石学特征和谱学特征因其所含矿物种类的不同也存在一定差异。深绿色印章石样品主要含85%的金云母(其衍射特征峰为1.001 9、0.502 3、0.335 3、0.201 3 nm)和14.1%的滑石(其衍射特征峰0.932 0、0.458 1、0.311 2、0.2916、0.261 4、0.167 4 nm);青白色印章石样品主要含斜绿泥石(其衍射特征峰1.419 9、0.710 9、0.473 6、0.459 1、0.354 8、0.284 1、0.253 6 nm);粉色印章石样品含97.6%的滑石和少量的蛇纹石(其衍射特征峰0.724 9、0.360 7、0.233 9、0.209 8 nm);结合化学成分和紫外-可见光谱分析其颜色成因发现,深绿色印章石样品的致色成因与Fe元素有关,是Fe^(3+)d轨道的^(6)A_(1)→^(4)T_(2)(D)电子跃迁和Fe^(2+)-Fe^(3+)之间的电荷迁移的共同作用,青白色印章石的致色成因主要与Fe^(2+)有关,Fe^(2+)-Ti^(4+)电荷迁移可能起到少部分贡献作用。

关键词：印章石矿物组成形貌特征化学成分谱学特征

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