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Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy

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Bioactive Materials 2021年第12期6卷 4389-4401页

作者： xianwen wang Qianqian Shi Zhengbao Zha Dongdong Zhu Lirong Zheng Luoxiang Shi xianwen Wei Lian Lian Konglin Wu Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou215123PR China School of Food and Biological Engineering Hefei University of TechnologyHefei230009PR China Institute of Clean Energy and Advanced Nanocatalysis School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan243002PR China Beijing Synchrotron Radiation Facility(NSRF) Institute of High Energy PhysicsChinese Academy of ScienceBeijing100049China Department of Oncology Suzhou Xiangcheng People’s HospitalSuzhou215131China

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological ***,their inherent low catalytic activity limits their antibacterial ***,Cu single-atom sites/N doped porous carbon(Cu SASs/NPC)is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis(PEAP)*** SASs/NPC have stronger peroxidase-like catalytic activity,glutathione(GSH)-depleting function,and photothermal property compared with non-Cu-doped NPC,indicating that Cu doping significantly improves the catalytic performance of *** SASs/NPC can effectively induce peroxidase-like activity in the presence of H2O2,thereby generating a large amount of hydroxyl radicals(•OH),which have a certain killing effect on bacteria and make bacteria more susceptible to *** introduction of near-infrared(NIR)light can generate hyperthermia to fight bacteria,and enhance the peroxidase-like catalytic activity,thereby generating additional•OH to destroy ***,Cu SASs/NPC can act as GSH peroxidase(GSH-Px)-like nanozymes,which can deplete GSH in bacteria,thereby significantly improving the sterilization ***-catalytic synergistic antibacterial strategy produces almost 100%antibacterial efficiency against Escherichia coli(***)and methicillin-resistant Staphylococcus aureus(MRSA).In vivo experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse ***,our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts.

关键词： Copper single-atom catalysts Nanozymes Photothermal therapy Antibacterial Catalytic therapy

Biomimetic copper single-atom nanozyme system for self-enhanced nanocatalytic tumor therapy

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Nano Research 2022年第8期15卷 7320-7328页

作者： Daoming Zhu Ruoyu Ling Hao Chen Meng Lyu Haisheng Qian Konglin Wu Guoxin Li xianwen wang Department of General Surgery&Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang HospitalThe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Medical UniversityHefei 230032China Institute of Clean Energy and Advanced Nanocatalysis School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China

Single-atom nanozymes(SAZs)with peroxidase(POD)-like activity have good nanocatalytic tumor therapy(NCT)***,insufficient hydrogen peroxide(H2O2)and hydrogen ions in the cells limit their therapeutic ***,to overcome these limitations,a biomimetic single-atom nanozyme system was developed for self-enhanced *** used a previously described approach to produce platelet membrane *** a high-temperature carbonization approach,copper SAZs with excellent POD-like activity were successfully ***,through physical extrusion,a proton pump inhibitor(PPI;pantoprazole sodium)and the SAZs were combined with platelet membrane vesicles to create *** in vivo and in vitro,PPS displayed good tumor-targeting and accumulation *** were able to simultaneously regulate the hydrogen ion,glutathione(GSH),and H2O2 content in tumor cells,significantly improve the catalytic ability of SAZs,and achieve self-enhanced *** in vivo studies showed that PPS had a tumor suppression rate of>90%.PPS also limited the synthesis of GSH in cells at the source;thus,glutamine metabolism therapy and NCT were integrated into an innovative method,which provides a novel strategy for multimodal tumor therapy.

关键词： single-atom nanozymes biomimetic system self-enhanced nanocatalytic tumor therapy glutamine metabolism inhibition glutathione(GSH)depletion

Platelet membrane-coated C-TiO_(2) hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy

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Nano Research 2023年第1期16卷 782-791页

作者： Weihong Guo Tao wang Chunyu Huang Shipeng Ning Qinglong Guo Wei Zhang Huawei Yang Daoming Zhu Qinqin Huang Haisheng Qian xianwen wang Department of Molecular Pathology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450014China Department of Orthopaedics The Second Hospital of Anhui Medical UniversityHefei 230601China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Medical UniversityHefei 230032China Department of General Surgery&Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang HospitalThe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515China Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Breast Surgery Guangxi Medical University Cancer HospitalNanning 530000China

The therapeutic efficiency of sonodynamic therapy(SDT)mainly depends on the presence of oxygen(O_(2))to generate harmful reactive oxygen species(ROS);thus,the hypoxic tumor microenvironment significantly limits the efficacy of ***,the development of oxygen-independent free radical generators and associated combination therapy tactics can be a promising field to facilitate the anticancer capability of *** this study,a biomimetic drug delivery system(C-TiO_(2)/AIPH@PM)composed of an alkyl-radical generator(2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride,AIPH)-loaded C-TiO_(2) hollow nanoshells(HNSs)as the inner cores,and a platelet membrane(PM)as the outer shells is successfully prepared for synergistic SDT and oxygen-independent alkyl-radical *** PM encapsulation can significantly prolong the blood circulation time of CTiO_(2)/AIPH@PM compared with C-TiO_(2)/AIPH while enabling C-TiO_(2)/AIPH@PM to achieve tumor targeting.C-TiO_(2)/AIPH@PM can efficiently produce ROS and alkyl radicals,which can achieve a more thorough tumor eradication regardless of the normoxic or hypoxic ***,the generation of these radicals improves the efficiency of *** addition,nitrogen(N_(2))produced due to the decomposition of AIPH enhances the acoustic cavitation effect and lowers the cavitation threshold,thereby enhancing the penetration of CTiO_(2)/AIPH@PM at the tumor *** in vitro and in vivo experiments demonstrate that CTiO_(2)/AIPH@PM possesses good biosafety,ultrasound imaging performance,and excellent anticancer *** study provides a new strategy to achieve oxygen-independent free radical production and enhance therapeutic efficacy by combining SDT and free radical therapy.

关键词： C-TiO_(2) sonodynamic therapy alkyl-radical therapy combination therapy biomimetic nanomaterials

Assessing the spread risk of COVID-19 associated with multi-mode transportation networks in China

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Fundamental Research 2023年第2期3卷 305-310页

作者： Xiao-Ke Xu Xiao Fan Liu Lin wang Ye Wu Xin Lu xianwen wang Sen Pei College of Information and Communication Engineering Dalian Minzu UniversityDalian 116600China Web Mining Laboratory Department of Media and CommunicationCity University of Hong KongHong Kong SARChina Department of Genetics University of CambridgeCambridge CB23EHUK School of Information Engineering Putian UniversityPutian 351100China School of Journalism and Communication Beijing Normal UniversityBeijing 100875China College of Systems Engineering National University of Defense TechnologyChangshaChina Department of Global Public Health Karolinska InstituteStockholmSweden WISE Lab Faculty of Humanities and Social SciencesDalian University of TechnologyDalian 116085China Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032USA

The spatial spread of COVID-19 during early 2020 in China was primarily driven by outbound travelers leaving the epicenter,Wuhan,Hubei *** studies focus on the influence of aggregated out-bound population flows originating from Wuhan;however,the impacts of different modes of transportation and the network structure of transportation systems on the early spread of COVID-19 in China are not well ***,we assess the roles of the road,railway,and air transportation networks in driving the spatial spread of COVID-19 in *** find that the short-range spread within Hubei province was dominated by ground traffic,notably,the railway *** contrast,long-range spread to cities in other provinces was mediated by multiple factors,including a higher risk of case importation associated with air transportation and a larger outbreak size in hub cities located at the center of transportation *** further show that,although the dissemination of SARS-CoV-2 across countries and continents is determined by the worldwide air transportation network,the early geographic dispersal of COVID-19 within China is better predicted by the railway *** the recent emergence of multiple more transmissible variants of SARS-CoV-2,our findings can support a better assessment of the spread risk of those variants and improve future pandemic preparedness and responses.

关键词： Complex network Human mobility COVID-19 Spatial spread Transportation networks

Scientific Value Weights more than Being Open or Toll Access:An analysis of the OA advantage in Nature and Science

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Journal of Data and Information Science 2021年第4期6卷 62-75页

作者： Howell Y.wang Shelia X.Wei Cong Cao xianwen wang Fred Y.Ye International Joint Informatics Laboratory&Jiangsu Key Laboratory of Data Engineering and Knowledge Service School of Information ManagementNanjing UniversityNanjing 210023China Nottingham University Business School China University of Nottingham Ningbo ChinaNingbo315100China WISE Lab. Dalian University of TechnologyDalian 116024China

Purpose:We attempt to find out whether OA or TA really affects the dissemination of scientific ***/methodology/approach:We design the indicators,hot-degree,and R-index to indicate a topic OA or TA ***,according to the OA classification of the Web of Science(WoS),we collect data from the WoS by downloading OA and TA articles,letters,and reviews published in Nature and Science during 2010–*** papers are divided into three broad disciplines,namely biomedicine,physics,and ***,taking a discipline in a journal and using the classical Latent Dirichlet Allocation(LDA)to cluster 100 topics of OA and TA papers respectively,we apply the Pearson correlation coefficient to match the topics of OA and TA,and calculate the hot-degree and R-index of every OA-TA topic ***,characteristics of the discipline can be *** qualitative comparison,we choose some high-quality papers which belong to Nature remarkable papers or Science breakthroughs,and analyze the relations between OA/TA and citation ***:The result shows that OA hot-degree in biomedicine is significantly greater than that of TA,but significantly less than that of TA in *** on the R-index,it is found that OA advantages exist in biomedicine and TA advantages do in ***,the dissemination of average scientific discoveries in all fields is not necessarily affected by OA or ***,OA promotes the spread of important scientific discoveries in high-quality *** limitations:We lost some citations by ignoring other open sources such as arXiv and *** limitation came from that Nature employs some strong measures for access-promoting subscription-based articles,on which the boundary between OA and TA became *** implications:It is useful to select hot topics in a set of publications by the hotdegree *** finding comprehensively reflects the differences of OA and TA in different disciplines,which is a u

关键词： Open access Toll access Scientific discovery Academic dissemination Data analysis

Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2298-2316页

作者： Jie Shan Xu Jin Cong Zhang Muchen Huang Jianghao Xing Qingrong Li Yuyu Cui Qiang Niu Xu Lin Chen xianwen wang Department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefei 230032China Division of Gastroenterology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China The Second Clinical Medical College Anhui Medical UniversityHefei 230022China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China College and Hospital of Stomatology Anhui Medical UniversityKey Lab.of Oral Diseases Research of Anhui ProvinceHefei 230032China

Bacterial infection hampers wound repair by impeding the healing ***,inflammation at the wound site triggers the production of reactive oxygen species(ROS),causing oxidative stress and damage to proteins and *** can lead to chronic wounds,posing severe ***,eliminating bacterial infection and reducing ROS levels are crucial for effective wound ***,possessing enzyme-like catalytic activity,can convert endogenous substances into highly toxic substances,such as ROS,to combat bacteria and biofilms without inducing drug ***,the current nanozyme model with single enzyme activity falls short of meeting the complex requirements of antimicrobial ***,developing nanozymes with multiple enzymatic activities is ***,we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles(Ru-PC NPs)with diverse enzymatic activities to aid wound healing and combat bacterial *** acidic conditions,due to their glutathione(GSH)depletion and peroxidase(POD)-like activity,Ru-PC NPs combined with H2O2 exhibit excellent antibacterial ***,in a neutral environment,the Ru-PC NPs,with catalase(CAT)activity,decompose H2O2 to O2,alleviating hypoxia and ensuring a sufficient oxygen ***,Ru-PC NPs possess exceptional antioxidant capacity through their superior superoxide dismutase(SOD)enzyme activity,effectively scavenging excess ROS and reactive nitrogen species(RNS)in a neutral *** maintains the balance of the antioxidant system and prevents ***-PC NPs also promote the polarization of macrophages from M1 to M2,facilitating wound *** importantly,Ru-PC NPs show good biosafety with negligible *** vivo wound infection models have confirmed the efficacy of Ru-PC NPs in inhibiting bacterial infection and promoting wound *** focus of this work highlights the quadruple enzymatic activity of Ru-PC NPs and its potential to reduce inf

关键词： Nanozymes Quadruple enzymatic activity Antibacterial therapy Wound therapy RNA-seqAnti-inflammatory Reactive oxygen species Reactive nitrogen species

Aspects of microstructure in low carbon steels produced by the CSP process

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Journal of University of Science and Technology Beijing 2003年第4期10卷 1-6页

作者： Delu Liu, Xiangdong Huo, Yuanli wang, and xianwen SunMaterials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China Univ Sci & Technol Beijing Mat Sci & Engn Sch Beijing 100083 Peoples R China

The solidification structure, microstructure evolution during rolling andprecipitates with nanometers in dimension of the low carbon steels produced by CSP process with thinslabs have been studied in recent years. Important differences in microstructure and mechanicalproperties between the CSP products and the conventional one were observed. These differences mayarise from the much rapider solidification rate and cooling rate after casting of the thin *** aspects of the microstructure for the low carbon steels of the CSP thin slabs are summarizedand compared with the conventional one.

关键词： low carbon steel CSP hot strip microstructure evolution grain refinement

Dynamic regulation of the wound repair process:achieving one-stop scar-free repair

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Biomaterials Translational 2024年第2期5卷 200-202页

作者： Min wang xianwen wang School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Medical UniversityHefeiAnhui ProvinceChina

At present,the clinical treatment of chronic refractory wounds still faces many challenges:on the one hand,the delivery efficiency of therapeutic drugs is seriously affected by physiological barriers such as bacterial membranes;on the other hand,how to dynamically deliver appropriate drugs at different stages of wound healing is also an important factor affecting wound healing.

关键词： wound drugs healing

The potential of three-dimensional printed stents in post-operative treatment of breast cancer

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Biomaterials Translational 2024年第3期5卷 331-333页

作者： Junjuan Fan Min wang xianwen wang Department of Pharmacy The Fourth Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina School of Biomedical Engineering Anhui Medical UniversityHefeiAnhui ProvinceChina

Breast cancer is among the most frequent cancers;it mostly strikes women and ranks second in female cancer fatality rates,behind only lung cancer.1 There is a need to create efficient treatments to eradicate leftover tumor cells because,although surgery has been the predominant clinical treatment technique for cancer,local tumor recurrence and metastasis may still occur following surgery.2 Typically prescribed as a neoadjuvant or auxiliary treatment to surgery,chemotherapy is a frequent and successful method of treating many cancer types.3 Systemic chemotherapy for breast cancer typically involves high dosages,which is associated with unpleasant side effects that are particularly noticeable,and chemotherapy treatment efficacy is *** resistance is easy to relapse.4 Based on patient requirements,local chemotherapy can help reconstruct after breast cancer surgery,which is one area where systemic chemotherapy falls *** biomedical area,particularly medication distribution,has benefited greatly from the advancements made possible by three-dimensional(3D)printing technology,a relatively new manufacturing technique.

关键词： dosage treatment prescribed