Platelet membrane-coated C-TiO_(2) hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy
作者机构：Department of Molecular PathologyThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450014China Department of OrthopaedicsThe Second Hospital of Anhui Medical UniversityHefei 230601China School of Biomedical EngineeringResearch and Engineering Center of Biomedical MaterialsAnhui Medical UniversityHefei 230032China Department of General Surgery&Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalThe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515China Department of Radiation and Medical OncologyHubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Breast SurgeryGuangxi Medical University Cancer HospitalNanning 530000China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第1期
页 面：782-791页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the Research fund of Anhui Institute of Translation Medicine(No.2021zhyx-C49) the Foundation of Anhui Medical University(No.2021xkj030) the Anhui Provincial Natural Science Foundation(No.2208085QC81) the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(No.2021xkjT028) Grants for Scientific Research of BSKY from Anhui Medical University(No.1406012201)
主 题：C-TiO_(2) sonodynamic therapy alkyl-radical therapy combination therapy biomimetic nanomaterials
摘 要：The therapeutic efficiency of sonodynamic therapy(SDT)mainly depends on the presence of oxygen(O_(2))to generate harmful reactive oxygen species(ROS);thus,the hypoxic tumor microenvironment significantly limits the efficacy of ***,the development of oxygen-independent free radical generators and associated combination therapy tactics can be a promising field to facilitate the anticancer capability of *** this study,a biomimetic drug delivery system(C-TiO_(2)/AIPH@PM)composed of an alkyl-radical generator(2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride,AIPH)-loaded C-TiO_(2) hollow nanoshells(HNSs)as the inner cores,and a platelet membrane(PM)as the outer shells is successfully prepared for synergistic SDT and oxygen-independent alkyl-radical *** PM encapsulation can significantly prolong the blood circulation time of CTiO_(2)/AIPH@PM compared with C-TiO_(2)/AIPH while enabling C-TiO_(2)/AIPH@PM to achieve tumor targeting.C-TiO_(2)/AIPH@PM can efficiently produce ROS and alkyl radicals,which can achieve a more thorough tumor eradication regardless of the normoxic or hypoxic ***,the generation of these radicals improves the efficiency of *** addition,nitrogen(N_(2))produced due to the decomposition of AIPH enhances the acoustic cavitation effect and lowers the cavitation threshold,thereby enhancing the penetration of CTiO_(2)/AIPH@PM at the tumor *** in vitro and in vivo experiments demonstrate that CTiO_(2)/AIPH@PM possesses good biosafety,ultrasound imaging performance,and excellent anticancer *** study provides a new strategy to achieve oxygen-independent free radical production and enhance therapeutic efficacy by combining SDT and free radical therapy.
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